Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN45_LEIBR

TriTrypDb:

LbrM.34.3720 , LBRM2903_340046700

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.565
CLV_NRD_NRD_1	288	290	PF00675	0.540
CLV_NRD_NRD_1	43	45	PF00675	0.531
CLV_NRD_NRD_1	88	90	PF00675	0.458
CLV_NRD_NRD_1	92	94	PF00675	0.458
CLV_NRD_NRD_1	95	97	PF00675	0.458
CLV_PCSK_FUR_1	89	93	PF00082	0.521
CLV_PCSK_KEX2_1	260	262	PF00082	0.561
CLV_PCSK_KEX2_1	288	290	PF00082	0.467
CLV_PCSK_KEX2_1	42	44	PF00082	0.384
CLV_PCSK_KEX2_1	76	78	PF00082	0.465
CLV_PCSK_KEX2_1	88	90	PF00082	0.444
CLV_PCSK_KEX2_1	91	93	PF00082	0.461
CLV_PCSK_KEX2_1	95	97	PF00082	0.460
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.554
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.449
CLV_PCSK_PC7_1	284	290	PF00082	0.534
CLV_PCSK_PC7_1	88	94	PF00082	0.531
CLV_PCSK_SKI1_1	96	100	PF00082	0.489
DEG_APCC_DBOX_1	260	268	PF00400	0.507
DEG_SCF_FBW7_2	337	342	PF00400	0.494
DEG_SPOP_SBC_1	35	39	PF00917	0.417
DOC_CDC14_PxL_1	192	200	PF14671	0.442
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.495
DOC_PP1_RVXF_1	186	193	PF00149	0.359
DOC_PP2B_LxvP_1	245	248	PF13499	0.461
DOC_PP2B_LxvP_1	358	361	PF13499	0.448
DOC_PP4_FxxP_1	172	175	PF00568	0.386
DOC_PP4_FxxP_1	376	379	PF00568	0.386
DOC_USP7_MATH_1	221	225	PF00917	0.691
DOC_USP7_MATH_1	305	309	PF00917	0.697
DOC_USP7_MATH_1	332	336	PF00917	0.291
DOC_USP7_MATH_1	35	39	PF00917	0.536
DOC_USP7_UBL2_3	57	61	PF12436	0.561
DOC_WW_Pin1_4	156	161	PF00397	0.290
DOC_WW_Pin1_4	238	243	PF00397	0.400
DOC_WW_Pin1_4	311	316	PF00397	0.596
DOC_WW_Pin1_4	335	340	PF00397	0.519
DOC_WW_Pin1_4	375	380	PF00397	0.411
LIG_14-3-3_CanoR_1	132	142	PF00244	0.612
LIG_14-3-3_CanoR_1	253	259	PF00244	0.494
LIG_14-3-3_CanoR_1	365	371	PF00244	0.484
LIG_14-3-3_CanoR_1	42	47	PF00244	0.585
LIG_AP2alpha_2	64	66	PF02296	0.424
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.350
LIG_Clathr_ClatBox_1	145	149	PF01394	0.307
LIG_deltaCOP1_diTrp_1	270	276	PF00928	0.587
LIG_DLG_GKlike_1	42	49	PF00625	0.589
LIG_FHA_1	133	139	PF00498	0.557
LIG_FHA_1	311	317	PF00498	0.616
LIG_FHA_1	319	325	PF00498	0.445
LIG_HCF-1_HBM_1	13	16	PF13415	0.441
LIG_Integrin_isoDGR_2	103	105	PF01839	0.482
LIG_LIR_Apic_2	169	175	PF02991	0.409
LIG_LIR_Apic_2	200	205	PF02991	0.417
LIG_LIR_Apic_2	373	379	PF02991	0.391
LIG_LIR_Gen_1	13	23	PF02991	0.395
LIG_LIR_Gen_1	45	52	PF02991	0.576
LIG_LIR_Nem_3	13	19	PF02991	0.386
LIG_LIR_Nem_3	270	276	PF02991	0.589
LIG_LIR_Nem_3	45	49	PF02991	0.562
LIG_LIR_Nem_3	64	70	PF02991	0.355
LIG_SH2_CRK	16	20	PF00017	0.361
LIG_SH2_CRK	202	206	PF00017	0.409
LIG_SH2_CRK	208	212	PF00017	0.383
LIG_SH2_CRK	67	71	PF00017	0.408
LIG_SH2_NCK_1	16	20	PF00017	0.482
LIG_SH2_NCK_1	62	66	PF00017	0.429
LIG_SH2_SRC	16	19	PF00017	0.446
LIG_SH2_SRC	263	266	PF00017	0.514
LIG_SH2_STAT5	240	243	PF00017	0.441
LIG_SH2_STAT5	263	266	PF00017	0.439
LIG_SH2_STAT5	62	65	PF00017	0.540
LIG_SH2_STAT5	79	82	PF00017	0.469
LIG_SH3_3	183	189	PF00018	0.415
LIG_SH3_3	272	278	PF00018	0.495
LIG_SH3_3	321	327	PF00018	0.349
LIG_SH3_3	377	383	PF00018	0.358
LIG_SH3_4	174	181	PF00018	0.494
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.391
LIG_SUMO_SIM_par_1	320	326	PF11976	0.404
LIG_TRAF2_1	111	114	PF00917	0.330
LIG_TYR_ITIM	206	211	PF00017	0.480
LIG_UBA3_1	70	76	PF00899	0.619
LIG_WRPW_2	273	276	PF00400	0.573
LIG_WW_1	383	386	PF00397	0.413
MOD_CK1_1	108	114	PF00069	0.462
MOD_CK1_1	308	314	PF00069	0.641
MOD_CK1_1	335	341	PF00069	0.294
MOD_CK2_1	108	114	PF00069	0.367
MOD_CK2_1	23	29	PF00069	0.463
MOD_GlcNHglycan	122	125	PF01048	0.546
MOD_GlcNHglycan	129	132	PF01048	0.501
MOD_GlcNHglycan	307	310	PF01048	0.698
MOD_GlcNHglycan	32	35	PF01048	0.521
MOD_GSK3_1	116	123	PF00069	0.468
MOD_GSK3_1	133	140	PF00069	0.581
MOD_GSK3_1	236	243	PF00069	0.474
MOD_GSK3_1	30	37	PF00069	0.413
MOD_GSK3_1	304	311	PF00069	0.578
MOD_GSK3_1	51	58	PF00069	0.557
MOD_N-GLC_1	335	340	PF02516	0.382
MOD_NEK2_1	23	28	PF00069	0.549
MOD_NEK2_1	252	257	PF00069	0.385
MOD_NEK2_1	292	297	PF00069	0.425
MOD_NEK2_1	36	41	PF00069	0.441
MOD_NEK2_1	55	60	PF00069	0.654
MOD_NEK2_2	134	139	PF00069	0.513
MOD_NEK2_2	263	268	PF00069	0.513
MOD_PIKK_1	174	180	PF00454	0.490
MOD_PIKK_1	252	258	PF00454	0.455
MOD_PKA_1	42	48	PF00069	0.393
MOD_PKA_2	166	172	PF00069	0.346
MOD_PKA_2	221	227	PF00069	0.652
MOD_PKA_2	252	258	PF00069	0.478
MOD_PKA_2	42	48	PF00069	0.623
MOD_PKB_1	289	297	PF00069	0.311
MOD_Plk_1	228	234	PF00069	0.523
MOD_Plk_1	292	298	PF00069	0.416
MOD_Plk_4	23	29	PF00069	0.424
MOD_Plk_4	231	237	PF00069	0.367
MOD_Plk_4	292	298	PF00069	0.416
MOD_Plk_4	318	324	PF00069	0.378
MOD_Plk_4	359	365	PF00069	0.382
MOD_Plk_4	51	57	PF00069	0.522
MOD_ProDKin_1	156	162	PF00069	0.284
MOD_ProDKin_1	238	244	PF00069	0.410
MOD_ProDKin_1	311	317	PF00069	0.575
MOD_ProDKin_1	335	341	PF00069	0.519
MOD_ProDKin_1	375	381	PF00069	0.404
TRG_DiLeu_BaEn_4	113	119	PF01217	0.341
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.481
TRG_ENDOCYTIC_2	16	19	PF00928	0.341
TRG_ENDOCYTIC_2	208	211	PF00928	0.478
TRG_ENDOCYTIC_2	67	70	PF00928	0.403
TRG_ENDOCYTIC_2	84	87	PF00928	0.561
TRG_ER_diArg_1	259	261	PF00400	0.544
TRG_ER_diArg_1	287	289	PF00400	0.536
TRG_ER_diArg_1	42	44	PF00400	0.422
TRG_ER_diArg_1	87	89	PF00400	0.520
TRG_ER_diArg_1	92	95	PF00400	0.492
TRG_NLS_Bipartite_1	76	95	PF00514	0.510
TRG_NLS_MonoExtC_3	90	95	PF00514	0.573
TRG_NLS_MonoExtN_4	88	95	PF00514	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF2	Leptomonas seymouri	71%	100%
A0A0S4J0E9	Bodo saltans	34%	96%
A0A1X0P564	Trypanosomatidae	49%	100%
A0A3Q8IJC4	Leishmania donovani	87%	100%
A0A3R7R9I8	Trypanosoma rangeli	49%	100%
A4IBR3	Leishmania infantum	87%	100%
C9ZYW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AFJ8	Leishmania major	87%	100%
E9B6Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BCU7	Trypanosoma cruzi	48%	100%