Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN43_LEIBR

TriTrypDb:

LbrM.34.3700 , LBRM2903_340046500

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.619
CLV_NRD_NRD_1	184	186	PF00675	0.543
CLV_NRD_NRD_1	258	260	PF00675	0.500
CLV_NRD_NRD_1	276	278	PF00675	0.492
CLV_NRD_NRD_1	345	347	PF00675	0.503
CLV_NRD_NRD_1	431	433	PF00675	0.714
CLV_NRD_NRD_1	85	87	PF00675	0.474
CLV_PCSK_KEX2_1	128	130	PF00082	0.691
CLV_PCSK_KEX2_1	184	186	PF00082	0.546
CLV_PCSK_KEX2_1	258	260	PF00082	0.500
CLV_PCSK_KEX2_1	276	278	PF00082	0.492
CLV_PCSK_KEX2_1	394	396	PF00082	0.599
CLV_PCSK_KEX2_1	84	86	PF00082	0.472
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.691
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.599
CLV_PCSK_SKI1_1	169	173	PF00082	0.528
CLV_PCSK_SKI1_1	211	215	PF00082	0.376
CLV_PCSK_SKI1_1	243	247	PF00082	0.514
CLV_PCSK_SKI1_1	300	304	PF00082	0.618
CLV_PCSK_SKI1_1	347	351	PF00082	0.512
CLV_PCSK_SKI1_1	364	368	PF00082	0.424
CLV_PCSK_SKI1_1	391	395	PF00082	0.617
CLV_Separin_Metazoa	338	342	PF03568	0.565
DEG_Nend_UBRbox_2	1	3	PF02207	0.726
DOC_MAPK_gen_1	166	174	PF00069	0.497
DOC_MAPK_gen_1	184	191	PF00069	0.482
DOC_MAPK_gen_1	346	352	PF00069	0.495
DOC_MAPK_MEF2A_6	166	174	PF00069	0.471
DOC_PP1_RVXF_1	127	134	PF00149	0.670
DOC_USP7_MATH_1	305	309	PF00917	0.609
DOC_USP7_MATH_1	413	417	PF00917	0.625
LIG_14-3-3_CanoR_1	16	24	PF00244	0.371
LIG_14-3-3_CanoR_1	184	191	PF00244	0.514
LIG_14-3-3_CanoR_1	211	219	PF00244	0.517
LIG_14-3-3_CanoR_1	276	282	PF00244	0.541
LIG_14-3-3_CanoR_1	412	422	PF00244	0.514
LIG_14-3-3_CanoR_1	432	438	PF00244	0.414
LIG_Actin_WH2_2	66	83	PF00022	0.490
LIG_APCC_ABBA_1	318	323	PF00400	0.405
LIG_FHA_1	16	22	PF00498	0.609
LIG_FHA_1	280	286	PF00498	0.596
LIG_FHA_1	327	333	PF00498	0.485
LIG_FHA_1	403	409	PF00498	0.529
LIG_FHA_2	223	229	PF00498	0.596
LIG_FHA_2	31	37	PF00498	0.539
LIG_LIR_Gen_1	130	141	PF02991	0.600
LIG_LIR_Gen_1	186	194	PF02991	0.596
LIG_LIR_Gen_1	374	382	PF02991	0.363
LIG_LIR_Nem_3	130	136	PF02991	0.615
LIG_LIR_Nem_3	186	191	PF02991	0.553
LIG_LIR_Nem_3	328	333	PF02991	0.465
LIG_LIR_Nem_3	374	378	PF02991	0.357
LIG_SH2_CRK	188	192	PF00017	0.532
LIG_SH2_NCK_1	54	58	PF00017	0.659
LIG_SH2_STAP1	24	28	PF00017	0.492
LIG_SH2_STAT5	368	371	PF00017	0.419
LIG_SH2_STAT5	430	433	PF00017	0.491
LIG_SUMO_SIM_par_1	170	175	PF11976	0.580
LIG_SUMO_SIM_par_1	348	353	PF11976	0.505
LIG_TRAF2_1	308	311	PF00917	0.603
LIG_TRAF2_1	95	98	PF00917	0.582
LIG_UBA3_1	349	354	PF00899	0.515
LIG_WRC_WIRS_1	327	332	PF05994	0.627
LIG_WW_1	427	430	PF00397	0.462
MOD_CK1_1	152	158	PF00069	0.594
MOD_CK1_1	160	166	PF00069	0.604
MOD_CK1_1	227	233	PF00069	0.550
MOD_CK1_1	30	36	PF00069	0.491
MOD_CK1_1	360	366	PF00069	0.458
MOD_CK1_1	385	391	PF00069	0.372
MOD_CK2_1	108	114	PF00069	0.622
MOD_CK2_1	131	137	PF00069	0.554
MOD_CK2_1	222	228	PF00069	0.525
MOD_CK2_1	238	244	PF00069	0.608
MOD_CK2_1	281	287	PF00069	0.532
MOD_CK2_1	30	36	PF00069	0.463
MOD_CK2_1	305	311	PF00069	0.619
MOD_CK2_1	411	417	PF00069	0.401
MOD_Cter_Amidation	126	129	PF01082	0.682
MOD_GlcNHglycan	174	177	PF01048	0.601
MOD_GlcNHglycan	300	303	PF01048	0.570
MOD_GlcNHglycan	305	308	PF01048	0.573
MOD_GlcNHglycan	384	387	PF01048	0.627
MOD_GSK3_1	152	159	PF00069	0.612
MOD_GSK3_1	222	229	PF00069	0.609
MOD_GSK3_1	277	284	PF00069	0.510
MOD_GSK3_1	30	37	PF00069	0.509
MOD_GSK3_1	353	360	PF00069	0.569
MOD_GSK3_1	378	385	PF00069	0.567
MOD_GSK3_1	418	425	PF00069	0.567
MOD_N-GLC_1	402	407	PF02516	0.368
MOD_N-GLC_2	193	195	PF02516	0.611
MOD_N-GLC_2	322	324	PF02516	0.382
MOD_NEK2_1	108	113	PF00069	0.514
MOD_NEK2_1	119	124	PF00069	0.537
MOD_NEK2_1	172	177	PF00069	0.520
MOD_NEK2_1	339	344	PF00069	0.538
MOD_NEK2_1	378	383	PF00069	0.564
MOD_NEK2_1	411	416	PF00069	0.543
MOD_NEK2_1	418	423	PF00069	0.524
MOD_NEK2_2	326	331	PF00069	0.622
MOD_PIKK_1	131	137	PF00454	0.482
MOD_PIKK_1	15	21	PF00454	0.372
MOD_PKA_2	15	21	PF00069	0.634
MOD_PKA_2	183	189	PF00069	0.557
MOD_PKA_2	411	417	PF00069	0.602
MOD_PKA_2	418	424	PF00069	0.580
MOD_PKA_2	431	437	PF00069	0.412
MOD_Plk_1	149	155	PF00069	0.508
MOD_Plk_1	227	233	PF00069	0.614
MOD_Plk_1	378	384	PF00069	0.618
MOD_Plk_2-3	2	8	PF00069	0.624
MOD_Plk_2-3	34	40	PF00069	0.606
MOD_Plk_4	114	120	PF00069	0.569
MOD_Plk_4	227	233	PF00069	0.613
MOD_Plk_4	353	359	PF00069	0.592
MOD_Plk_4	426	432	PF00069	0.638
MOD_SUMO_for_1	165	168	PF00179	0.473
MOD_SUMO_rev_2	150	160	PF00179	0.541
MOD_SUMO_rev_2	247	256	PF00179	0.539
MOD_SUMO_rev_2	356	366	PF00179	0.498
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.513
TRG_ENDOCYTIC_2	188	191	PF00928	0.495
TRG_ER_diArg_1	276	278	PF00400	0.631
TRG_ER_diArg_1	83	86	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ51	Leptomonas seymouri	69%	100%
A0A0S4JDF0	Bodo saltans	37%	99%
A0A1X0P5H1	Trypanosomatidae	43%	100%
A0A3Q8IFE4	Leishmania donovani	81%	100%
A0A3R7N172	Trypanosoma rangeli	45%	100%
A4IBR1	Leishmania infantum	81%	100%
C9ZYW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFJ6	Leishmania major	81%	100%
E9B6Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5BXZ9	Trypanosoma cruzi	41%	100%