Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN42_LEIBR

TriTrypDb:

LbrM.34.3690 , LBRM2903_340046400

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HN42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.618
CLV_NRD_NRD_1	78	80	PF00675	0.678
CLV_PCSK_KEX2_1	130	132	PF00082	0.595
CLV_PCSK_KEX2_1	78	80	PF00082	0.716
CLV_PCSK_SKI1_1	118	122	PF00082	0.671
CLV_PCSK_SKI1_1	275	279	PF00082	0.565
CLV_PCSK_SKI1_1	283	287	PF00082	0.353
DEG_MDM2_SWIB_1	236	244	PF02201	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DEG_SCF_TRCP1_1	60	66	PF00400	0.500
DOC_ANK_TNKS_1	77	84	PF00023	0.454
DOC_CKS1_1	276	281	PF01111	0.385
DOC_MAPK_gen_1	140	148	PF00069	0.412
DOC_MAPK_MEF2A_6	147	155	PF00069	0.337
DOC_PP1_RVXF_1	145	151	PF00149	0.363
DOC_USP7_MATH_1	116	120	PF00917	0.441
DOC_USP7_MATH_1	13	17	PF00917	0.527
DOC_USP7_MATH_1	20	24	PF00917	0.536
DOC_USP7_MATH_1	231	235	PF00917	0.506
DOC_USP7_MATH_1	332	336	PF00917	0.611
DOC_USP7_UBL2_3	190	194	PF12436	0.530
DOC_WW_Pin1_4	18	23	PF00397	0.506
DOC_WW_Pin1_4	243	248	PF00397	0.603
DOC_WW_Pin1_4	275	280	PF00397	0.374
LIG_14-3-3_CanoR_1	167	176	PF00244	0.289
LIG_14-3-3_CanoR_1	283	289	PF00244	0.493
LIG_14-3-3_CanoR_1	84	89	PF00244	0.493
LIG_14-3-3_CanoR_1	9	13	PF00244	0.382
LIG_BIR_III_2	331	335	PF00653	0.654
LIG_BRCT_BRCA1_1	10	14	PF00533	0.386
LIG_BRCT_BRCA1_1	288	292	PF00533	0.193
LIG_deltaCOP1_diTrp_1	318	324	PF00928	0.573
LIG_FHA_1	179	185	PF00498	0.524
LIG_FHA_1	207	213	PF00498	0.531
LIG_FHA_1	239	245	PF00498	0.553
LIG_FHA_1	265	271	PF00498	0.193
LIG_FHA_1	311	317	PF00498	0.612
LIG_FHA_1	85	91	PF00498	0.440
LIG_FHA_2	50	56	PF00498	0.533
LIG_LIR_Apic_2	318	323	PF02991	0.570
LIG_LIR_Gen_1	189	200	PF02991	0.532
LIG_LIR_Gen_1	233	244	PF02991	0.625
LIG_LIR_Gen_1	250	259	PF02991	0.374
LIG_LIR_Gen_1	267	277	PF02991	0.357
LIG_LIR_Gen_1	66	74	PF02991	0.436
LIG_LIR_Nem_3	189	195	PF02991	0.536
LIG_LIR_Nem_3	233	239	PF02991	0.599
LIG_LIR_Nem_3	250	255	PF02991	0.370
LIG_LIR_Nem_3	267	272	PF02991	0.344
LIG_LIR_Nem_3	3	7	PF02991	0.465
LIG_LIR_Nem_3	315	320	PF02991	0.529
LIG_Pex14_2	100	104	PF04695	0.449
LIG_Pex14_2	236	240	PF04695	0.574
LIG_SH2_CRK	192	196	PF00017	0.564
LIG_SH2_CRK	274	278	PF00017	0.354
LIG_SH2_GRB2like	126	129	PF00017	0.398
LIG_SH2_SRC	124	127	PF00017	0.456
LIG_SH2_STAT3	308	311	PF00017	0.565
LIG_SH2_STAT5	165	168	PF00017	0.272
LIG_SH2_STAT5	183	186	PF00017	0.519
LIG_SH2_STAT5	269	272	PF00017	0.404
LIG_SH2_STAT5	302	305	PF00017	0.480
LIG_SH3_3	16	22	PF00018	0.407
LIG_SUMO_SIM_par_1	284	290	PF11976	0.366
LIG_TYR_ITIM	163	168	PF00017	0.193
LIG_WRPW_2	305	308	PF00400	0.543
LIG_WRPW_2	321	324	PF00400	0.549
MOD_CDC14_SPxK_1	246	249	PF00782	0.582
MOD_CDK_SPxK_1	243	249	PF00069	0.594
MOD_CK1_1	18	24	PF00069	0.490
MOD_CK1_1	234	240	PF00069	0.490
MOD_CK1_1	258	264	PF00069	0.335
MOD_CK1_1	287	293	PF00069	0.368
MOD_CK1_1	92	98	PF00069	0.505
MOD_CMANNOS	321	324	PF00535	0.367
MOD_GlcNHglycan	15	18	PF01048	0.674
MOD_GlcNHglycan	214	217	PF01048	0.244
MOD_GlcNHglycan	260	263	PF01048	0.223
MOD_GlcNHglycan	60	63	PF01048	0.739
MOD_GSK3_1	18	25	PF00069	0.509
MOD_GSK3_1	184	191	PF00069	0.618
MOD_GSK3_1	208	215	PF00069	0.505
MOD_GSK3_1	230	237	PF00069	0.538
MOD_GSK3_1	238	245	PF00069	0.612
MOD_GSK3_1	37	44	PF00069	0.357
MOD_GSK3_1	8	15	PF00069	0.455
MOD_N-GLC_1	255	260	PF02516	0.335
MOD_NEK2_1	188	193	PF00069	0.577
MOD_NEK2_1	220	225	PF00069	0.591
MOD_NEK2_1	255	260	PF00069	0.435
MOD_NEK2_1	264	269	PF00069	0.315
MOD_NEK2_1	286	291	PF00069	0.426
MOD_NEK2_1	7	12	PF00069	0.410
MOD_NEK2_2	231	236	PF00069	0.454
MOD_PIKK_1	63	69	PF00454	0.495
MOD_PIKK_1	8	14	PF00454	0.385
MOD_PKA_2	8	14	PF00069	0.427
MOD_PKA_2	83	89	PF00069	0.514
MOD_Plk_1	188	194	PF00069	0.602
MOD_Plk_1	255	261	PF00069	0.339
MOD_Plk_2-3	43	49	PF00069	0.478
MOD_Plk_2-3	89	95	PF00069	0.435
MOD_Plk_4	231	237	PF00069	0.614
MOD_Plk_4	92	98	PF00069	0.481
MOD_ProDKin_1	18	24	PF00069	0.506
MOD_ProDKin_1	243	249	PF00069	0.594
MOD_ProDKin_1	275	281	PF00069	0.369
MOD_SUMO_rev_2	26	36	PF00179	0.493
MOD_SUMO_rev_2	69	77	PF00179	0.345
TRG_ENDOCYTIC_2	165	168	PF00928	0.193
TRG_ENDOCYTIC_2	185	188	PF00928	0.516
TRG_ENDOCYTIC_2	192	195	PF00928	0.534
TRG_ENDOCYTIC_2	269	272	PF00928	0.404
TRG_ENDOCYTIC_2	274	277	PF00928	0.405
TRG_ENDOCYTIC_2	65	68	PF00928	0.450
TRG_ER_diArg_1	130	132	PF00400	0.412
TRG_ER_diArg_1	77	79	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB50	Leptomonas seymouri	58%	100%
A0A1X0P6A1	Trypanosomatidae	42%	100%
A0A3S7X9N6	Leishmania donovani	86%	100%
A0A422MTB0	Trypanosoma rangeli	42%	100%
A4IBR0	Leishmania infantum	86%	100%
C9ZYW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFJ5	Leishmania major	86%	100%
E9B6P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5C2T1	Trypanosoma cruzi	42%	100%