Putative ribulose-phosphate 3-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribulose-phosphate 3-epimerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HN39_LEIBR

TriTrypDb:

LbrM.34.3660 , LBRM2903_340046100

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	19
GO:0110165	cellular anatomical entity	1	20
GO:0005654	nucleoplasm	2	1
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HN39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN39

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0006098	pentose-phosphate shunt	5	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006739	NADP metabolic process	7	9
GO:0006740	NADPH regeneration	4	9
GO:0006753	nucleoside phosphate metabolic process	4	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0009117	nucleotide metabolic process	5	9
GO:0009987	cellular process	1	11
GO:0019362	pyridine nucleotide metabolic process	5	9
GO:0019637	organophosphate metabolic process	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0044237	cellular metabolic process	2	11
GO:0044281	small molecule metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0046496	nicotinamide nucleotide metabolic process	6	9
GO:0051156	glucose 6-phosphate metabolic process	4	9
GO:0055086	nucleobase-containing small molecule metabolic process	3	9
GO:0072524	pyridine-containing compound metabolic process	4	9
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0009052	pentose-phosphate shunt, non-oxidative branch	4	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004750	D-ribulose-phosphate 3-epimerase activity	5	16
GO:0016853	isomerase activity	2	20
GO:0016854	racemase and epimerase activity	3	20
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	20
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.294
CLV_NRD_NRD_1	127	129	PF00675	0.373
CLV_NRD_NRD_1	130	132	PF00675	0.373
CLV_NRD_NRD_1	229	231	PF00675	0.422
CLV_NRD_NRD_1	80	82	PF00675	0.226
CLV_PCSK_FUR_1	17	21	PF00082	0.287
CLV_PCSK_KEX2_1	19	21	PF00082	0.467
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.467
CLV_PCSK_SKI1_1	222	226	PF00082	0.348
CLV_PCSK_SKI1_1	38	42	PF00082	0.159
DOC_CKS1_1	143	148	PF01111	0.270
DOC_CYCLIN_RxL_1	35	45	PF00134	0.159
DOC_MAPK_gen_1	17	26	PF00069	0.478
DOC_MAPK_gen_1	188	196	PF00069	0.302
DOC_MAPK_MEF2A_6	17	26	PF00069	0.518
DOC_MAPK_MEF2A_6	188	196	PF00069	0.294
DOC_USP7_MATH_1	108	112	PF00917	0.302
DOC_USP7_MATH_1	75	79	PF00917	0.429
DOC_WW_Pin1_4	142	147	PF00397	0.240
DOC_WW_Pin1_4	25	30	PF00397	0.286
LIG_Actin_WH2_2	234	250	PF00022	0.250
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_Clathr_ClatBox_1	195	199	PF01394	0.435
LIG_DLG_GKlike_1	230	237	PF00625	0.348
LIG_FHA_1	204	210	PF00498	0.331
LIG_FHA_1	35	41	PF00498	0.293
LIG_FHA_2	143	149	PF00498	0.299
LIG_FHA_2	74	80	PF00498	0.376
LIG_FHA_2	85	91	PF00498	0.248
LIG_Integrin_isoDGR_2	15	17	PF01839	0.521
LIG_LIR_Gen_1	53	62	PF02991	0.289
LIG_LIR_Nem_3	148	154	PF02991	0.387
LIG_LIR_Nem_3	53	59	PF02991	0.289
LIG_LRP6_Inhibitor_1	94	100	PF00058	0.212
LIG_LYPXL_yS_3	191	194	PF13949	0.321
LIG_PDZ_Class_1	248	253	PF00595	0.481
LIG_Pex14_1	101	105	PF04695	0.283
LIG_Pex14_2	66	70	PF04695	0.344
LIG_SH3_1	19	25	PF00018	0.358
LIG_SH3_3	140	146	PF00018	0.270
LIG_SH3_3	19	25	PF00018	0.350
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.273
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.276
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.276
LIG_WRC_WIRS_1	102	107	PF05994	0.276
MOD_CDK_SPxxK_3	142	149	PF00069	0.159
MOD_CK1_1	246	252	PF00069	0.408
MOD_CK1_1	68	74	PF00069	0.316
MOD_CK2_1	142	148	PF00069	0.380
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.324
MOD_GlcNHglycan	52	55	PF01048	0.276
MOD_GSK3_1	243	250	PF00069	0.395
MOD_N-GLC_1	68	73	PF02516	0.302
MOD_NEK2_1	237	242	PF00069	0.443
MOD_NEK2_1	247	252	PF00069	0.469
MOD_NEK2_1	93	98	PF00069	0.234
MOD_NEK2_2	172	177	PF00069	0.324
MOD_PKA_1	230	236	PF00069	0.459
MOD_PKA_2	237	243	PF00069	0.470
MOD_PKA_2	247	253	PF00069	0.528
MOD_Plk_1	68	74	PF00069	0.302
MOD_Plk_4	101	107	PF00069	0.343
MOD_Plk_4	109	115	PF00069	0.407
MOD_Plk_4	27	33	PF00069	0.298
MOD_Plk_4	84	90	PF00069	0.323
MOD_ProDKin_1	142	148	PF00069	0.240
MOD_ProDKin_1	25	31	PF00069	0.286
MOD_SUMO_for_1	176	179	PF00179	0.324
MOD_SUMO_rev_2	227	233	PF00179	0.563
TRG_DiLeu_BaEn_1	182	187	PF01217	0.159
TRG_DiLeu_BaEn_1	205	210	PF01217	0.159
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.231
TRG_DiLeu_LyEn_5	182	187	PF01217	0.159
TRG_ENDOCYTIC_2	191	194	PF00928	0.321
TRG_ER_diArg_1	187	190	PF00400	0.322
TRG_NLS_MonoExtC_3	127	132	PF00514	0.159
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.343
TRG_PTS1	250	253	PF00515	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P388	Leptomonas seymouri	44%	100%
A0A0N0P4Y1	Leptomonas seymouri	71%	100%
A0A0S4JIP2	Bodo saltans	50%	100%
A0A1X0P1B6	Trypanosomatidae	48%	100%
A0A1X0P628	Trypanosomatidae	55%	100%
A0A3Q8IDT1	Leishmania donovani	45%	96%
A0A3R7KMA2	Trypanosoma rangeli	48%	100%
A0A3R7LEK7	Trypanosoma rangeli	57%	100%
A0A3S7X9N8	Leishmania donovani	82%	100%
A4HLL7	Leishmania braziliensis	43%	100%
A4I928	Leishmania infantum	45%	96%
A4IBQ7	Leishmania infantum	83%	100%
A9MZG7	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	25%	100%
C9ZN91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A531	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AFJ2	Leishmania major	83%	100%
E9B3Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
O14105	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O34557	Bacillus subtilis (strain 168)	37%	100%
O66107	Treponema pallidum (strain Nichols)	36%	100%
O67098	Aquifex aeolicus (strain VF5)	33%	100%
O84123	Chlamydia trachomatis (strain D/UW-3/Cx)	35%	100%
P0AG07	Escherichia coli (strain K12)	32%	100%
P0AG08	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	32%	100%
P0AG09	Escherichia coli O157:H7	32%	100%
P0AG10	Shigella flexneri	32%	100%
P32719	Escherichia coli (strain K12)	34%	100%
P39362	Escherichia coli (strain K12)	31%	100%
P40117	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	32%	100%
P44756	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P45455	Serratia marcescens	32%	100%
P46969	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P51012	Rhodobacter capsulatus	38%	100%
P51013	Rhodospirillum rubrum	30%	100%
P56188	Helicobacter pylori (strain ATCC 700392 / 26695)	31%	100%
P57603	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	31%	100%
P65761	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	38%	100%
P74061	Synechocystis sp. (strain PCC 6803 / Kazusa)	36%	100%
P9WI50	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	100%
P9WI51	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	100%
Q04539	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	32%	100%
Q2QD12	Homo sapiens	37%	100%
Q43157	Spinacia oleracea	36%	89%
Q43843	Solanum tuberosum	37%	90%
Q4Q431	Leishmania major	44%	100%
Q57HD7	Salmonella choleraesuis (strain SC-B67)	25%	100%
Q58093	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
Q5PJE1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	25%	100%
Q5R5Y2	Pongo abelii	40%	100%
Q6FL81	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	100%
Q755M2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q89A59	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	28%	100%
Q8K940	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	31%	100%
Q8SRP6	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8VEE0	Mus musculus	40%	100%
Q8Z2Y1	Salmonella typhi	25%	100%
Q8ZKP8	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
Q96AT9	Homo sapiens	40%	100%
Q9CCP9	Mycobacterium leprae (strain TN)	39%	100%
Q9L0Z5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	38%	100%
Q9PKR7	Chlamydia muridarum (strain MoPn / Nigg)	37%	100%
Q9SAU2	Arabidopsis thaliana	36%	90%
Q9SE42	Oryza sativa subsp. japonica	44%	100%
Q9Z8Z9	Chlamydia pneumoniae	36%	100%
Q9ZJ75	Helicobacter pylori (strain J99 / ATCC 700824)	31%	100%
Q9ZTP5	Oryza sativa subsp. japonica	36%	92%
V5BCV0	Trypanosoma cruzi	55%	100%
V5BHA6	Trypanosoma cruzi	49%	100%