NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), putative

Species:

Leishmania braziliensis

UniProt:

A4HN38_LEIBR

TriTrypDb:

LbrM.34.3640 , LBRM2903_340045700

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0005758	mitochondrial intermembrane space	6	11
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0031970	organelle envelope lumen	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0070469	respirasome	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HN38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.568
CLV_PCSK_KEX2_1	220	222	PF00082	0.570
CLV_PCSK_KEX2_1	45	47	PF00082	0.568
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.570
CLV_PCSK_PC7_1	41	47	PF00082	0.584
CLV_PCSK_SKI1_1	129	133	PF00082	0.518
CLV_PCSK_SKI1_1	46	50	PF00082	0.628
CLV_PCSK_SKI1_1	80	84	PF00082	0.339
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.602
DOC_PP1_RVXF_1	81	88	PF00149	0.355
DOC_PP2B_LxvP_1	138	141	PF13499	0.545
DOC_PP4_FxxP_1	214	217	PF00568	0.573
DOC_USP7_MATH_1	13	17	PF00917	0.602
DOC_USP7_MATH_1	174	178	PF00917	0.649
DOC_WW_Pin1_4	181	186	PF00397	0.537
LIG_14-3-3_CanoR_1	45	51	PF00244	0.546
LIG_AP2alpha_2	35	37	PF02296	0.588
LIG_BRCT_BRCA1_1	50	54	PF00533	0.335
LIG_CtBP_PxDLS_1	19	23	PF00389	0.601
LIG_FHA_1	105	111	PF00498	0.480
LIG_FHA_2	123	129	PF00498	0.518
LIG_FHA_2	184	190	PF00498	0.506
LIG_LIR_Gen_1	115	124	PF02991	0.521
LIG_LIR_Gen_1	205	216	PF02991	0.424
LIG_LIR_Gen_1	51	62	PF02991	0.335
LIG_LIR_Nem_3	115	120	PF02991	0.536
LIG_LIR_Nem_3	134	140	PF02991	0.397
LIG_LIR_Nem_3	146	151	PF02991	0.509
LIG_LIR_Nem_3	205	211	PF02991	0.398
LIG_LIR_Nem_3	51	57	PF02991	0.335
LIG_LIR_Nem_3	86	90	PF02991	0.408
LIG_Pex14_2	95	99	PF04695	0.335
LIG_SH2_CRK	208	212	PF00017	0.449
LIG_SH2_CRK	25	29	PF00017	0.568
LIG_SH2_GRB2like	148	151	PF00017	0.601
LIG_SH2_GRB2like	25	28	PF00017	0.571
LIG_SH2_GRB2like	4	7	PF00017	0.580
LIG_SH2_NCK_1	208	212	PF00017	0.449
LIG_SH2_SRC	25	28	PF00017	0.558
LIG_SH2_STAT3	108	111	PF00017	0.504
LIG_SH2_STAT5	124	127	PF00017	0.523
LIG_SH2_STAT5	137	140	PF00017	0.523
LIG_SH2_STAT5	4	7	PF00017	0.585
LIG_SH3_3	162	168	PF00018	0.580
LIG_SH3_3	209	215	PF00018	0.538
LIG_TYR_ITIM	135	140	PF00017	0.600
LIG_TYR_ITIM	206	211	PF00017	0.426
LIG_WRC_WIRS_1	144	149	PF05994	0.533
MOD_CK1_1	181	187	PF00069	0.554
MOD_CK2_1	183	189	PF00069	0.506
MOD_GlcNHglycan	157	160	PF01048	0.583
MOD_GlcNHglycan	194	197	PF01048	0.661
MOD_GlcNHglycan	9	12	PF01048	0.462
MOD_GSK3_1	118	125	PF00069	0.505
MOD_GSK3_1	151	158	PF00069	0.602
MOD_GSK3_1	174	181	PF00069	0.647
MOD_N-GLC_1	174	179	PF02516	0.644
MOD_N-GLC_2	76	78	PF02516	0.480
MOD_NEK2_1	112	117	PF00069	0.323
MOD_NEK2_1	151	156	PF00069	0.559
MOD_NEK2_1	95	100	PF00069	0.379
MOD_PIKK_1	151	157	PF00454	0.547
MOD_PKA_2	155	161	PF00069	0.581
MOD_Plk_1	174	180	PF00069	0.648
MOD_Plk_1	95	101	PF00069	0.360
MOD_Plk_4	131	137	PF00069	0.537
MOD_Plk_4	143	149	PF00069	0.490
MOD_Plk_4	95	101	PF00069	0.378
MOD_ProDKin_1	181	187	PF00069	0.535
MOD_SUMO_rev_2	123	132	PF00179	0.522
MOD_SUMO_rev_2	158	165	PF00179	0.631
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.560
TRG_ENDOCYTIC_2	137	140	PF00928	0.536
TRG_ENDOCYTIC_2	148	151	PF00928	0.517
TRG_ENDOCYTIC_2	208	211	PF00928	0.436
TRG_ER_diArg_1	45	47	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J1	Leptomonas seymouri	92%	100%
A0A0S4KFC0	Bodo saltans	77%	100%
A0A1X0P5E0	Trypanosomatidae	85%	100%
A0A3S7X9N2	Leishmania donovani	97%	100%
A4IBQ6	Leishmania infantum	97%	100%
C9ZYW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AFJ1	Leishmania major	97%	100%
E9B6P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DUW8	Trypanosoma cruzi	82%	100%