LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HN35_LEIBR
TriTrypDb:
LbrM.34.3610 , LBRM2903_340045300 *
Length:
202

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN35

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.564
CLV_C14_Caspase3-7 96 100 PF00656 0.598
DOC_CKS1_1 144 149 PF01111 0.638
DOC_MAPK_gen_1 25 34 PF00069 0.578
DOC_PP2B_LxvP_1 113 116 PF13499 0.593
DOC_USP7_MATH_1 105 109 PF00917 0.557
DOC_USP7_MATH_1 49 53 PF00917 0.654
DOC_WW_Pin1_4 143 148 PF00397 0.645
LIG_14-3-3_CanoR_1 126 130 PF00244 0.378
LIG_14-3-3_CanoR_1 18 23 PF00244 0.504
LIG_14-3-3_CanoR_1 25 34 PF00244 0.598
LIG_14-3-3_CanoR_1 3 10 PF00244 0.657
LIG_14-3-3_CanoR_1 38 47 PF00244 0.411
LIG_BIR_II_1 1 5 PF00653 0.662
LIG_EH1_1 16 24 PF00400 0.491
LIG_eIF4E_1 17 23 PF01652 0.508
LIG_FHA_1 26 32 PF00498 0.605
LIG_FHA_1 3 9 PF00498 0.594
LIG_FHA_1 39 45 PF00498 0.442
LIG_FHA_1 83 89 PF00498 0.707
LIG_LIR_Gen_1 45 55 PF02991 0.629
LIG_LIR_Nem_3 60 66 PF02991 0.713
LIG_SH3_3 141 147 PF00018 0.681
LIG_SUMO_SIM_anti_2 167 177 PF11976 0.701
LIG_SUMO_SIM_par_1 28 36 PF11976 0.448
MOD_CK1_1 153 159 PF00069 0.623
MOD_CK1_1 2 8 PF00069 0.650
MOD_CK1_1 68 74 PF00069 0.776
MOD_CK2_1 69 75 PF00069 0.705
MOD_CK2_1 76 82 PF00069 0.698
MOD_GlcNHglycan 139 142 PF01048 0.616
MOD_GlcNHglycan 150 155 PF01048 0.634
MOD_GlcNHglycan 67 70 PF01048 0.723
MOD_GSK3_1 142 149 PF00069 0.475
MOD_GSK3_1 33 40 PF00069 0.631
MOD_GSK3_1 65 72 PF00069 0.726
MOD_NEK2_1 37 42 PF00069 0.599
MOD_PKA_2 125 131 PF00069 0.378
MOD_PKA_2 2 8 PF00069 0.678
MOD_PKA_2 37 43 PF00069 0.580
MOD_Plk_1 105 111 PF00069 0.494
MOD_Plk_1 169 175 PF00069 0.505
MOD_Plk_2-3 184 190 PF00069 0.712
MOD_Plk_2-3 76 82 PF00069 0.722
MOD_Plk_4 18 24 PF00069 0.477
MOD_ProDKin_1 143 149 PF00069 0.650
TRG_Pf-PMV_PEXEL_1 196 200 PF00026 0.694

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI1 Leptomonas seymouri 44% 91%
A0A1X0P5H7 Trypanosomatidae 37% 100%
A0A3Q8IMQ4 Leishmania donovani 72% 99%
A0A422NR35 Trypanosoma rangeli 37% 100%
A4IBQ3 Leishmania infantum 71% 99%
C9ZYX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 80%
E9AFI8 Leishmania major 71% 100%
E9B6P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
V5BD49 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS