Multidrug and toxic compound extrusion protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN33_LEIBR

TriTrypDb:

LbrM.34.3590 , LBRM2903_340045200

Length:

620

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

A4HN33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN33

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0042908	xenobiotic transport	4	12
GO:0046618	xenobiotic export from cell	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0140115	export across plasma membrane	3	12
GO:0140352	export from cell	2	12
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	30
GO:0015291	secondary active transmembrane transporter activity	4	30
GO:0015297	antiporter activity	5	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022857	transmembrane transporter activity	2	30
GO:0042910	xenobiotic transmembrane transporter activity	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.328
CLV_NRD_NRD_1	401	403	PF00675	0.260
CLV_PCSK_KEX2_1	155	157	PF00082	0.424
CLV_PCSK_KEX2_1	401	403	PF00082	0.243
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.424
CLV_PCSK_SKI1_1	329	333	PF00082	0.399
CLV_PCSK_SKI1_1	396	400	PF00082	0.249
CLV_PCSK_SKI1_1	401	405	PF00082	0.254
CLV_PCSK_SKI1_1	531	535	PF00082	0.307
CLV_PCSK_SKI1_1	77	81	PF00082	0.264
DOC_CDC14_PxL_1	354	362	PF14671	0.146
DOC_CKS1_1	520	525	PF01111	0.424
DOC_CYCLIN_RxL_1	274	284	PF00134	0.203
DOC_CYCLIN_yClb3_PxF_3	427	435	PF00134	0.146
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.159
DOC_MAPK_MEF2A_6	447	454	PF00069	0.308
DOC_MAPK_MEF2A_6	477	485	PF00069	0.424
DOC_MAPK_NFAT4_5	447	455	PF00069	0.146
DOC_PIKK_1	10	18	PF02985	0.595
DOC_PP1_RVXF_1	275	282	PF00149	0.295
DOC_PP1_RVXF_1	308	314	PF00149	0.622
DOC_PP1_RVXF_1	399	406	PF00149	0.535
DOC_PP1_RVXF_1	529	536	PF00149	0.482
DOC_PP2B_LxvP_1	452	455	PF13499	0.159
DOC_PP2B_LxvP_1	616	619	PF13499	0.738
DOC_PP4_FxxP_1	233	236	PF00568	0.313
DOC_USP7_MATH_1	331	335	PF00917	0.278
DOC_USP7_MATH_1	375	379	PF00917	0.291
DOC_USP7_MATH_1	41	45	PF00917	0.663
DOC_USP7_MATH_1	556	560	PF00917	0.731
DOC_USP7_MATH_1	597	601	PF00917	0.729
DOC_USP7_UBL2_3	503	507	PF12436	0.364
DOC_USP7_UBL2_3	608	612	PF12436	0.673
DOC_WW_Pin1_4	281	286	PF00397	0.246
DOC_WW_Pin1_4	519	524	PF00397	0.429
DOC_WW_Pin1_4	589	594	PF00397	0.736
DOC_WW_Pin1_4	606	611	PF00397	0.745
LIG_14-3-3_CanoR_1	246	253	PF00244	0.483
LIG_14-3-3_CanoR_1	401	406	PF00244	0.455
LIG_14-3-3_CanoR_1	47	53	PF00244	0.736
LIG_14-3-3_CanoR_1	539	548	PF00244	0.689
LIG_14-3-3_CanoR_1	557	564	PF00244	0.713
LIG_Actin_WH2_2	289	306	PF00022	0.346
LIG_AP2alpha_1	458	462	PF02296	0.424
LIG_APCC_ABBA_1	3	8	PF00400	0.555
LIG_APCC_ABBA_1	538	543	PF00400	0.583
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_BRCT_BRCA1_1	142	146	PF00533	0.462
LIG_BRCT_BRCA1_1	483	487	PF00533	0.412
LIG_CaM_IQ_9	238	253	PF13499	0.337
LIG_CaM_NSCaTE_8	288	295	PF13499	0.159
LIG_Clathr_ClatBox_1	107	111	PF01394	0.218
LIG_FHA_1	176	182	PF00498	0.494
LIG_FHA_1	252	258	PF00498	0.432
LIG_FHA_1	291	297	PF00498	0.315
LIG_FHA_1	298	304	PF00498	0.311
LIG_FHA_1	362	368	PF00498	0.216
LIG_FHA_1	513	519	PF00498	0.359
LIG_FHA_1	543	549	PF00498	0.701
LIG_FHA_1	571	577	PF00498	0.735
LIG_FHA_1	70	76	PF00498	0.498
LIG_FHA_2	167	173	PF00498	0.492
LIG_FHA_2	354	360	PF00498	0.238
LIG_FHA_2	547	553	PF00498	0.636
LIG_LIR_Gen_1	340	350	PF02991	0.219
LIG_LIR_Gen_1	37	46	PF02991	0.502
LIG_LIR_Gen_1	404	412	PF02991	0.321
LIG_LIR_Gen_1	431	441	PF02991	0.288
LIG_LIR_Gen_1	484	494	PF02991	0.408
LIG_LIR_Gen_1	495	504	PF02991	0.399
LIG_LIR_Gen_1	522	533	PF02991	0.310
LIG_LIR_Nem_3	143	149	PF02991	0.469
LIG_LIR_Nem_3	300	305	PF02991	0.378
LIG_LIR_Nem_3	340	345	PF02991	0.238
LIG_LIR_Nem_3	37	43	PF02991	0.549
LIG_LIR_Nem_3	404	408	PF02991	0.317
LIG_LIR_Nem_3	431	436	PF02991	0.268
LIG_LIR_Nem_3	443	449	PF02991	0.171
LIG_LIR_Nem_3	484	490	PF02991	0.408
LIG_LIR_Nem_3	495	499	PF02991	0.363
LIG_LIR_Nem_3	522	528	PF02991	0.333
LIG_NRBOX	323	329	PF00104	0.492
LIG_NRBOX	420	426	PF00104	0.329
LIG_PCNA_PIPBox_1	73	82	PF02747	0.471
LIG_Pex14_1	510	514	PF04695	0.346
LIG_Pex14_2	202	206	PF04695	0.393
LIG_Pex14_2	370	374	PF04695	0.286
LIG_Pex14_2	428	432	PF04695	0.314
LIG_Pex14_2	458	462	PF04695	0.403
LIG_Pex14_2	496	500	PF04695	0.263
LIG_PTB_Apo_2	14	21	PF02174	0.726
LIG_REV1ctd_RIR_1	430	439	PF16727	0.146
LIG_REV1ctd_RIR_1	497	507	PF16727	0.371
LIG_SH2_CRK	40	44	PF00017	0.501
LIG_SH2_NCK_1	40	44	PF00017	0.501
LIG_SH2_PTP2	525	528	PF00017	0.269
LIG_SH2_SRC	40	43	PF00017	0.505
LIG_SH2_SRC	525	528	PF00017	0.367
LIG_SH2_STAP1	177	181	PF00017	0.473
LIG_SH2_STAP1	185	189	PF00017	0.389
LIG_SH2_STAP1	363	367	PF00017	0.335
LIG_SH2_STAT3	248	251	PF00017	0.430
LIG_SH2_STAT5	177	180	PF00017	0.451
LIG_SH2_STAT5	223	226	PF00017	0.257
LIG_SH2_STAT5	302	305	PF00017	0.366
LIG_SH2_STAT5	363	366	PF00017	0.310
LIG_SH2_STAT5	501	504	PF00017	0.294
LIG_SH2_STAT5	525	528	PF00017	0.288
LIG_SH2_STAT5	532	535	PF00017	0.491
LIG_SH3_3	168	174	PF00018	0.476
LIG_SH3_3	263	269	PF00018	0.283
LIG_SH3_3	424	430	PF00018	0.283
LIG_SH3_3	487	493	PF00018	0.273
LIG_SH3_3	517	523	PF00018	0.305
LIG_SH3_3	79	85	PF00018	0.468
LIG_SUMO_SIM_anti_2	440	446	PF11976	0.274
LIG_SUMO_SIM_par_1	288	293	PF11976	0.234
LIG_SUMO_SIM_par_1	84	90	PF11976	0.273
LIG_TYR_ITIM	38	43	PF00017	0.502
LIG_TYR_ITIM	444	449	PF00017	0.245
LIG_UBA3_1	270	277	PF00899	0.349
LIG_UBA3_1	529	534	PF00899	0.498
LIG_WRC_WIRS_1	429	434	PF05994	0.317
MOD_CDC14_SPxK_1	609	612	PF00782	0.534
MOD_CDK_SPxK_1	606	612	PF00069	0.558
MOD_CK1_1	19	25	PF00069	0.534
MOD_CK1_1	378	384	PF00069	0.316
MOD_CK1_1	546	552	PF00069	0.559
MOD_CK2_1	166	172	PF00069	0.491
MOD_CK2_1	353	359	PF00069	0.235
MOD_CMANNOS	227	230	PF00535	0.424
MOD_CMANNOS	313	316	PF00535	0.296
MOD_GlcNHglycan	211	214	PF01048	0.400
MOD_GlcNHglycan	216	219	PF01048	0.410
MOD_GlcNHglycan	262	265	PF01048	0.373
MOD_GlcNHglycan	377	380	PF01048	0.286
MOD_GlcNHglycan	54	57	PF01048	0.535
MOD_GlcNHglycan	545	548	PF01048	0.334
MOD_GlcNHglycan	570	573	PF01048	0.461
MOD_GlcNHglycan	63	66	PF01048	0.483
MOD_GSK3_1	18	25	PF00069	0.742
MOD_GSK3_1	374	381	PF00069	0.347
MOD_GSK3_1	42	49	PF00069	0.683
MOD_GSK3_1	539	546	PF00069	0.641
MOD_GSK3_1	568	575	PF00069	0.639
MOD_N-GLC_1	123	128	PF02516	0.258
MOD_N-GLC_1	16	21	PF02516	0.521
MOD_N-GLC_1	543	548	PF02516	0.493
MOD_NEK2_1	123	128	PF00069	0.241
MOD_NEK2_1	142	147	PF00069	0.403
MOD_NEK2_1	18	23	PF00069	0.550
MOD_NEK2_1	206	211	PF00069	0.347
MOD_NEK2_1	214	219	PF00069	0.335
MOD_NEK2_1	262	267	PF00069	0.270
MOD_NEK2_1	279	284	PF00069	0.202
MOD_NEK2_1	303	308	PF00069	0.358
MOD_NEK2_1	462	467	PF00069	0.322
MOD_NEK2_1	86	91	PF00069	0.287
MOD_NEK2_2	580	585	PF00069	0.525
MOD_PKA_1	401	407	PF00069	0.346
MOD_PKA_2	303	309	PF00069	0.414
MOD_PKA_2	401	407	PF00069	0.346
MOD_PKA_2	46	52	PF00069	0.677
MOD_PKA_2	556	562	PF00069	0.693
MOD_Plk_1	16	22	PF00069	0.710
MOD_Plk_1	543	549	PF00069	0.677
MOD_Plk_1	68	74	PF00069	0.551
MOD_Plk_2-3	69	75	PF00069	0.550
MOD_Plk_4	137	143	PF00069	0.268
MOD_Plk_4	206	212	PF00069	0.303
MOD_Plk_4	292	298	PF00069	0.300
MOD_Plk_4	323	329	PF00069	0.505
MOD_Plk_4	382	388	PF00069	0.256
MOD_Plk_4	428	434	PF00069	0.261
MOD_Plk_4	440	446	PF00069	0.220
MOD_Plk_4	448	454	PF00069	0.235
MOD_Plk_4	462	468	PF00069	0.298
MOD_Plk_4	492	498	PF00069	0.332
MOD_ProDKin_1	281	287	PF00069	0.246
MOD_ProDKin_1	519	525	PF00069	0.429
MOD_ProDKin_1	589	595	PF00069	0.736
MOD_ProDKin_1	606	612	PF00069	0.740
MOD_SUMO_for_1	533	536	PF00179	0.560
MOD_SUMO_rev_2	152	157	PF00179	0.636
TRG_DiLeu_BaEn_1	448	453	PF01217	0.159
TRG_DiLeu_BaEn_4	152	158	PF01217	0.487
TRG_DiLeu_LyEn_5	394	399	PF01217	0.438
TRG_ENDOCYTIC_2	40	43	PF00928	0.704
TRG_ENDOCYTIC_2	446	449	PF00928	0.231
TRG_ENDOCYTIC_2	456	459	PF00928	0.277
TRG_ENDOCYTIC_2	501	504	PF00928	0.288
TRG_ENDOCYTIC_2	525	528	PF00928	0.273
TRG_ER_diArg_1	401	403	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I213	Leptomonas seymouri	67%	99%
A0A0N1I703	Leptomonas seymouri	23%	68%
A0A0N1IJ56	Leptomonas seymouri	39%	88%
A0A0N1ILQ1	Leptomonas seymouri	21%	100%
A0A0S4IHH9	Bodo saltans	34%	100%
A0A0S4INI5	Bodo saltans	39%	100%
A0A0S4JTQ3	Bodo saltans	25%	100%
A0A0S4JV08	Bodo saltans	21%	100%
A0A0S4JVA6	Bodo saltans	23%	84%
A0A0S4JZ61	Bodo saltans	22%	91%
A0A1X0NM81	Trypanosomatidae	23%	100%
A0A1X0NU76	Trypanosomatidae	43%	100%
A0A1X0P579	Trypanosomatidae	52%	100%
A0A1X0P5F0	Trypanosomatidae	38%	100%
A0A1X0P8J4	Trypanosomatidae	21%	100%
A0A3Q8ID83	Leishmania donovani	24%	70%
A0A3Q8IGH9	Leishmania donovani	38%	89%
A0A3Q8II95	Leishmania donovani	74%	100%
A0A3R7M3E2	Trypanosoma rangeli	43%	100%
A0A3R7NUJ8	Trypanosoma rangeli	51%	100%
A0A422NN08	Trypanosoma rangeli	24%	74%
A0A422NR58	Trypanosoma rangeli	37%	100%
A1L1P9	Danio rerio	25%	100%
A4HN34	Leishmania braziliensis	96%	100%
A4IBQ2	Leishmania infantum	74%	100%
A4IIS8	Xenopus tropicalis	27%	100%
A7KAU2	Oryctolagus cuniculus	25%	100%
A7KAU3	Oryctolagus cuniculus	24%	100%
C9ZP79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZP80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZQ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZYX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZYX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZYY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZYY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AD56	Leishmania major	24%	70%
E9AFI2	Leishmania major	39%	100%
E9AFI7	Leishmania major	73%	100%
E9AHF1	Leishmania infantum	24%	70%
E9AHW7	Leishmania infantum	38%	89%
E9AYY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	70%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
E9B6P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
F4HPH2	Arabidopsis thaliana	23%	100%
F4HQ05	Arabidopsis thaliana	25%	100%
F4HZH9	Arabidopsis thaliana	24%	100%
F4I4Q3	Arabidopsis thaliana	24%	100%
F4IHU9	Arabidopsis thaliana	26%	100%
F4JH46	Arabidopsis thaliana	22%	100%
O49660	Arabidopsis thaliana	22%	100%
P38767	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P45272	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
Q10085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q1PDX9	Arabidopsis thaliana	25%	100%
Q1PFG9	Arabidopsis thaliana	23%	100%
Q38956	Arabidopsis thaliana	24%	100%
Q3V050	Mus musculus	28%	100%
Q4PSF4	Arabidopsis thaliana	21%	100%
Q5I0E9	Rattus norvegicus	26%	100%
Q5R7E4	Pongo abelii	24%	100%
Q5RFD2	Pongo abelii	27%	100%
Q62LW6	Burkholderia mallei (strain ATCC 23344)	24%	100%
Q63S57	Burkholderia pseudomallei (strain K96243)	24%	100%
Q6NB79	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	26%	100%
Q86VL8	Homo sapiens	25%	100%
Q89W72	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	24%	100%
Q8GXM8	Arabidopsis thaliana	25%	100%
Q8K0H1	Mus musculus	25%	100%
Q8L731	Arabidopsis thaliana	26%	100%
Q8RWF5	Arabidopsis thaliana	25%	100%
Q8RXK1	Arabidopsis thaliana	25%	100%
Q8UDF5	Agrobacterium fabrum (strain C58 / ATCC 33970)	22%	100%
Q8VYL8	Arabidopsis thaliana	25%	100%
Q8W488	Arabidopsis thaliana	24%	100%
Q94AL1	Arabidopsis thaliana	25%	100%
Q96FL8	Homo sapiens	26%	100%
Q98D15	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	24%	100%
Q9C994	Arabidopsis thaliana	24%	100%
Q9C9M8	Arabidopsis thaliana	23%	100%
Q9C9U1	Arabidopsis thaliana	27%	100%
Q9FH21	Arabidopsis thaliana	24%	100%
Q9FHB6	Arabidopsis thaliana	27%	100%
Q9FJ87	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	26%	100%
Q9LE20	Arabidopsis thaliana	24%	100%
Q9LPV4	Arabidopsis thaliana	24%	100%
Q9LS19	Arabidopsis thaliana	24%	100%
Q9LUH2	Arabidopsis thaliana	25%	100%
Q9LUH3	Arabidopsis thaliana	26%	100%
Q9LVD9	Arabidopsis thaliana	25%	100%
Q9LYT3	Arabidopsis thaliana	25%	100%
Q9SIA1	Arabidopsis thaliana	25%	100%
Q9SIA3	Arabidopsis thaliana	24%	100%
Q9SIA4	Arabidopsis thaliana	25%	100%
Q9SIA5	Arabidopsis thaliana	24%	100%
Q9SLV0	Arabidopsis thaliana	22%	100%
Q9SX83	Arabidopsis thaliana	24%	100%
Q9SZE2	Arabidopsis thaliana	24%	100%
Q9USK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9UT92	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9ZVH5	Arabidopsis thaliana	23%	100%
V5BE59	Trypanosoma cruzi	23%	76%
V5BJE3	Trypanosoma cruzi	39%	100%
V5C2T9	Trypanosoma cruzi	47%	100%