Putative iron-sulfur cluster assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron-sulfur cluster assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN32_LEIBR

TriTrypDb:

LbrM.34.3580 , LBRM2903_340045100

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN32

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006879	intracellular iron ion homeostasis	8	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055072	obsolete iron ion homeostasis	9	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051540	metal cluster binding	2	12
GO:0008198	ferrous iron binding	7	1
GO:0016530	metallochaperone activity	2	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0140104	molecular carrier activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.471
CLV_NRD_NRD_1	157	159	PF00675	0.710
CLV_PCSK_KEX2_1	157	159	PF00082	0.675
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.675
CLV_PCSK_SKI1_1	154	158	PF00082	0.445
CLV_PCSK_SKI1_1	2	6	PF00082	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.423
DOC_PP2B_LxvP_1	120	123	PF13499	0.404
DOC_USP7_MATH_1	11	15	PF00917	0.585
DOC_USP7_MATH_1	91	95	PF00917	0.404
DOC_USP7_UBL2_3	110	114	PF12436	0.447
DOC_USP7_UBL2_3	159	163	PF12436	0.462
LIG_14-3-3_CanoR_1	101	106	PF00244	0.420
LIG_FHA_1	71	77	PF00498	0.404
LIG_FHA_2	110	116	PF00498	0.429
LIG_LIR_Apic_2	31	36	PF02991	0.406
LIG_LIR_Nem_3	78	84	PF02991	0.413
LIG_REV1ctd_RIR_1	2	10	PF16727	0.392
LIG_SH2_CRK	33	37	PF00017	0.458
LIG_SH2_STAP1	25	29	PF00017	0.447
LIG_SH2_STAP1	95	99	PF00017	0.415
LIG_SH2_STAT3	95	98	PF00017	0.415
LIG_SH2_STAT5	144	147	PF00017	0.404
LIG_SUMO_SIM_par_1	72	78	PF11976	0.456
LIG_TRAF2_1	162	165	PF00917	0.521
MOD_CK1_1	94	100	PF00069	0.404
MOD_CK2_1	109	115	PF00069	0.402
MOD_GlcNHglycan	14	17	PF01048	0.611
MOD_GlcNHglycan	87	90	PF01048	0.204
MOD_GSK3_1	143	150	PF00069	0.415
MOD_GSK3_1	7	14	PF00069	0.452
MOD_GSK3_1	90	97	PF00069	0.430
MOD_NEK2_1	109	114	PF00069	0.435
MOD_NEK2_1	127	132	PF00069	0.404
MOD_NEK2_2	133	138	PF00069	0.471
MOD_NEK2_2	20	25	PF00069	0.555
MOD_PIKK_1	60	66	PF00454	0.415
MOD_PIKK_1	94	100	PF00454	0.421
MOD_PK_1	101	107	PF00069	0.347
MOD_Plk_1	118	124	PF00069	0.418
MOD_Plk_1	133	139	PF00069	0.383
MOD_Plk_1	60	66	PF00069	0.410
MOD_Plk_4	127	133	PF00069	0.405
MOD_Plk_4	70	76	PF00069	0.430
MOD_SUMO_for_1	162	165	PF00179	0.665
MOD_SUMO_rev_2	72	81	PF00179	0.415
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH5	Leptomonas seymouri	86%	97%
A0A0S4KK43	Bodo saltans	78%	100%
A0A1X0P6B0	Trypanosomatidae	87%	94%
A0A3R7KQV6	Trypanosoma rangeli	78%	100%
A0A3S7X9M5	Leishmania donovani	96%	100%
A4IBQ1	Leishmania infantum	96%	100%
B0YLW7	Trachipleistophora hominis	60%	100%
C9ZYX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	92%
E9AFI6	Leishmania major	92%	100%
E9B6P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O31270	Azotobacter vinelandii	59%	100%
O32163	Bacillus subtilis (strain 168)	31%	100%
O49627	Arabidopsis thaliana	56%	99%
O51885	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	56%	100%
O67045	Aquifex aeolicus (strain VF5)	52%	100%
O81433	Arabidopsis thaliana	63%	96%
P0ACD4	Escherichia coli (strain K12)	58%	100%
P0ACD5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	58%	100%
P0ACD6	Escherichia coli O157:H7	58%	100%
P0ACD7	Shigella flexneri	58%	100%
P0DMG1	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	100%
P0DMG2	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	100%
P57658	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	55%	100%
Q03020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	63%	100%
Q12056	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
Q57074	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	59%	100%
Q6BGU0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	58%	92%
Q6CFQ0	Yarrowia lipolytica (strain CLIB 122 / E 150)	61%	91%
Q6CRQ9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	62%	92%
Q6FJY3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	63%	77%
Q75C07	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	65%	100%
Q89A18	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	56%	100%
Q8LR34	Oryza sativa subsp. japonica	52%	96%
Q8SSM2	Encephalitozoon cuniculi (strain GB-M1)	55%	100%
Q9A1G2	Streptococcus pyogenes serotype M1	31%	100%
Q9D7P6	Mus musculus	57%	98%
Q9H1K1	Homo sapiens	57%	99%
Q9MAB6	Arabidopsis thaliana	55%	100%
Q9UTC6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	86%
Q9ZD61	Rickettsia prowazekii (strain Madrid E)	63%	100%
V5BTL0	Trypanosoma cruzi	79%	100%