Putative cyclophilin 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 7, putative

Species:

Leishmania braziliensis

UniProt:

A4HN31_LEIBR

TriTrypDb:

LbrM.34.3570 , LBRM2903_340045000

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HN31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN31

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0018193	peptidyl-amino acid modification	5	8
GO:0018208	peptidyl-proline modification	6	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	8
GO:0003824	catalytic activity	1	8
GO:0016853	isomerase activity	2	8
GO:0016859	cis-trans isomerase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.325
CLV_PCSK_SKI1_1	197	201	PF00082	0.192
DEG_APCC_DBOX_1	57	65	PF00400	0.399
DEG_Nend_UBRbox_2	1	3	PF02207	0.412
DOC_CDC14_PxL_1	139	147	PF14671	0.192
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.420
DOC_MAPK_FxFP_2	24	27	PF00069	0.417
DOC_MAPK_gen_1	68	77	PF00069	0.312
DOC_MAPK_MEF2A_6	116	123	PF00069	0.349
DOC_MAPK_MEF2A_6	133	142	PF00069	0.164
DOC_MAPK_MEF2A_6	16	24	PF00069	0.412
DOC_MAPK_MEF2A_6	58	65	PF00069	0.481
DOC_MAPK_MEF2A_6	68	77	PF00069	0.283
DOC_MAPK_NFAT4_5	58	66	PF00069	0.397
DOC_PP2B_LxvP_1	20	23	PF13499	0.419
DOC_PP4_FxxP_1	24	27	PF00568	0.490
DOC_PP4_FxxP_1	32	35	PF00568	0.502
DOC_USP7_MATH_1	149	153	PF00917	0.312
DOC_USP7_MATH_1	214	218	PF00917	0.332
DOC_USP7_MATH_1	94	98	PF00917	0.427
DOC_USP7_UBL2_3	287	291	PF12436	0.469
DOC_WW_Pin1_4	210	215	PF00397	0.280
LIG_14-3-3_CanoR_1	189	195	PF00244	0.332
LIG_14-3-3_CanoR_1	299	309	PF00244	0.298
LIG_14-3-3_CanoR_1	58	64	PF00244	0.399
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.312
LIG_BRCT_BRCA1_1	205	209	PF00533	0.273
LIG_BRCT_BRCA1_1	61	65	PF00533	0.392
LIG_BRCT_BRCA1_1	96	100	PF00533	0.349
LIG_EH_1	309	313	PF12763	0.433
LIG_eIF4E_1	33	39	PF01652	0.391
LIG_FHA_1	15	21	PF00498	0.406
LIG_FHA_1	70	76	PF00498	0.465
LIG_FHA_1	90	96	PF00498	0.354
LIG_FHA_2	247	253	PF00498	0.556
LIG_FHA_2	78	84	PF00498	0.332
LIG_LIR_Gen_1	136	146	PF02991	0.332
LIG_LIR_Gen_1	219	230	PF02991	0.332
LIG_LIR_Gen_1	97	108	PF02991	0.349
LIG_LIR_Nem_3	113	118	PF02991	0.337
LIG_LIR_Nem_3	136	142	PF02991	0.332
LIG_LIR_Nem_3	217	221	PF02991	0.367
LIG_LIR_Nem_3	223	228	PF02991	0.373
LIG_LIR_Nem_3	306	312	PF02991	0.421
LIG_LIR_Nem_3	5	9	PF02991	0.391
LIG_LIR_Nem_3	97	103	PF02991	0.396
LIG_LYPXL_yS_3	118	121	PF13949	0.192
LIG_MLH1_MIPbox_1	205	209	PF16413	0.273
LIG_SH2_SRC	33	36	PF00017	0.402
LIG_SH2_STAT5	175	178	PF00017	0.332
LIG_SH2_STAT5	222	225	PF00017	0.337
LIG_SH2_STAT5	33	36	PF00017	0.402
LIG_SH2_STAT5	6	9	PF00017	0.393
LIG_SH3_3	137	143	PF00018	0.192
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.395
LIG_WRC_WIRS_1	95	100	PF05994	0.349
MOD_CK1_1	59	65	PF00069	0.427
MOD_CK2_1	232	238	PF00069	0.509
MOD_CK2_1	246	252	PF00069	0.626
MOD_GlcNHglycan	105	108	PF01048	0.296
MOD_GlcNHglycan	234	237	PF01048	0.478
MOD_GlcNHglycan	257	260	PF01048	0.640
MOD_GlcNHglycan	284	287	PF01048	0.474
MOD_GlcNHglycan	303	306	PF01048	0.273
MOD_GSK3_1	122	129	PF00069	0.307
MOD_GSK3_1	210	217	PF00069	0.374
MOD_N-GLC_1	203	208	PF02516	0.276
MOD_N-GLC_1	246	251	PF02516	0.592
MOD_N-GLC_1	255	260	PF02516	0.582
MOD_N-GLC_1	59	64	PF02516	0.396
MOD_NEK2_1	103	108	PF00069	0.332
MOD_NEK2_1	14	19	PF00069	0.445
MOD_NEK2_1	181	186	PF00069	0.344
MOD_NEK2_1	208	213	PF00069	0.275
MOD_NEK2_1	77	82	PF00069	0.284
MOD_NEK2_2	134	139	PF00069	0.273
MOD_PIKK_1	203	209	PF00454	0.298
MOD_PKA_2	188	194	PF00069	0.397
MOD_Plk_1	203	209	PF00069	0.332
MOD_Plk_1	255	261	PF00069	0.614
MOD_Plk_1	59	65	PF00069	0.395
MOD_Plk_2-3	156	162	PF00069	0.192
MOD_Plk_4	110	116	PF00069	0.337
MOD_Plk_4	134	140	PF00069	0.273
MOD_Plk_4	2	8	PF00069	0.395
MOD_Plk_4	303	309	PF00069	0.442
MOD_Plk_4	59	65	PF00069	0.395
MOD_ProDKin_1	210	216	PF00069	0.280
MOD_SUMO_rev_2	285	293	PF00179	0.454
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.388
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.380
TRG_ENDOCYTIC_2	118	121	PF00928	0.336
TRG_ENDOCYTIC_2	222	225	PF00928	0.371
TRG_ENDOCYTIC_2	309	312	PF00928	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUZ6	Leptomonas seymouri	63%	100%
A0A0S4J2C4	Bodo saltans	29%	69%
A0A3Q8IPW3	Leishmania donovani	81%	100%
A4IBQ0	Leishmania infantum	81%	100%
E9AFI5	Leishmania major	83%	100%
E9B6P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P0C1I1	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	27%	88%