tRNA N(3)-methylcytidine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN30_LEIBR

TriTrypDb:

LbrM.34.3560 , LBRM2903_340044900

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN30

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	13
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0032259	methylation	2	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.350
CLV_C14_Caspase3-7	232	236	PF00656	0.196
CLV_C14_Caspase3-7	305	309	PF00656	0.293
CLV_NRD_NRD_1	28	30	PF00675	0.633
CLV_NRD_NRD_1	300	302	PF00675	0.381
CLV_NRD_NRD_1	357	359	PF00675	0.466
CLV_NRD_NRD_1	366	368	PF00675	0.360
CLV_PCSK_FUR_1	298	302	PF00082	0.196
CLV_PCSK_KEX2_1	173	175	PF00082	0.380
CLV_PCSK_KEX2_1	30	32	PF00082	0.618
CLV_PCSK_KEX2_1	300	302	PF00082	0.321
CLV_PCSK_KEX2_1	366	368	PF00082	0.441
CLV_PCSK_KEX2_1	65	67	PF00082	0.522
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.380
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.618
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.563
CLV_PCSK_SKI1_1	155	159	PF00082	0.402
CLV_PCSK_SKI1_1	335	339	PF00082	0.314
DEG_SPOP_SBC_1	119	123	PF00917	0.196
DEG_SPOP_SBC_1	212	216	PF00917	0.450
DOC_CYCLIN_RxL_1	152	161	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.176
DOC_MAPK_gen_1	358	364	PF00069	0.499
DOC_MAPK_RevD_3	160	174	PF00069	0.368
DOC_MAPK_RevD_3	343	359	PF00069	0.426
DOC_PP2B_LxvP_1	202	205	PF13499	0.196
DOC_PP4_FxxP_1	240	243	PF00568	0.196
DOC_USP7_MATH_1	124	128	PF00917	0.369
DOC_USP7_MATH_1	192	196	PF00917	0.402
DOC_USP7_MATH_1	212	216	PF00917	0.118
DOC_USP7_MATH_1	233	237	PF00917	0.250
DOC_USP7_MATH_1	256	260	PF00917	0.420
DOC_USP7_MATH_1	39	43	PF00917	0.669
DOC_USP7_MATH_1	4	8	PF00917	0.760
DOC_WW_Pin1_4	120	125	PF00397	0.410
DOC_WW_Pin1_4	160	165	PF00397	0.458
DOC_WW_Pin1_4	197	202	PF00397	0.403
DOC_WW_Pin1_4	239	244	PF00397	0.254
LIG_14-3-3_CanoR_1	292	298	PF00244	0.248
LIG_14-3-3_CanoR_1	358	363	PF00244	0.552
LIG_14-3-3_CanoR_1	73	78	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	199	203	PF00533	0.404
LIG_BRCT_BRCA1_1	241	245	PF00533	0.312
LIG_BRCT_BRCA1_1	246	250	PF00533	0.325
LIG_BRCT_BRCA1_1	325	329	PF00533	0.313
LIG_BRCT_BRCA1_1	360	364	PF00533	0.553
LIG_Clathr_ClatBox_1	157	161	PF01394	0.368
LIG_EVH1_1	34	38	PF00568	0.458
LIG_FHA_1	229	235	PF00498	0.417
LIG_FHA_1	350	356	PF00498	0.298
LIG_FHA_1	97	103	PF00498	0.364
LIG_FHA_2	230	236	PF00498	0.364
LIG_FHA_2	3	9	PF00498	0.719
LIG_FHA_2	334	340	PF00498	0.332
LIG_Integrin_RGD_1	301	303	PF01839	0.448
LIG_LIR_Gen_1	127	133	PF02991	0.367
LIG_LIR_Gen_1	242	252	PF02991	0.327
LIG_LIR_Gen_1	89	97	PF02991	0.276
LIG_LIR_Nem_3	242	248	PF02991	0.428
LIG_LIR_Nem_3	326	331	PF02991	0.313
LIG_LIR_Nem_3	42	47	PF02991	0.534
LIG_LIR_Nem_3	89	93	PF02991	0.314
LIG_MLH1_MIPbox_1	325	329	PF16413	0.313
LIG_PCNA_yPIPBox_3	320	329	PF02747	0.313
LIG_PDZ_Class_2	372	377	PF00595	0.404
LIG_Pex14_1	68	72	PF04695	0.403
LIG_Pex14_2	364	368	PF04695	0.510
LIG_SH2_CRK	148	152	PF00017	0.283
LIG_SH2_GRB2like	47	50	PF00017	0.408
LIG_SH2_STAT3	150	153	PF00017	0.196
LIG_SH2_STAT5	150	153	PF00017	0.196
LIG_SH2_STAT5	279	282	PF00017	0.328
LIG_SH2_STAT5	85	88	PF00017	0.381
LIG_SH3_1	33	39	PF00018	0.645
LIG_SH3_3	186	192	PF00018	0.326
LIG_SH3_3	32	38	PF00018	0.647
LIG_SH3_3	54	60	PF00018	0.591
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.395
LIG_SUMO_SIM_par_1	344	349	PF11976	0.370
LIG_TRAF2_1	330	333	PF00917	0.448
LIG_WRPW_2	44	47	PF00400	0.558
MOD_CK1_1	2	8	PF00069	0.777
MOD_CK1_1	217	223	PF00069	0.397
MOD_CK2_1	126	132	PF00069	0.376
MOD_CK2_1	2	8	PF00069	0.688
MOD_CK2_1	327	333	PF00069	0.309
MOD_Cter_Amidation	27	30	PF01082	0.656
MOD_GlcNHglycan	235	238	PF01048	0.410
MOD_GSK3_1	120	127	PF00069	0.432
MOD_GSK3_1	213	220	PF00069	0.417
MOD_GSK3_1	229	236	PF00069	0.195
MOD_GSK3_1	251	258	PF00069	0.429
MOD_GSK3_1	314	321	PF00069	0.320
MOD_GSK3_1	323	330	PF00069	0.326
MOD_GSK3_1	349	356	PF00069	0.328
MOD_GSK3_1	4	11	PF00069	0.728
MOD_N-GLC_1	229	234	PF02516	0.196
MOD_N-GLC_1	321	326	PF02516	0.306
MOD_N-GLC_1	73	78	PF02516	0.510
MOD_NEK2_1	213	218	PF00069	0.196
MOD_NEK2_1	293	298	PF00069	0.390
MOD_PK_1	358	364	PF00069	0.566
MOD_PKA_1	358	364	PF00069	0.483
MOD_PKA_2	357	363	PF00069	0.557
MOD_PKA_2	58	64	PF00069	0.464
MOD_Plk_1	229	235	PF00069	0.380
MOD_Plk_1	73	79	PF00069	0.514
MOD_Plk_2-3	314	320	PF00069	0.349
MOD_Plk_2-3	333	339	PF00069	0.405
MOD_Plk_4	244	250	PF00069	0.314
MOD_ProDKin_1	120	126	PF00069	0.410
MOD_ProDKin_1	160	166	PF00069	0.458
MOD_ProDKin_1	197	203	PF00069	0.403
MOD_ProDKin_1	239	245	PF00069	0.254
TRG_DiLeu_BaEn_1	244	249	PF01217	0.427
TRG_DiLeu_BaEn_2	240	246	PF01217	0.448
TRG_ENDOCYTIC_2	148	151	PF00928	0.328
TRG_ENDOCYTIC_2	37	40	PF00928	0.697
TRG_ER_diArg_1	174	177	PF00400	0.196
TRG_ER_diArg_1	299	301	PF00400	0.382
TRG_ER_diArg_1	31	34	PF00400	0.608
TRG_ER_diArg_1	366	368	PF00400	0.459
TRG_ER_diArg_1	373	376	PF00400	0.439
TRG_NLS_MonoExtC_3	28	33	PF00514	0.639
TRG_NLS_MonoExtN_4	26	33	PF00514	0.726
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J3	Leptomonas seymouri	64%	100%
A0A0N1I1R8	Leptomonas seymouri	26%	100%
A0A0S4ISJ6	Bodo saltans	26%	85%
A0A0S4KFU5	Bodo saltans	34%	100%
A0A1X0NXB7	Trypanosomatidae	24%	100%
A0A1X0P5J2	Trypanosomatidae	44%	100%
A0A3Q8IDT0	Leishmania donovani	24%	100%
A0A3R7M2M3	Trypanosoma rangeli	44%	100%
A0A3S7X9Q3	Leishmania donovani	77%	97%
A0A422MZQ7	Trypanosoma rangeli	28%	100%
A4HBJ6	Leishmania braziliensis	24%	100%
A4HZL8	Leishmania infantum	24%	100%
A4IBP9	Leishmania infantum	77%	97%
A8KBL7	Danio rerio	25%	100%
C9ZYX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A1J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AFI4	Leishmania major	78%	100%
E9AUW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B6N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q0P5B2	Bos taurus	24%	100%
Q4QCL7	Leishmania major	24%	98%
Q5RDV8	Pongo abelii	29%	100%
Q6AXU8	Rattus norvegicus	29%	100%
Q6P1Q9	Homo sapiens	23%	100%
Q86BS6	Drosophila melanogaster	29%	100%
Q8BMK1	Mus musculus	24%	97%
Q8BVH9	Mus musculus	29%	100%
Q8TCB7	Homo sapiens	29%	100%
Q96IZ6	Homo sapiens	23%	100%
V5BCV4	Trypanosoma cruzi	45%	100%
V5DGW7	Trypanosoma cruzi	30%	100%