CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO, N-terminal domain/CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN25_LEIBR

TriTrypDb:

LbrM.34.3490

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN25

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005548	phospholipid transporter activity	3	1
GO:0008526	phosphatidylinositol transfer activity	5	1
GO:0120013	lipid transfer activity	3	1
GO:0120014	phospholipid transfer activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.297
CLV_NRD_NRD_1	74	76	PF00675	0.495
CLV_NRD_NRD_1	83	85	PF00675	0.523
CLV_PCSK_KEX2_1	355	357	PF00082	0.728
CLV_PCSK_KEX2_1	74	76	PF00082	0.506
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.656
CLV_PCSK_SKI1_1	111	115	PF00082	0.382
CLV_PCSK_SKI1_1	256	260	PF00082	0.375
CLV_PCSK_SKI1_1	334	338	PF00082	0.527
DEG_APCC_DBOX_1	329	337	PF00400	0.372
DEG_MDM2_SWIB_1	251	259	PF02201	0.297
DOC_CYCLIN_RxL_1	108	117	PF00134	0.205
DOC_MAPK_MEF2A_6	220	227	PF00069	0.375
DOC_PP1_RVXF_1	164	171	PF00149	0.277
DOC_PP1_RVXF_1	267	273	PF00149	0.279
DOC_PP1_RVXF_1	309	316	PF00149	0.422
DOC_PP2B_LxvP_1	257	260	PF13499	0.400
DOC_PP2B_LxvP_1	31	34	PF13499	0.442
DOC_PP4_FxxP_1	38	41	PF00568	0.358
DOC_PP4_FxxP_1	47	50	PF00568	0.306
DOC_USP7_MATH_1	277	281	PF00917	0.509
DOC_USP7_UBL2_3	334	338	PF12436	0.627
DOC_USP7_UBL2_3	340	344	PF12436	0.657
DOC_WW_Pin1_4	13	18	PF00397	0.614
LIG_14-3-3_CanoR_1	249	254	PF00244	0.229
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.277
LIG_EVH1_2	247	251	PF00568	0.322
LIG_FHA_2	135	141	PF00498	0.469
LIG_FHA_2	206	212	PF00498	0.295
LIG_FHA_2	266	272	PF00498	0.361
LIG_LIR_Apic_2	304	309	PF02991	0.514
LIG_LIR_Apic_2	36	41	PF02991	0.356
LIG_LIR_Apic_2	45	50	PF02991	0.330
LIG_LIR_Gen_1	105	115	PF02991	0.312
LIG_LIR_Gen_1	121	131	PF02991	0.351
LIG_LIR_Gen_1	202	210	PF02991	0.246
LIG_LIR_Gen_1	211	217	PF02991	0.252
LIG_LIR_Gen_1	87	97	PF02991	0.432
LIG_LIR_Nem_3	105	110	PF02991	0.315
LIG_LIR_Nem_3	121	127	PF02991	0.350
LIG_LIR_Nem_3	202	207	PF02991	0.248
LIG_LIR_Nem_3	208	213	PF02991	0.166
LIG_LIR_Nem_3	252	258	PF02991	0.286
LIG_LIR_Nem_3	283	288	PF02991	0.357
LIG_MYND_1	286	290	PF01753	0.479
LIG_NRBOX	109	115	PF00104	0.193
LIG_PCNA_yPIPBox_3	83	91	PF02747	0.251
LIG_Pex14_2	251	255	PF04695	0.262
LIG_Pex14_2	285	289	PF04695	0.338
LIG_SH2_CRK	306	310	PF00017	0.537
LIG_SH2_NCK_1	306	310	PF00017	0.532
LIG_SH2_STAP1	213	217	PF00017	0.172
LIG_SH2_STAT5	112	115	PF00017	0.306
LIG_SH2_STAT5	296	299	PF00017	0.322
LIG_SH2_STAT5	51	54	PF00017	0.411
LIG_SH3_1	306	312	PF00018	0.543
LIG_SH3_3	306	312	PF00018	0.425
LIG_TRAF2_1	325	328	PF00917	0.483
LIG_TRAF2_1	54	57	PF00917	0.384
LIG_UBA3_1	250	256	PF00899	0.395
LIG_WW_3	246	250	PF00397	0.172
MOD_CK1_1	15	21	PF00069	0.615
MOD_CK1_1	2	8	PF00069	0.712
MOD_CK1_1	22	28	PF00069	0.551
MOD_CK2_1	122	128	PF00069	0.483
MOD_CK2_1	134	140	PF00069	0.384
MOD_CK2_1	15	21	PF00069	0.546
MOD_CK2_1	205	211	PF00069	0.295
MOD_CK2_1	22	28	PF00069	0.428
MOD_CK2_1	265	271	PF00069	0.400
MOD_CK2_1	277	283	PF00069	0.496
MOD_CK2_1	322	328	PF00069	0.478
MOD_CK2_1	51	57	PF00069	0.373
MOD_GlcNHglycan	21	24	PF01048	0.637
MOD_GlcNHglycan	93	96	PF01048	0.345
MOD_GSK3_1	134	141	PF00069	0.445
MOD_GSK3_1	15	22	PF00069	0.610
MOD_GSK3_1	205	212	PF00069	0.270
MOD_GSK3_1	277	284	PF00069	0.521
MOD_GSK3_1	291	298	PF00069	0.246
MOD_GSK3_1	63	70	PF00069	0.319
MOD_N-GLC_1	301	306	PF02516	0.394
MOD_NEK2_1	127	132	PF00069	0.324
MOD_NEK2_1	169	174	PF00069	0.410
MOD_NEK2_1	297	302	PF00069	0.264
MOD_PK_1	249	255	PF00069	0.287
MOD_Plk_4	284	290	PF00069	0.464
MOD_Plk_4	63	69	PF00069	0.289
MOD_ProDKin_1	13	19	PF00069	0.613
MOD_SUMO_for_1	336	339	PF00179	0.419
MOD_SUMO_rev_2	172	182	PF00179	0.400
MOD_SUMO_rev_2	214	222	PF00179	0.400
TRG_ENDOCYTIC_2	213	216	PF00928	0.297
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG0	Leptomonas seymouri	74%	96%
A0A0S4IKI1	Bodo saltans	46%	100%
A0A1X0P588	Trypanosomatidae	51%	100%
A0A3Q8IJP6	Leishmania donovani	77%	99%
A0A3R7L5B2	Trypanosoma rangeli	56%	100%
A4IBP3	Leishmania infantum	77%	99%
C9ZYY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AFI0	Leishmania major	80%	100%
E9B6N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q55CU8	Dictyostelium discoideum	26%	100%
V5BCV8	Trypanosoma cruzi	55%	100%