Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HN22_LEIBR

TriTrypDb:

LbrM.34.3460 , LBRM2903_340043700

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	224	226	PF00082	0.447
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.447
CLV_PCSK_SKI1_1	146	150	PF00082	0.610
CLV_PCSK_SKI1_1	191	195	PF00082	0.432
CLV_PCSK_SKI1_1	206	210	PF00082	0.444
DEG_APCC_DBOX_1	190	198	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DEG_SPOP_SBC_1	86	90	PF00917	0.554
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.607
DOC_MAPK_gen_1	224	231	PF00069	0.468
DOC_MAPK_gen_1	345	354	PF00069	0.427
DOC_MAPK_MEF2A_6	176	183	PF00069	0.525
DOC_MAPK_MEF2A_6	187	196	PF00069	0.526
DOC_MAPK_MEF2A_6	347	356	PF00069	0.478
DOC_PP1_RVXF_1	158	164	PF00149	0.649
DOC_PP1_SILK_1	270	275	PF00149	0.596
DOC_PP2B_LxvP_1	44	47	PF13499	0.528
DOC_USP7_MATH_1	104	108	PF00917	0.723
DOC_USP7_MATH_1	109	113	PF00917	0.654
DOC_USP7_MATH_1	86	90	PF00917	0.554
DOC_USP7_MATH_1	96	100	PF00917	0.573
DOC_USP7_UBL2_3	81	85	PF12436	0.718
DOC_WW_Pin1_4	235	240	PF00397	0.649
DOC_WW_Pin1_4	88	93	PF00397	0.625
LIG_14-3-3_CanoR_1	199	203	PF00244	0.470
LIG_14-3-3_CanoR_1	51	55	PF00244	0.568
LIG_Actin_WH2_2	147	164	PF00022	0.547
LIG_Actin_WH2_2	261	276	PF00022	0.598
LIG_APCC_ABBA_1	140	145	PF00400	0.581
LIG_BIR_III_4	95	99	PF00653	0.728
LIG_CaM_NSCaTE_8	269	276	PF13499	0.590
LIG_deltaCOP1_diTrp_1	155	163	PF00928	0.486
LIG_deltaCOP1_diTrp_1	349	353	PF00928	0.574
LIG_eIF4E_1	251	257	PF01652	0.583
LIG_EVH1_1	291	295	PF00568	0.550
LIG_FHA_1	2	8	PF00498	0.581
LIG_FHA_1	268	274	PF00498	0.425
LIG_FHA_1	313	319	PF00498	0.642
LIG_FHA_1	389	395	PF00498	0.449
LIG_FHA_1	39	45	PF00498	0.563
LIG_FHA_1	55	61	PF00498	0.558
LIG_FHA_1	67	73	PF00498	0.600
LIG_FHA_2	215	221	PF00498	0.611
LIG_FHA_2	243	249	PF00498	0.592
LIG_FHA_2	360	366	PF00498	0.609
LIG_LIR_Gen_1	216	227	PF02991	0.523
LIG_LIR_Gen_1	266	276	PF02991	0.595
LIG_LIR_Gen_1	349	359	PF02991	0.668
LIG_LIR_Gen_1	380	390	PF02991	0.518
LIG_LIR_Nem_3	216	222	PF02991	0.604
LIG_LIR_Nem_3	248	254	PF02991	0.581
LIG_LIR_Nem_3	266	272	PF02991	0.489
LIG_LIR_Nem_3	349	354	PF02991	0.671
LIG_LIR_Nem_3	380	386	PF02991	0.517
LIG_NRBOX	372	378	PF00104	0.467
LIG_PDZ_Wminus1_1	399	401	PF00595	0.486
LIG_Rb_LxCxE_1	303	320	PF01857	0.621
LIG_SH2_STAP1	390	394	PF00017	0.522
LIG_SH2_STAT5	13	16	PF00017	0.548
LIG_SH2_STAT5	221	224	PF00017	0.452
LIG_SH2_STAT5	260	263	PF00017	0.560
LIG_SH2_STAT5	390	393	PF00017	0.522
LIG_SH3_3	189	195	PF00018	0.508
LIG_SH3_3	220	226	PF00018	0.567
LIG_SH3_3	236	242	PF00018	0.672
LIG_SH3_3	286	292	PF00018	0.571
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.562
LIG_TRAF2_1	245	248	PF00917	0.584
LIG_UBA3_1	218	224	PF00899	0.601
LIG_WRC_WIRS_1	301	306	PF05994	0.486
LIG_WRC_WIRS_1	64	69	PF05994	0.647
LIG_WW_2	292	295	PF00397	0.544
MOD_CK1_1	112	118	PF00069	0.530
MOD_CK1_1	234	240	PF00069	0.712
MOD_CK1_1	335	341	PF00069	0.534
MOD_CK1_1	369	375	PF00069	0.468
MOD_CK1_1	53	59	PF00069	0.635
MOD_CK1_1	65	71	PF00069	0.513
MOD_CK1_1	80	86	PF00069	0.728
MOD_CK1_1	88	94	PF00069	0.594
MOD_CK2_1	242	248	PF00069	0.600
MOD_GlcNHglycan	319	322	PF01048	0.631
MOD_GlcNHglycan	338	341	PF01048	0.582
MOD_GlcNHglycan	373	376	PF01048	0.485
MOD_GlcNHglycan	72	75	PF01048	0.600
MOD_GSK3_1	13	20	PF00069	0.650
MOD_GSK3_1	198	205	PF00069	0.638
MOD_GSK3_1	231	238	PF00069	0.700
MOD_GSK3_1	242	249	PF00069	0.548
MOD_GSK3_1	264	271	PF00069	0.705
MOD_GSK3_1	308	315	PF00069	0.546
MOD_GSK3_1	332	339	PF00069	0.449
MOD_GSK3_1	359	366	PF00069	0.557
MOD_GSK3_1	50	57	PF00069	0.680
MOD_GSK3_1	62	69	PF00069	0.606
MOD_GSK3_1	77	84	PF00069	0.634
MOD_GSK3_1	96	103	PF00069	0.573
MOD_NEK2_1	14	19	PF00069	0.591
MOD_NEK2_1	153	158	PF00069	0.533
MOD_NEK2_1	300	305	PF00069	0.486
MOD_NEK2_1	359	364	PF00069	0.616
MOD_NEK2_1	62	67	PF00069	0.597
MOD_PIKK_1	104	110	PF00454	0.539
MOD_PKA_2	100	106	PF00069	0.564
MOD_PKA_2	198	204	PF00069	0.558
MOD_PKA_2	50	56	PF00069	0.571
MOD_Plk_1	246	252	PF00069	0.416
MOD_Plk_1	369	375	PF00069	0.485
MOD_Plk_1	54	60	PF00069	0.582
MOD_Plk_4	214	220	PF00069	0.494
MOD_Plk_4	264	270	PF00069	0.603
MOD_ProDKin_1	235	241	PF00069	0.647
MOD_ProDKin_1	88	94	PF00069	0.627
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.506
TRG_ENDOCYTIC_2	251	254	PF00928	0.504
TRG_ENDOCYTIC_2	382	385	PF00928	0.561
TRG_ENDOCYTIC_2	390	393	PF00928	0.483
TRG_ER_diArg_1	160	163	PF00400	0.654
TRG_NES_CRM1_1	48	61	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P5	Leptomonas seymouri	37%	84%
A0A3S7X9Q8	Leishmania donovani	73%	94%
A4IBP6	Leishmania infantum	73%	94%
E9AFH7	Leishmania major	74%	100%
E9B6N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	94%