FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HN21_LEIBR

TriTrypDb:

LbrM.34.3450 , LBRM2903_340043600

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN21

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.792
CLV_NRD_NRD_1	383	385	PF00675	0.433
CLV_NRD_NRD_1	390	392	PF00675	0.351
CLV_NRD_NRD_1	411	413	PF00675	0.678
CLV_NRD_NRD_1	81	83	PF00675	0.678
CLV_PCSK_KEX2_1	111	113	PF00082	0.792
CLV_PCSK_KEX2_1	125	127	PF00082	0.606
CLV_PCSK_KEX2_1	383	385	PF00082	0.433
CLV_PCSK_KEX2_1	410	412	PF00082	0.665
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.792
CLV_PCSK_SKI1_1	384	388	PF00082	0.433
DOC_CYCLIN_RxL_1	169	180	PF00134	0.672
DOC_MAPK_gen_1	380	388	PF00069	0.530
DOC_MAPK_MEF2A_6	235	242	PF00069	0.512
DOC_MAPK_MEF2A_6	467	475	PF00069	0.610
DOC_PP2B_LxvP_1	140	143	PF13499	0.596
DOC_PP2B_LxvP_1	168	171	PF13499	0.576
DOC_PP2B_LxvP_1	475	478	PF13499	0.363
DOC_PP2B_PxIxI_1	327	333	PF00149	0.637
DOC_USP7_MATH_1	2	6	PF00917	0.668
DOC_USP7_MATH_1	264	268	PF00917	0.296
DOC_USP7_UBL2_3	283	287	PF12436	0.530
DOC_WW_Pin1_4	117	122	PF00397	0.575
DOC_WW_Pin1_4	125	130	PF00397	0.568
DOC_WW_Pin1_4	212	217	PF00397	0.601
DOC_WW_Pin1_4	343	348	PF00397	0.590
DOC_WW_Pin1_4	362	367	PF00397	0.437
LIG_14-3-3_CanoR_1	112	117	PF00244	0.704
LIG_14-3-3_CanoR_1	125	129	PF00244	0.721
LIG_14-3-3_CanoR_1	157	167	PF00244	0.671
LIG_14-3-3_CanoR_1	235	239	PF00244	0.478
LIG_14-3-3_CanoR_1	32	36	PF00244	0.601
LIG_14-3-3_CanoR_1	38	48	PF00244	0.571
LIG_14-3-3_CanoR_1	69	78	PF00244	0.596
LIG_14-3-3_CterR_2	503	506	PF00244	0.512
LIG_Clathr_ClatBox_1	297	301	PF01394	0.491
LIG_DLG_GKlike_1	112	119	PF00625	0.652
LIG_FHA_1	21	27	PF00498	0.716
LIG_FHA_1	235	241	PF00498	0.501
LIG_FHA_1	370	376	PF00498	0.378
LIG_FHA_1	383	389	PF00498	0.467
LIG_FHA_1	446	452	PF00498	0.743
LIG_FHA_1	468	474	PF00498	0.606
LIG_FHA_2	176	182	PF00498	0.798
LIG_Integrin_RGD_1	59	61	PF01839	0.609
LIG_LIR_Gen_1	293	303	PF02991	0.530
LIG_LIR_Nem_3	103	109	PF02991	0.645
LIG_LIR_Nem_3	293	298	PF02991	0.366
LIG_LIR_Nem_3	301	306	PF02991	0.398
LIG_LIR_Nem_3	325	330	PF02991	0.470
LIG_MYND_1	196	200	PF01753	0.524
LIG_MYND_1	224	228	PF01753	0.550
LIG_PCNA_TLS_4	289	296	PF02747	0.530
LIG_PCNA_yPIPBox_3	383	397	PF02747	0.530
LIG_PTB_Apo_2	216	223	PF02174	0.731
LIG_SH2_CRK	400	404	PF00017	0.530
LIG_SH2_SRC	225	228	PF00017	0.407
LIG_SH2_STAP1	315	319	PF00017	0.530
LIG_SH2_STAP1	371	375	PF00017	0.433
LIG_SH2_STAT5	177	180	PF00017	0.580
LIG_SH2_STAT5	225	228	PF00017	0.507
LIG_SH2_STAT5	371	374	PF00017	0.394
LIG_SH3_1	221	227	PF00018	0.435
LIG_SH3_2	22	27	PF14604	0.566
LIG_SH3_3	140	146	PF00018	0.577
LIG_SH3_3	19	25	PF00018	0.760
LIG_SH3_3	221	227	PF00018	0.435
LIG_SH3_3	260	266	PF00018	0.358
LIG_SH3_3	274	280	PF00018	0.229
LIG_SH3_3	341	347	PF00018	0.582
LIG_SH3_3	393	399	PF00018	0.530
LIG_SUMO_SIM_par_1	236	241	PF11976	0.530
LIG_SUMO_SIM_par_1	384	389	PF11976	0.530
LIG_TRAF2_1	178	181	PF00917	0.711
LIG_TRAF2_1	417	420	PF00917	0.479
LIG_TRAF2_2	227	232	PF00917	0.461
LIG_WRC_WIRS_1	491	496	PF05994	0.607
LIG_WW_3	144	148	PF00397	0.573
LIG_WW_3	169	173	PF00397	0.574
LIG_WW_3	56	60	PF00397	0.593
MOD_CDK_SPxxK_3	343	350	PF00069	0.575
MOD_CK1_1	120	126	PF00069	0.618
MOD_CK1_1	31	37	PF00069	0.638
MOD_CK1_1	455	461	PF00069	0.542
MOD_CK1_1	5	11	PF00069	0.678
MOD_CK1_1	99	105	PF00069	0.695
MOD_CK2_1	175	181	PF00069	0.797
MOD_CK2_1	435	441	PF00069	0.707
MOD_CK2_1	47	53	PF00069	0.608
MOD_CK2_1	483	489	PF00069	0.608
MOD_Cter_Amidation	109	112	PF01082	0.791
MOD_GlcNHglycan	339	342	PF01048	0.804
MOD_GlcNHglycan	437	440	PF01048	0.742
MOD_GlcNHglycan	44	47	PF01048	0.643
MOD_GlcNHglycan	454	457	PF01048	0.473
MOD_GlcNHglycan	91	94	PF01048	0.636
MOD_GSK3_1	120	127	PF00069	0.663
MOD_GSK3_1	242	249	PF00069	0.407
MOD_GSK3_1	3	10	PF00069	0.804
MOD_GSK3_1	431	438	PF00069	0.643
MOD_GSK3_1	446	453	PF00069	0.472
MOD_GSK3_1	70	77	PF00069	0.659
MOD_GSK3_1	95	102	PF00069	0.713
MOD_N-GLC_1	100	105	PF02516	0.744
MOD_N-GLC_1	212	217	PF02516	0.724
MOD_N-GLC_1	337	342	PF02516	0.574
MOD_N-GLC_1	94	99	PF02516	0.788
MOD_N-GLC_2	163	165	PF02516	0.581
MOD_N-GLC_2	41	43	PF02516	0.696
MOD_NEK2_1	100	105	PF00069	0.697
MOD_NEK2_1	242	247	PF00069	0.530
MOD_NEK2_1	308	313	PF00069	0.530
MOD_NEK2_1	382	387	PF00069	0.530
MOD_NEK2_1	431	436	PF00069	0.618
MOD_NEK2_1	451	456	PF00069	0.500
MOD_NEK2_1	495	500	PF00069	0.654
MOD_PIKK_1	120	126	PF00454	0.582
MOD_PKA_2	124	130	PF00069	0.777
MOD_PKA_2	158	164	PF00069	0.614
MOD_PKA_2	234	240	PF00069	0.413
MOD_PKA_2	31	37	PF00069	0.599
MOD_PKA_2	382	388	PF00069	0.530
MOD_Plk_1	242	248	PF00069	0.407
MOD_Plk_1	273	279	PF00069	0.296
MOD_Plk_1	431	437	PF00069	0.562
MOD_Plk_1	467	473	PF00069	0.613
MOD_Plk_1	74	80	PF00069	0.839
MOD_Plk_4	112	118	PF00069	0.612
MOD_Plk_4	163	169	PF00069	0.707
MOD_Plk_4	234	240	PF00069	0.501
MOD_Plk_4	242	248	PF00069	0.362
MOD_Plk_4	31	37	PF00069	0.592
MOD_Plk_4	467	473	PF00069	0.613
MOD_Plk_4	490	496	PF00069	0.608
MOD_ProDKin_1	117	123	PF00069	0.576
MOD_ProDKin_1	125	131	PF00069	0.568
MOD_ProDKin_1	212	218	PF00069	0.604
MOD_ProDKin_1	343	349	PF00069	0.586
MOD_ProDKin_1	362	368	PF00069	0.437
MOD_SUMO_rev_2	415	423	PF00179	0.481
TRG_DiLeu_BaEn_1	468	473	PF01217	0.601
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.566
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.757
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.511
TRG_ENDOCYTIC_2	282	285	PF00928	0.530
TRG_ENDOCYTIC_2	400	403	PF00928	0.530
TRG_ER_diArg_1	382	384	PF00400	0.433
TRG_ER_diArg_1	410	412	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIK2	Leishmania donovani	59%	90%
A4IBP7	Leishmania infantum	59%	90%
E9AFH6	Leishmania major	59%	100%
E9B6N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	93%