FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN19_LEIBR

TriTrypDb:

LbrM.34.3430 , LBRM2903_340043300

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HN19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN19

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.597
CLV_NRD_NRD_1	31	33	PF00675	0.293
CLV_PCSK_KEX2_1	183	185	PF00082	0.577
CLV_PCSK_KEX2_1	276	278	PF00082	0.613
CLV_PCSK_KEX2_1	31	33	PF00082	0.293
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.612
CLV_PCSK_SKI1_1	193	197	PF00082	0.546
CLV_PCSK_SKI1_1	277	281	PF00082	0.637
CLV_PCSK_SKI1_1	56	60	PF00082	0.352
DEG_SPOP_SBC_1	25	29	PF00917	0.421
DOC_MAPK_MEF2A_6	193	201	PF00069	0.623
DOC_PP2B_LxvP_1	240	243	PF13499	0.724
DOC_USP7_MATH_1	128	132	PF00917	0.602
DOC_WW_Pin1_4	173	178	PF00397	0.696
DOC_WW_Pin1_4	288	293	PF00397	0.610
DOC_WW_Pin1_4	93	98	PF00397	0.624
LIG_14-3-3_CanoR_1	117	124	PF00244	0.759
LIG_14-3-3_CanoR_1	188	193	PF00244	0.628
LIG_14-3-3_CanoR_1	244	253	PF00244	0.565
LIG_14-3-3_CanoR_1	56	61	PF00244	0.352
LIG_14-3-3_CanoR_1	73	78	PF00244	0.364
LIG_FHA_1	194	200	PF00498	0.584
LIG_FHA_1	219	225	PF00498	0.725
LIG_FHA_1	235	241	PF00498	0.752
LIG_FHA_1	257	263	PF00498	0.580
LIG_FHA_1	273	279	PF00498	0.563
LIG_FHA_2	211	217	PF00498	0.643
LIG_FHA_2	263	269	PF00498	0.648
LIG_FHA_2	57	63	PF00498	0.352
LIG_IBAR_NPY_1	150	152	PF08397	0.516
LIG_LIR_Apic_2	145	151	PF02991	0.626
LIG_LIR_Gen_1	196	203	PF02991	0.640
LIG_LIR_Gen_1	66	77	PF02991	0.374
LIG_LIR_Nem_3	196	201	PF02991	0.640
LIG_LIR_Nem_3	293	298	PF02991	0.721
LIG_LIR_Nem_3	66	72	PF02991	0.340
LIG_SH2_CRK	148	152	PF00017	0.759
LIG_SH2_GRB2like	148	151	PF00017	0.753
LIG_SH2_PTP2	198	201	PF00017	0.666
LIG_SH2_SRC	198	201	PF00017	0.666
LIG_SH2_STAT5	198	201	PF00017	0.657
LIG_SH2_STAT5	252	255	PF00017	0.673
LIG_SH2_STAT5	40	43	PF00017	0.312
LIG_SH2_STAT5	69	72	PF00017	0.421
LIG_SH3_3	225	231	PF00018	0.584
LIG_SH3_3	94	100	PF00018	0.532
LIG_SxIP_EBH_1	275	285	PF03271	0.516
LIG_TRAF2_1	170	173	PF00917	0.543
LIG_TYR_ITSM	194	201	PF00017	0.663
MOD_CDC14_SPxK_1	291	294	PF00782	0.509
MOD_CDK_SPxK_1	288	294	PF00069	0.509
MOD_CDK_SPxK_1	93	99	PF00069	0.629
MOD_CK1_1	162	168	PF00069	0.562
MOD_CK1_1	218	224	PF00069	0.704
MOD_CK1_1	256	262	PF00069	0.503
MOD_CK1_1	288	294	PF00069	0.580
MOD_CK1_1	80	86	PF00069	0.648
MOD_CK2_1	210	216	PF00069	0.670
MOD_CK2_1	262	268	PF00069	0.608
MOD_CK2_1	56	62	PF00069	0.472
MOD_GlcNHglycan	112	115	PF01048	0.676
MOD_GlcNHglycan	131	134	PF01048	0.778
MOD_GlcNHglycan	248	251	PF01048	0.652
MOD_GSK3_1	101	108	PF00069	0.614
MOD_GSK3_1	116	123	PF00069	0.640
MOD_GSK3_1	73	80	PF00069	0.539
MOD_N-GLC_1	73	78	PF02516	0.642
MOD_N-GLC_2	20	22	PF02516	0.421
MOD_NEK2_1	253	258	PF00069	0.593
MOD_NEK2_1	26	31	PF00069	0.289
MOD_NEK2_1	72	77	PF00069	0.586
MOD_PK_1	73	79	PF00069	0.436
MOD_PKA_2	116	122	PF00069	0.755
MOD_PKA_2	218	224	PF00069	0.693
MOD_PKA_2	243	249	PF00069	0.490
MOD_PKA_2	72	78	PF00069	0.541
MOD_Plk_1	73	79	PF00069	0.473
MOD_Plk_4	193	199	PF00069	0.663
MOD_Plk_4	262	268	PF00069	0.684
MOD_Plk_4	73	79	PF00069	0.462
MOD_ProDKin_1	173	179	PF00069	0.690
MOD_ProDKin_1	288	294	PF00069	0.612
MOD_ProDKin_1	93	99	PF00069	0.623
MOD_SUMO_rev_2	176	185	PF00179	0.605
TRG_DiLeu_BaEn_1	181	186	PF01217	0.562
TRG_DiLeu_BaEn_1	220	225	PF01217	0.496
TRG_DiLeu_LyEn_5	181	186	PF01217	0.530
TRG_ENDOCYTIC_2	198	201	PF00928	0.666
TRG_ENDOCYTIC_2	69	72	PF00928	0.338
TRG_ER_diArg_1	276	278	PF00400	0.457
TRG_ER_diArg_1	30	32	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9N1	Leptomonas seymouri	57%	98%
A0A1X0P5K3	Trypanosomatidae	31%	96%
A0A3Q8II84	Leishmania donovani	75%	100%
A0A3S5IRP0	Trypanosoma rangeli	32%	100%
A4IBP0	Leishmania infantum	74%	100%
C9ZYZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AFH4	Leishmania major	74%	100%
E9B6M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BTD8	Trypanosoma cruzi	35%	100%