Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN18_LEIBR

TriTrypDb:

LbrM.34.3420 , LBRM2903_340043200

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN18

PDB structure(s): 7ane_q

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.495
CLV_C14_Caspase3-7	207	211	PF00656	0.410
CLV_C14_Caspase3-7	246	250	PF00656	0.672
CLV_C14_Caspase3-7	337	341	PF00656	0.572
CLV_NRD_NRD_1	102	104	PF00675	0.515
CLV_NRD_NRD_1	26	28	PF00675	0.432
CLV_NRD_NRD_1	268	270	PF00675	0.643
CLV_NRD_NRD_1	286	288	PF00675	0.400
CLV_NRD_NRD_1	302	304	PF00675	0.657
CLV_NRD_NRD_1	324	326	PF00675	0.615
CLV_NRD_NRD_1	57	59	PF00675	0.367
CLV_NRD_NRD_1	9	11	PF00675	0.462
CLV_NRD_NRD_1	99	101	PF00675	0.522
CLV_PCSK_FUR_1	100	104	PF00082	0.511
CLV_PCSK_KEX2_1	101	103	PF00082	0.432
CLV_PCSK_KEX2_1	26	28	PF00082	0.432
CLV_PCSK_KEX2_1	286	288	PF00082	0.500
CLV_PCSK_KEX2_1	302	304	PF00082	0.657
CLV_PCSK_KEX2_1	323	325	PF00082	0.617
CLV_PCSK_KEX2_1	362	364	PF00082	0.625
CLV_PCSK_KEX2_1	62	64	PF00082	0.375
CLV_PCSK_KEX2_1	9	11	PF00082	0.462
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.432
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.614
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.625
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.388
CLV_PCSK_PC7_1	282	288	PF00082	0.488
CLV_PCSK_PC7_1	58	64	PF00082	0.368
CLV_PCSK_SKI1_1	112	116	PF00082	0.425
CLV_PCSK_SKI1_1	129	133	PF00082	0.316
CLV_PCSK_SKI1_1	26	30	PF00082	0.404
CLV_PCSK_SKI1_1	298	302	PF00082	0.585
CLV_PCSK_SKI1_1	349	353	PF00082	0.599
CLV_PCSK_SKI1_1	376	380	PF00082	0.573
DEG_SCF_FBW7_2	377	383	PF00400	0.494
DOC_ANK_TNKS_1	304	311	PF00023	0.517
DOC_CKS1_1	31	36	PF01111	0.376
DOC_CKS1_1	377	382	PF01111	0.493
DOC_CYCLIN_RxL_1	112	125	PF00134	0.403
DOC_MAPK_gen_1	116	122	PF00069	0.401
DOC_PP4_FxxP_1	301	304	PF00568	0.601
DOC_PP4_FxxP_1	31	34	PF00568	0.382
DOC_USP7_MATH_1	19	23	PF00917	0.444
DOC_USP7_UBL2_3	294	298	PF12436	0.560
DOC_USP7_UBL2_3	345	349	PF12436	0.721
DOC_WW_Pin1_4	30	35	PF00397	0.392
DOC_WW_Pin1_4	310	315	PF00397	0.724
DOC_WW_Pin1_4	317	322	PF00397	0.624
DOC_WW_Pin1_4	376	381	PF00397	0.709
DOC_WW_Pin1_4	385	390	PF00397	0.658
LIG_14-3-3_CanoR_1	137	145	PF00244	0.356
LIG_14-3-3_CanoR_1	147	151	PF00244	0.397
LIG_14-3-3_CanoR_1	325	335	PF00244	0.691
LIG_14-3-3_CanoR_1	400	407	PF00244	0.621
LIG_Actin_WH2_2	42	60	PF00022	0.286
LIG_BRCT_BRCA1_1	262	266	PF00533	0.430
LIG_FHA_1	2	8	PF00498	0.577
LIG_FHA_1	27	33	PF00498	0.403
LIG_FHA_1	377	383	PF00498	0.546
LIG_FHA_1	401	407	PF00498	0.661
LIG_FHA_2	212	218	PF00498	0.582
LIG_FHA_2	254	260	PF00498	0.413
LIG_FHA_2	276	282	PF00498	0.508
LIG_LIR_Apic_2	214	219	PF02991	0.606
LIG_LIR_Apic_2	29	34	PF02991	0.384
LIG_LIR_Gen_1	51	61	PF02991	0.369
LIG_LIR_Nem_3	44	49	PF02991	0.362
LIG_LIR_Nem_3	51	57	PF02991	0.372
LIG_MYND_3	183	187	PF01753	0.447
LIG_PDZ_Class_3	421	426	PF00595	0.614
LIG_Pex14_1	65	69	PF04695	0.356
LIG_SH2_CRK	16	20	PF00017	0.416
LIG_SH2_GRB2like	15	18	PF00017	0.426
LIG_SH2_NCK_1	135	139	PF00017	0.348
LIG_SH2_NCK_1	16	20	PF00017	0.400
LIG_SH2_NCK_1	216	220	PF00017	0.550
LIG_SH2_SRC	216	219	PF00017	0.413
LIG_SH2_STAT3	150	153	PF00017	0.427
LIG_SH2_STAT3	61	64	PF00017	0.372
LIG_SH2_STAT5	150	153	PF00017	0.393
LIG_SH2_STAT5	167	170	PF00017	0.392
LIG_SH2_STAT5	289	292	PF00017	0.511
LIG_SH2_STAT5	76	79	PF00017	0.369
LIG_TRAF2_1	155	158	PF00917	0.465
LIG_TRAF2_1	235	238	PF00917	0.550
LIG_TRAF2_1	274	277	PF00917	0.598
LIG_TRAF2_1	278	281	PF00917	0.662
LIG_TRAF2_1	334	337	PF00917	0.564
LIG_WRC_WIRS_1	66	71	PF05994	0.357
MOD_CDK_SPxK_1	30	36	PF00069	0.386
MOD_CDK_SPxK_1	317	323	PF00069	0.637
MOD_CDK_SPxxK_3	317	324	PF00069	0.633
MOD_CK1_1	149	155	PF00069	0.506
MOD_CK1_1	381	387	PF00069	0.690
MOD_CK2_1	152	158	PF00069	0.471
MOD_CK2_1	17	23	PF00069	0.478
MOD_CK2_1	211	217	PF00069	0.560
MOD_CK2_1	232	238	PF00069	0.560
MOD_CK2_1	271	277	PF00069	0.629
MOD_Cter_Amidation	24	27	PF01082	0.452
MOD_GlcNHglycan	234	237	PF01048	0.497
MOD_GlcNHglycan	262	265	PF01048	0.696
MOD_GlcNHglycan	314	317	PF01048	0.630
MOD_GlcNHglycan	4	7	PF01048	0.703
MOD_GlcNHglycan	84	87	PF01048	0.506
MOD_GSK3_1	199	206	PF00069	0.530
MOD_GSK3_1	249	256	PF00069	0.500
MOD_GSK3_1	26	33	PF00069	0.393
MOD_GSK3_1	271	278	PF00069	0.501
MOD_GSK3_1	312	319	PF00069	0.584
MOD_GSK3_1	354	361	PF00069	0.554
MOD_GSK3_1	381	388	PF00069	0.665
MOD_LATS_1	24	30	PF00433	0.430
MOD_N-GLC_1	80	85	PF02516	0.364
MOD_NEK2_1	1	6	PF00069	0.562
MOD_NEK2_1	232	237	PF00069	0.503
MOD_NEK2_2	211	216	PF00069	0.600
MOD_NEK2_2	65	70	PF00069	0.358
MOD_PIKK_1	102	108	PF00454	0.528
MOD_PIKK_1	149	155	PF00454	0.415
MOD_PKA_1	102	108	PF00069	0.528
MOD_PKA_1	26	32	PF00069	0.413
MOD_PKA_1	324	330	PF00069	0.667
MOD_PKA_2	102	108	PF00069	0.528
MOD_PKA_2	136	142	PF00069	0.351
MOD_PKA_2	146	152	PF00069	0.393
MOD_PKA_2	26	32	PF00069	0.540
MOD_PKA_2	324	330	PF00069	0.679
MOD_PKB_1	100	108	PF00069	0.512
MOD_Plk_2-3	253	259	PF00069	0.406
MOD_Plk_4	211	217	PF00069	0.574
MOD_ProDKin_1	30	36	PF00069	0.386
MOD_ProDKin_1	310	316	PF00069	0.725
MOD_ProDKin_1	317	323	PF00069	0.623
MOD_ProDKin_1	376	382	PF00069	0.711
MOD_ProDKin_1	385	391	PF00069	0.656
MOD_SUMO_for_1	351	354	PF00179	0.630
MOD_SUMO_rev_2	220	230	PF00179	0.636
TRG_ENDOCYTIC_2	15	18	PF00928	0.426
TRG_ER_diArg_1	100	103	PF00400	0.510
TRG_ER_diArg_1	241	244	PF00400	0.587
TRG_ER_diArg_1	26	28	PF00400	0.534
TRG_ER_diArg_1	301	303	PF00400	0.673
TRG_ER_diArg_1	370	373	PF00400	0.582
TRG_ER_diArg_1	8	10	PF00400	0.489
TRG_NLS_Bipartite_1	100	120	PF00514	0.432
TRG_NLS_MonoCore_2	322	327	PF00514	0.628
TRG_NLS_MonoExtC_3	115	121	PF00514	0.407
TRG_NLS_MonoExtC_3	324	330	PF00514	0.548
TRG_NLS_MonoExtN_4	321	327	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P6	Leptomonas seymouri	78%	100%
A0A0S4IKL5	Bodo saltans	52%	91%
A0A1X0P5A6	Trypanosomatidae	62%	96%
A0A3Q8IPV2	Leishmania donovani	93%	100%
A0A3R7NKQ1	Trypanosoma rangeli	62%	97%
A4IBN9	Leishmania infantum	93%	100%
C9ZYZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	97%
E9AFH3	Leishmania major	92%	100%
E9B6M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BY99	Trypanosoma cruzi	62%	96%