GPS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN17_LEIBR

TriTrypDb:

LbrM.34.3410 , LBRM2903_340043100

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.528
CLV_C14_Caspase3-7	424	428	PF00656	0.497
CLV_MEL_PAP_1	623	629	PF00089	0.586
CLV_NRD_NRD_1	200	202	PF00675	0.748
CLV_NRD_NRD_1	235	237	PF00675	0.709
CLV_NRD_NRD_1	450	452	PF00675	0.801
CLV_NRD_NRD_1	563	565	PF00675	0.597
CLV_PCSK_FUR_1	198	202	PF00082	0.739
CLV_PCSK_KEX2_1	11	13	PF00082	0.451
CLV_PCSK_KEX2_1	200	202	PF00082	0.755
CLV_PCSK_KEX2_1	235	237	PF00082	0.709
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.451
CLV_PCSK_SKI1_1	137	141	PF00082	0.428
CLV_PCSK_SKI1_1	386	390	PF00082	0.588
CLV_PCSK_SKI1_1	508	512	PF00082	0.654
CLV_PCSK_SKI1_1	713	717	PF00082	0.790
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DEG_SCF_FBW7_1	388	395	PF00400	0.570
DEG_SCF_FBW7_1	536	543	PF00400	0.591
DEG_SCF_FBW7_1	591	598	PF00400	0.752
DEG_SIAH_1	155	163	PF03145	0.807
DEG_SPOP_SBC_1	290	294	PF00917	0.666
DOC_CKS1_1	389	394	PF01111	0.533
DOC_CKS1_1	509	514	PF01111	0.686
DOC_CKS1_1	555	560	PF01111	0.647
DOC_CKS1_1	571	576	PF01111	0.533
DOC_CKS1_1	592	597	PF01111	0.757
DOC_CKS1_1	696	701	PF01111	0.734
DOC_CKS1_1	714	719	PF01111	0.624
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	686	689	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	728	734	PF00134	0.788
DOC_MAPK_HePTP_8	29	41	PF00069	0.592
DOC_MAPK_MEF2A_6	185	193	PF00069	0.641
DOC_MAPK_MEF2A_6	309	317	PF00069	0.437
DOC_MAPK_MEF2A_6	32	41	PF00069	0.496
DOC_MAPK_MEF2A_6	94	102	PF00069	0.356
DOC_PP1_RVXF_1	30	37	PF00149	0.550
DOC_PP2B_LxvP_1	100	103	PF13499	0.402
DOC_PP2B_LxvP_1	351	354	PF13499	0.519
DOC_PP2B_LxvP_1	549	552	PF13499	0.695
DOC_PP2B_LxvP_1	686	689	PF13499	0.747
DOC_PP2B_LxvP_1	691	694	PF13499	0.693
DOC_PP2B_LxvP_1	697	700	PF13499	0.634
DOC_PP2B_LxvP_1	728	731	PF13499	0.761
DOC_USP7_MATH_1	132	136	PF00917	0.400
DOC_USP7_MATH_1	156	160	PF00917	0.780
DOC_USP7_MATH_1	21	25	PF00917	0.494
DOC_USP7_MATH_1	225	229	PF00917	0.808
DOC_USP7_MATH_1	285	289	PF00917	0.713
DOC_USP7_MATH_1	355	359	PF00917	0.551
DOC_USP7_MATH_1	392	396	PF00917	0.623
DOC_USP7_MATH_1	474	478	PF00917	0.768
DOC_USP7_MATH_1	531	535	PF00917	0.811
DOC_USP7_MATH_1	540	544	PF00917	0.823
DOC_USP7_MATH_1	581	585	PF00917	0.754
DOC_USP7_MATH_1	595	599	PF00917	0.605
DOC_USP7_MATH_1	607	611	PF00917	0.736
DOC_USP7_MATH_1	625	629	PF00917	0.655
DOC_USP7_MATH_1	644	648	PF00917	0.695
DOC_USP7_UBL2_3	283	287	PF12436	0.748
DOC_WW_Pin1_4	158	163	PF00397	0.776
DOC_WW_Pin1_4	277	282	PF00397	0.551
DOC_WW_Pin1_4	322	327	PF00397	0.625
DOC_WW_Pin1_4	388	393	PF00397	0.523
DOC_WW_Pin1_4	508	513	PF00397	0.750
DOC_WW_Pin1_4	536	541	PF00397	0.747
DOC_WW_Pin1_4	554	559	PF00397	0.756
DOC_WW_Pin1_4	565	570	PF00397	0.748
DOC_WW_Pin1_4	591	596	PF00397	0.745
DOC_WW_Pin1_4	600	605	PF00397	0.658
DOC_WW_Pin1_4	663	668	PF00397	0.791
DOC_WW_Pin1_4	677	682	PF00397	0.770
DOC_WW_Pin1_4	692	697	PF00397	0.730
DOC_WW_Pin1_4	702	707	PF00397	0.763
DOC_WW_Pin1_4	713	718	PF00397	0.571
LIG_14-3-3_CanoR_1	177	186	PF00244	0.595
LIG_14-3-3_CanoR_1	224	234	PF00244	0.790
LIG_14-3-3_CanoR_1	490	497	PF00244	0.692
LIG_14-3-3_CanoR_1	564	569	PF00244	0.601
LIG_14-3-3_CanoR_1	94	98	PF00244	0.581
LIG_EH1_1	301	309	PF00400	0.467
LIG_EVH1_1	549	553	PF00568	0.676
LIG_FHA_1	291	297	PF00498	0.560
LIG_FHA_1	413	419	PF00498	0.483
LIG_FHA_1	430	436	PF00498	0.580
LIG_FHA_1	492	498	PF00498	0.574
LIG_FHA_1	51	57	PF00498	0.460
LIG_FHA_1	524	530	PF00498	0.575
LIG_FHA_1	709	715	PF00498	0.690
LIG_FHA_1	727	733	PF00498	0.552
LIG_FHA_2	177	183	PF00498	0.755
LIG_FHA_2	204	210	PF00498	0.732
LIG_FHA_2	592	598	PF00498	0.572
LIG_LIR_Apic_2	554	558	PF02991	0.630
LIG_LIR_Apic_2	598	604	PF02991	0.686
LIG_LIR_Gen_1	30	41	PF02991	0.470
LIG_LIR_Gen_1	379	388	PF02991	0.535
LIG_LIR_Nem_3	115	119	PF02991	0.549
LIG_LIR_Nem_3	205	211	PF02991	0.591
LIG_LIR_Nem_3	30	36	PF02991	0.467
LIG_LIR_Nem_3	379	383	PF02991	0.537
LIG_LIR_Nem_3	480	486	PF02991	0.733
LIG_MYND_1	677	681	PF01753	0.816
LIG_MYND_1	684	688	PF01753	0.738
LIG_NRBOX	246	252	PF00104	0.596
LIG_Pex14_1	601	605	PF04695	0.582
LIG_PTAP_UEV_1	541	546	PF05743	0.586
LIG_SH2_CRK	365	369	PF00017	0.457
LIG_SH2_CRK	380	384	PF00017	0.506
LIG_SH2_CRK	385	389	PF00017	0.284
LIG_SH2_CRK	555	559	PF00017	0.630
LIG_SH2_GRB2like	116	119	PF00017	0.425
LIG_SH2_NCK_1	253	257	PF00017	0.495
LIG_SH2_NCK_1	555	559	PF00017	0.833
LIG_SH2_NCK_1	578	582	PF00017	0.767
LIG_SH2_SRC	119	122	PF00017	0.573
LIG_SH2_STAP1	116	120	PF00017	0.602
LIG_SH2_STAP1	253	257	PF00017	0.495
LIG_SH2_STAP1	365	369	PF00017	0.510
LIG_SH2_STAP1	578	582	PF00017	0.767
LIG_SH2_STAT3	257	260	PF00017	0.531
LIG_SH2_STAT3	369	372	PF00017	0.518
LIG_SH2_STAT5	119	122	PF00017	0.460
LIG_SH2_STAT5	187	190	PF00017	0.634
LIG_SH2_STAT5	362	365	PF00017	0.481
LIG_SH2_STAT5	403	406	PF00017	0.605
LIG_SH2_STAT5	578	581	PF00017	0.841
LIG_SH3_3	162	168	PF00018	0.697
LIG_SH3_3	323	329	PF00018	0.645
LIG_SH3_3	506	512	PF00018	0.684
LIG_SH3_3	513	519	PF00018	0.739
LIG_SH3_3	522	528	PF00018	0.785
LIG_SH3_3	539	545	PF00018	0.662
LIG_SH3_3	547	553	PF00018	0.757
LIG_SH3_3	566	572	PF00018	0.768
LIG_SH3_3	577	583	PF00018	0.611
LIG_SH3_3	601	607	PF00018	0.678
LIG_SH3_3	619	625	PF00018	0.659
LIG_SH3_3	678	684	PF00018	0.751
LIG_SH3_3	693	699	PF00018	0.552
LIG_SH3_3	701	707	PF00018	0.714
LIG_SH3_3	716	722	PF00018	0.580
LIG_SH3_3	731	737	PF00018	0.692
LIG_SH3_3	99	105	PF00018	0.606
LIG_SUMO_SIM_par_1	24	30	PF11976	0.534
LIG_SUMO_SIM_par_1	80	86	PF11976	0.472
LIG_TYR_ITIM	363	368	PF00017	0.439
LIG_TYR_ITIM	378	383	PF00017	0.495
LIG_WRC_WIRS_1	483	488	PF05994	0.796
LIG_WW_1	552	555	PF00397	0.831
LIG_WW_1	575	578	PF00397	0.744
LIG_WW_3	232	236	PF00397	0.835
LIG_WW_3	327	331	PF00397	0.670
LIG_WW_3	642	646	PF00397	0.587
MOD_CDK_SPK_2	559	564	PF00069	0.598
MOD_CDK_SPxK_1	277	283	PF00069	0.669
MOD_CDK_SPxK_1	559	565	PF00069	0.598
MOD_CK1_1	112	118	PF00069	0.416
MOD_CK1_1	176	182	PF00069	0.721
MOD_CK1_1	203	209	PF00069	0.741
MOD_CK1_1	22	28	PF00069	0.554
MOD_CK1_1	238	244	PF00069	0.563
MOD_CK1_1	294	300	PF00069	0.633
MOD_CK1_1	379	385	PF00069	0.392
MOD_CK1_1	477	483	PF00069	0.698
MOD_CK1_1	484	490	PF00069	0.693
MOD_CK1_1	493	499	PF00069	0.605
MOD_CK1_1	500	506	PF00069	0.687
MOD_CK1_1	554	560	PF00069	0.753
MOD_CK1_1	570	576	PF00069	0.660
MOD_CK1_1	652	658	PF00069	0.814
MOD_CK1_1	663	669	PF00069	0.628
MOD_CK2_1	168	174	PF00069	0.640
MOD_CK2_1	258	264	PF00069	0.550
MOD_CK2_1	591	597	PF00069	0.572
MOD_CK2_1	607	613	PF00069	0.502
MOD_CK2_1	80	86	PF00069	0.509
MOD_DYRK1A_RPxSP_1	508	512	PF00069	0.654
MOD_GlcNHglycan	13	16	PF01048	0.489
MOD_GlcNHglycan	170	173	PF01048	0.779
MOD_GlcNHglycan	179	182	PF01048	0.557
MOD_GlcNHglycan	21	24	PF01048	0.539
MOD_GlcNHglycan	225	228	PF01048	0.607
MOD_GlcNHglycan	237	240	PF01048	0.533
MOD_GlcNHglycan	435	438	PF01048	0.617
MOD_GlcNHglycan	456	459	PF01048	0.573
MOD_GlcNHglycan	471	474	PF01048	0.677
MOD_GlcNHglycan	542	545	PF01048	0.583
MOD_GlcNHglycan	583	586	PF01048	0.831
MOD_GlcNHglycan	662	665	PF01048	0.643
MOD_GlcNHglycan	700	703	PF01048	0.778
MOD_GSK3_1	173	180	PF00069	0.648
MOD_GSK3_1	258	265	PF00069	0.396
MOD_GSK3_1	285	292	PF00069	0.715
MOD_GSK3_1	388	395	PF00069	0.580
MOD_GSK3_1	412	419	PF00069	0.525
MOD_GSK3_1	429	436	PF00069	0.636
MOD_GSK3_1	474	481	PF00069	0.694
MOD_GSK3_1	482	489	PF00069	0.655
MOD_GSK3_1	491	498	PF00069	0.626
MOD_GSK3_1	532	539	PF00069	0.788
MOD_GSK3_1	554	561	PF00069	0.825
MOD_GSK3_1	581	588	PF00069	0.743
MOD_GSK3_1	591	598	PF00069	0.663
MOD_GSK3_1	698	705	PF00069	0.787
MOD_GSK3_1	709	716	PF00069	0.705
MOD_N-GLC_1	376	381	PF02516	0.515
MOD_N-GLC_2	55	57	PF02516	0.523
MOD_NEK2_1	19	24	PF00069	0.579
MOD_NEK2_1	262	267	PF00069	0.506
MOD_NEK2_1	291	296	PF00069	0.443
MOD_NEK2_1	421	426	PF00069	0.529
MOD_NEK2_1	478	483	PF00069	0.762
MOD_NEK2_1	486	491	PF00069	0.726
MOD_NEK2_1	497	502	PF00069	0.637
MOD_NEK2_1	636	641	PF00069	0.653
MOD_NEK2_1	660	665	PF00069	0.716
MOD_NEK2_1	709	714	PF00069	0.705
MOD_NEK2_2	109	114	PF00069	0.452
MOD_NEK2_2	132	137	PF00069	0.464
MOD_NEK2_2	644	649	PF00069	0.598
MOD_PIKK_1	200	206	PF00454	0.824
MOD_PIKK_1	446	452	PF00454	0.750
MOD_PIKK_1	511	517	PF00454	0.591
MOD_PIKK_1	595	601	PF00454	0.767
MOD_PIKK_1	615	621	PF00454	0.615
MOD_PIKK_1	649	655	PF00454	0.735
MOD_PK_1	416	422	PF00069	0.370
MOD_PKA_1	11	17	PF00069	0.341
MOD_PKA_1	200	206	PF00069	0.777
MOD_PKA_1	235	241	PF00069	0.587
MOD_PKA_1	564	570	PF00069	0.600
MOD_PKA_2	11	17	PF00069	0.341
MOD_PKA_2	176	182	PF00069	0.725
MOD_PKA_2	200	206	PF00069	0.777
MOD_PKA_2	223	229	PF00069	0.790
MOD_PKA_2	235	241	PF00069	0.649
MOD_PKA_2	294	300	PF00069	0.614
MOD_PKA_2	489	495	PF00069	0.746
MOD_PKA_2	625	631	PF00069	0.583
MOD_PKA_2	644	650	PF00069	0.502
MOD_PKA_2	93	99	PF00069	0.569
MOD_PKB_1	198	206	PF00069	0.819
MOD_Plk_1	218	224	PF00069	0.584
MOD_Plk_1	376	382	PF00069	0.509
MOD_Plk_1	585	591	PF00069	0.591
MOD_Plk_4	22	28	PF00069	0.527
MOD_Plk_4	243	249	PF00069	0.515
MOD_Plk_4	303	309	PF00069	0.556
MOD_Plk_4	376	382	PF00069	0.509
MOD_Plk_4	517	523	PF00069	0.745
MOD_Plk_4	682	688	PF00069	0.592
MOD_ProDKin_1	158	164	PF00069	0.776
MOD_ProDKin_1	277	283	PF00069	0.562
MOD_ProDKin_1	322	328	PF00069	0.632
MOD_ProDKin_1	388	394	PF00069	0.531
MOD_ProDKin_1	508	514	PF00069	0.752
MOD_ProDKin_1	536	542	PF00069	0.742
MOD_ProDKin_1	554	560	PF00069	0.756
MOD_ProDKin_1	565	571	PF00069	0.744
MOD_ProDKin_1	591	597	PF00069	0.747
MOD_ProDKin_1	600	606	PF00069	0.656
MOD_ProDKin_1	663	669	PF00069	0.788
MOD_ProDKin_1	677	683	PF00069	0.770
MOD_ProDKin_1	692	698	PF00069	0.729
MOD_ProDKin_1	702	708	PF00069	0.762
MOD_ProDKin_1	713	719	PF00069	0.567
TRG_DiLeu_BaEn_1	243	248	PF01217	0.644
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.618
TRG_ENDOCYTIC_2	131	134	PF00928	0.434
TRG_ENDOCYTIC_2	365	368	PF00928	0.439
TRG_ENDOCYTIC_2	380	383	PF00928	0.504
TRG_ENDOCYTIC_2	385	388	PF00928	0.293
TRG_ENDOCYTIC_2	483	486	PF00928	0.801
TRG_ER_diArg_1	198	201	PF00400	0.737
TRG_ER_diArg_1	234	236	PF00400	0.742
TRG_NES_CRM1_1	343	356	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHM5	Leptomonas seymouri	48%	100%
A0A1X0P647	Trypanosomatidae	36%	100%
A0A3S5H801	Leishmania donovani	74%	100%
A4IBN8	Leishmania infantum	74%	100%
E9AFH2	Leishmania major	72%	100%
E9B6M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%