QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4HN16_LEIBR

TriTrypDb:

LbrM.34.3400 , LBRM2903_340043000

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	14
GO:0032991	protein-containing complex	1	14
GO:0098796	membrane protein complex	2	14
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HN16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN16

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006886	intracellular protein transport	4	14
GO:0008104	protein localization	4	14
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	14
GO:0016192	vesicle-mediated transport	4	13
GO:0033036	macromolecule localization	2	14
GO:0045184	establishment of protein localization	3	14
GO:0046907	intracellular transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051641	cellular localization	2	14
GO:0051649	establishment of localization in cell	3	14
GO:0070727	cellular macromolecule localization	3	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.478
CLV_NRD_NRD_1	266	268	PF00675	0.598
CLV_NRD_NRD_1	280	282	PF00675	0.276
CLV_NRD_NRD_1	78	80	PF00675	0.363
CLV_PCSK_KEX2_1	156	158	PF00082	0.472
CLV_PCSK_KEX2_1	280	282	PF00082	0.453
CLV_PCSK_KEX2_1	78	80	PF00082	0.363
CLV_PCSK_SKI1_1	124	128	PF00082	0.546
CLV_PCSK_SKI1_1	211	215	PF00082	0.499
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_CKS1_1	31	36	PF01111	0.704
DOC_CYCLIN_RxL_1	135	146	PF00134	0.502
DOC_MAPK_gen_1	136	144	PF00069	0.484
DOC_MAPK_gen_1	280	286	PF00069	0.325
DOC_MAPK_MEF2A_6	136	144	PF00069	0.497
DOC_PP1_RVXF_1	6	13	PF00149	0.354
DOC_PP4_FxxP_1	39	42	PF00568	0.617
DOC_PP4_FxxP_1	72	75	PF00568	0.446
DOC_USP7_MATH_1	251	255	PF00917	0.580
DOC_USP7_MATH_1	306	310	PF00917	0.463
DOC_USP7_UBL2_3	264	268	PF12436	0.381
DOC_USP7_UBL2_3	76	80	PF12436	0.609
DOC_WW_Pin1_4	298	303	PF00397	0.422
DOC_WW_Pin1_4	30	35	PF00397	0.593
LIG_14-3-3_CanoR_1	15	23	PF00244	0.629
LIG_14-3-3_CanoR_1	270	276	PF00244	0.614
LIG_14-3-3_CanoR_1	280	284	PF00244	0.572
LIG_Actin_WH2_2	101	117	PF00022	0.557
LIG_BRCT_BRCA1_1	66	70	PF00533	0.439
LIG_FHA_1	105	111	PF00498	0.508
LIG_FHA_1	230	236	PF00498	0.544
LIG_FHA_1	33	39	PF00498	0.693
LIG_FHA_1	66	72	PF00498	0.401
LIG_FHA_1	92	98	PF00498	0.475
LIG_FHA_2	115	121	PF00498	0.505
LIG_FHA_2	190	196	PF00498	0.462
LIG_FHA_2	207	213	PF00498	0.407
LIG_FHA_2	31	37	PF00498	0.459
LIG_FHA_2	86	92	PF00498	0.505
LIG_GBD_Chelix_1	125	133	PF00786	0.454
LIG_LIR_Apic_2	36	42	PF02991	0.644
LIG_LIR_Gen_1	162	173	PF02991	0.596
LIG_LIR_Gen_1	282	291	PF02991	0.317
LIG_LIR_Gen_1	67	77	PF02991	0.528
LIG_LIR_Gen_1	7	13	PF02991	0.357
LIG_LIR_Nem_3	134	140	PF02991	0.506
LIG_LIR_Nem_3	162	168	PF02991	0.572
LIG_LIR_Nem_3	171	177	PF02991	0.542
LIG_LIR_Nem_3	282	286	PF02991	0.321
LIG_LIR_Nem_3	67	73	PF02991	0.426
LIG_LIR_Nem_3	7	12	PF02991	0.339
LIG_SH2_CRK	165	169	PF00017	0.534
LIG_SH2_NCK_1	165	169	PF00017	0.426
LIG_SH2_NCK_1	174	178	PF00017	0.512
LIG_SH2_STAT3	218	221	PF00017	0.286
LIG_SH2_STAT5	165	168	PF00017	0.571
LIG_SH2_STAT5	275	278	PF00017	0.325
LIG_SH2_STAT5	285	288	PF00017	0.292
LIG_SH3_3	28	34	PF00018	0.630
LIG_SUMO_SIM_par_1	231	236	PF11976	0.629
LIG_SUMO_SIM_par_1	251	256	PF11976	0.417
LIG_TRAF2_1	119	122	PF00917	0.570
LIG_TRAF2_1	219	222	PF00917	0.523
MOD_CDC14_SPxK_1	301	304	PF00782	0.442
MOD_CDK_SPxK_1	298	304	PF00069	0.428
MOD_CDK_SPxxK_3	30	37	PF00069	0.453
MOD_CK1_1	128	134	PF00069	0.446
MOD_CK1_1	26	32	PF00069	0.570
MOD_CK1_1	266	272	PF00069	0.489
MOD_CK1_1	274	280	PF00069	0.448
MOD_CK1_1	298	304	PF00069	0.428
MOD_CK2_1	114	120	PF00069	0.513
MOD_CK2_1	206	212	PF00069	0.505
MOD_CK2_1	216	222	PF00069	0.381
MOD_CK2_1	30	36	PF00069	0.555
MOD_GlcNHglycan	218	221	PF01048	0.286
MOD_GlcNHglycan	287	290	PF01048	0.487
MOD_GSK3_1	128	135	PF00069	0.330
MOD_GSK3_1	14	21	PF00069	0.559
MOD_GSK3_1	159	166	PF00069	0.390
MOD_GSK3_1	26	33	PF00069	0.417
MOD_GSK3_1	262	269	PF00069	0.446
MOD_GSK3_1	285	292	PF00069	0.318
MOD_N-GLC_1	306	311	PF02516	0.464
MOD_NEK2_1	104	109	PF00069	0.414
MOD_NEK2_1	114	119	PF00069	0.436
MOD_NEK2_1	262	267	PF00069	0.320
MOD_NEK2_1	296	301	PF00069	0.404
MOD_NEK2_1	56	61	PF00069	0.434
MOD_NEK2_1	65	70	PF00069	0.431
MOD_OFUCOSY	295	300	PF10250	0.394
MOD_PIKK_1	128	134	PF00454	0.479
MOD_PKA_2	14	20	PF00069	0.584
MOD_PKA_2	266	272	PF00069	0.510
MOD_PKA_2	279	285	PF00069	0.277
MOD_Plk_1	104	110	PF00069	0.527
MOD_Plk_1	26	32	PF00069	0.631
MOD_Plk_2-3	236	242	PF00069	0.516
MOD_Plk_4	104	110	PF00069	0.477
MOD_Plk_4	229	235	PF00069	0.454
MOD_Plk_4	236	242	PF00069	0.491
MOD_Plk_4	271	277	PF00069	0.565
MOD_Plk_4	85	91	PF00069	0.472
MOD_ProDKin_1	298	304	PF00069	0.428
MOD_ProDKin_1	30	36	PF00069	0.592
MOD_SUMO_rev_2	207	216	PF00179	0.568
TRG_DiLeu_BaEn_1	96	101	PF01217	0.445
TRG_DiLeu_BaEn_2	278	284	PF01217	0.552
TRG_DiLeu_BaEn_3	120	126	PF01217	0.555
TRG_DiLeu_BaEn_4	81	87	PF01217	0.433
TRG_ENDOCYTIC_2	165	168	PF00928	0.545
TRG_ENDOCYTIC_2	174	177	PF00928	0.278
TRG_ER_diArg_1	155	158	PF00400	0.375
TRG_ER_diArg_1	77	79	PF00400	0.388
TRG_NLS_MonoExtN_4	264	271	PF00514	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I246	Leptomonas seymouri	59%	100%
A0A0N1IMN0	Leptomonas seymouri	25%	100%
A0A0S4J7F1	Bodo saltans	32%	100%
A0A0S4JKJ1	Bodo saltans	27%	100%
A0A1X0P0Y0	Trypanosomatidae	37%	100%
A0A1X0P5S4	Trypanosomatidae	24%	100%
A0A3Q8IK46	Leishmania donovani	77%	100%
A0A3R7MIN3	Trypanosoma rangeli	33%	100%
A0A3S7X9G5	Leishmania donovani	24%	100%
A0A422P2Q8	Trypanosoma rangeli	24%	100%
A4HLJ5	Leishmania braziliensis	97%	100%
A4HMT8	Leishmania braziliensis	23%	100%
A4I905	Leishmania infantum	77%	100%
A4IBD9	Leishmania infantum	24%	100%
A8WVD0	Caenorhabditis briggsae	25%	100%
C9ZZ78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A501	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AF95	Leishmania major	24%	100%
E9B3X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9B6F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O14662	Homo sapiens	25%	97%
O16000	Caenorhabditis elegans	26%	100%
O65359	Arabidopsis thaliana	26%	98%
Q16932	Aplysia californica	25%	100%
Q4Q454	Leishmania major	75%	100%
Q8BVI5	Mus musculus	24%	96%
Q9P6P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9SUJ1	Arabidopsis thaliana	27%	95%
Q9SWH4	Arabidopsis thaliana	25%	97%
V5BLU5	Trypanosoma cruzi	33%	100%
V5C306	Trypanosoma cruzi	23%	100%