LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MFS_1_like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
MFS_1_like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HN15_LEIBR
TriTrypDb:
LbrM.34.3390 , LBRM2903_330020200
Length:
341

Annotations

LeishMANIAdb annotations

Appears to be a transporter, related to vertebrate MFSD6 proteins (whose function is likewise unexplored).. Only expanded in Leptomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HN15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 119 123 PF00656 0.549
CLV_NRD_NRD_1 238 240 PF00675 0.663
CLV_NRD_NRD_1 282 284 PF00675 0.665
CLV_NRD_NRD_1 297 299 PF00675 0.474
CLV_NRD_NRD_1 308 310 PF00675 0.544
CLV_NRD_NRD_1 328 330 PF00675 0.433
CLV_PCSK_FUR_1 236 240 PF00082 0.655
CLV_PCSK_FUR_1 306 310 PF00082 0.680
CLV_PCSK_KEX2_1 102 104 PF00082 0.449
CLV_PCSK_KEX2_1 238 240 PF00082 0.663
CLV_PCSK_KEX2_1 297 299 PF00082 0.661
CLV_PCSK_KEX2_1 305 307 PF00082 0.579
CLV_PCSK_KEX2_1 308 310 PF00082 0.544
CLV_PCSK_KEX2_1 316 318 PF00082 0.452
CLV_PCSK_KEX2_1 328 330 PF00082 0.433
CLV_PCSK_PC1ET2_1 102 104 PF00082 0.449
CLV_PCSK_PC1ET2_1 305 307 PF00082 0.679
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.552
CLV_PCSK_SKI1_1 103 107 PF00082 0.449
CLV_PCSK_SKI1_1 165 169 PF00082 0.449
CLV_PCSK_SKI1_1 231 235 PF00082 0.601
CLV_PCSK_SKI1_1 284 288 PF00082 0.672
DEG_APCC_DBOX_1 4 12 PF00400 0.764
DEG_SPOP_SBC_1 331 335 PF00917 0.877
DOC_CDC14_PxL_1 204 212 PF14671 0.549
DOC_CYCLIN_RxL_1 96 110 PF00134 0.650
DOC_MAPK_gen_1 83 91 PF00069 0.650
DOC_MAPK_gen_1 96 106 PF00069 0.487
DOC_MAPK_MEF2A_6 83 91 PF00069 0.650
DOC_MAPK_MEF2A_6 99 108 PF00069 0.449
DOC_PP1_RVXF_1 196 203 PF00149 0.549
DOC_PP2B_LxvP_1 193 196 PF13499 0.549
DOC_PP4_FxxP_1 290 293 PF00568 0.865
DOC_USP7_MATH_1 266 270 PF00917 0.865
DOC_WW_Pin1_4 6 11 PF00397 0.758
LIG_14-3-3_CanoR_1 157 163 PF00244 0.650
LIG_14-3-3_CanoR_1 165 174 PF00244 0.549
LIG_14-3-3_CanoR_1 283 293 PF00244 0.869
LIG_14-3-3_CanoR_1 300 307 PF00244 0.660
LIG_14-3-3_CanoR_1 5 9 PF00244 0.780
LIG_AP2alpha_1 120 124 PF02296 0.549
LIG_BRCT_BRCA1_1 213 217 PF00533 0.650
LIG_BRCT_BRCA1_1 47 51 PF00533 0.549
LIG_CSL_BTD_1 205 208 PF09270 0.549
LIG_FHA_1 138 144 PF00498 0.549
LIG_FHA_1 331 337 PF00498 0.875
LIG_FHA_1 82 88 PF00498 0.650
LIG_FHA_2 159 165 PF00498 0.650
LIG_FHA_2 333 339 PF00498 0.878
LIG_LIR_Apic_2 287 293 PF02991 0.869
LIG_LIR_Gen_1 122 130 PF02991 0.449
LIG_LIR_Gen_1 186 197 PF02991 0.449
LIG_LIR_Gen_1 26 37 PF02991 0.650
LIG_LIR_Gen_1 54 65 PF02991 0.449
LIG_LIR_Nem_3 122 127 PF02991 0.449
LIG_LIR_Nem_3 176 180 PF02991 0.549
LIG_LIR_Nem_3 186 192 PF02991 0.324
LIG_LIR_Nem_3 26 32 PF02991 0.650
LIG_LIR_Nem_3 34 38 PF02991 0.549
LIG_LIR_Nem_3 54 60 PF02991 0.199
LIG_MYND_1 245 249 PF01753 0.872
LIG_Pex14_2 120 124 PF04695 0.549
LIG_Pex14_2 202 206 PF04695 0.549
LIG_Pex14_2 217 221 PF04695 0.462
LIG_PTB_Apo_2 120 127 PF02174 0.549
LIG_RPA_C_Fungi 295 307 PF08784 0.853
LIG_SH2_CRK 182 186 PF00017 0.549
LIG_SH2_CRK 73 77 PF00017 0.549
LIG_SH2_STAP1 73 77 PF00017 0.549
LIG_SH2_STAT5 182 185 PF00017 0.549
LIG_SH2_STAT5 31 34 PF00017 0.549
LIG_SH2_STAT5 53 56 PF00017 0.549
LIG_SH2_STAT5 64 67 PF00017 0.357
LIG_SH3_1 238 244 PF00018 0.851
LIG_SH3_3 238 244 PF00018 0.851
LIG_SH3_3 245 251 PF00018 0.741
LIG_SH3_3 262 268 PF00018 0.559
LIG_SH3_3 74 80 PF00018 0.549
LIG_Sin3_3 190 197 PF02671 0.549
LIG_SUMO_SIM_par_1 139 144 PF11976 0.549
LIG_TRAF2_1 21 24 PF00917 0.549
LIG_TYR_ITIM 180 185 PF00017 0.549
LIG_TYR_ITIM 71 76 PF00017 0.549
LIG_UBA3_1 16 22 PF00899 0.549
LIG_WRC_WIRS_1 174 179 PF05994 0.549
LIG_WW_3 325 329 PF00397 0.873
MOD_CK1_1 173 179 PF00069 0.549
MOD_CK1_1 4 10 PF00069 0.728
MOD_CK2_1 158 164 PF00069 0.549
MOD_CK2_1 266 272 PF00069 0.854
MOD_CK2_1 332 338 PF00069 0.869
MOD_GlcNHglycan 154 157 PF01048 0.549
MOD_GlcNHglycan 267 271 PF01048 0.855
MOD_GlcNHglycan 290 293 PF01048 0.852
MOD_GSK3_1 109 116 PF00069 0.549
MOD_GSK3_1 137 144 PF00069 0.549
MOD_GSK3_1 23 30 PF00069 0.549
MOD_GSK3_1 284 291 PF00069 0.861
MOD_NEK2_1 1 6 PF00069 0.776
MOD_NEK2_1 107 112 PF00069 0.549
MOD_NEK2_1 113 118 PF00069 0.444
MOD_NEK2_1 137 142 PF00069 0.549
MOD_NEK2_1 152 157 PF00069 0.287
MOD_NEK2_1 158 163 PF00069 0.444
MOD_NEK2_1 45 50 PF00069 0.549
MOD_NEK2_1 51 56 PF00069 0.444
MOD_NEK2_1 71 76 PF00069 0.199
MOD_PKA_1 315 321 PF00069 0.883
MOD_PKA_2 158 164 PF00069 0.549
MOD_PKA_2 4 10 PF00069 0.728
MOD_PKB_1 298 306 PF00069 0.857
MOD_Plk_4 109 115 PF00069 0.549
MOD_Plk_4 116 122 PF00069 0.427
MOD_Plk_4 170 176 PF00069 0.549
MOD_Plk_4 180 186 PF00069 0.375
MOD_Plk_4 45 51 PF00069 0.549
MOD_Plk_4 53 59 PF00069 0.410
MOD_Plk_4 71 77 PF00069 0.234
MOD_ProDKin_1 6 12 PF00069 0.549
MOD_SUMO_for_1 21 24 PF00179 0.549
TRG_DiLeu_BaLyEn_6 7 12 PF01217 0.549
TRG_ENDOCYTIC_2 182 185 PF00928 0.549
TRG_ENDOCYTIC_2 73 76 PF00928 0.549
TRG_ER_diArg_1 235 238 PF00400 0.817
TRG_ER_diArg_1 251 254 PF00400 0.602
TRG_ER_diArg_1 297 300 PF00400 0.850
TRG_ER_diArg_1 306 309 PF00400 0.716
TRG_ER_diArg_1 327 329 PF00400 0.878

Homologs

Protein Taxonomy Sequence identity Coverage
A1DWM3 PIG 28% 43%
Q6ZSS7 HUMAN 27% 43%
Q8CBH5 MOUSE 26% 44%
Q8IWD5 HUMAN 27% 58%
Q8R3N2 MOUSE 24% 58%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS