PKS_AT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl transferase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN14_LEIBR

TriTrypDb:

LbrM.34.3380 , LBRM2903_340042600

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005835	fatty acid synthase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

A4HN14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN14

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0004312	fatty acid synthase activity	5	3
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	6	1
GO:0016417	S-acyltransferase activity	5	1
GO:0016419	S-malonyltransferase activity	6	1
GO:0016420	malonyltransferase activity	5	1
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.570
CLV_C14_Caspase3-7	91	95	PF00656	0.493
CLV_MEL_PAP_1	518	524	PF00089	0.327
CLV_NRD_NRD_1	174	176	PF00675	0.420
CLV_NRD_NRD_1	178	180	PF00675	0.396
CLV_NRD_NRD_1	307	309	PF00675	0.575
CLV_NRD_NRD_1	358	360	PF00675	0.403
CLV_NRD_NRD_1	394	396	PF00675	0.525
CLV_NRD_NRD_1	504	506	PF00675	0.547
CLV_PCSK_KEX2_1	161	163	PF00082	0.319
CLV_PCSK_KEX2_1	178	180	PF00082	0.281
CLV_PCSK_KEX2_1	307	309	PF00082	0.540
CLV_PCSK_KEX2_1	358	360	PF00082	0.403
CLV_PCSK_KEX2_1	394	396	PF00082	0.557
CLV_PCSK_KEX2_1	504	506	PF00082	0.397
CLV_PCSK_KEX2_1	71	73	PF00082	0.429
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.378
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.441
CLV_PCSK_PC7_1	303	309	PF00082	0.552
CLV_PCSK_SKI1_1	162	166	PF00082	0.335
CLV_PCSK_SKI1_1	178	182	PF00082	0.150
CLV_PCSK_SKI1_1	2	6	PF00082	0.404
CLV_PCSK_SKI1_1	266	270	PF00082	0.320
CLV_PCSK_SKI1_1	308	312	PF00082	0.551
CLV_PCSK_SKI1_1	369	373	PF00082	0.448
CLV_PCSK_SKI1_1	379	383	PF00082	0.373
CLV_PCSK_SKI1_1	457	461	PF00082	0.495
CLV_PCSK_SKI1_1	505	509	PF00082	0.369
DEG_APCC_DBOX_1	265	273	PF00400	0.322
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_SCF_SKP2-CKS1_1	169	176	PF00560	0.208
DEG_SPOP_SBC_1	213	217	PF00917	0.411
DOC_CKS1_1	149	154	PF01111	0.266
DOC_CYCLIN_RxL_1	159	167	PF00134	0.447
DOC_CYCLIN_RxL_1	175	184	PF00134	0.150
DOC_CYCLIN_RxL_1	376	385	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.399
DOC_MAPK_gen_1	338	346	PF00069	0.452
DOC_MAPK_gen_1	394	401	PF00069	0.494
DOC_MAPK_gen_1	435	444	PF00069	0.599
DOC_MAPK_MEF2A_6	339	348	PF00069	0.440
DOC_MAPK_RevD_3	147	162	PF00069	0.335
DOC_USP7_MATH_1	134	138	PF00917	0.330
DOC_USP7_MATH_1	213	217	PF00917	0.447
DOC_USP7_MATH_1	268	272	PF00917	0.459
DOC_USP7_MATH_1	293	297	PF00917	0.690
DOC_USP7_MATH_1	351	355	PF00917	0.377
DOC_USP7_MATH_1	411	415	PF00917	0.453
DOC_USP7_MATH_1	452	456	PF00917	0.308
DOC_USP7_MATH_1	495	499	PF00917	0.316
DOC_USP7_MATH_1	520	524	PF00917	0.326
DOC_WW_Pin1_4	148	153	PF00397	0.355
DOC_WW_Pin1_4	170	175	PF00397	0.404
DOC_WW_Pin1_4	181	186	PF00397	0.475
DOC_WW_Pin1_4	315	320	PF00397	0.563
DOC_WW_Pin1_4	491	496	PF00397	0.466
DOC_WW_Pin1_4	516	521	PF00397	0.380
DOC_WW_Pin1_4	81	86	PF00397	0.412
LIG_14-3-3_CanoR_1	187	197	PF00244	0.227
LIG_14-3-3_CanoR_1	303	307	PF00244	0.577
LIG_14-3-3_CanoR_1	33	39	PF00244	0.441
LIG_14-3-3_CanoR_1	521	526	PF00244	0.560
LIG_14-3-3_CanoR_1	72	80	PF00244	0.401
LIG_Actin_WH2_2	343	360	PF00022	0.444
LIG_AP2alpha_2	410	412	PF02296	0.267
LIG_APCC_ABBAyCdc20_2	504	510	PF00400	0.383
LIG_BRCT_BRCA1_1	499	503	PF00533	0.495
LIG_BRCT_BRCA1_1	60	64	PF00533	0.441
LIG_FHA_1	316	322	PF00498	0.572
LIG_FHA_1	403	409	PF00498	0.511
LIG_FHA_1	439	445	PF00498	0.477
LIG_FHA_1	458	464	PF00498	0.185
LIG_FHA_1	53	59	PF00498	0.227
LIG_FHA_1	73	79	PF00498	0.424
LIG_FHA_1	85	91	PF00498	0.441
LIG_FHA_2	201	207	PF00498	0.423
LIG_FHA_2	326	332	PF00498	0.601
LIG_FHA_2	375	381	PF00498	0.544
LIG_FHA_2	474	480	PF00498	0.451
LIG_FHA_2	89	95	PF00498	0.441
LIG_LIR_Apic_2	341	345	PF02991	0.429
LIG_LIR_Gen_1	140	149	PF02991	0.335
LIG_LIR_Gen_1	199	209	PF02991	0.293
LIG_LIR_Gen_1	215	226	PF02991	0.364
LIG_LIR_Nem_3	140	144	PF02991	0.377
LIG_LIR_Nem_3	198	204	PF02991	0.338
LIG_LIR_Nem_3	215	221	PF02991	0.252
LIG_LIR_Nem_3	304	309	PF02991	0.572
LIG_LIR_Nem_3	341	346	PF02991	0.410
LIG_LIR_Nem_3	362	367	PF02991	0.378
LIG_LIR_Nem_3	67	73	PF02991	0.227
LIG_PALB2_WD40_1	338	346	PF16756	0.495
LIG_PCNA_TLS_4	358	365	PF02747	0.433
LIG_PCNA_yPIPBox_3	496	505	PF02747	0.420
LIG_Pex14_2	412	416	PF04695	0.326
LIG_SH2_CRK	70	74	PF00017	0.227
LIG_SH2_GRB2like	115	118	PF00017	0.227
LIG_SH2_STAT3	101	104	PF00017	0.426
LIG_SH2_STAT5	101	104	PF00017	0.378
LIG_SH2_STAT5	231	234	PF00017	0.334
LIG_SH3_3	146	152	PF00018	0.355
LIG_SH3_3	345	351	PF00018	0.318
LIG_SH3_3	405	411	PF00018	0.505
LIG_SUMO_SIM_anti_2	215	223	PF11976	0.354
LIG_SUMO_SIM_par_1	344	349	PF11976	0.381
LIG_SUMO_SIM_par_1	439	446	PF11976	0.567
LIG_TRAF2_1	320	323	PF00917	0.614
LIG_TRAF2_1	328	331	PF00917	0.659
LIG_TRAF2_1	477	480	PF00917	0.515
LIG_TYR_ITIM	113	118	PF00017	0.451
LIG_WRC_WIRS_1	197	202	PF05994	0.227
LIG_WRC_WIRS_1	444	449	PF05994	0.550
MOD_CDC14_SPxK_1	184	187	PF00782	0.476
MOD_CDC14_SPxK_1	494	497	PF00782	0.490
MOD_CDK_SPK_2	170	175	PF00069	0.227
MOD_CDK_SPK_2	516	521	PF00069	0.361
MOD_CDK_SPxK_1	170	176	PF00069	0.397
MOD_CDK_SPxK_1	181	187	PF00069	0.476
MOD_CDK_SPxK_1	491	497	PF00069	0.475
MOD_CK1_1	302	308	PF00069	0.674
MOD_CK1_1	385	391	PF00069	0.384
MOD_CK1_1	84	90	PF00069	0.345
MOD_CK2_1	134	140	PF00069	0.335
MOD_CK2_1	200	206	PF00069	0.338
MOD_CK2_1	214	220	PF00069	0.333
MOD_CK2_1	317	323	PF00069	0.593
MOD_CK2_1	325	331	PF00069	0.618
MOD_CK2_1	374	380	PF00069	0.494
MOD_CK2_1	416	422	PF00069	0.538
MOD_CK2_1	452	458	PF00069	0.334
MOD_CK2_1	473	479	PF00069	0.514
MOD_CK2_1	495	501	PF00069	0.412
MOD_DYRK1A_RPxSP_1	516	520	PF00069	0.357
MOD_GlcNHglycan	295	298	PF01048	0.632
MOD_GlcNHglycan	334	337	PF01048	0.581
MOD_GlcNHglycan	413	416	PF01048	0.541
MOD_GlcNHglycan	418	421	PF01048	0.518
MOD_GlcNHglycan	7	10	PF01048	0.335
MOD_GSK3_1	196	203	PF00069	0.413
MOD_GSK3_1	208	215	PF00069	0.371
MOD_GSK3_1	491	498	PF00069	0.420
MOD_GSK3_1	5	12	PF00069	0.257
MOD_GSK3_1	516	523	PF00069	0.549
MOD_GSK3_1	80	87	PF00069	0.381
MOD_N-GLC_1	385	390	PF02516	0.417
MOD_N-GLC_1	402	407	PF02516	0.367
MOD_N-GLC_1	514	519	PF02516	0.628
MOD_NEK2_1	17	22	PF00069	0.368
MOD_NEK2_1	200	205	PF00069	0.339
MOD_NEK2_1	212	217	PF00069	0.333
MOD_NEK2_1	292	297	PF00069	0.547
MOD_NEK2_1	352	357	PF00069	0.383
MOD_NEK2_1	382	387	PF00069	0.388
MOD_NEK2_1	399	404	PF00069	0.398
MOD_NEK2_1	416	421	PF00069	0.305
MOD_NEK2_1	438	443	PF00069	0.543
MOD_NEK2_1	5	10	PF00069	0.341
MOD_NEK2_1	97	102	PF00069	0.262
MOD_NEK2_2	452	457	PF00069	0.307
MOD_PIKK_1	100	106	PF00454	0.367
MOD_PK_1	514	520	PF00069	0.488
MOD_PKA_1	128	134	PF00069	0.227
MOD_PKA_1	338	344	PF00069	0.457
MOD_PKA_2	302	308	PF00069	0.584
MOD_PKA_2	32	38	PF00069	0.383
MOD_PKA_2	520	526	PF00069	0.309
MOD_Plk_1	139	145	PF00069	0.346
MOD_Plk_1	156	162	PF00069	0.150
MOD_Plk_1	322	328	PF00069	0.608
MOD_Plk_1	385	391	PF00069	0.516
MOD_Plk_1	438	444	PF00069	0.543
MOD_Plk_1	514	520	PF00069	0.438
MOD_Plk_2-3	374	380	PF00069	0.351
MOD_Plk_4	17	23	PF00069	0.419
MOD_Plk_4	196	202	PF00069	0.351
MOD_Plk_4	214	220	PF00069	0.309
MOD_Plk_4	338	344	PF00069	0.457
MOD_Plk_4	385	391	PF00069	0.512
MOD_Plk_4	438	444	PF00069	0.545
MOD_ProDKin_1	148	154	PF00069	0.355
MOD_ProDKin_1	170	176	PF00069	0.404
MOD_ProDKin_1	181	187	PF00069	0.475
MOD_ProDKin_1	315	321	PF00069	0.567
MOD_ProDKin_1	491	497	PF00069	0.475
MOD_ProDKin_1	516	522	PF00069	0.372
MOD_ProDKin_1	81	87	PF00069	0.412
TRG_DiLeu_BaEn_4	322	328	PF01217	0.595
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.569
TRG_ENDOCYTIC_2	115	118	PF00928	0.442
TRG_ENDOCYTIC_2	70	73	PF00928	0.227
TRG_ER_diArg_1	178	180	PF00400	0.397
TRG_ER_diArg_1	306	308	PF00400	0.561
TRG_ER_diArg_1	357	359	PF00400	0.413
TRG_ER_diArg_1	394	396	PF00400	0.575
TRG_ER_diArg_1	503	505	PF00400	0.536
TRG_NLS_Bipartite_1	161	179	PF00514	0.208
TRG_NLS_MonoExtC_3	174	179	PF00514	0.383
TRG_NLS_MonoExtN_4	174	179	PF00514	0.391
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM7	Leptomonas seymouri	65%	94%
A0A0S4IR28	Bodo saltans	39%	99%
A0A1X0P5F7	Trypanosomatidae	53%	97%
A0A3Q8IGH2	Leishmania donovani	82%	100%
A0A422NRA5	Trypanosoma rangeli	53%	99%
A4IBN7	Leishmania infantum	83%	100%
C9ZYZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AFH1	Leishmania major	81%	100%
E9B6M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%