LeishMANIAdb
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NAC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:
NAC domain-containing protein
Gene product:
peroxidase, putative
Species:
Leishmania braziliensis
UniProt:
A4HN13_LEIBR
TriTrypDb:
LbrM.34.3370 , LBRM2903_340042500 *
Length:
200

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN13

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 2
GO:0006979 response to oxidative stress 3 2
GO:0009987 cellular process 1 2
GO:0033554 cellular response to stress 3 2
GO:0034599 cellular response to oxidative stress 4 2
GO:0042221 response to chemical 2 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
GO:0062197 cellular response to chemical stress 4 2
GO:0070887 cellular response to chemical stimulus 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004601 peroxidase activity 2 2
GO:0005488 binding 1 2
GO:0016209 antioxidant activity 1 2
GO:0016491 oxidoreductase activity 2 2
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3 2
GO:0020037 heme binding 4 2
GO:0046906 tetrapyrrole binding 3 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 60 62 PF00675 0.815
CLV_PCSK_KEX2_1 59 61 PF00082 0.828
CLV_PCSK_SKI1_1 105 109 PF00082 0.833
DEG_Nend_UBRbox_2 1 3 PF02207 0.804
DOC_CYCLIN_yClb1_LxF_4 170 176 PF00134 0.766
DOC_MAPK_gen_1 38 47 PF00069 0.828
DOC_USP7_MATH_1 177 181 PF00917 0.745
DOC_USP7_MATH_2 142 148 PF00917 0.808
LIG_APCC_ABBA_1 47 52 PF00400 0.812
LIG_BRCT_BRCA1_1 7 11 PF00533 0.783
LIG_deltaCOP1_diTrp_1 16 25 PF00928 0.794
LIG_FHA_1 131 137 PF00498 0.834
LIG_LIR_Apic_2 16 22 PF02991 0.789
LIG_LIR_Gen_1 174 184 PF02991 0.750
LIG_LIR_Gen_1 8 17 PF02991 0.782
LIG_LIR_Nem_3 174 179 PF02991 0.750
LIG_LIR_Nem_3 8 14 PF02991 0.783
LIG_MLH1_MIPbox_1 7 11 PF16413 0.783
LIG_Pex14_1 164 168 PF04695 0.812
LIG_REV1ctd_RIR_1 22 31 PF16727 0.814
LIG_SH2_CRK 176 180 PF00017 0.745
LIG_SH2_NCK_1 176 180 PF00017 0.745
LIG_SH2_STAT5 10 13 PF00017 0.677
LIG_SH2_STAT5 4 7 PF00017 0.785
LIG_SUMO_SIM_anti_2 152 158 PF11976 0.790
LIG_SUMO_SIM_par_1 43 48 PF11976 0.825
MOD_CK1_1 51 57 PF00069 0.809
MOD_CK1_1 78 84 PF00069 0.846
MOD_CK1_1 86 92 PF00069 0.707
MOD_GlcNHglycan 29 32 PF01048 0.819
MOD_GlcNHglycan 72 75 PF01048 0.834
MOD_GlcNHglycan 96 100 PF01048 0.824
MOD_N-GLC_1 78 83 PF02516 0.841
MOD_N-GLC_2 93 95 PF02516 0.838
MOD_Plk_4 194 200 PF00069 0.807
TRG_DiLeu_BaEn_1 9 14 PF01217 0.783
TRG_ENDOCYTIC_2 10 13 PF00928 0.782
TRG_ENDOCYTIC_2 176 179 PF00928 0.746
TRG_ER_diArg_1 59 61 PF00400 0.828

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS