Putative DNA-repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-repair protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HN12_LEIBR

TriTrypDb:

LbrM.34.3360 , LBRM2903_340042400

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000111	nucleotide-excision repair factor 2 complex	4	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071942	XPC complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HN12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN12

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006289	nucleotide-excision repair	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006298	mismatch repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003684	damaged DNA binding	5	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.552
CLV_NRD_NRD_1	244	246	PF00675	0.654
CLV_NRD_NRD_1	413	415	PF00675	0.563
CLV_NRD_NRD_1	427	429	PF00675	0.497
CLV_NRD_NRD_1	532	534	PF00675	0.330
CLV_NRD_NRD_1	739	741	PF00675	0.247
CLV_NRD_NRD_1	755	757	PF00675	0.247
CLV_NRD_NRD_1	761	763	PF00675	0.247
CLV_NRD_NRD_1	801	803	PF00675	0.326
CLV_PCSK_FUR_1	425	429	PF00082	0.542
CLV_PCSK_KEX2_1	157	159	PF00082	0.566
CLV_PCSK_KEX2_1	194	196	PF00082	0.555
CLV_PCSK_KEX2_1	208	210	PF00082	0.709
CLV_PCSK_KEX2_1	413	415	PF00082	0.565
CLV_PCSK_KEX2_1	427	429	PF00082	0.494
CLV_PCSK_KEX2_1	447	449	PF00082	0.155
CLV_PCSK_KEX2_1	532	534	PF00082	0.314
CLV_PCSK_KEX2_1	639	641	PF00082	0.247
CLV_PCSK_KEX2_1	739	741	PF00082	0.247
CLV_PCSK_KEX2_1	754	756	PF00082	0.247
CLV_PCSK_KEX2_1	761	763	PF00082	0.250
CLV_PCSK_KEX2_1	800	802	PF00082	0.320
CLV_PCSK_KEX2_1	820	822	PF00082	0.233
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.642
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.627
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.708
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.479
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.155
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.247
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.312
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.233
CLV_PCSK_SKI1_1	151	155	PF00082	0.627
CLV_PCSK_SKI1_1	17	21	PF00082	0.684
CLV_PCSK_SKI1_1	194	198	PF00082	0.528
CLV_PCSK_SKI1_1	233	237	PF00082	0.480
CLV_PCSK_SKI1_1	323	327	PF00082	0.464
CLV_PCSK_SKI1_1	371	375	PF00082	0.383
CLV_PCSK_SKI1_1	657	661	PF00082	0.404
CLV_PCSK_SKI1_1	739	743	PF00082	0.302
CLV_Separin_Metazoa	558	562	PF03568	0.502
DEG_APCC_DBOX_1	412	420	PF00400	0.738
DEG_SPOP_SBC_1	287	291	PF00917	0.493
DOC_CYCLIN_RxL_1	320	327	PF00134	0.273
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.364
DOC_MAPK_gen_1	100	108	PF00069	0.395
DOC_MAPK_gen_1	162	172	PF00069	0.302
DOC_MAPK_gen_1	194	201	PF00069	0.302
DOC_MAPK_gen_1	218	226	PF00069	0.396
DOC_MAPK_gen_1	413	421	PF00069	0.710
DOC_MAPK_gen_1	639	646	PF00069	0.447
DOC_MAPK_gen_1	708	718	PF00069	0.389
DOC_MAPK_gen_1	736	745	PF00069	0.447
DOC_MAPK_HePTP_8	261	273	PF00069	0.325
DOC_MAPK_MEF2A_6	165	174	PF00069	0.293
DOC_MAPK_MEF2A_6	264	273	PF00069	0.319
DOC_MAPK_MEF2A_6	736	745	PF00069	0.447
DOC_PP1_RVXF_1	179	185	PF00149	0.328
DOC_PP1_RVXF_1	545	551	PF00149	0.387
DOC_PP1_RVXF_1	740	746	PF00149	0.530
DOC_PP2B_LxvP_1	199	202	PF13499	0.346
DOC_PP4_FxxP_1	678	681	PF00568	0.585
DOC_USP7_MATH_1	207	211	PF00917	0.495
DOC_USP7_MATH_1	287	291	PF00917	0.536
DOC_USP7_MATH_1	449	453	PF00917	0.544
DOC_USP7_MATH_1	569	573	PF00917	0.530
DOC_USP7_MATH_1	642	646	PF00917	0.623
DOC_USP7_MATH_1	679	683	PF00917	0.571
DOC_USP7_UBL2_3	96	100	PF12436	0.387
DOC_WW_Pin1_4	372	377	PF00397	0.500
DOC_WW_Pin1_4	514	519	PF00397	0.460
DOC_WW_Pin1_4	718	723	PF00397	0.447
LIG_14-3-3_CanoR_1	158	166	PF00244	0.414
LIG_14-3-3_CanoR_1	17	24	PF00244	0.597
LIG_14-3-3_CanoR_1	335	342	PF00244	0.440
LIG_14-3-3_CanoR_1	448	455	PF00244	0.393
LIG_14-3-3_CanoR_1	561	565	PF00244	0.530
LIG_14-3-3_CanoR_1	584	590	PF00244	0.524
LIG_14-3-3_CanoR_1	657	667	PF00244	0.574
LIG_14-3-3_CanoR_1	687	692	PF00244	0.597
LIG_14-3-3_CanoR_1	708	718	PF00244	0.532
LIG_14-3-3_CanoR_1	815	820	PF00244	0.457
LIG_Actin_WH2_2	269	285	PF00022	0.244
LIG_APCC_ABBA_1	419	424	PF00400	0.588
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BIR_III_2	515	519	PF00653	0.530
LIG_BRCT_BRCA1_1	350	354	PF00533	0.353
LIG_BRCT_BRCA1_1	674	678	PF00533	0.556
LIG_CaM_IQ_9	419	435	PF13499	0.601
LIG_Clathr_ClatBox_1	105	109	PF01394	0.531
LIG_deltaCOP1_diTrp_1	478	487	PF00928	0.465
LIG_DLG_GKlike_1	815	822	PF00625	0.459
LIG_FHA_1	503	509	PF00498	0.447
LIG_FHA_1	551	557	PF00498	0.541
LIG_FHA_1	561	567	PF00498	0.512
LIG_FHA_1	569	575	PF00498	0.465
LIG_FHA_1	73	79	PF00498	0.410
LIG_FHA_1	775	781	PF00498	0.504
LIG_FHA_2	18	24	PF00498	0.557
LIG_FHA_2	373	379	PF00498	0.668
LIG_FHA_2	388	394	PF00498	0.646
LIG_FHA_2	87	93	PF00498	0.532
LIG_GBD_Chelix_1	174	182	PF00786	0.540
LIG_Integrin_RGD_1	400	402	PF01839	0.420
LIG_LIR_Apic_2	243	247	PF02991	0.313
LIG_LIR_Apic_2	314	319	PF02991	0.368
LIG_LIR_Apic_2	675	681	PF02991	0.588
LIG_LIR_Gen_1	121	128	PF02991	0.502
LIG_LIR_Gen_1	141	148	PF02991	0.312
LIG_LIR_Gen_1	168	178	PF02991	0.340
LIG_LIR_Gen_1	33	41	PF02991	0.457
LIG_LIR_Gen_1	351	361	PF02991	0.353
LIG_LIR_Gen_1	473	482	PF02991	0.454
LIG_LIR_Gen_1	485	492	PF02991	0.430
LIG_LIR_Gen_1	712	723	PF02991	0.447
LIG_LIR_Gen_1	787	793	PF02991	0.589
LIG_LIR_LC3C_4	364	369	PF02991	0.400
LIG_LIR_Nem_3	121	125	PF02991	0.505
LIG_LIR_Nem_3	168	174	PF02991	0.345
LIG_LIR_Nem_3	33	37	PF02991	0.457
LIG_LIR_Nem_3	351	357	PF02991	0.353
LIG_LIR_Nem_3	473	479	PF02991	0.454
LIG_LIR_Nem_3	485	490	PF02991	0.447
LIG_LIR_Nem_3	690	696	PF02991	0.557
LIG_LIR_Nem_3	712	718	PF02991	0.447
LIG_LIR_Nem_3	787	792	PF02991	0.507
LIG_MYND_1	247	251	PF01753	0.341
LIG_NBox_RRM_1	225	235	PF00076	0.354
LIG_NRBOX	169	175	PF00104	0.352
LIG_Pex14_1	500	504	PF04695	0.465
LIG_Pex14_2	350	354	PF04695	0.344
LIG_Pex14_2	684	688	PF04695	0.446
LIG_SH2_CRK	244	248	PF00017	0.303
LIG_SH2_CRK	667	671	PF00017	0.553
LIG_SH2_NCK_1	524	528	PF00017	0.447
LIG_SH2_PTP2	223	226	PF00017	0.356
LIG_SH2_PTP2	715	718	PF00017	0.447
LIG_SH2_STAP1	504	508	PF00017	0.447
LIG_SH2_STAP1	524	528	PF00017	0.355
LIG_SH2_STAP1	591	595	PF00017	0.447
LIG_SH2_STAP1	76	80	PF00017	0.394
LIG_SH2_STAP1	786	790	PF00017	0.577
LIG_SH2_STAT5	223	226	PF00017	0.438
LIG_SH2_STAT5	279	282	PF00017	0.332
LIG_SH2_STAT5	349	352	PF00017	0.308
LIG_SH2_STAT5	504	507	PF00017	0.476
LIG_SH2_STAT5	520	523	PF00017	0.518
LIG_SH2_STAT5	528	531	PF00017	0.545
LIG_SH2_STAT5	608	611	PF00017	0.530
LIG_SH2_STAT5	685	688	PF00017	0.444
LIG_SH2_STAT5	715	718	PF00017	0.447
LIG_SH3_1	281	287	PF00018	0.311
LIG_SH3_3	281	287	PF00018	0.471
LIG_SH3_3	316	322	PF00018	0.431
LIG_SH3_3	339	345	PF00018	0.334
LIG_SH3_3	34	40	PF00018	0.445
LIG_SH3_3	563	569	PF00018	0.502
LIG_SH3_3	666	672	PF00018	0.534
LIG_SH3_3	689	695	PF00018	0.526
LIG_SH3_3	7	13	PF00018	0.555
LIG_SH3_3	701	707	PF00018	0.578
LIG_SUMO_SIM_anti_2	776	784	PF11976	0.502
LIG_SUMO_SIM_par_1	503	509	PF11976	0.502
LIG_SUMO_SIM_par_1	641	648	PF11976	0.545
LIG_TRAF2_1	202	205	PF00917	0.337
LIG_TRAF2_1	785	788	PF00917	0.538
LIG_TRFH_1	280	284	PF08558	0.267
LIG_UBA3_1	272	281	PF00899	0.334
LIG_UBA3_1	816	820	PF00899	0.597
MOD_CDK_SPK_2	514	519	PF00069	0.447
MOD_CDK_SPxxK_3	372	379	PF00069	0.504
MOD_CK1_1	131	137	PF00069	0.435
MOD_CK1_1	314	320	PF00069	0.372
MOD_CK1_1	431	437	PF00069	0.765
MOD_CK1_1	486	492	PF00069	0.520
MOD_CK1_1	522	528	PF00069	0.496
MOD_CK1_1	645	651	PF00069	0.548
MOD_CK1_1	658	664	PF00069	0.577
MOD_CK2_1	143	149	PF00069	0.293
MOD_CK2_1	207	213	PF00069	0.542
MOD_CK2_1	286	292	PF00069	0.540
MOD_CK2_1	304	310	PF00069	0.427
MOD_CK2_1	334	340	PF00069	0.355
MOD_CK2_1	372	378	PF00069	0.612
MOD_CK2_1	86	92	PF00069	0.501
MOD_Cter_Amidation	530	533	PF01082	0.330
MOD_GlcNHglycan	114	117	PF01048	0.665
MOD_GlcNHglycan	215	218	PF01048	0.662
MOD_GlcNHglycan	265	268	PF01048	0.512
MOD_GlcNHglycan	294	298	PF01048	0.679
MOD_GlcNHglycan	336	339	PF01048	0.684
MOD_GlcNHglycan	436	439	PF01048	0.566
MOD_GlcNHglycan	440	443	PF01048	0.565
MOD_GlcNHglycan	451	454	PF01048	0.350
MOD_GlcNHglycan	480	483	PF01048	0.302
MOD_GlcNHglycan	5	8	PF01048	0.749
MOD_GlcNHglycan	508	511	PF01048	0.292
MOD_GlcNHglycan	571	574	PF01048	0.244
MOD_GlcNHglycan	640	643	PF01048	0.247
MOD_GlcNHglycan	681	684	PF01048	0.262
MOD_GlcNHglycan	830	833	PF01048	0.346
MOD_GSK3_1	233	240	PF00069	0.291
MOD_GSK3_1	434	441	PF00069	0.693
MOD_GSK3_1	500	507	PF00069	0.471
MOD_GSK3_1	519	526	PF00069	0.425
MOD_GSK3_1	546	553	PF00069	0.521
MOD_GSK3_1	585	592	PF00069	0.663
MOD_GSK3_1	624	631	PF00069	0.447
MOD_GSK3_1	638	645	PF00069	0.447
MOD_GSK3_1	72	79	PF00069	0.567
MOD_GSK3_1	86	93	PF00069	0.532
MOD_N-GLC_1	17	22	PF02516	0.785
MOD_N-GLC_1	262	267	PF02516	0.499
MOD_NEK2_1	272	277	PF00069	0.331
MOD_NEK2_1	3	8	PF00069	0.574
MOD_NEK2_1	324	329	PF00069	0.370
MOD_NEK2_1	348	353	PF00069	0.399
MOD_NEK2_1	506	511	PF00069	0.543
MOD_NEK2_1	560	565	PF00069	0.502
MOD_NEK2_2	184	189	PF00069	0.366
MOD_NEK2_2	361	366	PF00069	0.360
MOD_NEK2_2	642	647	PF00069	0.563
MOD_PIKK_1	687	693	PF00454	0.561
MOD_PIKK_1	727	733	PF00454	0.525
MOD_PIKK_1	86	92	PF00454	0.469
MOD_PK_1	417	423	PF00069	0.741
MOD_PKA_1	157	163	PF00069	0.430
MOD_PKA_1	245	251	PF00069	0.397
MOD_PKA_1	428	434	PF00069	0.723
MOD_PKA_1	754	760	PF00069	0.491
MOD_PKA_2	157	163	PF00069	0.351
MOD_PKA_2	334	340	PF00069	0.447
MOD_PKA_2	449	455	PF00069	0.486
MOD_PKA_2	483	489	PF00069	0.490
MOD_PKA_2	560	566	PF00069	0.530
MOD_PKA_2	580	586	PF00069	0.355
MOD_PKA_2	710	716	PF00069	0.530
MOD_PKA_2	754	760	PF00069	0.472
MOD_PKB_1	138	146	PF00069	0.315
MOD_Plk_1	314	320	PF00069	0.398
MOD_Plk_2-3	405	411	PF00069	0.656
MOD_Plk_2-3	546	552	PF00069	0.444
MOD_Plk_4	143	149	PF00069	0.293
MOD_Plk_4	166	172	PF00069	0.345
MOD_Plk_4	417	423	PF00069	0.683
MOD_Plk_4	483	489	PF00069	0.469
MOD_Plk_4	495	501	PF00069	0.418
MOD_Plk_4	585	591	PF00069	0.553
MOD_Plk_4	710	716	PF00069	0.530
MOD_Plk_4	76	82	PF00069	0.398
MOD_Plk_4	764	770	PF00069	0.481
MOD_ProDKin_1	372	378	PF00069	0.501
MOD_ProDKin_1	514	520	PF00069	0.460
MOD_ProDKin_1	718	724	PF00069	0.447
MOD_SUMO_for_1	101	104	PF00179	0.350
MOD_SUMO_for_1	70	73	PF00179	0.522
MOD_SUMO_for_1	81	84	PF00179	0.539
MOD_SUMO_rev_2	452	462	PF00179	0.534
MOD_SUMO_rev_2	463	467	PF00179	0.524
TRG_DiLeu_BaEn_1	149	154	PF01217	0.352
TRG_DiLeu_BaEn_1	655	660	PF01217	0.604
TRG_DiLeu_BaEn_1	788	793	PF01217	0.588
TRG_DiLeu_BaEn_2	482	488	PF01217	0.530
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.438
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.348
TRG_DiLeu_BaLyEn_6	812	817	PF01217	0.549
TRG_ENDOCYTIC_2	144	147	PF00928	0.348
TRG_ENDOCYTIC_2	223	226	PF00928	0.353
TRG_ENDOCYTIC_2	279	282	PF00928	0.346
TRG_ENDOCYTIC_2	349	352	PF00928	0.308
TRG_ENDOCYTIC_2	667	670	PF00928	0.531
TRG_ENDOCYTIC_2	715	718	PF00928	0.447
TRG_ER_diArg_1	137	140	PF00400	0.434
TRG_ER_diArg_1	178	181	PF00400	0.322
TRG_ER_diArg_1	413	415	PF00400	0.760
TRG_ER_diArg_1	532	534	PF00400	0.530
TRG_ER_diArg_1	646	649	PF00400	0.502
TRG_ER_diArg_1	739	741	PF00400	0.447
TRG_ER_diArg_1	754	756	PF00400	0.447
TRG_ER_diArg_1	801	804	PF00400	0.544
TRG_NES_CRM1_1	733	744	PF08389	0.530
TRG_NLS_Bipartite_1	194	212	PF00514	0.337
TRG_NLS_MonoCore_2	446	451	PF00514	0.444
TRG_NLS_MonoExtC_3	207	213	PF00514	0.528
TRG_NLS_MonoExtC_3	799	804	PF00514	0.512
TRG_NLS_MonoExtN_4	207	212	PF00514	0.484
TRG_NLS_MonoExtN_4	444	451	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	541	546	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G5	Leptomonas seymouri	64%	94%
A0A1X0P5A4	Trypanosomatidae	40%	100%
A0A3Q8IJN2	Leishmania donovani	81%	100%
A0A3R7KHS6	Trypanosoma rangeli	42%	100%
A4IBN5	Leishmania infantum	80%	100%
C9ZYZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AFG9	Leishmania major	81%	100%
E9B6M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%