Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN10_LEIBR

TriTrypDb:

LbrM.34.3340 , LBRM2903_340042200

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	525	529	PF00656	0.498
CLV_NRD_NRD_1	185	187	PF00675	0.543
CLV_NRD_NRD_1	530	532	PF00675	0.447
CLV_PCSK_KEX2_1	185	187	PF00082	0.472
CLV_PCSK_KEX2_1	193	195	PF00082	0.464
CLV_PCSK_KEX2_1	234	236	PF00082	0.574
CLV_PCSK_KEX2_1	530	532	PF00082	0.447
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.479
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.633
CLV_PCSK_SKI1_1	348	352	PF00082	0.604
CLV_PCSK_SKI1_1	398	402	PF00082	0.584
CLV_PCSK_SKI1_1	482	486	PF00082	0.689
CLV_PCSK_SKI1_1	561	565	PF00082	0.447
DEG_APCC_DBOX_1	357	365	PF00400	0.475
DEG_APCC_DBOX_1	9	17	PF00400	0.429
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DEG_SPOP_SBC_1	33	37	PF00917	0.476
DOC_CYCLIN_RxL_1	14	25	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.438
DOC_MAPK_gen_1	129	137	PF00069	0.543
DOC_MAPK_gen_1	207	215	PF00069	0.601
DOC_MAPK_gen_1	530	536	PF00069	0.543
DOC_MAPK_MEF2A_6	114	122	PF00069	0.578
DOC_MAPK_MEF2A_6	352	361	PF00069	0.569
DOC_MAPK_MEF2A_6	98	106	PF00069	0.468
DOC_PP1_RVXF_1	212	218	PF00149	0.534
DOC_PP1_SILK_1	354	359	PF00149	0.567
DOC_USP7_MATH_1	166	170	PF00917	0.620
DOC_USP7_MATH_1	238	242	PF00917	0.581
DOC_USP7_MATH_1	248	252	PF00917	0.618
DOC_USP7_MATH_1	33	37	PF00917	0.600
DOC_USP7_MATH_1	521	525	PF00917	0.534
DOC_USP7_MATH_1	539	543	PF00917	0.610
DOC_USP7_MATH_1	549	553	PF00917	0.569
DOC_USP7_MATH_1	67	71	PF00917	0.431
DOC_WW_Pin1_4	249	254	PF00397	0.581
DOC_WW_Pin1_4	393	398	PF00397	0.583
DOC_WW_Pin1_4	506	511	PF00397	0.698
LIG_14-3-3_CanoR_1	149	157	PF00244	0.518
LIG_14-3-3_CanoR_1	214	218	PF00244	0.549
LIG_14-3-3_CanoR_1	221	226	PF00244	0.540
LIG_14-3-3_CanoR_1	29	33	PF00244	0.526
LIG_14-3-3_CanoR_1	309	313	PF00244	0.698
LIG_14-3-3_CanoR_1	358	362	PF00244	0.482
LIG_14-3-3_CanoR_1	522	528	PF00244	0.570
LIG_14-3-3_CanoR_1	561	571	PF00244	0.447
LIG_BRCT_BRCA1_1	541	545	PF00533	0.479
LIG_Clathr_ClatBox_1	119	123	PF01394	0.374
LIG_EH1_1	373	381	PF00400	0.484
LIG_FHA_1	203	209	PF00498	0.564
LIG_FHA_1	258	264	PF00498	0.551
LIG_FHA_1	293	299	PF00498	0.434
LIG_FHA_1	33	39	PF00498	0.477
LIG_FHA_1	373	379	PF00498	0.394
LIG_FHA_1	386	392	PF00498	0.536
LIG_FHA_1	394	400	PF00498	0.636
LIG_FHA_1	41	47	PF00498	0.442
LIG_FHA_1	412	418	PF00498	0.500
LIG_FHA_1	437	443	PF00498	0.541
LIG_FHA_1	463	469	PF00498	0.507
LIG_FHA_1	66	72	PF00498	0.407
LIG_FHA_1	95	101	PF00498	0.430
LIG_FHA_2	154	160	PF00498	0.433
LIG_FHA_2	334	340	PF00498	0.521
LIG_FHA_2	523	529	PF00498	0.564
LIG_FHA_2	6	12	PF00498	0.585
LIG_GBD_Chelix_1	533	541	PF00786	0.395
LIG_LIR_Gen_1	211	220	PF02991	0.515
LIG_LIR_Gen_1	565	574	PF02991	0.444
LIG_LIR_Nem_3	128	133	PF02991	0.384
LIG_LIR_Nem_3	211	215	PF02991	0.515
LIG_LIR_Nem_3	216	220	PF02991	0.552
LIG_LIR_Nem_3	314	320	PF02991	0.497
LIG_LIR_Nem_3	4	9	PF02991	0.591
LIG_LIR_Nem_3	475	479	PF02991	0.646
LIG_LIR_Nem_3	565	571	PF02991	0.447
LIG_NRBOX	262	268	PF00104	0.578
LIG_NRBOX	360	366	PF00104	0.468
LIG_Pex14_2	23	27	PF04695	0.446
LIG_Pex14_2	58	62	PF04695	0.408
LIG_SH2_CRK	302	306	PF00017	0.504
LIG_SH2_SRC	318	321	PF00017	0.548
LIG_SH2_STAP1	326	330	PF00017	0.548
LIG_SH2_STAT5	133	136	PF00017	0.544
LIG_SH2_STAT5	15	18	PF00017	0.434
LIG_SH2_STAT5	212	215	PF00017	0.439
LIG_SH2_STAT5	318	321	PF00017	0.479
LIG_SH2_STAT5	568	571	PF00017	0.568
LIG_SH2_STAT5	573	576	PF00017	0.504
LIG_SH3_3	115	121	PF00018	0.385
LIG_SH3_3	216	222	PF00018	0.447
LIG_SH3_3	332	338	PF00018	0.419
LIG_SH3_3	405	411	PF00018	0.580
LIG_SH3_3	426	432	PF00018	0.690
LIG_SH3_3	458	464	PF00018	0.512
LIG_SH3_3	51	57	PF00018	0.609
LIG_SUMO_SIM_anti_2	178	185	PF11976	0.489
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.600
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.397
LIG_SUMO_SIM_par_1	43	50	PF11976	0.654
LIG_SUMO_SIM_par_1	457	463	PF11976	0.511
LIG_TRAF2_1	121	124	PF00917	0.470
LIG_TRFH_1	317	321	PF08558	0.481
LIG_TRFH_1	428	432	PF08558	0.521
LIG_TYR_ITIM	300	305	PF00017	0.500
LIG_WRC_WIRS_1	533	538	PF05994	0.556
LIG_WW_3	509	513	PF00397	0.532
MOD_CDC14_SPxK_1	509	512	PF00782	0.643
MOD_CDK_SPK_2	249	254	PF00069	0.581
MOD_CDK_SPK_2	393	398	PF00069	0.651
MOD_CDK_SPxK_1	506	512	PF00069	0.595
MOD_CK1_1	171	177	PF00069	0.572
MOD_CK1_1	25	31	PF00069	0.558
MOD_CK1_1	37	43	PF00069	0.523
MOD_CK1_1	387	393	PF00069	0.543
MOD_CK1_1	44	50	PF00069	0.545
MOD_CK1_1	480	486	PF00069	0.594
MOD_CK2_1	153	159	PF00069	0.442
MOD_CK2_1	308	314	PF00069	0.594
MOD_CK2_1	333	339	PF00069	0.501
MOD_CK2_1	5	11	PF00069	0.523
MOD_CK2_1	532	538	PF00069	0.448
MOD_GlcNHglycan	114	117	PF01048	0.482
MOD_GlcNHglycan	236	239	PF01048	0.694
MOD_GlcNHglycan	254	257	PF01048	0.491
MOD_GlcNHglycan	339	342	PF01048	0.641
MOD_GlcNHglycan	366	369	PF01048	0.511
MOD_GlcNHglycan	391	394	PF01048	0.563
MOD_GlcNHglycan	402	405	PF01048	0.566
MOD_GlcNHglycan	442	445	PF01048	0.591
MOD_GlcNHglycan	450	453	PF01048	0.569
MOD_GlcNHglycan	479	482	PF01048	0.522
MOD_GlcNHglycan	551	554	PF01048	0.590
MOD_GSK3_1	149	156	PF00069	0.483
MOD_GSK3_1	167	174	PF00069	0.616
MOD_GSK3_1	221	228	PF00069	0.618
MOD_GSK3_1	234	241	PF00069	0.497
MOD_GSK3_1	248	255	PF00069	0.543
MOD_GSK3_1	28	35	PF00069	0.606
MOD_GSK3_1	288	295	PF00069	0.546
MOD_GSK3_1	333	340	PF00069	0.496
MOD_GSK3_1	360	367	PF00069	0.448
MOD_GSK3_1	37	44	PF00069	0.528
MOD_GSK3_1	385	392	PF00069	0.607
MOD_GSK3_1	436	443	PF00069	0.641
MOD_GSK3_1	5	12	PF00069	0.604
MOD_GSK3_1	569	576	PF00069	0.541
MOD_LATS_1	346	352	PF00433	0.606
MOD_LATS_1	520	526	PF00433	0.469
MOD_N-GLC_1	243	248	PF02516	0.494
MOD_NEK2_1	110	115	PF00069	0.534
MOD_NEK2_1	167	172	PF00069	0.654
MOD_NEK2_1	202	207	PF00069	0.551
MOD_NEK2_1	290	295	PF00069	0.524
MOD_NEK2_1	357	362	PF00069	0.457
MOD_NEK2_1	364	369	PF00069	0.416
MOD_NEK2_1	391	396	PF00069	0.483
MOD_NEK2_1	448	453	PF00069	0.488
MOD_NEK2_1	569	574	PF00069	0.606
MOD_PIKK_1	202	208	PF00454	0.527
MOD_PIKK_1	238	244	PF00454	0.473
MOD_PIKK_1	290	296	PF00454	0.662
MOD_PIKK_1	411	417	PF00454	0.513
MOD_PK_1	221	227	PF00069	0.479
MOD_PKA_1	234	240	PF00069	0.628
MOD_PKA_1	384	390	PF00069	0.452
MOD_PKA_2	213	219	PF00069	0.601
MOD_PKA_2	220	226	PF00069	0.686
MOD_PKA_2	234	240	PF00069	0.661
MOD_PKA_2	28	34	PF00069	0.437
MOD_PKA_2	308	314	PF00069	0.600
MOD_PKA_2	357	363	PF00069	0.483
MOD_PKA_2	448	454	PF00069	0.612
MOD_PKA_2	499	505	PF00069	0.595
MOD_PKA_2	521	527	PF00069	0.578
MOD_PKA_2	9	15	PF00069	0.590
MOD_PKB_1	147	155	PF00069	0.433
MOD_Plk_1	333	339	PF00069	0.501
MOD_Plk_1	348	354	PF00069	0.431
MOD_Plk_1	4	10	PF00069	0.437
MOD_Plk_2-3	5	11	PF00069	0.592
MOD_Plk_2-3	532	538	PF00069	0.561
MOD_Plk_4	22	28	PF00069	0.476
MOD_Plk_4	308	314	PF00069	0.594
MOD_Plk_4	34	40	PF00069	0.472
MOD_Plk_4	360	366	PF00069	0.476
MOD_Plk_4	41	47	PF00069	0.462
MOD_Plk_4	532	538	PF00069	0.636
MOD_Plk_4	569	575	PF00069	0.605
MOD_Plk_4	9	15	PF00069	0.590
MOD_ProDKin_1	249	255	PF00069	0.579
MOD_ProDKin_1	393	399	PF00069	0.582
MOD_ProDKin_1	506	512	PF00069	0.696
MOD_SUMO_rev_2	224	233	PF00179	0.451
MOD_SUMO_rev_2	532	542	PF00179	0.401
TRG_DiLeu_BaEn_1	55	60	PF01217	0.409
TRG_DiLeu_BaEn_2	531	537	PF01217	0.565
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.377
TRG_ENDOCYTIC_2	212	215	PF00928	0.439
TRG_ENDOCYTIC_2	302	305	PF00928	0.504
TRG_ENDOCYTIC_2	317	320	PF00928	0.487
TRG_ENDOCYTIC_2	568	571	PF00928	0.454
TRG_ER_diArg_1	184	186	PF00400	0.478
TRG_NES_CRM1_1	265	278	PF08389	0.434
TRG_NES_CRM1_1	327	339	PF08389	0.411
TRG_NES_CRM1_1	349	362	PF08389	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V6	Leptomonas seymouri	34%	98%
A0A3Q8IVE9	Leishmania donovani	68%	99%
A4IBN3	Leishmania infantum	68%	99%
E9AFG7	Leishmania major	69%	100%
E9B6M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%