Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN08_LEIBR

TriTrypDb:

LbrM.34.3320 , LBRM2903_340042000

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.522
CLV_NRD_NRD_1	108	110	PF00675	0.732
CLV_NRD_NRD_1	11	13	PF00675	0.755
CLV_NRD_NRD_1	177	179	PF00675	0.450
CLV_NRD_NRD_1	396	398	PF00675	0.461
CLV_NRD_NRD_1	589	591	PF00675	0.535
CLV_PCSK_FUR_1	393	397	PF00082	0.476
CLV_PCSK_FUR_1	587	591	PF00082	0.579
CLV_PCSK_KEX2_1	108	110	PF00082	0.734
CLV_PCSK_KEX2_1	11	13	PF00082	0.755
CLV_PCSK_KEX2_1	176	178	PF00082	0.481
CLV_PCSK_KEX2_1	395	397	PF00082	0.475
CLV_PCSK_KEX2_1	398	400	PF00082	0.439
CLV_PCSK_KEX2_1	589	591	PF00082	0.509
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.448
CLV_PCSK_SKI1_1	143	147	PF00082	0.378
CLV_PCSK_SKI1_1	177	181	PF00082	0.332
CLV_PCSK_SKI1_1	279	283	PF00082	0.361
CLV_PCSK_SKI1_1	532	536	PF00082	0.398
CLV_PCSK_SKI1_1	590	594	PF00082	0.521
CLV_PCSK_SKI1_1	609	613	PF00082	0.506
DEG_APCC_DBOX_1	142	150	PF00400	0.342
DEG_APCC_DBOX_1	176	184	PF00400	0.323
DEG_APCC_DBOX_1	461	469	PF00400	0.493
DEG_APCC_DBOX_1	529	537	PF00400	0.441
DEG_MDM2_SWIB_1	598	606	PF02201	0.522
DOC_CDC14_PxL_1	295	303	PF14671	0.389
DOC_CDC14_PxL_1	522	530	PF14671	0.561
DOC_CYCLIN_RxL_1	9	19	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	284	287	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.338
DOC_MAPK_gen_1	587	596	PF00069	0.498
DOC_PP1_RVXF_1	10	17	PF00149	0.636
DOC_PP2B_LxvP_1	120	123	PF13499	0.500
DOC_PP2B_LxvP_1	283	286	PF13499	0.507
DOC_PP2B_LxvP_1	296	299	PF13499	0.367
DOC_PP4_FxxP_1	359	362	PF00568	0.516
DOC_PP4_FxxP_1	592	595	PF00568	0.485
DOC_USP7_MATH_1	121	125	PF00917	0.664
DOC_USP7_MATH_1	134	138	PF00917	0.581
DOC_USP7_MATH_1	311	315	PF00917	0.661
DOC_USP7_MATH_1	325	329	PF00917	0.768
DOC_USP7_MATH_1	486	490	PF00917	0.631
DOC_USP7_MATH_1	570	574	PF00917	0.685
DOC_USP7_MATH_1	624	628	PF00917	0.664
DOC_USP7_UBL2_3	605	609	PF12436	0.552
DOC_USP7_UBL2_3	612	616	PF12436	0.589
DOC_WW_Pin1_4	16	21	PF00397	0.645
DOC_WW_Pin1_4	182	187	PF00397	0.565
DOC_WW_Pin1_4	2	7	PF00397	0.701
DOC_WW_Pin1_4	22	27	PF00397	0.495
DOC_WW_Pin1_4	239	244	PF00397	0.723
DOC_WW_Pin1_4	36	41	PF00397	0.530
DOC_WW_Pin1_4	409	414	PF00397	0.426
DOC_WW_Pin1_4	555	560	PF00397	0.676
DOC_WW_Pin1_4	566	571	PF00397	0.778
DOC_WW_Pin1_4	631	636	PF00397	0.655
LIG_14-3-3_CanoR_1	101	105	PF00244	0.598
LIG_14-3-3_CanoR_1	11	15	PF00244	0.763
LIG_14-3-3_CanoR_1	143	153	PF00244	0.440
LIG_14-3-3_CanoR_1	204	213	PF00244	0.610
LIG_14-3-3_CanoR_1	279	284	PF00244	0.327
LIG_14-3-3_CanoR_1	383	388	PF00244	0.601
LIG_14-3-3_CanoR_1	532	537	PF00244	0.484
LIG_Actin_WH2_2	417	433	PF00022	0.547
LIG_APCC_ABBA_1	544	549	PF00400	0.540
LIG_BRCT_BRCA1_1	462	466	PF00533	0.428
LIG_CSL_BTD_1	183	186	PF09270	0.319
LIG_CtBP_PxDLS_1	361	365	PF00389	0.506
LIG_deltaCOP1_diTrp_1	181	191	PF00928	0.331
LIG_EH1_1	533	541	PF00400	0.559
LIG_FHA_1	267	273	PF00498	0.574
LIG_FHA_1	280	286	PF00498	0.469
LIG_FHA_1	368	374	PF00498	0.382
LIG_FHA_1	503	509	PF00498	0.447
LIG_FHA_1	539	545	PF00498	0.298
LIG_FHA_2	164	170	PF00498	0.567
LIG_FHA_2	204	210	PF00498	0.680
LIG_FHA_2	308	314	PF00498	0.540
LIG_FHA_2	492	498	PF00498	0.520
LIG_FHA_2	533	539	PF00498	0.560
LIG_FHA_2	570	576	PF00498	0.619
LIG_GBD_Chelix_1	420	428	PF00786	0.453
LIG_HCF-1_HBM_1	218	221	PF13415	0.542
LIG_LIR_Apic_2	303	309	PF02991	0.591
LIG_LIR_Apic_2	356	362	PF02991	0.467
LIG_LIR_Apic_2	591	595	PF02991	0.514
LIG_LIR_Gen_1	218	229	PF02991	0.525
LIG_LIR_Gen_1	290	300	PF02991	0.499
LIG_LIR_Gen_1	348	355	PF02991	0.536
LIG_LIR_Gen_1	44	53	PF02991	0.457
LIG_LIR_Nem_3	218	224	PF02991	0.470
LIG_LIR_Nem_3	256	260	PF02991	0.412
LIG_LIR_Nem_3	290	295	PF02991	0.459
LIG_LIR_Nem_3	348	353	PF02991	0.533
LIG_LIR_Nem_3	44	49	PF02991	0.475
LIG_MAD2	178	186	PF02301	0.531
LIG_PCNA_yPIPBox_3	530	544	PF02747	0.559
LIG_Pex14_2	592	596	PF04695	0.509
LIG_Pex14_2	598	602	PF04695	0.517
LIG_SH2_PTP2	221	224	PF00017	0.456
LIG_SH2_PTP2	306	309	PF00017	0.404
LIG_SH2_SRC	217	220	PF00017	0.294
LIG_SH2_STAP1	337	341	PF00017	0.506
LIG_SH2_STAT3	610	613	PF00017	0.570
LIG_SH2_STAT5	156	159	PF00017	0.474
LIG_SH2_STAT5	221	224	PF00017	0.425
LIG_SH2_STAT5	306	309	PF00017	0.404
LIG_SH2_STAT5	350	353	PF00017	0.527
LIG_SH2_STAT5	407	410	PF00017	0.469
LIG_SH2_STAT5	41	44	PF00017	0.361
LIG_SH2_STAT5	414	417	PF00017	0.370
LIG_SH2_STAT5	610	613	PF00017	0.570
LIG_SH3_1	520	526	PF00018	0.605
LIG_SH3_3	113	119	PF00018	0.685
LIG_SH3_3	37	43	PF00018	0.389
LIG_SH3_3	520	526	PF00018	0.572
LIG_SH3_3	61	67	PF00018	0.609
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.473
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.411
LIG_SUMO_SIM_par_1	118	125	PF11976	0.503
LIG_TRAF2_1	494	497	PF00917	0.488
LIG_TRFH_1	425	429	PF08558	0.474
LIG_WW_1	635	638	PF00397	0.513
LIG_WW_3	634	638	PF00397	0.510
MOD_CDC14_SPxK_1	634	637	PF00782	0.505
MOD_CDK_SPxK_1	631	637	PF00069	0.496
MOD_CDK_SPxxK_3	182	189	PF00069	0.577
MOD_CDK_SPxxK_3	239	246	PF00069	0.733
MOD_CK1_1	125	131	PF00069	0.722
MOD_CK1_1	18	24	PF00069	0.699
MOD_CK1_1	203	209	PF00069	0.683
MOD_CK1_1	489	495	PF00069	0.484
MOD_CK1_1	504	510	PF00069	0.405
MOD_CK1_1	560	566	PF00069	0.703
MOD_CK1_1	569	575	PF00069	0.690
MOD_CK1_1	628	634	PF00069	0.728
MOD_CK2_1	163	169	PF00069	0.551
MOD_CK2_1	307	313	PF00069	0.426
MOD_CK2_1	491	497	PF00069	0.500
MOD_Cter_Amidation	587	590	PF01082	0.568
MOD_GlcNHglycan	102	105	PF01048	0.691
MOD_GlcNHglycan	206	209	PF01048	0.629
MOD_GlcNHglycan	296	299	PF01048	0.407
MOD_GlcNHglycan	323	326	PF01048	0.689
MOD_GlcNHglycan	329	332	PF01048	0.671
MOD_GlcNHglycan	390	393	PF01048	0.571
MOD_GlcNHglycan	436	439	PF01048	0.498
MOD_GlcNHglycan	627	630	PF01048	0.616
MOD_GSK3_1	10	17	PF00069	0.666
MOD_GSK3_1	121	128	PF00069	0.621
MOD_GSK3_1	132	139	PF00069	0.641
MOD_GSK3_1	18	25	PF00069	0.531
MOD_GSK3_1	2	9	PF00069	0.718
MOD_GSK3_1	200	207	PF00069	0.600
MOD_GSK3_1	307	314	PF00069	0.572
MOD_GSK3_1	315	322	PF00069	0.662
MOD_GSK3_1	337	344	PF00069	0.721
MOD_GSK3_1	41	48	PF00069	0.323
MOD_GSK3_1	439	446	PF00069	0.374
MOD_GSK3_1	514	521	PF00069	0.593
MOD_GSK3_1	555	562	PF00069	0.690
MOD_GSK3_1	565	572	PF00069	0.683
MOD_GSK3_1	624	631	PF00069	0.452
MOD_N-GLC_1	204	209	PF02516	0.530
MOD_N-GLC_1	367	372	PF02516	0.514
MOD_NEK2_1	10	15	PF00069	0.691
MOD_NEK2_1	126	131	PF00069	0.702
MOD_NEK2_1	163	168	PF00069	0.542
MOD_NEK2_1	345	350	PF00069	0.567
MOD_NEK2_1	439	444	PF00069	0.541
MOD_NEK2_1	502	507	PF00069	0.303
MOD_NEK2_1	564	569	PF00069	0.749
MOD_NEK2_2	6	11	PF00069	0.695
MOD_PIKK_1	236	242	PF00454	0.687
MOD_PK_1	383	389	PF00069	0.399
MOD_PK_1	557	563	PF00069	0.552
MOD_PK_1	618	624	PF00069	0.404
MOD_PKA_2	10	16	PF00069	0.524
MOD_PKA_2	100	106	PF00069	0.708
MOD_PKA_2	203	209	PF00069	0.698
MOD_PKA_2	624	630	PF00069	0.449
MOD_PKB_1	530	538	PF00069	0.413
MOD_PKB_1	623	631	PF00069	0.672
MOD_PKB_1	80	88	PF00069	0.344
MOD_Plk_1	211	217	PF00069	0.579
MOD_Plk_1	337	343	PF00069	0.565
MOD_Plk_1	367	373	PF00069	0.598
MOD_Plk_4	279	285	PF00069	0.494
MOD_Plk_4	345	351	PF00069	0.572
MOD_Plk_4	368	374	PF00069	0.611
MOD_ProDKin_1	16	22	PF00069	0.647
MOD_ProDKin_1	182	188	PF00069	0.561
MOD_ProDKin_1	2	8	PF00069	0.702
MOD_ProDKin_1	239	245	PF00069	0.718
MOD_ProDKin_1	24	30	PF00069	0.621
MOD_ProDKin_1	36	42	PF00069	0.525
MOD_ProDKin_1	409	415	PF00069	0.421
MOD_ProDKin_1	555	561	PF00069	0.670
MOD_ProDKin_1	566	572	PF00069	0.775
MOD_ProDKin_1	631	637	PF00069	0.659
MOD_SUMO_rev_2	81	88	PF00179	0.554
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.449
TRG_ENDOCYTIC_2	221	224	PF00928	0.438
TRG_ENDOCYTIC_2	350	353	PF00928	0.527
TRG_ER_diArg_1	10	12	PF00400	0.752
TRG_ER_diArg_1	108	110	PF00400	0.638
TRG_ER_diArg_1	175	178	PF00400	0.565
TRG_ER_diArg_1	393	396	PF00400	0.547
TRG_ER_diArg_1	586	589	PF00400	0.557
TRG_ER_diArg_1	622	625	PF00400	0.655
TRG_ER_diArg_1	94	97	PF00400	0.456
TRG_NLS_MonoCore_2	396	401	PF00514	0.471
TRG_NLS_MonoExtN_4	395	402	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU2	Leptomonas seymouri	51%	100%
A0A1X0P6R1	Trypanosomatidae	30%	100%
A0A3Q8IMM0	Leishmania donovani	81%	89%
A0A3R7L599	Trypanosoma rangeli	30%	100%
A4IBN1	Leishmania infantum	81%	89%
C9ZZ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFG5	Leishmania major	82%	100%
E9B6M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BY91	Trypanosoma cruzi	29%	100%