Lem3 cdc50 family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LEM3 (ligand-effect modulator 3) family / CDC50 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HN07_LEIBR

TriTrypDb:

LbrM.34.3310 , LBRM2903_340041900

Length:

422

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	28
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2

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Expansion

Sequence features

A4HN07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN07

Function

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Biological processes
Term	Name	Level	Count
GO:0033036	macromolecule localization	2	28
GO:0051179	localization	1	28

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.260
CLV_NRD_NRD_1	128	130	PF00675	0.412
CLV_NRD_NRD_1	332	334	PF00675	0.442
CLV_PCSK_KEX2_1	128	130	PF00082	0.412
CLV_PCSK_SKI1_1	108	112	PF00082	0.433
CLV_PCSK_SKI1_1	410	414	PF00082	0.419
DEG_SCF_FBW7_1	29	36	PF00400	0.593
DOC_CKS1_1	30	35	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.202
DOC_MAPK_gen_1	108	116	PF00069	0.248

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U8	Leptomonas seymouri	35%	67%
A0A0N1PBG2	Leptomonas seymouri	69%	100%
A0A0N1PDQ9	Leptomonas seymouri	33%	100%
A0A0S4IMK4	Bodo saltans	43%	100%
A0A0S4J4T1	Bodo saltans	33%	100%
A0A0S4JB98	Bodo saltans	35%	100%
A0A0S4JJY0	Bodo saltans	35%	100%
A0A0S4JQR9	Bodo saltans	31%	80%
A0A1X0NHQ5	Trypanosomatidae	33%	88%
A0A1X0NV71	Trypanosomatidae	32%	100%

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