Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HN06_LEIBR

TriTrypDb:

LbrM.34.3300 , LBRM2903_340041800

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.667
CLV_NRD_NRD_1	228	230	PF00675	0.538
CLV_PCSK_KEX2_1	228	230	PF00082	0.538
CLV_PCSK_SKI1_1	183	187	PF00082	0.594
CLV_PCSK_SKI1_1	217	221	PF00082	0.369
CLV_Separin_Metazoa	15	19	PF03568	0.630
DEG_COP1_1	80	87	PF00400	0.441
DEG_SCF_FBW7_1	172	179	PF00400	0.719
DEG_SPOP_SBC_1	176	180	PF00917	0.658
DEG_SPOP_SBC_1	255	259	PF00917	0.505
DOC_ANK_TNKS_1	188	195	PF00023	0.331
DOC_CKS1_1	173	178	PF01111	0.733
DOC_PP4_FxxP_1	93	96	PF00568	0.750
DOC_USP7_MATH_1	176	180	PF00917	0.658
DOC_USP7_UBL2_3	45	49	PF12436	0.470
DOC_WW_Pin1_4	127	132	PF00397	0.498
DOC_WW_Pin1_4	172	177	PF00397	0.752
DOC_WW_Pin1_4	88	93	PF00397	0.697
LIG_14-3-3_CanoR_1	232	237	PF00244	0.493
LIG_14-3-3_CanoR_1	28	37	PF00244	0.564
LIG_BRCT_BRCA1_1	140	144	PF00533	0.454
LIG_deltaCOP1_diTrp_1	137	144	PF00928	0.317
LIG_FHA_2	10	16	PF00498	0.634
LIG_FHA_2	132	138	PF00498	0.471
LIG_LIR_Apic_2	90	96	PF02991	0.704
LIG_LIR_Gen_1	141	152	PF02991	0.484
LIG_LIR_Gen_1	31	38	PF02991	0.548
LIG_LIR_Gen_1	56	65	PF02991	0.303
LIG_LIR_Nem_3	12	16	PF02991	0.602
LIG_LIR_Nem_3	141	147	PF02991	0.452
LIG_LIR_Nem_3	31	37	PF02991	0.558
LIG_LIR_Nem_3	42	47	PF02991	0.501
LIG_LIR_Nem_3	56	61	PF02991	0.315
LIG_NRBOX	215	221	PF00104	0.289
LIG_REV1ctd_RIR_1	41	49	PF16727	0.483
LIG_SH2_GRB2like	123	126	PF00017	0.312
LIG_SH2_STAT5	123	126	PF00017	0.523
LIG_SH2_STAT5	127	130	PF00017	0.568
LIG_SH2_STAT5	184	187	PF00017	0.501
LIG_SH3_3	79	85	PF00018	0.666
LIG_SH3_3	8	14	PF00018	0.650
LIG_SxIP_EBH_1	125	135	PF03271	0.348
MOD_CK1_1	91	97	PF00069	0.607
MOD_CK2_1	105	111	PF00069	0.674
MOD_CK2_1	131	137	PF00069	0.403
MOD_CK2_1	207	213	PF00069	0.418
MOD_CK2_1	255	261	PF00069	0.533
MOD_CK2_1	77	83	PF00069	0.542
MOD_CK2_1	9	15	PF00069	0.612
MOD_Cter_Amidation	226	229	PF01082	0.557
MOD_GlcNHglycan	160	163	PF01048	0.708
MOD_GlcNHglycan	30	33	PF01048	0.581
MOD_GSK3_1	101	108	PF00069	0.412
MOD_GSK3_1	127	134	PF00069	0.450
MOD_GSK3_1	171	178	PF00069	0.711
MOD_GSK3_1	231	238	PF00069	0.478
MOD_GSK3_1	28	35	PF00069	0.581
MOD_GSK3_1	83	90	PF00069	0.660
MOD_NEK2_1	126	131	PF00069	0.489
MOD_NEK2_1	146	151	PF00069	0.381
MOD_NEK2_1	254	259	PF00069	0.407
MOD_NEK2_1	87	92	PF00069	0.680
MOD_PKA_2	231	237	PF00069	0.561
MOD_PKB_1	52	60	PF00069	0.527
MOD_Plk_2-3	9	15	PF00069	0.633
MOD_Plk_4	207	213	PF00069	0.408
MOD_Plk_4	39	45	PF00069	0.597
MOD_ProDKin_1	127	133	PF00069	0.490
MOD_ProDKin_1	172	178	PF00069	0.739
MOD_ProDKin_1	88	94	PF00069	0.699
TRG_DiLeu_BaEn_1	215	220	PF01217	0.390
TRG_DiLeu_BaEn_4	111	117	PF01217	0.460
TRG_ENDOCYTIC_2	123	126	PF00928	0.554
TRG_ER_diArg_1	188	191	PF00400	0.330
TRG_ER_diArg_1	228	230	PF00400	0.535
TRG_NES_CRM1_1	66	81	PF08389	0.575
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X1	Leptomonas seymouri	40%	97%
A0A1X0P5B7	Trypanosomatidae	24%	100%
A0A3Q8II73	Leishmania donovani	74%	100%
A4IBM9	Leishmania infantum	73%	100%
C9ZZ03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AFG3	Leishmania major	74%	100%
E9B6L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BYA4	Trypanosoma cruzi	25%	100%