Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly A polymerase regulatory subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HN05_LEIBR

TriTrypDb:

LbrM.34.3290 , LBRM2903_340041700

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HN05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN05

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006370	7-methylguanosine mRNA capping	8	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009452	7-methylguanosine RNA capping	8	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0036260	RNA capping	7	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003746	translation elongation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	6	12
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008174	mRNA methyltransferase activity	5	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.479
CLV_NRD_NRD_1	164	166	PF00675	0.320
CLV_NRD_NRD_1	409	411	PF00675	0.455
CLV_NRD_NRD_1	434	436	PF00675	0.397
CLV_NRD_NRD_1	7	9	PF00675	0.537
CLV_NRD_NRD_1	80	82	PF00675	0.297
CLV_PCSK_KEX2_1	11	13	PF00082	0.419
CLV_PCSK_KEX2_1	164	166	PF00082	0.320
CLV_PCSK_KEX2_1	40	42	PF00082	0.293
CLV_PCSK_KEX2_1	433	435	PF00082	0.451
CLV_PCSK_KEX2_1	444	446	PF00082	0.530
CLV_PCSK_KEX2_1	7	9	PF00082	0.454
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.419
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.293
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.374
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.454
CLV_PCSK_SKI1_1	137	141	PF00082	0.289
CLV_PCSK_SKI1_1	164	168	PF00082	0.491
CLV_PCSK_SKI1_1	238	242	PF00082	0.326
CLV_PCSK_SKI1_1	37	41	PF00082	0.588
CLV_PCSK_SKI1_1	402	406	PF00082	0.507
CLV_PCSK_SKI1_1	411	415	PF00082	0.365
CLV_PCSK_SKI1_1	435	439	PF00082	0.448
CLV_PCSK_SKI1_1	70	74	PF00082	0.381
CLV_PCSK_SKI1_1	81	85	PF00082	0.249
CLV_Separin_Metazoa	412	416	PF03568	0.490
DOC_CYCLIN_RxL_1	235	245	PF00134	0.311
DOC_CYCLIN_RxL_1	77	87	PF00134	0.318
DOC_MAPK_DCC_7	165	175	PF00069	0.412
DOC_MAPK_gen_1	236	243	PF00069	0.331
DOC_MAPK_gen_1	360	367	PF00069	0.338
DOC_MAPK_gen_1	410	416	PF00069	0.503
DOC_MAPK_gen_1	433	440	PF00069	0.407
DOC_MAPK_MEF2A_6	224	232	PF00069	0.374
DOC_MAPK_MEF2A_6	236	243	PF00069	0.387
DOC_MAPK_MEF2A_6	316	323	PF00069	0.356
DOC_MAPK_NFAT4_5	316	324	PF00069	0.380
DOC_PP1_RVXF_1	236	243	PF00149	0.330
DOC_PP2B_LxvP_1	220	223	PF13499	0.395
DOC_PP2B_LxvP_1	319	322	PF13499	0.414
DOC_PP2B_LxvP_1	334	337	PF13499	0.351
DOC_PP4_FxxP_1	283	286	PF00568	0.335
DOC_PP4_FxxP_1	396	399	PF00568	0.369
DOC_USP7_MATH_1	181	185	PF00917	0.383
DOC_USP7_MATH_1	286	290	PF00917	0.498
DOC_USP7_MATH_1	64	68	PF00917	0.434
DOC_USP7_MATH_1	97	101	PF00917	0.205
DOC_USP7_UBL2_3	7	11	PF12436	0.356
DOC_WW_Pin1_4	24	29	PF00397	0.477
LIG_14-3-3_CanoR_1	124	128	PF00244	0.312
LIG_14-3-3_CanoR_1	164	173	PF00244	0.426
LIG_14-3-3_CanoR_1	284	294	PF00244	0.451
LIG_14-3-3_CanoR_1	326	336	PF00244	0.356
LIG_14-3-3_CanoR_1	507	512	PF00244	0.407
LIG_14-3-3_CanoR_1	96	102	PF00244	0.303
LIG_Actin_WH2_2	387	404	PF00022	0.426
LIG_APCC_ABBA_1	370	375	PF00400	0.321
LIG_BIR_III_4	457	461	PF00653	0.554
LIG_BRCT_BRCA1_1	470	474	PF00533	0.436
LIG_BRCT_BRCA1_1	48	52	PF00533	0.510
LIG_CaM_IQ_9	182	197	PF13499	0.483
LIG_eIF4E_1	314	320	PF01652	0.427
LIG_FHA_1	124	130	PF00498	0.294
LIG_FHA_1	165	171	PF00498	0.490
LIG_FHA_1	200	206	PF00498	0.448
LIG_FHA_1	207	213	PF00498	0.445
LIG_FHA_1	269	275	PF00498	0.459
LIG_FHA_1	301	307	PF00498	0.573
LIG_FHA_1	404	410	PF00498	0.508
LIG_FHA_1	419	425	PF00498	0.269
LIG_FHA_1	517	523	PF00498	0.395
LIG_FHA_2	326	332	PF00498	0.334
LIG_FHA_2	346	352	PF00498	0.361
LIG_FHA_2	425	431	PF00498	0.430
LIG_FHA_2	488	494	PF00498	0.477
LIG_GBD_Chelix_1	416	424	PF00786	0.424
LIG_HCF-1_HBM_1	378	381	PF13415	0.357
LIG_Integrin_RGD_1	316	318	PF01839	0.407
LIG_IRF3_LxIS_1	239	244	PF10401	0.442
LIG_LIR_Apic_2	42	47	PF02991	0.417
LIG_LIR_Gen_1	100	109	PF02991	0.309
LIG_LIR_Gen_1	126	135	PF02991	0.276
LIG_LIR_Gen_1	18	28	PF02991	0.493
LIG_LIR_Gen_1	268	274	PF02991	0.347
LIG_LIR_Gen_1	33	43	PF02991	0.266
LIG_LIR_Gen_1	392	401	PF02991	0.392
LIG_LIR_LC3C_4	331	336	PF02991	0.325
LIG_LIR_Nem_3	100	104	PF02991	0.290
LIG_LIR_Nem_3	126	130	PF02991	0.276
LIG_LIR_Nem_3	18	23	PF02991	0.482
LIG_LIR_Nem_3	268	273	PF02991	0.351
LIG_LIR_Nem_3	33	38	PF02991	0.268
LIG_LIR_Nem_3	351	357	PF02991	0.336
LIG_LIR_Nem_3	392	396	PF02991	0.374
LIG_LIR_Nem_3	49	55	PF02991	0.386
LIG_PCNA_PIPBox_1	13	22	PF02747	0.542
LIG_PCNA_yPIPBox_3	7	20	PF02747	0.555
LIG_PTB_Apo_2	14	21	PF02174	0.544
LIG_PTB_Apo_2	147	154	PF02174	0.274
LIG_PTB_Phospho_1	14	20	PF10480	0.543
LIG_REV1ctd_RIR_1	354	364	PF16727	0.311
LIG_SH2_CRK	101	105	PF00017	0.308
LIG_SH2_CRK	44	48	PF00017	0.421
LIG_SH2_CRK	94	98	PF00017	0.264
LIG_SH2_NCK_1	381	385	PF00017	0.338
LIG_SH2_SRC	177	180	PF00017	0.414
LIG_SH2_STAP1	159	163	PF00017	0.272
LIG_SH2_STAP1	20	24	PF00017	0.420
LIG_SH2_STAP1	381	385	PF00017	0.338
LIG_SH2_STAT3	294	297	PF00017	0.427
LIG_SH2_STAT5	287	290	PF00017	0.412
LIG_SH2_STAT5	314	317	PF00017	0.363
LIG_SH2_STAT5	393	396	PF00017	0.385
LIG_SH2_STAT5	5	8	PF00017	0.632
LIG_SH2_STAT5	94	97	PF00017	0.340
LIG_SH3_2	61	66	PF14604	0.432
LIG_SH3_3	136	142	PF00018	0.363
LIG_SH3_3	248	254	PF00018	0.483
LIG_SH3_3	58	64	PF00018	0.431
LIG_TYR_ITIM	99	104	PF00017	0.340
MOD_CK1_1	289	295	PF00069	0.557
MOD_CK1_1	480	486	PF00069	0.727
MOD_CK1_1	528	534	PF00069	0.586
MOD_CK2_1	325	331	PF00069	0.332
MOD_CK2_1	345	351	PF00069	0.396
MOD_CK2_1	416	422	PF00069	0.505
MOD_CK2_1	487	493	PF00069	0.633
MOD_GlcNHglycan	2	5	PF01048	0.643
MOD_GlcNHglycan	20	23	PF01048	0.334
MOD_GlcNHglycan	247	250	PF01048	0.381
MOD_GlcNHglycan	470	473	PF01048	0.602
MOD_GlcNHglycan	482	485	PF01048	0.532
MOD_GlcNHglycan	530	533	PF01048	0.522
MOD_GlcNHglycan	73	76	PF01048	0.417
MOD_GSK3_1	18	25	PF00069	0.474
MOD_GSK3_1	241	248	PF00069	0.330
MOD_GSK3_1	285	292	PF00069	0.512
MOD_GSK3_1	322	329	PF00069	0.326
MOD_GSK3_1	473	480	PF00069	0.622
MOD_GSK3_1	482	489	PF00069	0.672
MOD_N-GLC_1	154	159	PF02516	0.289
MOD_N-GLC_1	345	350	PF02516	0.399
MOD_N-GLC_1	445	450	PF02516	0.429
MOD_N-GLC_2	475	477	PF02516	0.472
MOD_NEK2_1	23	28	PF00069	0.588
MOD_NEK2_1	356	361	PF00069	0.451
MOD_NEK2_1	533	538	PF00069	0.585
MOD_PK_1	247	253	PF00069	0.428
MOD_PKA_1	164	170	PF00069	0.418
MOD_PKA_2	123	129	PF00069	0.308
MOD_PKA_2	164	170	PF00069	0.384
MOD_PKA_2	206	212	PF00069	0.497
MOD_PKA_2	300	306	PF00069	0.546
MOD_PKA_2	325	331	PF00069	0.332
MOD_PKA_2	480	486	PF00069	0.602
MOD_PKA_2	506	512	PF00069	0.497
MOD_Plk_1	154	160	PF00069	0.315
MOD_Plk_1	276	282	PF00069	0.403
MOD_Plk_1	345	351	PF00069	0.396
MOD_Plk_1	498	504	PF00069	0.545
MOD_Plk_2-3	482	488	PF00069	0.500
MOD_Plk_2-3	493	499	PF00069	0.390
MOD_Plk_4	276	282	PF00069	0.403
MOD_Plk_4	389	395	PF00069	0.366
MOD_ProDKin_1	24	30	PF00069	0.474
MOD_SUMO_rev_2	183	192	PF00179	0.555
MOD_SUMO_rev_2	462	472	PF00179	0.650
MOD_SUMO_rev_2	67	75	PF00179	0.308
TRG_DiLeu_BaEn_1	386	391	PF01217	0.392
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.381
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.557
TRG_ENDOCYTIC_2	101	104	PF00928	0.303
TRG_ENDOCYTIC_2	177	180	PF00928	0.311
TRG_ENDOCYTIC_2	20	23	PF00928	0.611
TRG_ENDOCYTIC_2	393	396	PF00928	0.346
TRG_ER_diArg_1	164	166	PF00400	0.232
TRG_ER_diArg_1	433	435	PF00400	0.413
TRG_ER_diArg_1	513	516	PF00400	0.340
TRG_ER_diArg_1	65	68	PF00400	0.325
TRG_ER_FFAT_2	14	25	PF00635	0.479
TRG_NLS_MonoCore_2	6	11	PF00514	0.522
TRG_NLS_MonoExtC_3	6	11	PF00514	0.463
TRG_NLS_MonoExtN_4	7	13	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB31	Leptomonas seymouri	75%	100%
A0A0S4IHM6	Bodo saltans	54%	100%
A0A0S4JS06	Bodo saltans	43%	100%
A0A1X0P597	Trypanosomatidae	62%	100%
A0A3S7X9K6	Leishmania donovani	87%	99%
A0A422NR92	Trypanosoma rangeli	59%	100%
A4IBM8	Leishmania infantum	88%	99%
C9ZZ04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFG2	Leishmania major	87%	100%
E9B6L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%