TP_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrapyrrole (Corrin/Porphyrin) Methylases, putative

Species:

Leishmania braziliensis

UniProt:

A4HN02_LEIBR

TriTrypDb:

LbrM.34.3260 , LBRM2903_340041300 , LBRM2903_340041400

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HN02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN02

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	284	286	PF00675	0.263
CLV_NRD_NRD_1	300	302	PF00675	0.263
CLV_NRD_NRD_1	365	367	PF00675	0.504
CLV_NRD_NRD_1	414	416	PF00675	0.588
CLV_NRD_NRD_1	425	427	PF00675	0.458
CLV_NRD_NRD_1	430	432	PF00675	0.403
CLV_NRD_NRD_1	52	54	PF00675	0.711
CLV_NRD_NRD_1	67	69	PF00675	0.609
CLV_PCSK_FUR_1	428	432	PF00082	0.533
CLV_PCSK_KEX2_1	226	228	PF00082	0.387
CLV_PCSK_KEX2_1	284	286	PF00082	0.263
CLV_PCSK_KEX2_1	299	301	PF00082	0.244
CLV_PCSK_KEX2_1	363	365	PF00082	0.488
CLV_PCSK_KEX2_1	414	416	PF00082	0.580
CLV_PCSK_KEX2_1	420	422	PF00082	0.515
CLV_PCSK_KEX2_1	425	427	PF00082	0.463
CLV_PCSK_KEX2_1	430	432	PF00082	0.410
CLV_PCSK_KEX2_1	52	54	PF00082	0.626
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.387
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.483
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.544
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.518
CLV_PCSK_PC7_1	421	427	PF00082	0.574
CLV_PCSK_PC7_1	428	434	PF00082	0.523
CLV_PCSK_SKI1_1	124	128	PF00082	0.276
CLV_PCSK_SKI1_1	89	93	PF00082	0.521
CLV_Separin_Metazoa	111	115	PF03568	0.396
CLV_Separin_Metazoa	281	285	PF03568	0.462
DEG_APCC_DBOX_1	153	161	PF00400	0.562
DEG_APCC_DBOX_1	420	428	PF00400	0.663
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SPOP_SBC_1	39	43	PF00917	0.712
DEG_SPOP_SBC_1	398	402	PF00917	0.789
DOC_CKS1_1	47	52	PF01111	0.475
DOC_CYCLIN_RxL_1	124	132	PF00134	0.482
DOC_MAPK_gen_1	284	290	PF00069	0.494
DOC_MAPK_gen_1	337	345	PF00069	0.402
DOC_MAPK_MEF2A_6	337	345	PF00069	0.402
DOC_MAPK_MEF2A_6	376	383	PF00069	0.457
DOC_MAPK_NFAT4_5	338	346	PF00069	0.396
DOC_PP1_RVXF_1	320	327	PF00149	0.532
DOC_PP4_FxxP_1	9	12	PF00568	0.455
DOC_USP7_MATH_1	200	204	PF00917	0.556
DOC_USP7_MATH_1	218	222	PF00917	0.402
DOC_USP7_MATH_1	32	36	PF00917	0.722
DOC_USP7_MATH_1	389	393	PF00917	0.775
DOC_USP7_MATH_1	39	43	PF00917	0.730
DOC_USP7_MATH_1	397	401	PF00917	0.787
DOC_USP7_MATH_1	439	443	PF00917	0.622
DOC_USP7_UBL2_3	359	363	PF12436	0.556
DOC_WW_Pin1_4	172	177	PF00397	0.482
DOC_WW_Pin1_4	237	242	PF00397	0.543
DOC_WW_Pin1_4	35	40	PF00397	0.598
DOC_WW_Pin1_4	46	51	PF00397	0.676
DOC_WW_Pin1_4	70	75	PF00397	0.588
LIG_14-3-3_CanoR_1	147	157	PF00244	0.482
LIG_14-3-3_CanoR_1	301	311	PF00244	0.476
LIG_14-3-3_CanoR_1	52	61	PF00244	0.508
LIG_14-3-3_CterR_2	460	462	PF00244	0.508
LIG_BRCT_BRCA1_1	247	251	PF00533	0.482
LIG_BRCT_BRCA1_1	61	65	PF00533	0.644
LIG_EH1_1	368	376	PF00400	0.388
LIG_EVH1_2	379	383	PF00568	0.474
LIG_FHA_1	125	131	PF00498	0.482
LIG_FHA_1	173	179	PF00498	0.482
LIG_FHA_1	303	309	PF00498	0.534
LIG_FHA_2	127	133	PF00498	0.476
LIG_FHA_2	241	247	PF00498	0.597
LIG_FHA_2	368	374	PF00498	0.645
LIG_FHA_2	407	413	PF00498	0.586
LIG_FHA_2	71	77	PF00498	0.543
LIG_FHA_2	83	89	PF00498	0.516
LIG_LIR_Nem_3	248	254	PF02991	0.534
LIG_LIR_Nem_3	274	278	PF02991	0.536
LIG_LIR_Nem_3	64	70	PF02991	0.628
LIG_MAD2	264	272	PF02301	0.584
LIG_MLH1_MIPbox_1	247	251	PF16413	0.482
LIG_NRBOX	156	162	PF00104	0.482
LIG_Pex14_2	275	279	PF04695	0.562
LIG_Pex14_2	61	65	PF04695	0.694
LIG_SH2_CRK	67	71	PF00017	0.614
LIG_SH2_STAT3	14	17	PF00017	0.466
LIG_SH2_STAT3	327	330	PF00017	0.449
LIG_SH2_STAT5	118	121	PF00017	0.482
LIG_SH2_STAT5	14	17	PF00017	0.466
LIG_SH2_STAT5	303	306	PF00017	0.562
LIG_SH2_STAT5	327	330	PF00017	0.542
LIG_SH3_3	131	137	PF00018	0.562
LIG_SH3_3	378	384	PF00018	0.643
LIG_SH3_3	92	98	PF00018	0.473
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.482
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.649
LIG_TRAF2_1	410	413	PF00917	0.700
LIG_TRAF2_1	442	445	PF00917	0.590
MOD_CDK_SPxK_1	46	52	PF00069	0.518
MOD_CDK_SPxxK_3	46	53	PF00069	0.475
MOD_CK1_1	212	218	PF00069	0.369
MOD_CK1_1	221	227	PF00069	0.345
MOD_CK1_1	24	30	PF00069	0.620
MOD_CK1_1	240	246	PF00069	0.447
MOD_CK1_1	35	41	PF00069	0.490
MOD_CK1_1	406	412	PF00069	0.745
MOD_CK2_1	149	155	PF00069	0.447
MOD_CK2_1	214	220	PF00069	0.335
MOD_CK2_1	406	412	PF00069	0.724
MOD_CK2_1	439	445	PF00069	0.600
MOD_GlcNHglycan	172	175	PF01048	0.335
MOD_GlcNHglycan	202	205	PF01048	0.365
MOD_GlcNHglycan	206	209	PF01048	0.348
MOD_GlcNHglycan	211	214	PF01048	0.279
MOD_GlcNHglycan	216	219	PF01048	0.361
MOD_GlcNHglycan	220	223	PF01048	0.221
MOD_GlcNHglycan	23	26	PF01048	0.680
MOD_GlcNHglycan	387	390	PF01048	0.749
MOD_GlcNHglycan	392	395	PF01048	0.753
MOD_GlcNHglycan	4	7	PF01048	0.698
MOD_GlcNHglycan	401	404	PF01048	0.793
MOD_GlcNHglycan	42	45	PF01048	0.419
MOD_GlcNHglycan	61	64	PF01048	0.605
MOD_GSK3_1	168	175	PF00069	0.447
MOD_GSK3_1	200	207	PF00069	0.404
MOD_GSK3_1	209	216	PF00069	0.316
MOD_GSK3_1	302	309	PF00069	0.403
MOD_GSK3_1	35	42	PF00069	0.604
MOD_GSK3_1	385	392	PF00069	0.780
MOD_GSK3_1	399	406	PF00069	0.662
MOD_N-GLC_1	148	153	PF02516	0.335
MOD_N-GLC_1	235	240	PF02516	0.436
MOD_N-GLC_1	311	316	PF02516	0.335
MOD_NEK2_1	169	174	PF00069	0.331
MOD_NEK2_1	2	7	PF00069	0.650
MOD_NEK2_1	209	214	PF00069	0.319
MOD_NEK2_1	311	316	PF00069	0.354
MOD_NEK2_1	367	372	PF00069	0.533
MOD_NEK2_1	405	410	PF00069	0.616
MOD_NEK2_1	54	59	PF00069	0.585
MOD_NEK2_1	61	66	PF00069	0.530
MOD_PIKK_1	24	30	PF00454	0.678
MOD_PKA_1	52	58	PF00069	0.602
MOD_PKA_2	194	200	PF00069	0.378
MOD_PKA_2	367	373	PF00069	0.571
MOD_PKA_2	385	391	PF00069	0.720
MOD_PKA_2	52	58	PF00069	0.659
MOD_PKA_2	59	65	PF00069	0.605
MOD_Plk_1	103	109	PF00069	0.335
MOD_Plk_1	235	241	PF00069	0.215
MOD_Plk_1	311	317	PF00069	0.335
MOD_Plk_1	456	462	PF00069	0.725
MOD_Plk_4	126	132	PF00069	0.335
MOD_Plk_4	245	251	PF00069	0.335
MOD_Plk_4	292	298	PF00069	0.463
MOD_ProDKin_1	172	178	PF00069	0.335
MOD_ProDKin_1	237	243	PF00069	0.420
MOD_ProDKin_1	35	41	PF00069	0.598
MOD_ProDKin_1	46	52	PF00069	0.676
MOD_ProDKin_1	70	76	PF00069	0.585
MOD_SUMO_for_1	410	413	PF00179	0.656
TRG_DiLeu_BaEn_1	331	336	PF01217	0.482
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.335
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.566
TRG_ENDOCYTIC_2	67	70	PF00928	0.620
TRG_ER_diArg_1	262	265	PF00400	0.319
TRG_ER_diArg_1	283	285	PF00400	0.308
TRG_ER_diArg_1	298	301	PF00400	0.308
TRG_ER_diArg_1	364	366	PF00400	0.486
TRG_ER_diArg_1	414	417	PF00400	0.589
TRG_ER_diArg_1	424	426	PF00400	0.524
TRG_ER_diArg_1	427	430	PF00400	0.489
TRG_ER_diArg_1	51	53	PF00400	0.605
TRG_NLS_Bipartite_1	52	72	PF00514	0.557
TRG_NLS_MonoCore_2	362	367	PF00514	0.624
TRG_NLS_MonoExtC_3	416	421	PF00514	0.655
TRG_NLS_MonoExtN_4	414	421	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G3	Leptomonas seymouri	66%	100%
A0A1X0P5K8	Trypanosomatidae	54%	100%
A0A3R7N6Y9	Trypanosoma rangeli	55%	100%
A0A3S7X9K0	Leishmania donovani	84%	100%
A4IBM5	Leishmania infantum	84%	100%
C9ZZ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AFF9	Leishmania major	84%	100%
E9B6L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BY28	Trypanosoma cruzi	64%	100%