6-phosphogluconate dehydrogenase, decarboxylating

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphogluconate dehydrogenase, decarboxylating, putative

Species:

Leishmania braziliensis

UniProt:

A4HN01_LEIBR

TriTrypDb:

LbrM.34.3250 , LBRM2903_340041200

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HN01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HN01

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006082	organic acid metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006098	pentose-phosphate shunt	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006739	NADP metabolic process	7	12
GO:0006740	NADPH regeneration	4	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0019362	pyridine nucleotide metabolic process	5	12
GO:0019520	aldonic acid metabolic process	4	12
GO:0019521	D-gluconate metabolic process	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044262	obsolete cellular carbohydrate metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046496	nicotinamide nucleotide metabolic process	6	12
GO:0051156	glucose 6-phosphate metabolic process	4	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009051	pentose-phosphate shunt, oxidative branch	5	1
GO:0009056	catabolic process	2	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044275	obsolete cellular carbohydrate catabolic process	4	1
GO:0044282	small molecule catabolic process	3	1
GO:0046176	aldonic acid catabolic process	5	1
GO:0046177	D-gluconate catabolic process	6	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0050661	NADP binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.236
CLV_NRD_NRD_1	137	139	PF00675	0.296
CLV_NRD_NRD_1	71	73	PF00675	0.300
CLV_PCSK_KEX2_1	113	115	PF00082	0.296
CLV_PCSK_KEX2_1	71	73	PF00082	0.372
CLV_PCSK_SKI1_1	24	28	PF00082	0.355
CLV_PCSK_SKI1_1	290	294	PF00082	0.259
CLV_PCSK_SKI1_1	402	406	PF00082	0.321
CLV_PCSK_SKI1_1	454	458	PF00082	0.259
CLV_PCSK_SKI1_1	71	75	PF00082	0.296
CLV_PCSK_SKI1_1	91	95	PF00082	0.330
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.459
DOC_MAPK_gen_1	68	77	PF00069	0.297
DOC_MAPK_MEF2A_6	231	239	PF00069	0.526
DOC_PP1_RVXF_1	89	95	PF00149	0.215
DOC_PP2B_LxvP_1	360	363	PF13499	0.477
DOC_PP2B_LxvP_1	379	382	PF13499	0.563
DOC_PP2B_LxvP_1	442	445	PF13499	0.594
DOC_PP4_FxxP_1	473	476	PF00568	0.501
DOC_USP7_MATH_1	279	283	PF00917	0.459
DOC_USP7_MATH_1	82	86	PF00917	0.355
DOC_WW_Pin1_4	145	150	PF00397	0.439
DOC_WW_Pin1_4	318	323	PF00397	0.491
LIG_14-3-3_CanoR_1	170	176	PF00244	0.372
LIG_14-3-3_CanoR_1	290	295	PF00244	0.470
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_deltaCOP1_diTrp_1	222	229	PF00928	0.470
LIG_FHA_1	146	152	PF00498	0.296
LIG_FHA_1	428	434	PF00498	0.481
LIG_FHA_1	439	445	PF00498	0.526
LIG_FHA_2	57	63	PF00498	0.353
LIG_LIR_Apic_2	471	476	PF02991	0.501
LIG_LIR_Gen_1	150	159	PF02991	0.330
LIG_LIR_Gen_1	193	199	PF02991	0.487
LIG_LIR_Gen_1	202	212	PF02991	0.487
LIG_LIR_Gen_1	341	349	PF02991	0.546
LIG_LIR_Nem_3	150	155	PF02991	0.296
LIG_LIR_Nem_3	193	197	PF02991	0.487
LIG_LIR_Nem_3	202	207	PF02991	0.487
LIG_LIR_Nem_3	301	306	PF02991	0.554
LIG_LYPXL_SIV_4	434	442	PF13949	0.401
LIG_PCNA_yPIPBox_3	214	225	PF02747	0.487
LIG_Pex14_1	200	204	PF04695	0.459
LIG_PTB_Apo_2	434	441	PF02174	0.470
LIG_PTB_Phospho_1	434	440	PF10480	0.561
LIG_SH2_CRK	194	198	PF00017	0.462
LIG_SH2_CRK	204	208	PF00017	0.462
LIG_SH2_CRK	331	335	PF00017	0.476
LIG_SH2_CRK	411	415	PF00017	0.480
LIG_SH2_CRK	440	444	PF00017	0.460
LIG_SH2_CRK	446	450	PF00017	0.458
LIG_SH2_GRB2like	188	191	PF00017	0.459
LIG_SH2_GRB2like	435	438	PF00017	0.470
LIG_SH2_NCK_1	462	466	PF00017	0.440
LIG_SH2_SRC	435	438	PF00017	0.483
LIG_SH2_STAP1	342	346	PF00017	0.459
LIG_SH2_STAP1	440	444	PF00017	0.573
LIG_SH2_STAT5	251	254	PF00017	0.483
LIG_SH2_STAT5	378	381	PF00017	0.487
LIG_SH2_STAT5	435	438	PF00017	0.459
LIG_SH2_STAT5	440	443	PF00017	0.459
LIG_SH3_1	304	310	PF00018	0.561
LIG_SH3_3	273	279	PF00018	0.483
LIG_SH3_3	304	310	PF00018	0.519
LIG_SH3_3	319	325	PF00018	0.402
LIG_SH3_3	388	394	PF00018	0.570
LIG_SH3_3	421	427	PF00018	0.511
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.441
LIG_SUMO_SIM_par_1	232	238	PF11976	0.460
LIG_TRAF2_1	269	272	PF00917	0.459
LIG_TRAF2_1	386	389	PF00917	0.561
LIG_TRFH_1	378	382	PF08558	0.459
LIG_TYR_ITIM	444	449	PF00017	0.459
LIG_UBA3_1	345	354	PF00899	0.470
LIG_UBA3_1	379	385	PF00899	0.561
LIG_WRC_WIRS_1	366	371	PF05994	0.459
MOD_CK1_1	262	268	PF00069	0.490
MOD_CK2_1	128	134	PF00069	0.296
MOD_CK2_1	147	153	PF00069	0.296
MOD_CK2_1	266	272	PF00069	0.459
MOD_CK2_1	309	315	PF00069	0.469
MOD_CK2_1	56	62	PF00069	0.299
MOD_CK2_1	82	88	PF00069	0.413
MOD_GlcNHglycan	130	133	PF01048	0.296
MOD_GlcNHglycan	162	165	PF01048	0.338
MOD_GlcNHglycan	204	207	PF01048	0.401
MOD_GlcNHglycan	268	271	PF01048	0.270
MOD_GSK3_1	262	269	PF00069	0.487
MOD_GSK3_1	286	293	PF00069	0.459
MOD_GSK3_1	305	312	PF00069	0.459
MOD_GSK3_1	31	38	PF00069	0.299
MOD_GSK3_1	334	341	PF00069	0.510
MOD_GSK3_1	418	425	PF00069	0.444
MOD_N-GLC_1	31	36	PF02516	0.296
MOD_NEK2_1	128	133	PF00069	0.296
MOD_NEK2_1	229	234	PF00069	0.459
MOD_NEK2_1	235	240	PF00069	0.459
MOD_NEK2_1	418	423	PF00069	0.437
MOD_NEK2_1	429	434	PF00069	0.493
MOD_NEK2_1	63	68	PF00069	0.355
MOD_NEK2_2	56	61	PF00069	0.330
MOD_PIKK_1	117	123	PF00454	0.372
MOD_PKA_2	469	475	PF00069	0.470
MOD_Plk_1	235	241	PF00069	0.487
MOD_Plk_1	83	89	PF00069	0.314
MOD_Plk_4	147	153	PF00069	0.296
MOD_Plk_4	229	235	PF00069	0.459
MOD_Plk_4	334	340	PF00069	0.515
MOD_Plk_4	438	444	PF00069	0.538
MOD_ProDKin_1	145	151	PF00069	0.439
MOD_ProDKin_1	318	324	PF00069	0.491
MOD_SUMO_for_1	164	167	PF00179	0.483
MOD_SUMO_rev_2	321	330	PF00179	0.522
TRG_DiLeu_BaEn_3	153	159	PF01217	0.330
TRG_DiLeu_BaEn_4	388	394	PF01217	0.561
TRG_ENDOCYTIC_2	194	197	PF00928	0.485
TRG_ENDOCYTIC_2	204	207	PF00928	0.482
TRG_ENDOCYTIC_2	331	334	PF00928	0.464
TRG_ENDOCYTIC_2	342	345	PF00928	0.490
TRG_ENDOCYTIC_2	378	381	PF00928	0.545
TRG_ENDOCYTIC_2	411	414	PF00928	0.458
TRG_ENDOCYTIC_2	440	443	PF00928	0.463
TRG_ENDOCYTIC_2	446	449	PF00928	0.455
TRG_ENDOCYTIC_2	462	465	PF00928	0.449
TRG_ENDOCYTIC_2	57	60	PF00928	0.394
TRG_ER_diArg_1	70	72	PF00400	0.372
TRG_NLS_MonoCore_2	67	72	PF00514	0.311
TRG_NLS_MonoExtC_3	67	72	PF00514	0.311
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4G8	Leptomonas seymouri	85%	100%
A0A0S4JHR8	Bodo saltans	67%	100%
A0A1X0P6E0	Trypanosomatidae	76%	100%
A0A3R7REV2	Trypanosoma rangeli	71%	100%
C8VP36	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	97%
C9ZZ10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B6L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
G5EBD7	Gluconobacter oxydans (strain 621H)	30%	100%
O13287	Candida albicans	37%	93%
O60037	Cunninghamella elegans	39%	99%
O83351	Treponema pallidum (strain Nichols)	37%	98%
O84066	Chlamydia trachomatis (strain D/UW-3/Cx)	37%	100%
P00349	Ovis aries	36%	99%
P00350	Escherichia coli (strain K12)	39%	100%
P12013	Bacillus subtilis (strain 168)	37%	100%
P14062	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	39%	100%
P21577	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	38%	100%
P31072	Trypanosoma brucei brucei	72%	100%
P37754	Escherichia coli	38%	100%
P37756	Shigella flexneri	39%	100%
P38720	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
P41570	Ceratitis capitata	38%	100%
P41572	Drosophila melanogaster	38%	100%
P41573	Drosophila simulans	38%	100%
P41574	Pseudescherichia vulneris	38%	100%
P41575	Raoultella planticola	39%	100%
P41576	Klebsiella pneumoniae	39%	100%
P41577	Raoultella terrigena	39%	100%
P41578	Shigella boydii	39%	100%
P41579	Shigella dysenteriae	39%	100%
P41580	Shigella sonnei	39%	100%
P41581	Citrobacter amalonaticus	38%	100%
P41582	Citrobacter koseri	39%	100%
P41583	Citrobacter freundii	39%	100%
P43774	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	39%	99%
P52207	Bacillus licheniformis	37%	100%
P52208	Synechocystis sp. (strain PCC 6803 / Kazusa)	38%	99%
P52209	Homo sapiens	37%	99%
P53319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	97%
P57208	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	35%	100%
P63334	Staphylococcus aureus (strain N315)	37%	100%
P63335	Staphylococcus aureus (strain MW2)	37%	100%
P70718	Aggregatibacter actinomycetemcomitans	38%	99%
P78812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	97%
P80859	Bacillus subtilis (strain 168)	40%	100%
P85968	Rattus norvegicus	36%	99%
P96789	Lactococcus lactis subsp. cremoris (strain MG1363)	40%	100%
Q17761	Caenorhabditis elegans	37%	99%
Q18L02	Leishmania donovani	86%	100%
Q18L04	Leishmania infantum	86%	100%
Q2R480	Oryza sativa subsp. japonica	39%	94%
Q5HFR2	Staphylococcus aureus (strain COL)	37%	100%
Q5HP42	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	35%	100%
Q6G954	Staphylococcus aureus (strain MSSA476)	37%	100%
Q6GGI7	Staphylococcus aureus (strain MRSA252)	37%	100%
Q7VMX4	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	38%	99%
Q89AX5	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	33%	100%
Q8CP47	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	35%	100%
Q8TA03	Dictyostelium discoideum	37%	97%
Q931R3	Staphylococcus aureus (strain Mu50 / ATCC 700699)	37%	100%
Q94KU1	Spinacia oleracea	40%	99%
Q94KU2	Spinacia oleracea	38%	89%
Q9CHU6	Lactococcus lactis subsp. lactis (strain IL1403)	39%	100%
Q9DCD0	Mus musculus	36%	99%
Q9FFR3	Arabidopsis thaliana	40%	98%
Q9FWA3	Arabidopsis thaliana	39%	99%
Q9LI00	Oryza sativa subsp. japonica	40%	100%
Q9NGR0	Leishmania major	87%	100%
Q9PKX7	Chlamydia muridarum (strain MoPn / Nigg)	36%	100%
Q9SH69	Arabidopsis thaliana	39%	98%
Q9Z8I3	Chlamydia pneumoniae	37%	100%
Q9ZHD9	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
V5C2V4	Trypanosoma cruzi	72%	100%