Putative transport protein particle (TRAPP) subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transport protein particle (TRAPP) subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HMZ9_LEIBR

TriTrypDb:

LbrM.34.3230 , LBRM2903_340041000

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0005794	Golgi apparatus	5	10
GO:0030008	TRAPP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1990070	TRAPPI protein complex	4	1
GO:1990071	TRAPPII protein complex	4	1
GO:1990072	TRAPPIII protein complex	4	1

Expansion

Sequence features

A4HMZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMZ9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.275
CLV_NRD_NRD_1	204	206	PF00675	0.490
CLV_NRD_NRD_1	88	90	PF00675	0.282
CLV_PCSK_KEX2_1	88	90	PF00082	0.275
CLV_PCSK_SKI1_1	124	128	PF00082	0.302
CLV_PCSK_SKI1_1	89	93	PF00082	0.297
DEG_Nend_UBRbox_1	1	4	PF02207	0.702
DOC_USP7_MATH_1	166	170	PF00917	0.332
DOC_USP7_MATH_1	187	191	PF00917	0.272
DOC_WW_Pin1_4	138	143	PF00397	0.271
LIG_14-3-3_CanoR_1	2	7	PF00244	0.692
LIG_14-3-3_CanoR_1	45	50	PF00244	0.326
LIG_14-3-3_CanoR_1	62	67	PF00244	0.213
LIG_BRCT_BRCA1_1	121	125	PF00533	0.361
LIG_BRCT_BRCA1_1	168	172	PF00533	0.297
LIG_BRCT_BRCA1_1	35	39	PF00533	0.272
LIG_deltaCOP1_diTrp_1	102	109	PF00928	0.254
LIG_deltaCOP1_diTrp_1	148	158	PF00928	0.272
LIG_FHA_1	3	9	PF00498	0.590
LIG_FHA_1	70	76	PF00498	0.348
LIG_LIR_Apic_2	178	182	PF02991	0.261
LIG_LIR_Gen_1	36	47	PF02991	0.259
LIG_LIR_Nem_3	122	128	PF02991	0.308
LIG_LIR_Nem_3	36	42	PF02991	0.259
LIG_MLH1_MIPbox_1	35	39	PF16413	0.172
LIG_Pex14_1	105	109	PF04695	0.254
LIG_Pex14_1	151	155	PF04695	0.254
LIG_Pex14_2	192	196	PF04695	0.272
LIG_Pex14_2	35	39	PF04695	0.254
LIG_SH2_CRK	47	51	PF00017	0.385
LIG_SH2_SRC	144	147	PF00017	0.275
LIG_SH2_STAT5	144	147	PF00017	0.274
LIG_SH2_STAT5	47	50	PF00017	0.385
LIG_SH3_3	181	187	PF00018	0.272
LIG_SH3_3	27	33	PF00018	0.396
LIG_SH3_3	77	83	PF00018	0.385
LIG_SH3_5	140	144	PF00018	0.332
LIG_SUMO_SIM_par_1	72	79	PF11976	0.300
LIG_SUMO_SIM_par_1	89	94	PF11976	0.332
LIG_UBA3_1	191	198	PF00899	0.330
MOD_CK1_1	25	31	PF00069	0.546
MOD_CK2_1	20	26	PF00069	0.590
MOD_CMANNOS	105	108	PF00535	0.254
MOD_GSK3_1	21	28	PF00069	0.584
MOD_GSK3_1	33	40	PF00069	0.201
MOD_NEK2_1	76	81	PF00069	0.283
MOD_NEK2_2	187	192	PF00069	0.272
MOD_NEK2_2	33	38	PF00069	0.172
MOD_PIKK_1	25	31	PF00454	0.616
MOD_PK_1	4	10	PF00069	0.457
MOD_PKA_2	117	123	PF00069	0.297
MOD_PKA_2	61	67	PF00069	0.272
MOD_PKB_1	2	10	PF00069	0.548
MOD_Plk_1	25	31	PF00069	0.596
MOD_Plk_4	187	193	PF00069	0.254
MOD_ProDKin_1	138	144	PF00069	0.271
MOD_SUMO_rev_2	202	207	PF00179	0.613
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.297
TRG_ENDOCYTIC_2	155	158	PF00928	0.254
TRG_ER_diArg_1	1	4	PF00400	0.682
TRG_ER_diArg_1	88	90	PF00400	0.274
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.276

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G1	Leptomonas seymouri	86%	100%
A0A0S4JDB1	Bodo saltans	45%	90%
A0A1X0P5M3	Trypanosomatidae	65%	100%
A0A3Q8IGG3	Leishmania donovani	92%	100%
A0A3R7K7K8	Trypanosoma rangeli	61%	100%
A4IBM2	Leishmania infantum	93%	100%
C9ZZ12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AFF6	Leishmania major	91%	100%
E9B6L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P15847	Plasmodium falciparum	26%	100%
Q2NL13	Bos taurus	26%	100%
Q54YG5	Dictyostelium discoideum	26%	100%
Q5F359	Gallus gallus	28%	100%
Q7KQM2	Plasmodium falciparum (isolate 3D7)	26%	100%
Q8IUR0	Homo sapiens	26%	100%
Q9CQA1	Mus musculus	26%	100%
Q9P7N9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%