LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HMZ8_LEIBR

TriTrypDb:

LbrM.34.3220 , LBRM2903_340040900

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4HMZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.521
CLV_NRD_NRD_1	108	110	PF00675	0.238
CLV_NRD_NRD_1	20	22	PF00675	0.402
CLV_NRD_NRD_1	225	227	PF00675	0.603
CLV_NRD_NRD_1	71	73	PF00675	0.230
CLV_PCSK_KEX2_1	108	110	PF00082	0.248
CLV_PCSK_KEX2_1	20	22	PF00082	0.521
CLV_PCSK_KEX2_1	225	227	PF00082	0.672
CLV_PCSK_SKI1_1	124	128	PF00082	0.339
DEG_SCF_FBW7_1	242	247	PF00400	0.503
DEG_SPOP_SBC_1	177	181	PF00917	0.651
DOC_MAPK_gen_1	20	27	PF00069	0.493
DOC_MAPK_MEF2A_6	39	46	PF00069	0.482
DOC_PP4_FxxP_1	144	147	PF00568	0.562
DOC_SPAK_OSR1_1	109	113	PF12202	0.448
DOC_USP7_MATH_1	114	118	PF00917	0.448
DOC_USP7_MATH_1	170	174	PF00917	0.516
DOC_USP7_MATH_1	177	181	PF00917	0.562
DOC_USP7_MATH_1	197	201	PF00917	0.751
DOC_USP7_MATH_1	217	221	PF00917	0.666
DOC_USP7_MATH_1	244	248	PF00917	0.728
DOC_USP7_MATH_1	267	271	PF00917	0.569
DOC_WW_Pin1_4	240	245	PF00397	0.642
DOC_WW_Pin1_4	283	288	PF00397	0.609
LIG_14-3-3_CanoR_1	178	185	PF00244	0.707
LIG_14-3-3_CanoR_1	260	266	PF00244	0.568
LIG_14-3-3_CanoR_1	65	71	PF00244	0.400
LIG_14-3-3_CanoR_1	87	92	PF00244	0.379
LIG_BIR_II_1	1	5	PF00653	0.386
LIG_DLG_GKlike_1	87	94	PF00625	0.379
LIG_FHA_1	14	20	PF00498	0.450
LIG_FHA_1	4	10	PF00498	0.354
LIG_FHA_2	125	131	PF00498	0.542
LIG_FHA_2	160	166	PF00498	0.671
LIG_Integrin_isoDGR_2	211	213	PF01839	0.672
LIG_Integrin_RGD_1	213	215	PF01839	0.518
LIG_LIR_Apic_2	143	147	PF02991	0.462
LIG_LIR_Apic_2	149	154	PF02991	0.468
LIG_LIR_Nem_3	104	110	PF02991	0.457
LIG_LIR_Nem_3	258	262	PF02991	0.645
LIG_LRP6_Inhibitor_1	71	77	PF00058	0.291
LIG_MAD2	279	287	PF02301	0.522
LIG_SH2_CRK	151	155	PF00017	0.686
LIG_SH2_CRK	259	263	PF00017	0.638
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.453
LIG_TRAF2_1	127	130	PF00917	0.539
LIG_TRAF2_1	162	165	PF00917	0.665
LIG_TRAF2_1	269	272	PF00917	0.584
LIG_WRC_WIRS_1	141	146	PF05994	0.612
LIG_WRC_WIRS_1	262	267	PF05994	0.490
MOD_CDK_SPxK_1	240	246	PF00069	0.680
MOD_CDK_SPxxK_3	245	252	PF00069	0.632
MOD_CK1_1	180	186	PF00069	0.723
MOD_CK1_1	199	205	PF00069	0.574
MOD_CK1_1	261	267	PF00069	0.661
MOD_CK1_1	283	289	PF00069	0.505
MOD_CK1_1	86	92	PF00069	0.543
MOD_CK2_1	124	130	PF00069	0.520
MOD_CK2_1	159	165	PF00069	0.687
MOD_CK2_1	86	92	PF00069	0.438
MOD_GlcNHglycan	132	135	PF01048	0.179
MOD_GlcNHglycan	180	183	PF01048	0.642
MOD_GlcNHglycan	199	202	PF01048	0.703
MOD_GlcNHglycan	215	218	PF01048	0.667
MOD_GlcNHglycan	300	303	PF01048	0.629
MOD_GSK3_1	176	183	PF00069	0.586
MOD_GSK3_1	213	220	PF00069	0.634
MOD_GSK3_1	240	247	PF00069	0.721
MOD_GSK3_1	83	90	PF00069	0.449
MOD_N-GLC_1	94	99	PF02516	0.225
MOD_N-GLC_2	26	28	PF02516	0.344
MOD_NEK2_1	11	16	PF00069	0.371
MOD_NEK2_1	296	301	PF00069	0.611
MOD_NEK2_1	47	52	PF00069	0.454
MOD_NEK2_1	83	88	PF00069	0.509
MOD_PIKK_1	27	33	PF00454	0.424
MOD_PKA_2	130	136	PF00069	0.379
MOD_PKA_2	177	183	PF00069	0.542
MOD_PKA_2	64	70	PF00069	0.418
MOD_PKA_2	86	92	PF00069	0.379
MOD_Plk_4	180	186	PF00069	0.708
MOD_Plk_4	261	267	PF00069	0.472
MOD_ProDKin_1	240	246	PF00069	0.644
MOD_ProDKin_1	283	289	PF00069	0.600
TRG_ENDOCYTIC_2	107	110	PF00928	0.471
TRG_ENDOCYTIC_2	259	262	PF00928	0.642
TRG_ER_diArg_1	107	109	PF00400	0.448
TRG_ER_diArg_1	19	21	PF00400	0.522
TRG_ER_diArg_1	224	226	PF00400	0.710
TRG_NES_CRM1_1	17	31	PF08389	0.382
TRG_NES_CRM1_1	33	45	PF08389	0.345
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM3	Leptomonas seymouri	61%	99%
A0A0S4JGU9	Bodo saltans	41%	96%
A0A1X0P674	Trypanosomatidae	48%	96%
A0A3S7X9J5	Leishmania donovani	80%	100%
A0A422N788	Trypanosoma rangeli	48%	100%
A4IBM1	Leishmania infantum	80%	100%
C9ZZ14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AFF5	Leishmania major	79%	100%
E9B6L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5DUQ3	Trypanosoma cruzi	48%	100%