WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMZ7_LEIBR

TriTrypDb:

LbrM.34.3210 , LBRM2903_340040800

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.493
CLV_NRD_NRD_1	178	180	PF00675	0.597
CLV_NRD_NRD_1	301	303	PF00675	0.387
CLV_NRD_NRD_1	383	385	PF00675	0.416
CLV_NRD_NRD_1	419	421	PF00675	0.388
CLV_PCSK_FUR_1	175	179	PF00082	0.607
CLV_PCSK_KEX2_1	177	179	PF00082	0.609
CLV_PCSK_KEX2_1	301	303	PF00082	0.388
CLV_PCSK_KEX2_1	383	385	PF00082	0.371
CLV_PCSK_KEX2_1	419	421	PF00082	0.390
CLV_PCSK_KEX2_1	583	585	PF00082	0.651
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.651
CLV_PCSK_PC7_1	379	385	PF00082	0.374
CLV_PCSK_SKI1_1	113	117	PF00082	0.320
CLV_PCSK_SKI1_1	294	298	PF00082	0.392
CLV_PCSK_SKI1_1	355	359	PF00082	0.563
CLV_PCSK_SKI1_1	383	387	PF00082	0.389
CLV_PCSK_SKI1_1	420	424	PF00082	0.487
CLV_PCSK_SKI1_1	430	434	PF00082	0.395
CLV_PCSK_SKI1_1	99	103	PF00082	0.591
DEG_APCC_DBOX_1	418	426	PF00400	0.362
DEG_SPOP_SBC_1	489	493	PF00917	0.526
DEG_SPOP_SBC_1	503	507	PF00917	0.461
DEG_SPOP_SBC_1	573	577	PF00917	0.623
DOC_CDC14_PxL_1	443	451	PF14671	0.338
DOC_CKS1_1	234	239	PF01111	0.366
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.473
DOC_MAPK_gen_1	175	183	PF00069	0.501
DOC_MAPK_gen_1	419	427	PF00069	0.335
DOC_MAPK_gen_1	483	490	PF00069	0.514
DOC_MAPK_MEF2A_6	419	428	PF00069	0.362
DOC_MAPK_NFAT4_5	419	427	PF00069	0.403
DOC_PP1_RVXF_1	428	435	PF00149	0.343
DOC_PP2B_LxvP_1	82	85	PF13499	0.583
DOC_USP7_MATH_1	152	156	PF00917	0.491
DOC_USP7_MATH_1	18	22	PF00917	0.421
DOC_USP7_MATH_1	230	234	PF00917	0.371
DOC_USP7_MATH_1	318	322	PF00917	0.478
DOC_USP7_MATH_1	333	337	PF00917	0.530
DOC_USP7_MATH_1	36	40	PF00917	0.572
DOC_USP7_MATH_1	390	394	PF00917	0.648
DOC_USP7_MATH_1	454	458	PF00917	0.505
DOC_USP7_MATH_1	467	471	PF00917	0.500
DOC_USP7_MATH_1	473	477	PF00917	0.501
DOC_USP7_MATH_1	489	493	PF00917	0.552
DOC_USP7_MATH_1	573	577	PF00917	0.623
DOC_USP7_MATH_1	7	11	PF00917	0.505
DOC_USP7_UBL2_3	460	464	PF12436	0.594
DOC_USP7_UBL2_3	579	583	PF12436	0.525
DOC_USP7_UBL2_3	625	629	PF12436	0.530
DOC_WW_Pin1_4	233	238	PF00397	0.369
DOC_WW_Pin1_4	432	437	PF00397	0.320
DOC_WW_Pin1_4	499	504	PF00397	0.549
DOC_WW_Pin1_4	507	512	PF00397	0.460
DOC_WW_Pin1_4	548	553	PF00397	0.480
DOC_WW_Pin1_4	77	82	PF00397	0.491
LIG_14-3-3_CanoR_1	12	16	PF00244	0.219
LIG_14-3-3_CanoR_1	139	148	PF00244	0.350
LIG_14-3-3_CanoR_1	170	174	PF00244	0.516
LIG_14-3-3_CanoR_1	202	211	PF00244	0.400
LIG_14-3-3_CanoR_1	291	297	PF00244	0.428
LIG_14-3-3_CanoR_1	399	403	PF00244	0.512
LIG_Actin_WH2_2	415	431	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	292	296	PF00533	0.296
LIG_FHA_1	234	240	PF00498	0.514
LIG_FHA_1	245	251	PF00498	0.327
LIG_FHA_1	264	270	PF00498	0.317
LIG_FHA_1	317	323	PF00498	0.446
LIG_FHA_1	421	427	PF00498	0.491
LIG_FHA_1	446	452	PF00498	0.385
LIG_FHA_1	48	54	PF00498	0.380
LIG_FHA_1	485	491	PF00498	0.573
LIG_FHA_1	504	510	PF00498	0.518
LIG_FHA_1	616	622	PF00498	0.600
LIG_FHA_2	115	121	PF00498	0.322
LIG_FHA_2	255	261	PF00498	0.335
LIG_IRF3_LxIS_1	446	452	PF10401	0.385
LIG_LIR_Apic_2	226	230	PF02991	0.389
LIG_LIR_Gen_1	5	15	PF02991	0.402
LIG_LIR_LC3C_4	236	241	PF02991	0.383
LIG_LIR_Nem_3	5	11	PF02991	0.423
LIG_NRBOX	421	427	PF00104	0.451
LIG_PROFILIN_1	556	562	PF00235	0.503
LIG_SH2_NCK_1	570	574	PF00017	0.514
LIG_SH2_PTP2	180	183	PF00017	0.481
LIG_SH2_PTP2	227	230	PF00017	0.394
LIG_SH2_SRC	180	183	PF00017	0.481
LIG_SH2_SRC	402	405	PF00017	0.384
LIG_SH2_STAP1	110	114	PF00017	0.332
LIG_SH2_STAP1	570	574	PF00017	0.514
LIG_SH2_STAT3	132	135	PF00017	0.358
LIG_SH2_STAT5	180	183	PF00017	0.486
LIG_SH2_STAT5	227	230	PF00017	0.394
LIG_SH2_STAT5	327	330	PF00017	0.461
LIG_SH2_STAT5	402	405	PF00017	0.384
LIG_SH2_STAT5	525	528	PF00017	0.535
LIG_SH2_STAT5	602	605	PF00017	0.504
LIG_SH3_3	123	129	PF00018	0.305
LIG_SH3_3	279	285	PF00018	0.485
LIG_SH3_3	369	375	PF00018	0.566
LIG_SH3_3	497	503	PF00018	0.503
LIG_SH3_3	554	560	PF00018	0.494
LIG_SH3_3	78	84	PF00018	0.509
LIG_SH3_4	579	586	PF00018	0.533
LIG_SUMO_SIM_anti_2	119	127	PF11976	0.254
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.392
LIG_SUMO_SIM_anti_2	235	242	PF11976	0.391
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.290
LIG_SUMO_SIM_anti_2	510	516	PF11976	0.417
LIG_SUMO_SIM_anti_2	618	627	PF11976	0.510
LIG_SUMO_SIM_par_1	88	95	PF11976	0.508
LIG_UBA3_1	424	430	PF00899	0.317
LIG_WRC_WIRS_1	8	13	PF05994	0.469
MOD_CK1_1	2	8	PF00069	0.410
MOD_CK1_1	233	239	PF00069	0.403
MOD_CK1_1	391	397	PF00069	0.426
MOD_CK1_1	398	404	PF00069	0.313
MOD_CK1_1	484	490	PF00069	0.524
MOD_CK1_1	502	508	PF00069	0.560
MOD_CK1_1	582	588	PF00069	0.656
MOD_CK1_1	595	601	PF00069	0.537
MOD_CK1_1	74	80	PF00069	0.527
MOD_CK2_1	114	120	PF00069	0.367
MOD_CK2_1	162	168	PF00069	0.635
MOD_CK2_1	278	284	PF00069	0.458
MOD_CK2_1	338	344	PF00069	0.386
MOD_CK2_1	507	513	PF00069	0.449
MOD_CK2_1	91	97	PF00069	0.587
MOD_GlcNHglycan	141	144	PF01048	0.305
MOD_GlcNHglycan	335	338	PF01048	0.455
MOD_GlcNHglycan	352	355	PF01048	0.514
MOD_GlcNHglycan	39	42	PF01048	0.243
MOD_GlcNHglycan	404	407	PF01048	0.392
MOD_GlcNHglycan	479	482	PF01048	0.511
MOD_GlcNHglycan	5	8	PF01048	0.434
MOD_GlcNHglycan	519	522	PF01048	0.328
MOD_GlcNHglycan	542	545	PF01048	0.402
MOD_GlcNHglycan	584	587	PF01048	0.621
MOD_GlcNHglycan	597	600	PF01048	0.435
MOD_GlcNHglycan	626	629	PF01048	0.570
MOD_GlcNHglycan	73	76	PF01048	0.540
MOD_GSK3_1	139	146	PF00069	0.302
MOD_GSK3_1	153	160	PF00069	0.684
MOD_GSK3_1	201	208	PF00069	0.416
MOD_GSK3_1	228	235	PF00069	0.505
MOD_GSK3_1	254	261	PF00069	0.340
MOD_GSK3_1	3	10	PF00069	0.460
MOD_GSK3_1	318	325	PF00069	0.431
MOD_GSK3_1	338	345	PF00069	0.361
MOD_GSK3_1	346	353	PF00069	0.441
MOD_GSK3_1	379	386	PF00069	0.410
MOD_GSK3_1	388	395	PF00069	0.534
MOD_GSK3_1	398	405	PF00069	0.543
MOD_GSK3_1	445	452	PF00069	0.478
MOD_GSK3_1	473	480	PF00069	0.549
MOD_GSK3_1	484	491	PF00069	0.609
MOD_GSK3_1	499	506	PF00069	0.511
MOD_GSK3_1	561	568	PF00069	0.561
MOD_GSK3_1	574	581	PF00069	0.560
MOD_N-GLC_1	18	23	PF02516	0.241
MOD_N-GLC_2	136	138	PF02516	0.282
MOD_N-GLC_2	197	199	PF02516	0.253
MOD_NEK2_1	11	16	PF00069	0.340
MOD_NEK2_1	201	206	PF00069	0.350
MOD_NEK2_1	232	237	PF00069	0.422
MOD_NEK2_1	388	393	PF00069	0.354
MOD_NEK2_1	414	419	PF00069	0.503
MOD_NEK2_1	449	454	PF00069	0.515
MOD_NEK2_1	490	495	PF00069	0.548
MOD_NEK2_1	504	509	PF00069	0.547
MOD_NEK2_1	623	628	PF00069	0.549
MOD_NEK2_1	71	76	PF00069	0.567
MOD_NEK2_2	191	196	PF00069	0.326
MOD_NEK2_2	467	472	PF00069	0.504
MOD_NEK2_2	7	12	PF00069	0.477
MOD_OFUCOSY	72	78	PF10250	0.437
MOD_PIKK_1	47	53	PF00454	0.428
MOD_PKA_1	383	389	PF00069	0.363
MOD_PKA_2	103	109	PF00069	0.466
MOD_PKA_2	11	17	PF00069	0.215
MOD_PKA_2	169	175	PF00069	0.557
MOD_PKA_2	201	207	PF00069	0.391
MOD_PKA_2	290	296	PF00069	0.308
MOD_PKA_2	383	389	PF00069	0.489
MOD_PKA_2	391	397	PF00069	0.571
MOD_PKA_2	398	404	PF00069	0.565
MOD_Plk_1	18	24	PF00069	0.441
MOD_Plk_1	420	426	PF00069	0.470
MOD_Plk_2-3	162	168	PF00069	0.535
MOD_Plk_2-3	278	284	PF00069	0.497
MOD_Plk_2-3	338	344	PF00069	0.374
MOD_Plk_4	223	229	PF00069	0.372
MOD_Plk_4	292	298	PF00069	0.404
MOD_Plk_4	338	344	PF00069	0.374
MOD_Plk_4	398	404	PF00069	0.488
MOD_Plk_4	420	426	PF00069	0.301
MOD_Plk_4	434	440	PF00069	0.288
MOD_ProDKin_1	233	239	PF00069	0.363
MOD_ProDKin_1	432	438	PF00069	0.314
MOD_ProDKin_1	499	505	PF00069	0.547
MOD_ProDKin_1	507	513	PF00069	0.446
MOD_ProDKin_1	548	554	PF00069	0.486
MOD_ProDKin_1	77	83	PF00069	0.493
MOD_SUMO_rev_2	452	461	PF00179	0.496
MOD_SUMO_rev_2	47	55	PF00179	0.304
TRG_DiLeu_BaEn_1	421	426	PF01217	0.396
TRG_DiLeu_BaEn_1	619	624	PF01217	0.496
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.366
TRG_ENDOCYTIC_2	180	183	PF00928	0.481
TRG_ENDOCYTIC_2	602	605	PF00928	0.405
TRG_ER_diArg_1	174	177	PF00400	0.594
TRG_ER_diArg_1	178	180	PF00400	0.586
TRG_ER_diArg_1	383	385	PF00400	0.376
TRG_ER_diArg_1	418	420	PF00400	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD2	Leptomonas seymouri	45%	100%
A0A3Q8IJ91	Leishmania donovani	71%	99%
A4IBM0	Leishmania infantum	71%	100%
E9AFF4	Leishmania major	70%	100%
E9B6K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%