Peroxin 19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin 19

Gene product:

Peroxin 19

Species:

Leishmania braziliensis

UniProt:

A4HMZ3_LEIBR

TriTrypDb:

LbrM.34.3170 , LBRM2903_340040400

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	11
GO:0042579	microbody	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HMZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0045046	protein import into peroxisome membrane	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	1
GO:0005048	signal sequence binding	4	1
GO:0005488	binding	1	1
GO:0033218	amide binding	2	1
GO:0033328	peroxisome membrane targeting sequence binding	6	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.710
CLV_NRD_NRD_1	148	150	PF00675	0.623
CLV_NRD_NRD_1	21	23	PF00675	0.544
CLV_NRD_NRD_1	300	302	PF00675	0.316
CLV_PCSK_KEX2_1	148	150	PF00082	0.651
CLV_PCSK_SKI1_1	31	35	PF00082	0.594
CLV_Separin_Metazoa	106	110	PF03568	0.625
DEG_SPOP_SBC_1	174	178	PF00917	0.797
DOC_MAPK_gen_1	103	110	PF00069	0.593
DOC_MAPK_gen_1	22	30	PF00069	0.631
DOC_PP4_FxxP_1	217	220	PF00568	0.447
DOC_USP7_MATH_1	174	178	PF00917	0.702
DOC_USP7_MATH_1	183	187	PF00917	0.721
DOC_USP7_MATH_1	203	207	PF00917	0.643
DOC_USP7_MATH_1	234	238	PF00917	0.534
DOC_USP7_UBL2_3	127	131	PF12436	0.717
DOC_WW_Pin1_4	168	173	PF00397	0.709
DOC_WW_Pin1_4	179	184	PF00397	0.646
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_FHA_1	84	90	PF00498	0.479
LIG_FHA_2	209	215	PF00498	0.617
LIG_LIR_Apic_2	214	220	PF02991	0.581
LIG_LIR_Nem_3	226	231	PF02991	0.562
LIG_NRBOX	272	278	PF00104	0.586
LIG_NRBOX	5	11	PF00104	0.521
LIG_PDZ_Class_1	307	312	PF00595	0.543
LIG_SH2_STAT3	247	250	PF00017	0.482
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.394
LIG_SUMO_SIM_par_1	85	91	PF11976	0.418
LIG_UBA3_1	122	131	PF00899	0.699
MOD_CK1_1	158	164	PF00069	0.686
MOD_CK1_1	176	182	PF00069	0.539
MOD_CK1_1	237	243	PF00069	0.513
MOD_CK1_1	79	85	PF00069	0.566
MOD_CK2_1	118	124	PF00069	0.473
MOD_CK2_1	263	269	PF00069	0.574
MOD_CK2_1	82	88	PF00069	0.543
MOD_GlcNHglycan	178	181	PF01048	0.592
MOD_GlcNHglycan	185	188	PF01048	0.683
MOD_GlcNHglycan	189	192	PF01048	0.582
MOD_GlcNHglycan	205	208	PF01048	0.581
MOD_GlcNHglycan	265	268	PF01048	0.369
MOD_GlcNHglycan	305	308	PF01048	0.670
MOD_GlcNHglycan	44	49	PF01048	0.645
MOD_GlcNHglycan	50	53	PF01048	0.595
MOD_GSK3_1	174	181	PF00069	0.584
MOD_GSK3_1	183	190	PF00069	0.549
MOD_GSK3_1	203	210	PF00069	0.614
MOD_GSK3_1	301	308	PF00069	0.624
MOD_GSK3_1	44	51	PF00069	0.600
MOD_GSK3_1	79	86	PF00069	0.546
MOD_N-GLC_1	158	163	PF02516	0.729
MOD_N-GLC_1	281	286	PF02516	0.205
MOD_NEK2_1	208	213	PF00069	0.576
MOD_NEK2_1	224	229	PF00069	0.534
MOD_NEK2_1	59	64	PF00069	0.538
MOD_NEK2_1	76	81	PF00069	0.598
MOD_PIKK_1	158	164	PF00454	0.743
MOD_PIKK_1	237	243	PF00454	0.593
MOD_PKA_1	301	307	PF00069	0.624
MOD_PKA_2	198	204	PF00069	0.675
MOD_PKA_2	224	230	PF00069	0.562
MOD_Plk_1	134	140	PF00069	0.668
MOD_Plk_1	69	75	PF00069	0.641
MOD_Plk_2-3	134	140	PF00069	0.653
MOD_Plk_2-3	69	75	PF00069	0.679
MOD_Plk_4	118	124	PF00069	0.424
MOD_Plk_4	208	214	PF00069	0.583
MOD_Plk_4	59	65	PF00069	0.570
MOD_Plk_4	76	82	PF00069	0.561
MOD_ProDKin_1	168	174	PF00069	0.710
MOD_ProDKin_1	179	185	PF00069	0.646
MOD_SUMO_for_1	126	129	PF00179	0.701
MOD_SUMO_for_1	33	36	PF00179	0.633
MOD_SUMO_rev_2	124	133	PF00179	0.694
MOD_SUMO_rev_2	26	35	PF00179	0.607
MOD_SUMO_rev_2	90	99	PF00179	0.627
TRG_DiLeu_BaEn_1	219	224	PF01217	0.562
TRG_DiLeu_BaEn_1	256	261	PF01217	0.586
TRG_DiLeu_BaEn_1	269	274	PF01217	0.420
TRG_ENDOCYTIC_2	283	286	PF00928	0.562
TRG_ER_diArg_1	28	31	PF00400	0.565
TRG_NES_CRM1_1	5	19	PF08389	0.630
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K6	Leptomonas seymouri	59%	100%
A0A1X0P5C4	Trypanosomatidae	29%	100%
A0A3Q8IFB3	Leishmania donovani	86%	100%
A0A422MWS6	Trypanosoma rangeli	28%	100%
A4IBL7	Leishmania infantum	87%	100%
C9ZZ22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFF0	Leishmania major	86%	100%
E9B6K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BY33	Trypanosoma cruzi	27%	100%