Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMZ1_LEIBR

TriTrypDb:

LbrM.34.3150 , LBRM2903_340040200

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.345
CLV_C14_Caspase3-7	598	602	PF00656	0.774
CLV_NRD_NRD_1	122	124	PF00675	0.673
CLV_NRD_NRD_1	23	25	PF00675	0.514
CLV_NRD_NRD_1	252	254	PF00675	0.453
CLV_NRD_NRD_1	261	263	PF00675	0.468
CLV_NRD_NRD_1	355	357	PF00675	0.538
CLV_NRD_NRD_1	437	439	PF00675	0.449
CLV_NRD_NRD_1	502	504	PF00675	0.573
CLV_NRD_NRD_1	56	58	PF00675	0.475
CLV_NRD_NRD_1	626	628	PF00675	0.676
CLV_NRD_NRD_1	640	642	PF00675	0.594
CLV_NRD_NRD_1	704	706	PF00675	0.751
CLV_NRD_NRD_1	734	736	PF00675	0.684
CLV_NRD_NRD_1	80	82	PF00675	0.584
CLV_PCSK_KEX2_1	122	124	PF00082	0.628
CLV_PCSK_KEX2_1	23	25	PF00082	0.514
CLV_PCSK_KEX2_1	252	254	PF00082	0.468
CLV_PCSK_KEX2_1	261	263	PF00082	0.514
CLV_PCSK_KEX2_1	354	356	PF00082	0.563
CLV_PCSK_KEX2_1	373	375	PF00082	0.340
CLV_PCSK_KEX2_1	426	428	PF00082	0.524
CLV_PCSK_KEX2_1	437	439	PF00082	0.382
CLV_PCSK_KEX2_1	501	503	PF00082	0.557
CLV_PCSK_KEX2_1	55	57	PF00082	0.476
CLV_PCSK_KEX2_1	626	628	PF00082	0.722
CLV_PCSK_KEX2_1	640	642	PF00082	0.594
CLV_PCSK_KEX2_1	704	706	PF00082	0.786
CLV_PCSK_KEX2_1	734	736	PF00082	0.706
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.346
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.605
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.769
CLV_PCSK_PC1ET2_1	640	642	PF00082	0.529
CLV_PCSK_PC7_1	52	58	PF00082	0.358
CLV_PCSK_SKI1_1	193	197	PF00082	0.538
CLV_PCSK_SKI1_1	390	394	PF00082	0.549
CLV_PCSK_SKI1_1	5	9	PF00082	0.626
CLV_PCSK_SKI1_1	510	514	PF00082	0.460
CLV_PCSK_SKI1_1	675	679	PF00082	0.721
CLV_PCSK_SKI1_1	88	92	PF00082	0.620
CLV_Separin_Metazoa	498	502	PF03568	0.456
CLV_Separin_Metazoa	578	582	PF03568	0.748
DEG_APCC_DBOX_1	141	149	PF00400	0.633
DEG_APCC_DBOX_1	190	198	PF00400	0.572
DEG_APCC_DBOX_1	658	666	PF00400	0.482
DEG_Nend_UBRbox_2	1	3	PF02207	0.626
DOC_CKS1_1	759	764	PF01111	0.495
DOC_CYCLIN_yClb5_NLxxxL_5	402	411	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.516
DOC_MAPK_gen_1	261	269	PF00069	0.466
DOC_PP2B_LxvP_1	721	724	PF13499	0.657
DOC_USP7_MATH_1	115	119	PF00917	0.594
DOC_USP7_MATH_1	127	131	PF00917	0.525
DOC_USP7_MATH_1	585	589	PF00917	0.505
DOC_USP7_MATH_1	610	614	PF00917	0.656
DOC_USP7_MATH_1	618	622	PF00917	0.783
DOC_USP7_MATH_1	744	748	PF00917	0.686
DOC_USP7_MATH_1	753	757	PF00917	0.663
DOC_WW_Pin1_4	758	763	PF00397	0.713
DOC_WW_Pin1_4	774	779	PF00397	0.733
LIG_14-3-3_CanoR_1	262	268	PF00244	0.597
LIG_14-3-3_CanoR_1	564	572	PF00244	0.624
LIG_AP_GAE_1	710	716	PF02883	0.489
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.484
LIG_BIR_III_2	584	588	PF00653	0.482
LIG_BIR_III_4	95	99	PF00653	0.470
LIG_Clathr_ClatBox_1	194	198	PF01394	0.573
LIG_deltaCOP1_diTrp_1	430	439	PF00928	0.449
LIG_FHA_1	112	118	PF00498	0.589
LIG_FHA_1	324	330	PF00498	0.665
LIG_FHA_1	367	373	PF00498	0.589
LIG_FHA_1	492	498	PF00498	0.320
LIG_FHA_1	782	788	PF00498	0.605
LIG_FHA_2	102	108	PF00498	0.617
LIG_FHA_2	163	169	PF00498	0.535
LIG_FHA_2	333	339	PF00498	0.702
LIG_FHA_2	347	353	PF00498	0.574
LIG_FHA_2	384	390	PF00498	0.581
LIG_FHA_2	417	423	PF00498	0.533
LIG_FHA_2	511	517	PF00498	0.519
LIG_FHA_2	596	602	PF00498	0.728
LIG_FHA_2	731	737	PF00498	0.518
LIG_Integrin_isoDGR_2	749	751	PF01839	0.528
LIG_KLC1_Yacidic_2	224	229	PF13176	0.497
LIG_LIR_Apic_2	681	687	PF02991	0.716
LIG_LIR_Gen_1	170	180	PF02991	0.535
LIG_LIR_Gen_1	782	789	PF02991	0.650
LIG_LIR_Nem_3	170	175	PF02991	0.510
LIG_LIR_Nem_3	782	786	PF02991	0.649
LIG_LIR_Nem_3	788	792	PF02991	0.644
LIG_NRBOX	86	92	PF00104	0.635
LIG_PCNA_PIPBox_1	294	303	PF02747	0.615
LIG_PDZ_Class_1	795	800	PF00595	0.622
LIG_Pex14_1	432	436	PF04695	0.445
LIG_SH2_SRC	227	230	PF00017	0.472
LIG_SH2_STAP1	172	176	PF00017	0.572
LIG_SH2_STAP1	346	350	PF00017	0.632
LIG_SH2_STAP1	66	70	PF00017	0.519
LIG_SH2_STAT5	227	230	PF00017	0.472
LIG_SH2_STAT5	300	303	PF00017	0.618
LIG_SH3_3	674	680	PF00018	0.645
LIG_SH3_3	684	690	PF00018	0.713
LIG_SH3_3	756	762	PF00018	0.708
LIG_SUMO_SIM_anti_2	464	472	PF11976	0.323
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.453
LIG_TRAF2_1	209	212	PF00917	0.562
LIG_TRAF2_1	284	287	PF00917	0.553
LIG_TRAF2_1	317	320	PF00917	0.521
LIG_TRAF2_1	419	422	PF00917	0.581
LIG_TRAF2_1	449	452	PF00917	0.535
LIG_WW_3	688	692	PF00397	0.725
MOD_CK1_1	200	206	PF00069	0.452
MOD_CK1_1	61	67	PF00069	0.343
MOD_CK1_1	766	772	PF00069	0.665
MOD_CK1_1	779	785	PF00069	0.741
MOD_CK2_1	162	168	PF00069	0.535
MOD_CK2_1	31	37	PF00069	0.557
MOD_CK2_1	346	352	PF00069	0.443
MOD_CK2_1	383	389	PF00069	0.479
MOD_CK2_1	40	46	PF00069	0.581
MOD_CK2_1	416	422	PF00069	0.532
MOD_CK2_1	510	516	PF00069	0.518
MOD_CK2_1	618	624	PF00069	0.523
MOD_CK2_1	730	736	PF00069	0.672
MOD_CK2_1	83	89	PF00069	0.517
MOD_GlcNHglycan	117	120	PF01048	0.548
MOD_GlcNHglycan	184	187	PF01048	0.549
MOD_GlcNHglycan	30	36	PF01048	0.514
MOD_GlcNHglycan	413	417	PF01048	0.566
MOD_GlcNHglycan	510	513	PF01048	0.608
MOD_GlcNHglycan	611	615	PF01048	0.801
MOD_GlcNHglycan	636	639	PF01048	0.760
MOD_GlcNHglycan	710	713	PF01048	0.708
MOD_GlcNHglycan	721	724	PF01048	0.645
MOD_GlcNHglycan	726	729	PF01048	0.664
MOD_GlcNHglycan	778	781	PF01048	0.710
MOD_GSK3_1	111	118	PF00069	0.522
MOD_GSK3_1	140	147	PF00069	0.595
MOD_GSK3_1	160	167	PF00069	0.335
MOD_GSK3_1	31	38	PF00069	0.467
MOD_GSK3_1	412	419	PF00069	0.555
MOD_GSK3_1	421	428	PF00069	0.537
MOD_GSK3_1	463	470	PF00069	0.475
MOD_GSK3_1	506	513	PF00069	0.581
MOD_GSK3_1	754	761	PF00069	0.655
MOD_GSK3_1	787	794	PF00069	0.635
MOD_LATS_1	364	370	PF00433	0.390
MOD_NEK2_1	197	202	PF00069	0.574
MOD_NEK2_1	246	251	PF00069	0.593
MOD_NEK2_1	378	383	PF00069	0.554
MOD_NEK2_1	461	466	PF00069	0.569
MOD_NEK2_1	792	797	PF00069	0.661
MOD_PIKK_1	162	168	PF00454	0.622
MOD_PIKK_1	378	384	PF00454	0.589
MOD_PIKK_1	395	401	PF00454	0.443
MOD_PIKK_1	40	46	PF00454	0.642
MOD_PIKK_1	416	422	PF00454	0.533
MOD_PIKK_1	519	525	PF00454	0.593
MOD_PIKK_1	565	571	PF00454	0.642
MOD_PIKK_1	744	750	PF00454	0.705
MOD_PIKK_1	763	769	PF00454	0.679
MOD_PIKK_1	793	799	PF00454	0.634
MOD_PKA_2	263	269	PF00069	0.578
MOD_PKA_2	40	46	PF00069	0.618
MOD_Plk_1	197	203	PF00069	0.589
MOD_Plk_1	246	252	PF00069	0.593
MOD_Plk_1	346	352	PF00069	0.381
MOD_Plk_1	388	394	PF00069	0.346
MOD_Plk_1	412	418	PF00069	0.561
MOD_Plk_1	421	427	PF00069	0.520
MOD_Plk_1	58	64	PF00069	0.342
MOD_Plk_1	83	89	PF00069	0.367
MOD_Plk_2-3	83	89	PF00069	0.367
MOD_Plk_4	144	150	PF00069	0.629
MOD_Plk_4	197	203	PF00069	0.485
MOD_Plk_4	664	670	PF00069	0.720
MOD_ProDKin_1	758	764	PF00069	0.715
MOD_ProDKin_1	774	780	PF00069	0.730
MOD_SUMO_for_1	62	65	PF00179	0.549
MOD_SUMO_rev_2	30	35	PF00179	0.550
MOD_SUMO_rev_2	36	40	PF00179	0.536
MOD_SUMO_rev_2	61	71	PF00179	0.570
TRG_DiLeu_BaEn_1	144	149	PF01217	0.540
TRG_DiLeu_BaEn_1	190	195	PF01217	0.573
TRG_DiLeu_BaEn_1	237	242	PF01217	0.558
TRG_DiLeu_BaEn_4	131	137	PF01217	0.663
TRG_DiLeu_BaEn_4	544	550	PF01217	0.519
TRG_DiLeu_LyEn_5	190	195	PF01217	0.573
TRG_DiLeu_LyEn_5	237	242	PF01217	0.584
TRG_ENDOCYTIC_2	172	175	PF00928	0.574
TRG_ER_diArg_1	121	123	PF00400	0.669
TRG_ER_diArg_1	22	24	PF00400	0.528
TRG_ER_diArg_1	260	262	PF00400	0.595
TRG_ER_diArg_1	354	356	PF00400	0.411
TRG_ER_diArg_1	436	438	PF00400	0.448
TRG_ER_diArg_1	500	503	PF00400	0.524
TRG_ER_diArg_1	55	57	PF00400	0.596
TRG_ER_diArg_1	703	705	PF00400	0.774
TRG_NES_CRM1_1	554	569	PF08389	0.632
TRG_NLS_MonoExtN_4	625	630	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW5	Leptomonas seymouri	58%	82%
A0A0S4IKJ1	Bodo saltans	29%	100%
A0A1X0P6F2	Trypanosomatidae	33%	92%
A0A3Q8IIH8	Leishmania donovani	79%	100%
A0A422MWV3	Trypanosoma rangeli	31%	95%
A4IBL5	Leishmania infantum	79%	100%
C9ZZ25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
E9AFE8	Leishmania major	78%	100%
E9B6K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
V5BCX8	Trypanosoma cruzi	32%	95%