RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMY7_LEIBR

TriTrypDb:

LbrM.34.3110 , LBRM2903_340039800

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMY7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.464
CLV_C14_Caspase3-7	565	569	PF00656	0.521
CLV_C14_Caspase3-7	635	639	PF00656	0.560
CLV_NRD_NRD_1	286	288	PF00675	0.592
CLV_NRD_NRD_1	349	351	PF00675	0.277
CLV_NRD_NRD_1	361	363	PF00675	0.277
CLV_NRD_NRD_1	390	392	PF00675	0.502
CLV_NRD_NRD_1	46	48	PF00675	0.516
CLV_NRD_NRD_1	60	62	PF00675	0.455
CLV_PCSK_FUR_1	347	351	PF00082	0.214
CLV_PCSK_KEX2_1	347	349	PF00082	0.275
CLV_PCSK_KEX2_1	390	392	PF00082	0.502
CLV_PCSK_KEX2_1	46	48	PF00082	0.521
CLV_PCSK_SKI1_1	106	110	PF00082	0.559
CLV_PCSK_SKI1_1	27	31	PF00082	0.494
CLV_PCSK_SKI1_1	349	353	PF00082	0.414
CLV_PCSK_SKI1_1	362	366	PF00082	0.277
CLV_PCSK_SKI1_1	61	65	PF00082	0.510
DEG_SCF_FBW7_2	640	645	PF00400	0.550
DOC_CDC14_PxL_1	275	283	PF14671	0.618
DOC_CYCLIN_RxL_1	58	65	PF00134	0.455
DOC_CYCLIN_yClb1_LxF_4	48	53	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	669	675	PF00134	0.694
DOC_MAPK_gen_1	347	355	PF00069	0.475
DOC_MAPK_gen_1	370	379	PF00069	0.477
DOC_MAPK_gen_1	390	397	PF00069	0.435
DOC_MAPK_gen_1	46	53	PF00069	0.496
DOC_MAPK_JIP1_4	47	53	PF00069	0.548
DOC_MAPK_MEF2A_6	270	278	PF00069	0.587
DOC_MAPK_MEF2A_6	373	381	PF00069	0.477
DOC_MAPK_MEF2A_6	390	399	PF00069	0.452
DOC_PP1_RVXF_1	48	54	PF00149	0.546
DOC_PP2B_LxvP_1	20	23	PF13499	0.502
DOC_PP2B_LxvP_1	435	438	PF13499	0.540
DOC_PP2B_LxvP_1	629	632	PF13499	0.563
DOC_PP2B_LxvP_1	669	672	PF13499	0.688
DOC_PP2B_LxvP_1	684	687	PF13499	0.552
DOC_PP2B_LxvP_1	689	692	PF13499	0.689
DOC_PP4_FxxP_1	328	331	PF00568	0.560
DOC_PP4_MxPP_1	683	686	PF00568	0.711
DOC_USP7_MATH_1	126	130	PF00917	0.628
DOC_USP7_MATH_1	149	153	PF00917	0.639
DOC_USP7_MATH_1	190	194	PF00917	0.481
DOC_USP7_MATH_1	274	278	PF00917	0.533
DOC_USP7_MATH_1	333	337	PF00917	0.535
DOC_USP7_MATH_1	404	408	PF00917	0.684
DOC_USP7_MATH_1	416	420	PF00917	0.735
DOC_USP7_MATH_1	431	435	PF00917	0.640
DOC_USP7_MATH_1	464	468	PF00917	0.545
DOC_USP7_MATH_1	483	487	PF00917	0.513
DOC_USP7_MATH_1	541	545	PF00917	0.658
DOC_USP7_MATH_1	577	581	PF00917	0.621
DOC_USP7_MATH_1	650	654	PF00917	0.733
DOC_USP7_MATH_1	660	664	PF00917	0.655
DOC_WW_Pin1_4	270	275	PF00397	0.483
DOC_WW_Pin1_4	379	384	PF00397	0.537
DOC_WW_Pin1_4	427	432	PF00397	0.795
DOC_WW_Pin1_4	493	498	PF00397	0.616
DOC_WW_Pin1_4	514	519	PF00397	0.532
DOC_WW_Pin1_4	543	548	PF00397	0.608
DOC_WW_Pin1_4	573	578	PF00397	0.705
DOC_WW_Pin1_4	596	601	PF00397	0.592
DOC_WW_Pin1_4	602	607	PF00397	0.613
DOC_WW_Pin1_4	638	643	PF00397	0.713
DOC_WW_Pin1_4	658	663	PF00397	0.653
LIG_14-3-3_CanoR_1	350	356	PF00244	0.477
LIG_14-3-3_CanoR_1	373	378	PF00244	0.607
LIG_14-3-3_CanoR_1	420	427	PF00244	0.566
LIG_14-3-3_CanoR_1	61	67	PF00244	0.550
LIG_14-3-3_CanoR_1	651	658	PF00244	0.592
LIG_BRCT_BRCA1_1	151	155	PF00533	0.632
LIG_BRCT_BRCA1_1	24	28	PF00533	0.501
LIG_BRCT_BRCA1_1	335	339	PF00533	0.535
LIG_Clathr_ClatBox_1	29	33	PF01394	0.476
LIG_deltaCOP1_diTrp_1	291	301	PF00928	0.514
LIG_EVH1_1	629	633	PF00568	0.700
LIG_EVH1_1	684	688	PF00568	0.715
LIG_FHA_1	205	211	PF00498	0.388
LIG_FHA_1	308	314	PF00498	0.395
LIG_FHA_1	374	380	PF00498	0.477
LIG_FHA_1	430	436	PF00498	0.572
LIG_FHA_1	463	469	PF00498	0.720
LIG_FHA_1	486	492	PF00498	0.614
LIG_FHA_1	78	84	PF00498	0.388
LIG_FHA_2	1	7	PF00498	0.621
LIG_FHA_2	319	325	PF00498	0.535
LIG_FHA_2	352	358	PF00498	0.419
LIG_FHA_2	563	569	PF00498	0.520
LIG_LIR_Apic_2	327	331	PF02991	0.535
LIG_LIR_Apic_2	382	388	PF02991	0.589
LIG_LIR_Apic_2	496	502	PF02991	0.635
LIG_LIR_Gen_1	13	22	PF02991	0.569
LIG_LIR_Gen_1	161	166	PF02991	0.625
LIG_LIR_Gen_1	212	220	PF02991	0.413
LIG_LIR_Gen_1	33	40	PF02991	0.350
LIG_LIR_Gen_1	354	360	PF02991	0.535
LIG_LIR_Gen_1	406	416	PF02991	0.537
LIG_LIR_Nem_3	13	17	PF02991	0.551
LIG_LIR_Nem_3	156	162	PF02991	0.553
LIG_LIR_Nem_3	212	216	PF02991	0.403
LIG_LIR_Nem_3	217	222	PF02991	0.421
LIG_LIR_Nem_3	291	297	PF02991	0.511
LIG_LIR_Nem_3	327	332	PF02991	0.535
LIG_LIR_Nem_3	33	37	PF02991	0.343
LIG_LIR_Nem_3	354	358	PF02991	0.535
LIG_LIR_Nem_3	59	63	PF02991	0.422
LIG_LIR_Nem_3	6	10	PF02991	0.552
LIG_LIR_Nem_3	611	617	PF02991	0.741
LIG_MYND_1	687	691	PF01753	0.710
LIG_MYND_3	278	282	PF01753	0.614
LIG_NRBOX	25	31	PF00104	0.494
LIG_PAM2_1	62	74	PF00658	0.524
LIG_Pex14_2	155	159	PF04695	0.547
LIG_Pex14_2	200	204	PF04695	0.511
LIG_Pex14_2	49	53	PF04695	0.532
LIG_Pex14_2	56	60	PF04695	0.483
LIG_Pex14_2	589	593	PF04695	0.799
LIG_RPA_C_Fungi	531	543	PF08784	0.640
LIG_SH2_CRK	139	143	PF00017	0.471
LIG_SH2_CRK	34	38	PF00017	0.481
LIG_SH2_CRK	499	503	PF00017	0.528
LIG_SH2_CRK	617	621	PF00017	0.661
LIG_SH2_CRK	667	671	PF00017	0.608
LIG_SH2_NCK_1	317	321	PF00017	0.227
LIG_SH2_NCK_1	667	671	PF00017	0.608
LIG_SH2_PTP2	385	388	PF00017	0.593
LIG_SH2_SRC	636	639	PF00017	0.715
LIG_SH2_SRC	98	101	PF00017	0.529
LIG_SH2_STAP1	139	143	PF00017	0.471
LIG_SH2_STAP1	162	166	PF00017	0.463
LIG_SH2_STAP1	34	38	PF00017	0.481
LIG_SH2_STAP1	95	99	PF00017	0.591
LIG_SH2_STAT3	227	230	PF00017	0.395
LIG_SH2_STAT5	180	183	PF00017	0.535
LIG_SH2_STAT5	385	388	PF00017	0.513
LIG_SH2_STAT5	636	639	PF00017	0.715
LIG_SH2_STAT5	657	660	PF00017	0.572
LIG_SH2_STAT5	667	670	PF00017	0.661
LIG_SH2_STAT5	673	676	PF00017	0.697
LIG_SH2_STAT5	98	101	PF00017	0.563
LIG_SH3_1	499	505	PF00018	0.522
LIG_SH3_2	547	552	PF14604	0.704
LIG_SH3_2	604	609	PF14604	0.672
LIG_SH3_3	268	274	PF00018	0.447
LIG_SH3_3	378	384	PF00018	0.532
LIG_SH3_3	499	505	PF00018	0.538
LIG_SH3_3	544	550	PF00018	0.615
LIG_SH3_3	601	607	PF00018	0.667
LIG_SH3_3	624	630	PF00018	0.642
LIG_SH3_3	659	665	PF00018	0.677
LIG_SH3_3	682	688	PF00018	0.633
LIG_SUMO_SIM_par_1	273	280	PF11976	0.452
LIG_TRFH_1	267	271	PF08558	0.417
LIG_TRFH_1	667	671	PF08558	0.688
LIG_TYR_ITIM	32	37	PF00017	0.470
LIG_WRC_WIRS_1	325	330	PF05994	0.395
LIG_WRC_WIRS_1	352	357	PF05994	0.315
LIG_WW_1	633	636	PF00397	0.674
LIG_WW_1	670	673	PF00397	0.643
LIG_WW_1	690	693	PF00397	0.706
LIG_WW_2	687	690	PF00397	0.713
MOD_CDC14_SPxK_1	387	390	PF00782	0.612
MOD_CDC14_SPxK_1	549	552	PF00782	0.702
MOD_CDK_SPxK_1	384	390	PF00069	0.604
MOD_CDK_SPxK_1	546	552	PF00069	0.621
MOD_CDK_SPxxK_3	384	391	PF00069	0.598
MOD_CDK_SPxxK_3	602	609	PF00069	0.606
MOD_CK1_1	167	173	PF00069	0.618
MOD_CK1_1	188	194	PF00069	0.493
MOD_CK1_1	21	27	PF00069	0.496
MOD_CK1_1	277	283	PF00069	0.453
MOD_CK1_1	419	425	PF00069	0.704
MOD_CK1_1	430	436	PF00069	0.724
MOD_CK1_1	440	446	PF00069	0.783
MOD_CK1_1	462	468	PF00069	0.650
MOD_CK1_1	477	483	PF00069	0.588
MOD_CK1_1	517	523	PF00069	0.574
MOD_CK1_1	546	552	PF00069	0.557
MOD_CK1_1	596	602	PF00069	0.560
MOD_CK1_1	653	659	PF00069	0.626
MOD_CK1_1	82	88	PF00069	0.439
MOD_CK2_1	255	261	PF00069	0.515
MOD_CK2_1	318	324	PF00069	0.327
MOD_DYRK1A_RPxSP_1	270	274	PF00069	0.468
MOD_GlcNHglycan	128	131	PF01048	0.628
MOD_GlcNHglycan	144	147	PF01048	0.537
MOD_GlcNHglycan	215	219	PF01048	0.402
MOD_GlcNHglycan	318	321	PF01048	0.247
MOD_GlcNHglycan	336	339	PF01048	0.482
MOD_GlcNHglycan	412	415	PF01048	0.665
MOD_GlcNHglycan	457	460	PF01048	0.591
MOD_GlcNHglycan	461	464	PF01048	0.720
MOD_GlcNHglycan	507	510	PF01048	0.620
MOD_GlcNHglycan	519	522	PF01048	0.591
MOD_GlcNHglycan	543	546	PF01048	0.699
MOD_GlcNHglycan	554	557	PF01048	0.665
MOD_GlcNHglycan	595	598	PF01048	0.610
MOD_GlcNHglycan	620	623	PF01048	0.524
MOD_GSK3_1	160	167	PF00069	0.495
MOD_GSK3_1	18	25	PF00069	0.580
MOD_GSK3_1	270	277	PF00069	0.412
MOD_GSK3_1	369	376	PF00069	0.497
MOD_GSK3_1	406	413	PF00069	0.693
MOD_GSK3_1	418	425	PF00069	0.588
MOD_GSK3_1	427	434	PF00069	0.639
MOD_GSK3_1	436	443	PF00069	0.716
MOD_GSK3_1	455	462	PF00069	0.665
MOD_GSK3_1	541	548	PF00069	0.521
MOD_GSK3_1	573	580	PF00069	0.724
MOD_GSK3_1	62	69	PF00069	0.354
MOD_GSK3_1	649	656	PF00069	0.692
MOD_N-GLC_1	427	432	PF02516	0.548
MOD_N-GLC_1	455	460	PF02516	0.668
MOD_N-GLC_1	514	519	PF02516	0.655
MOD_NEK2_1	155	160	PF00069	0.562
MOD_NEK2_1	166	171	PF00069	0.583
MOD_NEK2_1	316	321	PF00069	0.236
MOD_NEK2_1	358	363	PF00069	0.395
MOD_NEK2_1	56	61	PF00069	0.508
MOD_NEK2_1	593	598	PF00069	0.615
MOD_NEK2_1	66	71	PF00069	0.369
MOD_NEK2_1	84	89	PF00069	0.504
MOD_PIKK_1	240	246	PF00454	0.543
MOD_PIKK_1	485	491	PF00454	0.551
MOD_PK_1	18	24	PF00069	0.497
MOD_PKA_2	419	425	PF00069	0.552
MOD_PKA_2	650	656	PF00069	0.753
MOD_Plk_1	155	161	PF00069	0.625
MOD_Plk_1	167	173	PF00069	0.473
MOD_Plk_2-3	255	261	PF00069	0.537
MOD_Plk_2-3	318	324	PF00069	0.315
MOD_Plk_4	155	161	PF00069	0.562
MOD_Plk_4	307	313	PF00069	0.496
MOD_Plk_4	324	330	PF00069	0.205
MOD_Plk_4	632	638	PF00069	0.662
MOD_Plk_4	653	659	PF00069	0.734
MOD_Plk_4	79	85	PF00069	0.479
MOD_ProDKin_1	270	276	PF00069	0.493
MOD_ProDKin_1	379	385	PF00069	0.539
MOD_ProDKin_1	427	433	PF00069	0.796
MOD_ProDKin_1	493	499	PF00069	0.618
MOD_ProDKin_1	514	520	PF00069	0.532
MOD_ProDKin_1	543	549	PF00069	0.611
MOD_ProDKin_1	573	579	PF00069	0.703
MOD_ProDKin_1	596	602	PF00069	0.593
MOD_ProDKin_1	638	644	PF00069	0.713
MOD_ProDKin_1	658	664	PF00069	0.652
MOD_SUMO_for_1	395	398	PF00179	0.633
MOD_SUMO_for_1	608	611	PF00179	0.700
MOD_SUMO_rev_2	13	20	PF00179	0.488
MOD_SUMO_rev_2	336	345	PF00179	0.395
MOD_SUMO_rev_2	366	372	PF00179	0.359
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.590
TRG_ENDOCYTIC_2	139	142	PF00928	0.470
TRG_ENDOCYTIC_2	162	165	PF00928	0.621
TRG_ENDOCYTIC_2	180	183	PF00928	0.535
TRG_ENDOCYTIC_2	34	37	PF00928	0.479
TRG_ENDOCYTIC_2	617	620	PF00928	0.749
TRG_ER_diArg_1	347	350	PF00400	0.312
TRG_ER_diArg_1	46	48	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMJ6	Leishmania donovani	81%	99%
A4IBL1	Leishmania infantum	81%	99%
E9AFE4	Leishmania major	81%	100%
E9B6J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
V5C2W3	Trypanosoma cruzi	44%	100%