Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania braziliensis

UniProt:

A4HMY6_LEIBR

TriTrypDb:

LbrM.34.3100 , LBRM2903_340039700

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HMY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.725
CLV_C14_Caspase3-7	227	231	PF00656	0.587
CLV_C14_Caspase3-7	23	27	PF00656	0.563
CLV_C14_Caspase3-7	279	283	PF00656	0.652
CLV_C14_Caspase3-7	652	656	PF00656	0.582
CLV_C14_Caspase3-7	762	766	PF00656	0.659
CLV_NRD_NRD_1	24	26	PF00675	0.363
CLV_NRD_NRD_1	728	730	PF00675	0.501
CLV_NRD_NRD_1	752	754	PF00675	0.428
CLV_NRD_NRD_1	889	891	PF00675	0.343
CLV_PCSK_FUR_1	726	730	PF00082	0.500
CLV_PCSK_KEX2_1	141	143	PF00082	0.257
CLV_PCSK_KEX2_1	24	26	PF00082	0.363
CLV_PCSK_KEX2_1	728	730	PF00082	0.501
CLV_PCSK_KEX2_1	752	754	PF00082	0.428
CLV_PCSK_KEX2_1	815	817	PF00082	0.405
CLV_PCSK_KEX2_1	889	891	PF00082	0.343
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.257
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.405
CLV_PCSK_PC7_1	20	26	PF00082	0.363
CLV_PCSK_SKI1_1	508	512	PF00082	0.462
CLV_PCSK_SKI1_1	65	69	PF00082	0.238
CLV_PCSK_SKI1_1	805	809	PF00082	0.416
CLV_PCSK_SKI1_1	816	820	PF00082	0.327
DEG_APCC_DBOX_1	815	823	PF00400	0.542
DEG_ODPH_VHL_1	808	821	PF01847	0.562
DEG_SCF_FBW7_1	29	35	PF00400	0.438
DEG_SCF_FBW7_1	465	472	PF00400	0.793
DEG_SIAH_1	200	208	PF03145	0.658
DEG_SPOP_SBC_1	470	474	PF00917	0.752
DEG_SPOP_SBC_1	574	578	PF00917	0.652
DOC_ANK_TNKS_1	196	203	PF00023	0.651
DOC_ANK_TNKS_1	24	31	PF00023	0.438
DOC_CKS1_1	29	34	PF01111	0.485
DOC_MAPK_gen_1	110	119	PF00069	0.515
DOC_MAPK_gen_1	815	821	PF00069	0.548
DOC_MAPK_MEF2A_6	110	119	PF00069	0.515
DOC_MAPK_MEF2A_6	678	686	PF00069	0.253
DOC_PP2B_LxvP_1	117	120	PF13499	0.563
DOC_PP4_FxxP_1	739	742	PF00568	0.622
DOC_USP7_MATH_1	10	14	PF00917	0.625
DOC_USP7_MATH_1	234	238	PF00917	0.577
DOC_USP7_MATH_1	32	36	PF00917	0.543
DOC_USP7_MATH_1	341	345	PF00917	0.724
DOC_USP7_MATH_1	358	362	PF00917	0.679
DOC_USP7_MATH_1	440	444	PF00917	0.792
DOC_USP7_MATH_1	453	457	PF00917	0.682
DOC_USP7_MATH_1	46	50	PF00917	0.446
DOC_USP7_MATH_1	469	473	PF00917	0.764
DOC_USP7_MATH_1	612	616	PF00917	0.756
DOC_USP7_MATH_1	671	675	PF00917	0.428
DOC_USP7_MATH_1	787	791	PF00917	0.626
DOC_WW_Pin1_4	177	182	PF00397	0.691
DOC_WW_Pin1_4	203	208	PF00397	0.684
DOC_WW_Pin1_4	28	33	PF00397	0.438
DOC_WW_Pin1_4	359	364	PF00397	0.776
DOC_WW_Pin1_4	368	373	PF00397	0.716
DOC_WW_Pin1_4	406	411	PF00397	0.780
DOC_WW_Pin1_4	431	436	PF00397	0.669
DOC_WW_Pin1_4	465	470	PF00397	0.789
DOC_WW_Pin1_4	497	502	PF00397	0.690
DOC_WW_Pin1_4	6	11	PF00397	0.588
DOC_WW_Pin1_4	68	73	PF00397	0.563
DOC_WW_Pin1_4	760	765	PF00397	0.626
DOC_WW_Pin1_4	848	853	PF00397	0.320
LIG_14-3-3_CanoR_1	108	117	PF00244	0.486
LIG_14-3-3_CanoR_1	210	216	PF00244	0.689
LIG_14-3-3_CanoR_1	550	558	PF00244	0.718
LIG_14-3-3_CanoR_1	628	634	PF00244	0.718
LIG_14-3-3_CanoR_1	663	668	PF00244	0.671
LIG_14-3-3_CanoR_1	728	737	PF00244	0.707
LIG_14-3-3_CanoR_1	747	756	PF00244	0.593
LIG_14-3-3_CanoR_1	75	83	PF00244	0.560
LIG_14-3-3_CanoR_1	816	822	PF00244	0.545
LIG_Actin_WH2_2	818	836	PF00022	0.440
LIG_BIR_III_2	282	286	PF00653	0.647
LIG_BRCT_BRCA1_1	100	104	PF00533	0.486
LIG_BRCT_BRCA1_1	841	845	PF00533	0.401
LIG_Clathr_ClatBox_1	290	294	PF01394	0.656
LIG_FHA_1	362	368	PF00498	0.684
LIG_FHA_1	575	581	PF00498	0.670
LIG_FHA_1	590	596	PF00498	0.616
LIG_FHA_1	652	658	PF00498	0.704
LIG_FHA_1	677	683	PF00498	0.276
LIG_FHA_1	694	700	PF00498	0.297
LIG_FHA_1	705	711	PF00498	0.236
LIG_FHA_1	865	871	PF00498	0.305
LIG_FHA_2	225	231	PF00498	0.555
LIG_FHA_2	29	35	PF00498	0.438
LIG_FHA_2	576	582	PF00498	0.650
LIG_FHA_2	97	103	PF00498	0.563
LIG_GBD_Chelix_1	50	58	PF00786	0.363
LIG_LIR_Gen_1	252	261	PF02991	0.544
LIG_LIR_Gen_1	709	717	PF02991	0.428
LIG_LIR_Gen_1	842	853	PF02991	0.510
LIG_LIR_Nem_3	152	157	PF02991	0.636
LIG_LIR_Nem_3	247	253	PF02991	0.595
LIG_LIR_Nem_3	319	325	PF02991	0.640
LIG_LIR_Nem_3	547	552	PF02991	0.641
LIG_LIR_Nem_3	61	67	PF02991	0.438
LIG_LIR_Nem_3	666	672	PF02991	0.457
LIG_LIR_Nem_3	698	704	PF02991	0.407
LIG_LIR_Nem_3	709	715	PF02991	0.302
LIG_LIR_Nem_3	842	848	PF02991	0.401
LIG_LIR_Nem_3	858	864	PF02991	0.317
LIG_LIR_Nem_3	875	879	PF02991	0.313
LIG_MYND_3	586	590	PF01753	0.644
LIG_NRBOX	869	875	PF00104	0.401
LIG_PDZ_Class_3	893	898	PF00595	0.708
LIG_Pex14_1	700	704	PF04695	0.428
LIG_Pex14_1	708	712	PF04695	0.337
LIG_Pex14_2	143	147	PF04695	0.438
LIG_Pex14_2	683	687	PF04695	0.408
LIG_Pex14_2	704	708	PF04695	0.428
LIG_Pex14_2	843	847	PF04695	0.386
LIG_PTB_Apo_2	260	267	PF02174	0.631
LIG_PTB_Apo_2	423	430	PF02174	0.676
LIG_PTB_Apo_2	515	522	PF02174	0.654
LIG_PTB_Phospho_1	260	266	PF10480	0.633
LIG_PTB_Phospho_1	423	429	PF10480	0.677
LIG_PTB_Phospho_1	515	521	PF10480	0.655
LIG_SH2_CRK	549	553	PF00017	0.637
LIG_SH2_CRK	64	68	PF00017	0.438
LIG_SH2_CRK	876	880	PF00017	0.428
LIG_SH2_PTP2	322	325	PF00017	0.638
LIG_SH2_SRC	322	325	PF00017	0.638
LIG_SH2_STAP1	864	868	PF00017	0.328
LIG_SH2_STAT3	11	14	PF00017	0.648
LIG_SH2_STAT5	157	160	PF00017	0.636
LIG_SH2_STAT5	253	256	PF00017	0.520
LIG_SH2_STAT5	322	325	PF00017	0.638
LIG_SH2_STAT5	717	720	PF00017	0.280
LIG_SH3_3	100	106	PF00018	0.563
LIG_SH3_3	26	32	PF00018	0.554
LIG_SH3_3	282	288	PF00018	0.644
LIG_SH3_3	4	10	PF00018	0.608
LIG_SH3_3	538	544	PF00018	0.634
LIG_SH3_3	562	568	PF00018	0.735
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.590
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.616
LIG_SUMO_SIM_anti_2	632	637	PF11976	0.615
LIG_SUMO_SIM_par_1	222	227	PF11976	0.590
LIG_SUMO_SIM_par_1	401	407	PF11976	0.675
LIG_SUMO_SIM_par_1	66	71	PF11976	0.438
LIG_SUMO_SIM_par_1	834	839	PF11976	0.280
LIG_SUMO_SIM_par_1	869	875	PF11976	0.359
LIG_TRAF2_1	522	525	PF00917	0.721
LIG_TYR_ITIM	874	879	PF00017	0.428
LIG_UBA3_1	289	295	PF00899	0.655
LIG_WRC_WIRS_1	672	677	PF05994	0.269
LIG_WRC_WIRS_1	840	845	PF05994	0.253
LIG_WW_3	194	198	PF00397	0.765
MOD_CDK_SPxxK_3	203	210	PF00069	0.659
MOD_CDK_SPxxK_3	497	504	PF00069	0.679
MOD_CDK_SPxxK_3	68	75	PF00069	0.563
MOD_CK1_1	162	168	PF00069	0.660
MOD_CK1_1	177	183	PF00069	0.627
MOD_CK1_1	206	212	PF00069	0.741
MOD_CK1_1	361	367	PF00069	0.707
MOD_CK1_1	371	377	PF00069	0.656
MOD_CK1_1	389	395	PF00069	0.660
MOD_CK1_1	406	412	PF00069	0.654
MOD_CK1_1	473	479	PF00069	0.798
MOD_CK1_1	573	579	PF00069	0.690
MOD_CK1_1	6	12	PF00069	0.580
MOD_CK1_1	603	609	PF00069	0.670
MOD_CK1_1	615	621	PF00069	0.660
MOD_CK1_1	650	656	PF00069	0.586
MOD_CK1_1	740	746	PF00069	0.657
MOD_CK1_1	768	774	PF00069	0.638
MOD_CK1_1	790	796	PF00069	0.643
MOD_CK1_1	797	803	PF00069	0.640
MOD_CK1_1	839	845	PF00069	0.428
MOD_CK2_1	28	34	PF00069	0.438
MOD_CK2_1	353	359	PF00069	0.768
MOD_CK2_1	480	486	PF00069	0.670
MOD_CK2_1	519	525	PF00069	0.725
MOD_CK2_1	729	735	PF00069	0.701
MOD_CK2_1	96	102	PF00069	0.563
MOD_GlcNHglycan	169	172	PF01048	0.573
MOD_GlcNHglycan	232	235	PF01048	0.259
MOD_GlcNHglycan	26	29	PF01048	0.238
MOD_GlcNHglycan	301	304	PF01048	0.503
MOD_GlcNHglycan	387	391	PF01048	0.534
MOD_GlcNHglycan	442	445	PF01048	0.520
MOD_GlcNHglycan	483	486	PF01048	0.500
MOD_GlcNHglycan	497	500	PF01048	0.530
MOD_GlcNHglycan	572	575	PF01048	0.465
MOD_GlcNHglycan	592	595	PF01048	0.423
MOD_GlcNHglycan	649	652	PF01048	0.520
MOD_GlcNHglycan	722	725	PF01048	0.446
MOD_GlcNHglycan	731	734	PF01048	0.483
MOD_GlcNHglycan	742	745	PF01048	0.443
MOD_GlcNHglycan	783	786	PF01048	0.525
MOD_GlcNHglycan	795	799	PF01048	0.470
MOD_GSK3_1	206	213	PF00069	0.719
MOD_GSK3_1	230	237	PF00069	0.500
MOD_GSK3_1	24	31	PF00069	0.403
MOD_GSK3_1	323	330	PF00069	0.639
MOD_GSK3_1	349	356	PF00069	0.753
MOD_GSK3_1	366	373	PF00069	0.671
MOD_GSK3_1	429	436	PF00069	0.746
MOD_GSK3_1	465	472	PF00069	0.793
MOD_GSK3_1	550	557	PF00069	0.645
MOD_GSK3_1	563	570	PF00069	0.619
MOD_GSK3_1	590	597	PF00069	0.664
MOD_GSK3_1	6	13	PF00069	0.573
MOD_GSK3_1	647	654	PF00069	0.723
MOD_GSK3_1	716	723	PF00069	0.419
MOD_GSK3_1	765	772	PF00069	0.668
MOD_GSK3_1	790	797	PF00069	0.635
MOD_N-GLC_1	210	215	PF02516	0.474
MOD_N-GLC_1	3	8	PF02516	0.426
MOD_N-GLC_1	429	434	PF02516	0.574
MOD_N-GLC_1	453	458	PF02516	0.475
MOD_N-GLC_1	495	500	PF02516	0.581
MOD_N-GLC_2	518	520	PF02516	0.458
MOD_NEK2_1	189	194	PF00069	0.640
MOD_NEK2_1	268	273	PF00069	0.498
MOD_NEK2_1	388	393	PF00069	0.663
MOD_NEK2_1	534	539	PF00069	0.708
MOD_NEK2_1	589	594	PF00069	0.719
MOD_NEK2_1	716	721	PF00069	0.253
MOD_NEK2_1	73	78	PF00069	0.563
MOD_NEK2_1	737	742	PF00069	0.616
MOD_NEK2_1	780	785	PF00069	0.723
MOD_NEK2_1	872	877	PF00069	0.358
MOD_PIKK_1	10	16	PF00454	0.646
MOD_PIKK_1	108	114	PF00454	0.438
MOD_PK_1	663	669	PF00069	0.671
MOD_PKA_1	24	30	PF00069	0.563
MOD_PKA_2	209	215	PF00069	0.764
MOD_PKA_2	24	30	PF00069	0.563
MOD_PKA_2	376	382	PF00069	0.721
MOD_PKA_2	525	531	PF00069	0.655
MOD_PKA_2	746	752	PF00069	0.687
MOD_PKA_2	781	787	PF00069	0.616
MOD_PKB_1	461	469	PF00069	0.790
MOD_PKB_1	745	753	PF00069	0.622
MOD_Plk_1	165	171	PF00069	0.636
MOD_Plk_1	189	195	PF00069	0.639
MOD_Plk_1	268	274	PF00069	0.494
MOD_Plk_1	3	9	PF00069	0.616
MOD_Plk_1	429	435	PF00069	0.671
MOD_Plk_1	612	618	PF00069	0.694
MOD_Plk_1	864	870	PF00069	0.238
MOD_Plk_1	96	102	PF00069	0.563
MOD_Plk_2-3	765	771	PF00069	0.623
MOD_Plk_4	182	188	PF00069	0.624
MOD_Plk_4	249	255	PF00069	0.467
MOD_Plk_4	3	9	PF00069	0.635
MOD_Plk_4	567	573	PF00069	0.720
MOD_Plk_4	622	628	PF00069	0.632
MOD_Plk_4	629	635	PF00069	0.609
MOD_Plk_4	663	669	PF00069	0.550
MOD_Plk_4	695	701	PF00069	0.348
MOD_Plk_4	809	815	PF00069	0.568
MOD_Plk_4	817	823	PF00069	0.521
MOD_Plk_4	828	834	PF00069	0.281
MOD_Plk_4	836	842	PF00069	0.351
MOD_Plk_4	855	861	PF00069	0.307
MOD_ProDKin_1	177	183	PF00069	0.690
MOD_ProDKin_1	203	209	PF00069	0.685
MOD_ProDKin_1	28	34	PF00069	0.438
MOD_ProDKin_1	359	365	PF00069	0.778
MOD_ProDKin_1	368	374	PF00069	0.716
MOD_ProDKin_1	406	412	PF00069	0.778
MOD_ProDKin_1	431	437	PF00069	0.668
MOD_ProDKin_1	465	471	PF00069	0.792
MOD_ProDKin_1	497	503	PF00069	0.690
MOD_ProDKin_1	6	12	PF00069	0.580
MOD_ProDKin_1	68	74	PF00069	0.563
MOD_ProDKin_1	760	766	PF00069	0.626
MOD_ProDKin_1	848	854	PF00069	0.322
TRG_DiLeu_BaEn_1	294	299	PF01217	0.541
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.635
TRG_ENDOCYTIC_2	253	256	PF00928	0.452
TRG_ENDOCYTIC_2	322	325	PF00928	0.638
TRG_ENDOCYTIC_2	398	401	PF00928	0.652
TRG_ENDOCYTIC_2	549	552	PF00928	0.640
TRG_ENDOCYTIC_2	64	67	PF00928	0.438
TRG_ENDOCYTIC_2	669	672	PF00928	0.280
TRG_ENDOCYTIC_2	876	879	PF00928	0.428
TRG_ER_diArg_1	191	194	PF00400	0.662
TRG_ER_diArg_1	461	464	PF00400	0.792
TRG_ER_diArg_1	725	728	PF00400	0.700
TRG_ER_diArg_1	889	891	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	883	887	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II65	Leishmania donovani	53%	100%
A4IBL0	Leishmania infantum	53%	100%
E9AFE3	Leishmania major	52%	99%
E9B6J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%