TLDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

class I transcription factor A, subunit 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HMY2_LEIBR

TriTrypDb:

LbrM.34.3060 , LBRM2903_340039200

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.608
CLV_NRD_NRD_1	115	117	PF00675	0.538
CLV_NRD_NRD_1	161	163	PF00675	0.794
CLV_NRD_NRD_1	182	184	PF00675	0.681
CLV_NRD_NRD_1	239	241	PF00675	0.815
CLV_NRD_NRD_1	243	245	PF00675	0.754
CLV_NRD_NRD_1	302	304	PF00675	0.773
CLV_NRD_NRD_1	353	355	PF00675	0.723
CLV_NRD_NRD_1	92	94	PF00675	0.665
CLV_PCSK_FUR_1	351	355	PF00082	0.518
CLV_PCSK_KEX2_1	115	117	PF00082	0.538
CLV_PCSK_KEX2_1	182	184	PF00082	0.681
CLV_PCSK_KEX2_1	226	228	PF00082	0.836
CLV_PCSK_KEX2_1	243	245	PF00082	0.522
CLV_PCSK_KEX2_1	258	260	PF00082	0.480
CLV_PCSK_KEX2_1	302	304	PF00082	0.773
CLV_PCSK_KEX2_1	351	353	PF00082	0.744
CLV_PCSK_KEX2_1	92	94	PF00082	0.565
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.836
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.522
CLV_PCSK_PC7_1	222	228	PF00082	0.831
CLV_PCSK_SKI1_1	136	140	PF00082	0.637
CLV_PCSK_SKI1_1	182	186	PF00082	0.777
CLV_PCSK_SKI1_1	30	34	PF00082	0.527
DEG_APCC_DBOX_1	95	103	PF00400	0.587
DEG_Kelch_Keap1_1	271	276	PF01344	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_CKS1_1	137	142	PF01111	0.697
DOC_CYCLIN_RxL_1	84	95	PF00134	0.671
DOC_MAPK_gen_1	182	190	PF00069	0.667
DOC_MAPK_gen_1	240	250	PF00069	0.818
DOC_PP1_RVXF_1	85	92	PF00149	0.579
DOC_PP2B_LxvP_1	341	344	PF13499	0.793
DOC_USP7_MATH_1	17	21	PF00917	0.571
DOC_USP7_MATH_1	231	235	PF00917	0.745
DOC_USP7_MATH_1	288	292	PF00917	0.677
DOC_USP7_MATH_1	32	36	PF00917	0.674
DOC_USP7_MATH_1	365	369	PF00917	0.615
DOC_USP7_MATH_1	63	67	PF00917	0.578
DOC_USP7_MATH_1	85	89	PF00917	0.583
DOC_WW_Pin1_4	136	141	PF00397	0.627
DOC_WW_Pin1_4	286	291	PF00397	0.777
LIG_14-3-3_CanoR_1	103	113	PF00244	0.696
LIG_14-3-3_CanoR_1	18	26	PF00244	0.543
LIG_14-3-3_CanoR_1	182	190	PF00244	0.768
LIG_14-3-3_CanoR_1	243	249	PF00244	0.591
LIG_14-3-3_CanoR_1	30	37	PF00244	0.553
LIG_14-3-3_CanoR_1	351	360	PF00244	0.522
LIG_14-3-3_CanoR_1	374	379	PF00244	0.776
LIG_14-3-3_CanoR_1	47	57	PF00244	0.739
LIG_14-3-3_CanoR_1	93	102	PF00244	0.565
LIG_BRCT_BRCA1_1	367	371	PF00533	0.616
LIG_BRCT_BRCA1_1	87	91	PF00533	0.404
LIG_deltaCOP1_diTrp_1	301	311	PF00928	0.671
LIG_FHA_1	145	151	PF00498	0.476
LIG_FHA_1	183	189	PF00498	0.772
LIG_FHA_1	209	215	PF00498	0.526
LIG_FHA_1	275	281	PF00498	0.772
LIG_FHA_1	31	37	PF00498	0.677
LIG_FHA_2	190	196	PF00498	0.733
LIG_FHA_2	77	83	PF00498	0.617
LIG_LIR_Gen_1	125	134	PF02991	0.574
LIG_LIR_Nem_3	122	127	PF02991	0.594
LIG_LIR_Nem_3	334	340	PF02991	0.507
LIG_LIR_Nem_3	88	94	PF02991	0.549
LIG_Pex14_2	128	132	PF04695	0.565
LIG_RPA_C_Fungi	82	94	PF08784	0.634
LIG_SH2_CRK	124	128	PF00017	0.538
LIG_SH2_CRK	337	341	PF00017	0.772
LIG_SH2_CRK	360	364	PF00017	0.683
LIG_SH2_NCK_1	124	128	PF00017	0.425
LIG_SH2_SRC	124	127	PF00017	0.431
LIG_SUMO_SIM_par_1	116	122	PF11976	0.551
LIG_SUMO_SIM_par_1	195	203	PF11976	0.616
LIG_SUMO_SIM_par_1	209	216	PF11976	0.645
LIG_TYR_ITIM	358	363	PF00017	0.590
LIG_WW_3	237	241	PF00397	0.551
MOD_CK1_1	189	195	PF00069	0.739
MOD_CK1_1	289	295	PF00069	0.743
MOD_CK1_1	35	41	PF00069	0.661
MOD_CK1_1	53	59	PF00069	0.688
MOD_CK2_1	104	110	PF00069	0.709
MOD_CK2_1	270	276	PF00069	0.539
MOD_CK2_1	76	82	PF00069	0.609
MOD_GlcNHglycan	222	225	PF01048	0.775
MOD_GlcNHglycan	228	231	PF01048	0.727
MOD_GlcNHglycan	233	236	PF01048	0.662
MOD_GlcNHglycan	306	309	PF01048	0.604
MOD_GlcNHglycan	333	336	PF01048	0.513
MOD_GlcNHglycan	59	62	PF01048	0.737
MOD_GSK3_1	132	139	PF00069	0.589
MOD_GSK3_1	182	189	PF00069	0.775
MOD_GSK3_1	204	211	PF00069	0.478
MOD_GSK3_1	226	233	PF00069	0.732
MOD_GSK3_1	270	277	PF00069	0.721
MOD_GSK3_1	49	56	PF00069	0.751
MOD_N-GLC_1	186	191	PF02516	0.651
MOD_NEK2_1	132	137	PF00069	0.590
MOD_NEK2_1	143	148	PF00069	0.650
MOD_NEK2_1	2	7	PF00069	0.777
MOD_NEK2_1	48	53	PF00069	0.748
MOD_NEK2_1	71	76	PF00069	0.583
MOD_PIKK_1	166	172	PF00454	0.658
MOD_PIKK_1	17	23	PF00454	0.547
MOD_PIKK_1	3	9	PF00454	0.714
MOD_PIKK_1	35	41	PF00454	0.661
MOD_PIKK_1	50	56	PF00454	0.692
MOD_PK_1	105	111	PF00069	0.702
MOD_PK_1	244	250	PF00069	0.548
MOD_PKA_1	182	188	PF00069	0.775
MOD_PKA_1	226	232	PF00069	0.570
MOD_PKA_1	352	358	PF00069	0.787
MOD_PKA_1	92	98	PF00069	0.574
MOD_PKA_2	104	110	PF00069	0.613
MOD_PKA_2	17	23	PF00069	0.647
MOD_PKA_2	182	188	PF00069	0.775
MOD_PKA_2	226	232	PF00069	0.653
MOD_PKA_2	330	336	PF00069	0.519
MOD_PKA_2	352	358	PF00069	0.695
MOD_PKA_2	92	98	PF00069	0.574
MOD_PKB_1	103	111	PF00069	0.708
MOD_Plk_1	12	18	PF00069	0.650
MOD_Plk_1	186	192	PF00069	0.647
MOD_Plk_1	208	214	PF00069	0.512
MOD_Plk_2-3	151	157	PF00069	0.468
MOD_Plk_4	32	38	PF00069	0.671
MOD_Plk_4	71	77	PF00069	0.515
MOD_ProDKin_1	136	142	PF00069	0.627
MOD_ProDKin_1	286	292	PF00069	0.779
MOD_SUMO_rev_2	146	155	PF00179	0.739
MOD_SUMO_rev_2	203	210	PF00179	0.468
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.775
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.685
TRG_ENDOCYTIC_2	124	127	PF00928	0.558
TRG_ENDOCYTIC_2	337	340	PF00928	0.772
TRG_ENDOCYTIC_2	360	363	PF00928	0.692
TRG_ER_diArg_1	102	105	PF00400	0.630
TRG_ER_diArg_1	115	117	PF00400	0.451
TRG_ER_diArg_1	181	183	PF00400	0.681
TRG_ER_diArg_1	242	244	PF00400	0.693
TRG_ER_diArg_1	302	304	PF00400	0.776
TRG_ER_diArg_1	351	354	PF00400	0.738
TRG_ER_diArg_1	91	93	PF00400	0.671
TRG_NES_CRM1_1	65	78	PF08389	0.488
TRG_NLS_Bipartite_1	226	244	PF00514	0.560
TRG_NLS_MonoExtC_3	239	244	PF00514	0.550
TRG_NLS_MonoExtN_4	238	244	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5S0	Leptomonas seymouri	42%	73%
A0A3S7X9K7	Leishmania donovani	72%	74%
A4IBK6	Leishmania infantum	72%	74%
E9AFD9	Leishmania major	73%	100%
E9B6J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	74%