Kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase

Gene product:

inositol polyphosphate kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMY1_LEIBR

TriTrypDb:

LbrM.34.3050 , LBRM2903_340039100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMY1

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0032958	inositol phosphate biosynthetic process	5	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	6	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0051765	inositol tetrakisphosphate kinase activity	5	1
GO:0051766	inositol trisphosphate kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.292
CLV_MEL_PAP_1	229	235	PF00089	0.197
CLV_NRD_NRD_1	212	214	PF00675	0.482
CLV_NRD_NRD_1	263	265	PF00675	0.301
CLV_NRD_NRD_1	351	353	PF00675	0.282
CLV_PCSK_KEX2_1	212	214	PF00082	0.482
CLV_PCSK_SKI1_1	191	195	PF00082	0.329
CLV_PCSK_SKI1_1	96	100	PF00082	0.357
DEG_APCC_DBOX_1	337	345	PF00400	0.197
DEG_APCC_KENBOX_2	264	268	PF00400	0.197
DEG_SPOP_SBC_1	83	87	PF00917	0.239
DOC_CKS1_1	182	187	PF01111	0.297
DOC_CYCLIN_yClb5_NLxxxL_5	368	374	PF00134	0.355
DOC_MAPK_gen_1	264	272	PF00069	0.421
DOC_MAPK_gen_1	338	346	PF00069	0.361
DOC_MAPK_MEF2A_6	167	175	PF00069	0.357
DOC_PP1_RVXF_1	172	178	PF00149	0.357
DOC_PP1_RVXF_1	338	344	PF00149	0.236
DOC_PP4_FxxP_1	356	359	PF00568	0.186
DOC_USP7_MATH_1	253	257	PF00917	0.265
DOC_USP7_MATH_1	279	283	PF00917	0.489
DOC_USP7_MATH_1	320	324	PF00917	0.279
DOC_USP7_MATH_1	332	336	PF00917	0.279
DOC_USP7_UBL2_3	96	100	PF12436	0.448
DOC_WW_Pin1_4	178	183	PF00397	0.279
DOC_WW_Pin1_4	3	8	PF00397	0.649
DOC_WW_Pin1_4	306	311	PF00397	0.385
LIG_14-3-3_CanoR_1	202	208	PF00244	0.241
LIG_14-3-3_CanoR_1	245	255	PF00244	0.355
LIG_14-3-3_CanoR_1	30	34	PF00244	0.455
LIG_14-3-3_CanoR_1	348	352	PF00244	0.310
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	17	21	PF00533	0.571
LIG_BRCT_BRCA1_1	85	89	PF00533	0.382
LIG_FHA_1	311	317	PF00498	0.282
LIG_FHA_1	83	89	PF00498	0.346
LIG_FHA_2	182	188	PF00498	0.279
LIG_FHA_2	279	285	PF00498	0.413
LIG_FHA_2	36	42	PF00498	0.314
LIG_LIR_Apic_2	19	25	PF02991	0.314
LIG_LIR_Gen_1	113	122	PF02991	0.355
LIG_LIR_Gen_1	252	262	PF02991	0.373
LIG_LIR_Gen_1	37	48	PF02991	0.312
LIG_LIR_Gen_1	371	376	PF02991	0.421
LIG_LIR_Nem_3	252	257	PF02991	0.328
LIG_LIR_Nem_3	349	354	PF02991	0.329
LIG_LIR_Nem_3	371	376	PF02991	0.445
LIG_PDZ_Class_2	371	376	PF00595	0.414
LIG_Pex14_1	40	44	PF04695	0.425
LIG_Pex14_2	132	136	PF04695	0.447
LIG_Pex14_2	89	93	PF04695	0.434
LIG_PTB_Apo_2	130	137	PF02174	0.336
LIG_Rb_pABgroove_1	324	332	PF01858	0.357
LIG_SH2_CRK	22	26	PF00017	0.315
LIG_SH2_NCK_1	330	334	PF00017	0.297
LIG_SH2_SRC	239	242	PF00017	0.197
LIG_SH2_STAT5	107	110	PF00017	0.391
LIG_SH2_STAT5	214	217	PF00017	0.315
LIG_SH2_STAT5	373	376	PF00017	0.427
LIG_SH2_STAT5	45	48	PF00017	0.292
LIG_SH3_1	179	185	PF00018	0.297
LIG_SH3_3	124	130	PF00018	0.525
LIG_SH3_3	179	185	PF00018	0.297
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.304
LIG_SUMO_SIM_par_1	325	331	PF11976	0.286
LIG_TRAF2_1	184	187	PF00917	0.292
LIG_UBA3_1	88	96	PF00899	0.456
MOD_CDK_SPK_2	3	8	PF00069	0.433
MOD_CDK_SPxxK_3	181	188	PF00069	0.297
MOD_CK1_1	181	187	PF00069	0.318
MOD_CK1_1	2	8	PF00069	0.468
MOD_CK2_1	181	187	PF00069	0.215
MOD_CK2_1	216	222	PF00069	0.197
MOD_CK2_1	253	259	PF00069	0.197
MOD_CK2_1	278	284	PF00069	0.410
MOD_CK2_1	35	41	PF00069	0.339
MOD_GlcNHglycan	1	4	PF01048	0.728
MOD_GlcNHglycan	100	103	PF01048	0.488
MOD_GlcNHglycan	160	165	PF01048	0.367
MOD_GlcNHglycan	281	284	PF01048	0.485
MOD_GlcNHglycan	322	325	PF01048	0.389
MOD_GlcNHglycan	334	338	PF01048	0.312
MOD_GSK3_1	245	252	PF00069	0.333
MOD_GSK3_1	29	36	PF00069	0.303
MOD_GSK3_1	306	313	PF00069	0.239
MOD_GSK3_1	83	90	PF00069	0.386
MOD_NEK2_1	33	38	PF00069	0.387
MOD_NEK2_1	346	351	PF00069	0.431
MOD_NEK2_1	84	89	PF00069	0.380
MOD_NEK2_1	98	103	PF00069	0.304
MOD_PKA_2	201	207	PF00069	0.360
MOD_PKA_2	29	35	PF00069	0.465
MOD_PKA_2	347	353	PF00069	0.322
MOD_Plk_4	16	22	PF00069	0.554
MOD_Plk_4	196	202	PF00069	0.302
MOD_Plk_4	224	230	PF00069	0.240
MOD_Plk_4	298	304	PF00069	0.421
MOD_Plk_4	310	316	PF00069	0.273
MOD_Plk_4	322	328	PF00069	0.249
MOD_Plk_4	84	90	PF00069	0.310
MOD_ProDKin_1	178	184	PF00069	0.279
MOD_ProDKin_1	3	9	PF00069	0.641
MOD_ProDKin_1	306	312	PF00069	0.385
MOD_SUMO_for_1	193	196	PF00179	0.292
MOD_SUMO_rev_2	181	190	PF00179	0.357
TRG_DiLeu_BaEn_1	196	201	PF01217	0.292
TRG_DiLeu_BaEn_1	298	303	PF01217	0.330
TRG_ENDOCYTIC_2	373	376	PF00928	0.427
TRG_ENDOCYTIC_2	45	48	PF00928	0.292
TRG_ER_diArg_1	212	214	PF00400	0.488
TRG_NES_CRM1_1	317	331	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC0	Leptomonas seymouri	59%	100%
A0A1X0NEH0	Trypanosomatidae	32%	100%
A0A3S7X9M0	Leishmania donovani	75%	100%
A0A422N9V2	Trypanosoma rangeli	31%	100%
A4IBK5	Leishmania infantum	75%	100%
C9ZZ39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFD8	Leishmania major	75%	100%
E9B6J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
V5BTG0	Trypanosoma cruzi	32%	100%