Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain type 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HMY0_LEIBR

TriTrypDb:

LbrM.34.3040 , LBRM2903_340039000

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005874	microtubule	6	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	12
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HMY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMY0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.493
CLV_NRD_NRD_1	107	109	PF00675	0.434
CLV_PCSK_KEX2_1	107	109	PF00082	0.603
CLV_PCSK_KEX2_1	153	155	PF00082	0.302
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.336
CLV_PCSK_SKI1_1	116	120	PF00082	0.303
CLV_PCSK_SKI1_1	128	132	PF00082	0.258
DEG_APCC_DBOX_1	115	123	PF00400	0.284
DEG_SPOP_SBC_1	2	6	PF00917	0.524
DOC_CYCLIN_RxL_1	72	83	PF00134	0.257
DOC_PP1_RVXF_1	151	158	PF00149	0.536
DOC_USP7_MATH_1	2	6	PF00917	0.579
LIG_14-3-3_CanoR_1	59	65	PF00244	0.506
LIG_14-3-3_CanoR_1	86	95	PF00244	0.458
LIG_14-3-3_CanoR_1	97	101	PF00244	0.370
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_FHA_1	129	135	PF00498	0.528
LIG_KLC1_Yacidic_2	66	71	PF13176	0.429
LIG_LIR_Gen_1	66	77	PF02991	0.416
LIG_LIR_Nem_3	145	149	PF02991	0.458
LIG_LIR_Nem_3	66	72	PF02991	0.416
LIG_Pex14_1	138	142	PF04695	0.433
LIG_SH2_PTP2	69	72	PF00017	0.437
LIG_SH2_SRC	69	72	PF00017	0.318
LIG_SH2_STAT5	149	152	PF00017	0.378
LIG_SH2_STAT5	69	72	PF00017	0.378
LIG_SH3_3	67	73	PF00018	0.415
LIG_SH3_3	89	95	PF00018	0.357
LIG_TRAF2_1	49	52	PF00917	0.520
MOD_CK1_1	30	36	PF00069	0.559
MOD_CK2_1	103	109	PF00069	0.395
MOD_CK2_1	2	8	PF00069	0.473
MOD_CK2_1	20	26	PF00069	0.576
MOD_GlcNHglycan	82	85	PF01048	0.474
MOD_GSK3_1	29	36	PF00069	0.627
MOD_N-GLC_1	30	35	PF02516	0.618
MOD_NEK2_1	1	6	PF00069	0.487
MOD_NEK2_1	12	17	PF00069	0.675
MOD_PKA_2	20	26	PF00069	0.572
MOD_PKA_2	58	64	PF00069	0.582
MOD_PKA_2	96	102	PF00069	0.496
MOD_Plk_1	114	120	PF00069	0.314
MOD_Plk_1	12	18	PF00069	0.767
MOD_Plk_1	30	36	PF00069	0.700
MOD_Plk_4	145	151	PF00069	0.433
MOD_Plk_4	30	36	PF00069	0.697
TRG_DiLeu_BaEn_4	51	57	PF01217	0.398
TRG_ENDOCYTIC_2	69	72	PF00928	0.358
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR6	Leptomonas seymouri	66%	99%
A0A0S4JHJ3	Bodo saltans	48%	100%
A0A1X0NDA2	Trypanosomatidae	60%	100%
A0A3R7LS25	Trypanosoma rangeli	56%	100%
A0A3S7X9I0	Leishmania donovani	82%	100%
A4IBK4	Leishmania infantum	82%	100%
C9ZZ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AFD7	Leishmania major	82%	99%
E9B6J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5BTL8	Trypanosoma cruzi	57%	100%