Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 7

Species:

Leishmania braziliensis

UniProt:

A4HMX8_LEIBR

TriTrypDb:

LbrM.34.3020 , LBRM2903_340038800

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HMX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.705
CLV_C14_Caspase3-7	574	578	PF00656	0.464
CLV_NRD_NRD_1	194	196	PF00675	0.783
CLV_NRD_NRD_1	251	253	PF00675	0.585
CLV_NRD_NRD_1	27	29	PF00675	0.421
CLV_NRD_NRD_1	33	35	PF00675	0.456
CLV_NRD_NRD_1	7	9	PF00675	0.691
CLV_PCSK_FUR_1	192	196	PF00082	0.708
CLV_PCSK_KEX2_1	161	163	PF00082	0.685
CLV_PCSK_KEX2_1	194	196	PF00082	0.783
CLV_PCSK_KEX2_1	253	255	PF00082	0.624
CLV_PCSK_KEX2_1	27	29	PF00082	0.435
CLV_PCSK_KEX2_1	32	34	PF00082	0.474
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.544
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.545
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.538
CLV_PCSK_PC7_1	28	34	PF00082	0.539
CLV_PCSK_SKI1_1	136	140	PF00082	0.552
CLV_PCSK_SKI1_1	365	369	PF00082	0.357
CLV_PCSK_SKI1_1	514	518	PF00082	0.403
CLV_PCSK_SKI1_1	563	567	PF00082	0.456
CLV_PCSK_SKI1_1	571	575	PF00082	0.345
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DOC_CKS1_1	341	346	PF01111	0.685
DOC_CYCLIN_RxL_1	133	141	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.775
DOC_MAPK_DCC_7	278	288	PF00069	0.556
DOC_MAPK_HePTP_8	314	326	PF00069	0.726
DOC_MAPK_MEF2A_6	278	285	PF00069	0.645
DOC_MAPK_MEF2A_6	317	326	PF00069	0.727
DOC_MAPK_MEF2A_6	365	373	PF00069	0.728
DOC_MAPK_RevD_3	147	162	PF00069	0.323
DOC_PP2B_LxvP_1	324	327	PF13499	0.682
DOC_PP2B_LxvP_1	87	90	PF13499	0.628
DOC_PP2B_PxIxI_1	220	226	PF00149	0.233
DOC_PP4_FxxP_1	77	80	PF00568	0.637
DOC_USP7_MATH_1	279	283	PF00917	0.529
DOC_USP7_MATH_1	300	304	PF00917	0.737
DOC_USP7_MATH_1	434	438	PF00917	0.759
DOC_USP7_MATH_1	530	534	PF00917	0.609
DOC_WW_Pin1_4	168	173	PF00397	0.528
DOC_WW_Pin1_4	240	245	PF00397	0.706
DOC_WW_Pin1_4	256	261	PF00397	0.833
DOC_WW_Pin1_4	296	301	PF00397	0.633
DOC_WW_Pin1_4	340	345	PF00397	0.742
DOC_WW_Pin1_4	371	376	PF00397	0.626
LIG_14-3-3_CanoR_1	194	200	PF00244	0.560
LIG_14-3-3_CanoR_1	201	208	PF00244	0.360
LIG_14-3-3_CanoR_1	278	284	PF00244	0.506
LIG_14-3-3_CanoR_1	555	560	PF00244	0.591
LIG_14-3-3_CanoR_1	563	568	PF00244	0.625
LIG_14-3-3_CanoR_1	571	577	PF00244	0.414
LIG_BIR_III_2	175	179	PF00653	0.417
LIG_BIR_III_2	596	600	PF00653	0.627
LIG_deltaCOP1_diTrp_1	329	333	PF00928	0.552
LIG_deltaCOP1_diTrp_1	577	586	PF00928	0.632
LIG_FHA_1	11	17	PF00498	0.383
LIG_FHA_1	122	128	PF00498	0.454
LIG_FHA_1	133	139	PF00498	0.472
LIG_FHA_1	278	284	PF00498	0.657
LIG_FHA_1	336	342	PF00498	0.652
LIG_FHA_1	366	372	PF00498	0.610
LIG_FHA_1	422	428	PF00498	0.659
LIG_FHA_1	439	445	PF00498	0.732
LIG_FHA_1	503	509	PF00498	0.669
LIG_FHA_1	556	562	PF00498	0.584
LIG_FHA_1	564	570	PF00498	0.539
LIG_FHA_1	590	596	PF00498	0.637
LIG_FHA_2	139	145	PF00498	0.485
LIG_FHA_2	180	186	PF00498	0.424
LIG_FHA_2	188	194	PF00498	0.405
LIG_FHA_2	260	266	PF00498	0.787
LIG_FHA_2	341	347	PF00498	0.722
LIG_FHA_2	355	361	PF00498	0.738
LIG_FHA_2	37	43	PF00498	0.783
LIG_FHA_2	508	514	PF00498	0.574
LIG_FHA_2	523	529	PF00498	0.630
LIG_FHA_2	533	539	PF00498	0.640
LIG_FHA_2	572	578	PF00498	0.613
LIG_LIR_Apic_2	445	451	PF02991	0.711
LIG_LIR_Apic_2	558	562	PF02991	0.539
LIG_LIR_Gen_1	19	26	PF02991	0.233
LIG_LIR_Gen_1	202	208	PF02991	0.397
LIG_LIR_Gen_1	391	400	PF02991	0.691
LIG_LIR_Gen_1	505	513	PF02991	0.620
LIG_LIR_LC3C_4	13	18	PF02991	0.213
LIG_LIR_Nem_3	19	25	PF02991	0.233
LIG_LIR_Nem_3	202	206	PF02991	0.397
LIG_LIR_Nem_3	210	215	PF02991	0.398
LIG_LIR_Nem_3	331	336	PF02991	0.666
LIG_LIR_Nem_3	391	396	PF02991	0.685
LIG_LIR_Nem_3	476	482	PF02991	0.672
LIG_LIR_Nem_3	505	509	PF02991	0.597
LIG_NRBOX	148	154	PF00104	0.381
LIG_Pex14_1	3	7	PF04695	0.353
LIG_Pex14_2	231	235	PF04695	0.447
LIG_Pex14_2	453	457	PF04695	0.684
LIG_PTB_Apo_2	206	213	PF02174	0.282
LIG_PTB_Phospho_1	206	212	PF10480	0.286
LIG_SH2_CRK	311	315	PF00017	0.699
LIG_SH2_PTP2	222	225	PF00017	0.233
LIG_SH2_PTP2	448	451	PF00017	0.733
LIG_SH2_PTP2	559	562	PF00017	0.544
LIG_SH2_SRC	222	225	PF00017	0.339
LIG_SH2_STAT5	212	215	PF00017	0.345
LIG_SH2_STAT5	222	225	PF00017	0.334
LIG_SH2_STAT5	315	318	PF00017	0.640
LIG_SH2_STAT5	336	339	PF00017	0.745
LIG_SH2_STAT5	448	451	PF00017	0.711
LIG_SH2_STAT5	498	501	PF00017	0.621
LIG_SH2_STAT5	559	562	PF00017	0.544
LIG_SH3_3	278	284	PF00018	0.652
LIG_SH3_3	413	419	PF00018	0.754
LIG_SH3_3	463	469	PF00018	0.642
LIG_SH3_3	497	503	PF00018	0.678
LIG_SH3_3	69	75	PF00018	0.629
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.288
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.609
LIG_SUMO_SIM_par_1	13	19	PF11976	0.233
LIG_SUMO_SIM_par_1	366	372	PF11976	0.687
LIG_SUMO_SIM_par_1	85	92	PF11976	0.586
LIG_TRAF2_1	356	359	PF00917	0.629
LIG_TYR_ITAM	209	225	PF00017	0.263
LIG_TYR_ITIM	477	482	PF00017	0.618
LIG_WW_3	490	494	PF00397	0.544
MOD_CDK_SPxK_1	240	246	PF00069	0.627
MOD_CK1_1	237	243	PF00069	0.740
MOD_CK1_1	328	334	PF00069	0.635
MOD_CK1_1	339	345	PF00069	0.732
MOD_CK1_1	377	383	PF00069	0.632
MOD_CK1_1	411	417	PF00069	0.750
MOD_CK1_1	522	528	PF00069	0.643
MOD_CK1_1	575	581	PF00069	0.476
MOD_CK2_1	179	185	PF00069	0.516
MOD_CK2_1	187	193	PF00069	0.527
MOD_CK2_1	242	248	PF00069	0.756
MOD_CK2_1	259	265	PF00069	0.811
MOD_CK2_1	353	359	PF00069	0.793
MOD_CK2_1	379	385	PF00069	0.568
MOD_CK2_1	41	47	PF00069	0.675
MOD_CK2_1	532	538	PF00069	0.606
MOD_CMANNOS	330	333	PF00535	0.349
MOD_Cter_Amidation	250	253	PF01082	0.621
MOD_GlcNHglycan	101	104	PF01048	0.580
MOD_GlcNHglycan	185	188	PF01048	0.782
MOD_GlcNHglycan	248	252	PF01048	0.563
MOD_GlcNHglycan	256	259	PF01048	0.505
MOD_GlcNHglycan	34	37	PF01048	0.461
MOD_GlcNHglycan	388	391	PF01048	0.467
MOD_GlcNHglycan	393	396	PF01048	0.460
MOD_GlcNHglycan	410	413	PF01048	0.410
MOD_GlcNHglycan	462	465	PF01048	0.472
MOD_GlcNHglycan	532	535	PF01048	0.426
MOD_GlcNHglycan	538	542	PF01048	0.385
MOD_GSK3_1	179	186	PF00069	0.550
MOD_GSK3_1	195	202	PF00069	0.474
MOD_GSK3_1	252	259	PF00069	0.835
MOD_GSK3_1	260	267	PF00069	0.770
MOD_GSK3_1	290	297	PF00069	0.682
MOD_GSK3_1	32	39	PF00069	0.608
MOD_GSK3_1	331	338	PF00069	0.699
MOD_GSK3_1	365	372	PF00069	0.674
MOD_GSK3_1	373	380	PF00069	0.657
MOD_GSK3_1	434	441	PF00069	0.760
MOD_GSK3_1	469	476	PF00069	0.691
MOD_GSK3_1	48	55	PF00069	0.713
MOD_GSK3_1	530	537	PF00069	0.649
MOD_GSK3_1	571	578	PF00069	0.595
MOD_N-GLC_1	289	294	PF02516	0.398
MOD_NEK2_1	127	132	PF00069	0.447
MOD_NEK2_1	138	143	PF00069	0.383
MOD_NEK2_1	16	21	PF00069	0.302
MOD_NEK2_1	369	374	PF00069	0.696
MOD_NEK2_1	379	384	PF00069	0.702
MOD_NEK2_1	48	53	PF00069	0.710
MOD_PIKK_1	138	144	PF00454	0.341
MOD_PKA_1	194	200	PF00069	0.563
MOD_PKA_1	252	258	PF00069	0.800
MOD_PKA_1	32	38	PF00069	0.677
MOD_PKA_2	194	200	PF00069	0.407
MOD_PKA_2	277	283	PF00069	0.523
MOD_PKA_2	32	38	PF00069	0.695
MOD_PKA_2	492	498	PF00069	0.589
MOD_PKA_2	97	103	PF00069	0.732
MOD_PKB_1	192	200	PF00069	0.414
MOD_PKB_1	252	260	PF00069	0.799
MOD_Plk_1	328	334	PF00069	0.745
MOD_Plk_1	345	351	PF00069	0.671
MOD_Plk_1	365	371	PF00069	0.669
MOD_Plk_2-3	346	352	PF00069	0.621
MOD_Plk_4	374	380	PF00069	0.706
MOD_Plk_4	403	409	PF00069	0.690
MOD_Plk_4	443	449	PF00069	0.727
MOD_Plk_4	473	479	PF00069	0.707
MOD_Plk_4	52	58	PF00069	0.680
MOD_Plk_4	563	569	PF00069	0.601
MOD_ProDKin_1	168	174	PF00069	0.532
MOD_ProDKin_1	240	246	PF00069	0.708
MOD_ProDKin_1	256	262	PF00069	0.832
MOD_ProDKin_1	296	302	PF00069	0.630
MOD_ProDKin_1	340	346	PF00069	0.744
MOD_ProDKin_1	371	377	PF00069	0.631
MOD_SUMO_rev_2	346	355	PF00179	0.625
MOD_SUMO_rev_2	358	367	PF00179	0.746
MOD_SUMO_rev_2	507	516	PF00179	0.513
TRG_ENDOCYTIC_2	212	215	PF00928	0.410
TRG_ENDOCYTIC_2	222	225	PF00928	0.437
TRG_ENDOCYTIC_2	310	313	PF00928	0.679
TRG_ENDOCYTIC_2	479	482	PF00928	0.602
TRG_ER_diArg_1	26	28	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ7	Leptomonas seymouri	43%	94%
A0A1X0P5E3	Trypanosomatidae	28%	100%
A0A3R7NG87	Trypanosoma rangeli	27%	100%
A0A3S7X9K3	Leishmania donovani	70%	100%
A4IBK2	Leishmania infantum	70%	100%
E9AFD5	Leishmania major	70%	100%
E9B6J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
V5DUQ9	Trypanosoma cruzi	24%	100%