Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMX7_LEIBR

TriTrypDb:

LbrM.34.3010 , LBRM2903_340038700

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HMX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	13
GO:0003724	RNA helicase activity	3	13
GO:0003743	translation initiation factor activity	4	13
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0008186	ATP-dependent activity, acting on RNA	2	13
GO:0016787	hydrolase activity	2	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140098	catalytic activity, acting on RNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003723	RNA binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	836	840	PF00656	0.677
CLV_NRD_NRD_1	187	189	PF00675	0.674
CLV_NRD_NRD_1	215	217	PF00675	0.668
CLV_NRD_NRD_1	225	227	PF00675	0.577
CLV_NRD_NRD_1	260	262	PF00675	0.718
CLV_NRD_NRD_1	267	269	PF00675	0.655
CLV_NRD_NRD_1	289	291	PF00675	0.686
CLV_NRD_NRD_1	32	34	PF00675	0.675
CLV_NRD_NRD_1	353	355	PF00675	0.659
CLV_NRD_NRD_1	362	364	PF00675	0.493
CLV_NRD_NRD_1	42	44	PF00675	0.716
CLV_NRD_NRD_1	477	479	PF00675	0.339
CLV_NRD_NRD_1	501	503	PF00675	0.341
CLV_NRD_NRD_1	610	612	PF00675	0.436
CLV_NRD_NRD_1	672	674	PF00675	0.328
CLV_NRD_NRD_1	688	690	PF00675	0.253
CLV_NRD_NRD_1	763	765	PF00675	0.500
CLV_NRD_NRD_1	807	809	PF00675	0.647
CLV_NRD_NRD_1	850	852	PF00675	0.667
CLV_PCSK_FUR_1	40	44	PF00082	0.726
CLV_PCSK_KEX2_1	187	189	PF00082	0.674
CLV_PCSK_KEX2_1	215	217	PF00082	0.668
CLV_PCSK_KEX2_1	225	227	PF00082	0.577
CLV_PCSK_KEX2_1	260	262	PF00082	0.718
CLV_PCSK_KEX2_1	267	269	PF00082	0.655
CLV_PCSK_KEX2_1	289	291	PF00082	0.686
CLV_PCSK_KEX2_1	32	34	PF00082	0.675
CLV_PCSK_KEX2_1	353	355	PF00082	0.718
CLV_PCSK_KEX2_1	362	364	PF00082	0.547
CLV_PCSK_KEX2_1	42	44	PF00082	0.716
CLV_PCSK_KEX2_1	606	608	PF00082	0.413
CLV_PCSK_KEX2_1	610	612	PF00082	0.425
CLV_PCSK_KEX2_1	672	674	PF00082	0.335
CLV_PCSK_KEX2_1	688	690	PF00082	0.254
CLV_PCSK_KEX2_1	763	765	PF00082	0.518
CLV_PCSK_KEX2_1	806	808	PF00082	0.640
CLV_PCSK_KEX2_1	850	852	PF00082	0.667
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.464
CLV_PCSK_SKI1_1	353	357	PF00082	0.604
CLV_PCSK_SKI1_1	399	403	PF00082	0.532
CLV_PCSK_SKI1_1	502	506	PF00082	0.379
CLV_PCSK_SKI1_1	538	542	PF00082	0.296
CLV_PCSK_SKI1_1	626	630	PF00082	0.462
CLV_PCSK_SKI1_1	764	768	PF00082	0.501
DEG_Nend_UBRbox_2	1	3	PF02207	0.704
DEG_SPOP_SBC_1	621	625	PF00917	0.547
DOC_CYCLIN_RxL_1	549	560	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.488
DOC_MAPK_DCC_7	701	709	PF00069	0.550
DOC_MAPK_gen_1	378	386	PF00069	0.538
DOC_MAPK_gen_1	476	485	PF00069	0.498
DOC_MAPK_gen_1	610	618	PF00069	0.403
DOC_MAPK_gen_1	701	709	PF00069	0.526
DOC_MAPK_gen_1	760	769	PF00069	0.534
DOC_MAPK_MEF2A_6	433	440	PF00069	0.496
DOC_MAPK_MEF2A_6	478	487	PF00069	0.496
DOC_MAPK_MEF2A_6	760	769	PF00069	0.513
DOC_PP1_RVXF_1	500	507	PF00149	0.539
DOC_PP2B_LxvP_1	316	319	PF13499	0.551
DOC_PP2B_LxvP_1	718	721	PF13499	0.533
DOC_PP4_FxxP_1	459	462	PF00568	0.509
DOC_PP4_FxxP_1	729	732	PF00568	0.539
DOC_USP7_MATH_1	109	113	PF00917	0.641
DOC_USP7_MATH_1	140	144	PF00917	0.532
DOC_USP7_MATH_1	312	316	PF00917	0.718
DOC_USP7_MATH_1	46	50	PF00917	0.712
DOC_WW_Pin1_4	116	121	PF00397	0.608
DOC_WW_Pin1_4	122	127	PF00397	0.570
DOC_WW_Pin1_4	326	331	PF00397	0.778
DOC_WW_Pin1_4	339	344	PF00397	0.669
DOC_WW_Pin1_4	426	431	PF00397	0.487
DOC_WW_Pin1_4	470	475	PF00397	0.496
DOC_WW_Pin1_4	702	707	PF00397	0.496
LIG_14-3-3_CanoR_1	260	265	PF00244	0.540
LIG_14-3-3_CanoR_1	476	482	PF00244	0.499
LIG_14-3-3_CanoR_1	502	507	PF00244	0.537
LIG_14-3-3_CanoR_1	578	585	PF00244	0.534
LIG_14-3-3_CanoR_1	588	592	PF00244	0.541
LIG_14-3-3_CanoR_1	620	628	PF00244	0.547
LIG_APCC_ABBA_1	495	500	PF00400	0.533
LIG_APCC_ABBA_1	657	662	PF00400	0.523
LIG_BRCT_BRCA1_1	593	597	PF00533	0.533
LIG_Clathr_ClatBox_1	658	662	PF01394	0.533
LIG_CtBP_PxDLS_1	393	397	PF00389	0.524
LIG_deltaCOP1_diTrp_1	50	54	PF00928	0.607
LIG_EH1_1	650	658	PF00400	0.539
LIG_FHA_1	109	115	PF00498	0.543
LIG_FHA_1	131	137	PF00498	0.554
LIG_FHA_1	488	494	PF00498	0.541
LIG_FHA_1	623	629	PF00498	0.501
LIG_FHA_1	703	709	PF00498	0.496
LIG_FHA_1	737	743	PF00498	0.473
LIG_FHA_2	25	31	PF00498	0.698
LIG_FHA_2	582	588	PF00498	0.539
LIG_FHA_2	95	101	PF00498	0.676
LIG_LIR_Apic_2	274	280	PF02991	0.670
LIG_LIR_Apic_2	456	462	PF02991	0.541
LIG_LIR_Gen_1	310	319	PF02991	0.717
LIG_LIR_Gen_1	387	397	PF02991	0.527
LIG_LIR_Gen_1	405	415	PF02991	0.557
LIG_LIR_Gen_1	509	516	PF02991	0.478
LIG_LIR_Gen_1	543	553	PF02991	0.546
LIG_LIR_Gen_1	577	585	PF02991	0.539
LIG_LIR_Nem_3	11	17	PF02991	0.537
LIG_LIR_Nem_3	291	295	PF02991	0.724
LIG_LIR_Nem_3	310	316	PF02991	0.662
LIG_LIR_Nem_3	387	392	PF02991	0.564
LIG_LIR_Nem_3	405	410	PF02991	0.599
LIG_LIR_Nem_3	508	514	PF02991	0.491
LIG_LIR_Nem_3	543	548	PF02991	0.561
LIG_Pex14_2	593	597	PF04695	0.509
LIG_PTAP_UEV_1	841	846	PF05743	0.669
LIG_PTB_Apo_2	539	546	PF02174	0.498
LIG_PTB_Phospho_1	539	545	PF10480	0.539
LIG_SH2_CRK	277	281	PF00017	0.679
LIG_SH2_CRK	389	393	PF00017	0.578
LIG_SH2_CRK	425	429	PF00017	0.493
LIG_SH2_CRK	434	438	PF00017	0.508
LIG_SH2_CRK	466	470	PF00017	0.509
LIG_SH2_CRK	512	516	PF00017	0.539
LIG_SH2_NCK_1	389	393	PF00017	0.518
LIG_SH2_NCK_1	512	516	PF00017	0.539
LIG_SH2_SRC	234	237	PF00017	0.534
LIG_SH2_STAP1	201	205	PF00017	0.651
LIG_SH2_STAP1	512	516	PF00017	0.539
LIG_SH2_STAP1	738	742	PF00017	0.496
LIG_SH2_STAT5	189	192	PF00017	0.540
LIG_SH2_STAT5	3	6	PF00017	0.649
LIG_SH2_STAT5	545	548	PF00017	0.574
LIG_SH2_STAT5	579	582	PF00017	0.506
LIG_SH2_STAT5	608	611	PF00017	0.403
LIG_SH2_STAT5	614	617	PF00017	0.400
LIG_SH2_STAT5	738	741	PF00017	0.541
LIG_SH2_STAT5	772	775	PF00017	0.452
LIG_SH3_1	327	333	PF00018	0.568
LIG_SH3_2	330	335	PF14604	0.568
LIG_SH3_3	133	139	PF00018	0.565
LIG_SH3_3	320	326	PF00018	0.594
LIG_SH3_3	327	333	PF00018	0.590
LIG_SH3_3	337	343	PF00018	0.701
LIG_SH3_3	483	489	PF00018	0.546
LIG_SH3_3	528	534	PF00018	0.535
LIG_SH3_3	839	845	PF00018	0.690
LIG_Sin3_3	408	415	PF02671	0.503
LIG_SUMO_SIM_par_1	705	712	PF11976	0.488
LIG_TRAF2_1	139	142	PF00917	0.528
LIG_TRAF2_1	192	195	PF00917	0.650
LIG_TRAF2_1	301	304	PF00917	0.712
LIG_TYR_ITIM	464	469	PF00017	0.509
LIG_TYR_ITIM	510	515	PF00017	0.539
LIG_UBA3_1	601	606	PF00899	0.451
LIG_WRC_WIRS_1	25	30	PF05994	0.697
LIG_WRC_WIRS_1	292	297	PF05994	0.722
LIG_WRC_WIRS_1	545	550	PF05994	0.539
MOD_CDC14_SPxK_1	473	476	PF00782	0.539
MOD_CDK_SPxK_1	470	476	PF00069	0.539
MOD_CDK_SPxxK_3	426	433	PF00069	0.389
MOD_CK1_1	173	179	PF00069	0.528
MOD_CK1_1	204	210	PF00069	0.536
MOD_CK1_1	453	459	PF00069	0.541
MOD_CK1_1	577	583	PF00069	0.496
MOD_CK1_1	680	686	PF00069	0.509
MOD_CK1_1	822	828	PF00069	0.555
MOD_CK1_1	840	846	PF00069	0.740
MOD_CK1_1	89	95	PF00069	0.550
MOD_CK2_1	7	13	PF00069	0.654
MOD_CK2_1	94	100	PF00069	0.677
MOD_Cter_Amidation	185	188	PF01082	0.718
MOD_Cter_Amidation	223	226	PF01082	0.695
MOD_Cter_Amidation	287	290	PF01082	0.715
MOD_Cter_Amidation	40	43	PF01082	0.686
MOD_Cter_Amidation	804	807	PF01082	0.695
MOD_Cter_Amidation	848	851	PF01082	0.687
MOD_GlcNHglycan	127	130	PF01048	0.604
MOD_GlcNHglycan	175	178	PF01048	0.606
MOD_GlcNHglycan	206	209	PF01048	0.655
MOD_GlcNHglycan	262	265	PF01048	0.676
MOD_GlcNHglycan	303	307	PF01048	0.680
MOD_GlcNHglycan	349	352	PF01048	0.666
MOD_GlcNHglycan	452	455	PF01048	0.325
MOD_GlcNHglycan	548	551	PF01048	0.339
MOD_GlcNHglycan	55	59	PF01048	0.776
MOD_GlcNHglycan	593	596	PF01048	0.341
MOD_GlcNHglycan	64	68	PF01048	0.624
MOD_GlcNHglycan	821	824	PF01048	0.717
MOD_GlcNHglycan	842	845	PF01048	0.829
MOD_GSK3_1	116	123	PF00069	0.634
MOD_GSK3_1	2	9	PF00069	0.582
MOD_GSK3_1	317	324	PF00069	0.651
MOD_GSK3_1	577	584	PF00069	0.543
MOD_GSK3_1	587	594	PF00069	0.534
MOD_GSK3_1	622	629	PF00069	0.538
MOD_GSK3_1	708	715	PF00069	0.533
MOD_GSK3_1	833	840	PF00069	0.679
MOD_GSK3_1	94	101	PF00069	0.665
MOD_N-GLC_1	626	631	PF02516	0.519
MOD_NEK2_1	157	162	PF00069	0.545
MOD_NEK2_1	302	307	PF00069	0.660
MOD_NEK2_1	546	551	PF00069	0.505
MOD_NEK2_1	574	579	PF00069	0.488
MOD_NEK2_1	591	596	PF00069	0.606
MOD_NEK2_1	660	665	PF00069	0.520
MOD_PIKK_1	199	205	PF00454	0.546
MOD_PIKK_1	345	351	PF00454	0.637
MOD_PIKK_1	626	632	PF00454	0.519
MOD_PKA_1	260	266	PF00069	0.541
MOD_PKA_1	353	359	PF00069	0.603
MOD_PKA_1	502	508	PF00069	0.573
MOD_PKA_1	7	13	PF00069	0.695
MOD_PKA_2	259	265	PF00069	0.543
MOD_PKA_2	353	359	PF00069	0.645
MOD_PKA_2	379	385	PF00069	0.760
MOD_PKA_2	477	483	PF00069	0.473
MOD_PKA_2	577	583	PF00069	0.534
MOD_PKA_2	587	593	PF00069	0.541
MOD_PKA_2	840	846	PF00069	0.669
MOD_PKA_2	86	92	PF00069	0.723
MOD_PKA_2	98	104	PF00069	0.700
MOD_Plk_1	23	29	PF00069	0.532
MOD_Plk_2-3	24	30	PF00069	0.654
MOD_Plk_2-3	581	587	PF00069	0.539
MOD_Plk_4	587	593	PF00069	0.541
MOD_ProDKin_1	116	122	PF00069	0.610
MOD_ProDKin_1	326	332	PF00069	0.777
MOD_ProDKin_1	339	345	PF00069	0.669
MOD_ProDKin_1	426	432	PF00069	0.393
MOD_ProDKin_1	470	476	PF00069	0.496
MOD_ProDKin_1	702	708	PF00069	0.496
MOD_SUMO_for_1	334	337	PF00179	0.577
MOD_SUMO_rev_2	2	10	PF00179	0.694
MOD_SUMO_rev_2	367	372	PF00179	0.558
MOD_SUMO_rev_2	395	404	PF00179	0.494
TRG_DiLeu_BaEn_1	526	531	PF01217	0.496
TRG_DiLeu_BaEn_1	792	797	PF01217	0.551
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.539
TRG_ENDOCYTIC_2	17	20	PF00928	0.542
TRG_ENDOCYTIC_2	389	392	PF00928	0.572
TRG_ENDOCYTIC_2	466	469	PF00928	0.509
TRG_ENDOCYTIC_2	512	515	PF00928	0.539
TRG_ENDOCYTIC_2	545	548	PF00928	0.561
TRG_ENDOCYTIC_2	579	582	PF00928	0.539
TRG_ENDOCYTIC_2	613	616	PF00928	0.381
TRG_ER_diArg_1	187	189	PF00400	0.725
TRG_ER_diArg_1	214	216	PF00400	0.708
TRG_ER_diArg_1	225	227	PF00400	0.690
TRG_ER_diArg_1	259	261	PF00400	0.686
TRG_ER_diArg_1	266	268	PF00400	0.648
TRG_ER_diArg_1	280	283	PF00400	0.602
TRG_ER_diArg_1	352	354	PF00400	0.726
TRG_ER_diArg_1	361	363	PF00400	0.567
TRG_ER_diArg_1	40	43	PF00400	0.699
TRG_ER_diArg_1	609	611	PF00400	0.403
TRG_ER_diArg_1	672	674	PF00400	0.539
TRG_ER_diArg_1	763	765	PF00400	0.500
TRG_ER_diArg_1	806	808	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	672	677	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	763	768	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW9	Leptomonas seymouri	68%	97%
A0A0S4JDN6	Bodo saltans	49%	100%
A0A3Q8IJ79	Leishmania donovani	80%	94%
A0A3Q8IQY6	Leishmania donovani	36%	100%
A4H4Y0	Leishmania braziliensis	39%	100%
A4HK20	Leishmania braziliensis	50%	100%
A4HP82	Leishmania braziliensis	36%	100%
A4IBK1	Leishmania infantum	79%	93%
A4IDI7	Leishmania infantum	36%	100%
E9AFD4	Leishmania major	91%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B6I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	93%
P24346	Xenopus laevis	39%	100%
Q4Q1K8	Leishmania major	36%	100%
Q4Q5M6	Leishmania major	27%	100%
Q4Q5P5	Leishmania major	49%	100%
Q4QIQ9	Leishmania major	40%	100%