J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMX6_LEIBR

TriTrypDb:

LbrM.34.3000 , LBRM2903_340038600

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	8
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HMX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX6

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.429
CLV_MEL_PAP_1	263	269	PF00089	0.450
CLV_NRD_NRD_1	116	118	PF00675	0.464
CLV_NRD_NRD_1	135	137	PF00675	0.465
CLV_NRD_NRD_1	187	189	PF00675	0.677
CLV_NRD_NRD_1	235	237	PF00675	0.591
CLV_NRD_NRD_1	239	241	PF00675	0.591
CLV_NRD_NRD_1	259	261	PF00675	0.419
CLV_NRD_NRD_1	3	5	PF00675	0.520
CLV_PCSK_FUR_1	133	137	PF00082	0.462
CLV_PCSK_KEX2_1	135	137	PF00082	0.446
CLV_PCSK_KEX2_1	141	143	PF00082	0.425
CLV_PCSK_KEX2_1	185	187	PF00082	0.607
CLV_PCSK_KEX2_1	235	237	PF00082	0.602
CLV_PCSK_KEX2_1	279	281	PF00082	0.610
CLV_PCSK_KEX2_1	3	5	PF00082	0.520
CLV_PCSK_KEX2_1	405	407	PF00082	0.619
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.408
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.607
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.579
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.600
CLV_PCSK_PC7_1	401	407	PF00082	0.620
CLV_PCSK_SKI1_1	142	146	PF00082	0.457
CLV_PCSK_SKI1_1	187	191	PF00082	0.624
CLV_PCSK_SKI1_1	235	239	PF00082	0.628
CLV_PCSK_SKI1_1	3	7	PF00082	0.517
CLV_PCSK_SKI1_1	396	400	PF00082	0.617
CLV_PCSK_SKI1_1	406	410	PF00082	0.579
CLV_PCSK_SKI1_1	95	99	PF00082	0.407
DEG_APCC_DBOX_1	185	193	PF00400	0.417
DEG_APCC_DBOX_1	2	10	PF00400	0.664
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DEG_SCF_FBW7_2	29	35	PF00400	0.466
DOC_CKS1_1	29	34	PF01111	0.457
DOC_CKS1_1	9	14	PF01111	0.564
DOC_CYCLIN_RxL_1	1	11	PF00134	0.561
DOC_CYCLIN_RxL_1	362	372	PF00134	0.402
DOC_CYCLIN_RxL_1	401	413	PF00134	0.267
DOC_MAPK_DCC_7	383	391	PF00069	0.279
DOC_MAPK_gen_1	3	9	PF00069	0.638
DOC_MAPK_MEF2A_6	153	161	PF00069	0.189
DOC_PP1_RVXF_1	363	370	PF00149	0.393
DOC_PP2B_LxvP_1	419	422	PF13499	0.385
DOC_USP7_MATH_1	256	260	PF00917	0.379
DOC_USP7_MATH_1	422	426	PF00917	0.510
DOC_USP7_MATH_1	89	93	PF00917	0.684
DOC_USP7_MATH_1	97	101	PF00917	0.679
DOC_USP7_UBL2_3	351	355	PF12436	0.324
DOC_WW_Pin1_4	17	22	PF00397	0.559
DOC_WW_Pin1_4	28	33	PF00397	0.454
DOC_WW_Pin1_4	332	337	PF00397	0.329
DOC_WW_Pin1_4	8	13	PF00397	0.616
DOC_WW_Pin1_4	99	104	PF00397	0.739
LIG_14-3-3_CanoR_1	235	242	PF00244	0.401
LIG_14-3-3_CanoR_1	266	272	PF00244	0.319
LIG_14-3-3_CanoR_1	377	381	PF00244	0.248
LIG_BRCT_BRCA1_1	263	267	PF00533	0.414
LIG_BRCT_BRCA1_1	90	94	PF00533	0.675
LIG_EH1_1	175	183	PF00400	0.421
LIG_FHA_1	161	167	PF00498	0.389
LIG_FHA_1	356	362	PF00498	0.361
LIG_FHA_2	29	35	PF00498	0.549
LIG_FHA_2	340	346	PF00498	0.273
LIG_FHA_2	408	414	PF00498	0.349
LIG_FHA_2	9	15	PF00498	0.565
LIG_LIR_Apic_2	309	315	PF02991	0.309
LIG_LIR_Gen_1	143	152	PF02991	0.425
LIG_LIR_Gen_1	173	182	PF02991	0.340
LIG_LIR_Gen_1	209	216	PF02991	0.490
LIG_LIR_Gen_1	247	256	PF02991	0.315
LIG_LIR_Gen_1	31	41	PF02991	0.458
LIG_LIR_Gen_1	338	349	PF02991	0.292
LIG_LIR_Nem_3	143	148	PF02991	0.536
LIG_LIR_Nem_3	173	178	PF02991	0.325
LIG_LIR_Nem_3	209	215	PF02991	0.503
LIG_LIR_Nem_3	243	248	PF02991	0.327
LIG_LIR_Nem_3	293	299	PF02991	0.401
LIG_LIR_Nem_3	31	36	PF02991	0.469
LIG_LIR_Nem_3	338	344	PF02991	0.289
LIG_PTB_Apo_2	363	370	PF02174	0.289
LIG_SH2_CRK	175	179	PF00017	0.353
LIG_SH2_CRK	212	216	PF00017	0.486
LIG_SH2_CRK	66	70	PF00017	0.431
LIG_SH2_STAT5	346	349	PF00017	0.391
LIG_SH3_2	12	17	PF14604	0.738
LIG_SH3_3	195	201	PF00018	0.398
LIG_SH3_3	248	254	PF00018	0.341
LIG_SH3_3	26	32	PF00018	0.451
LIG_SH3_3	9	15	PF00018	0.649
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.321
LIG_SUMO_SIM_par_1	165	171	PF11976	0.336
LIG_SUMO_SIM_par_1	199	205	PF11976	0.437
LIG_TRAF2_1	32	35	PF00917	0.529
MOD_CK1_1	13	19	PF00069	0.674
MOD_CK1_1	160	166	PF00069	0.411
MOD_CK1_1	335	341	PF00069	0.325
MOD_CK1_1	407	413	PF00069	0.339
MOD_CK1_1	78	84	PF00069	0.659
MOD_CK2_1	28	34	PF00069	0.540
MOD_CK2_1	339	345	PF00069	0.272
MOD_CK2_1	407	413	PF00069	0.355
MOD_GlcNHglycan	212	215	PF01048	0.586
MOD_GlcNHglycan	312	315	PF01048	0.625
MOD_GlcNHglycan	77	80	PF01048	0.550
MOD_GlcNHglycan	91	94	PF01048	0.576
MOD_GSK3_1	13	20	PF00069	0.633
MOD_GSK3_1	206	213	PF00069	0.504
MOD_GSK3_1	261	268	PF00069	0.332
MOD_GSK3_1	286	293	PF00069	0.414
MOD_GSK3_1	332	339	PF00069	0.339
MOD_GSK3_1	351	358	PF00069	0.362
MOD_GSK3_1	74	81	PF00069	0.686
MOD_GSK3_1	97	104	PF00069	0.756
MOD_NEK2_1	369	374	PF00069	0.427
MOD_NEK2_1	7	12	PF00069	0.724
MOD_NEK2_2	422	427	PF00069	0.532
MOD_PIKK_1	235	241	PF00454	0.392
MOD_PK_1	417	423	PF00069	0.347
MOD_PKA_1	235	241	PF00069	0.392
MOD_PKA_2	235	241	PF00069	0.392
MOD_PKA_2	265	271	PF00069	0.328
MOD_PKA_2	376	382	PF00069	0.235
MOD_PKA_2	73	79	PF00069	0.611
MOD_PKB_1	227	235	PF00069	0.464
MOD_Plk_1	229	235	PF00069	0.465
MOD_Plk_1	417	423	PF00069	0.356
MOD_Plk_4	160	166	PF00069	0.356
MOD_Plk_4	229	235	PF00069	0.502
MOD_ProDKin_1	17	23	PF00069	0.557
MOD_ProDKin_1	28	34	PF00069	0.454
MOD_ProDKin_1	332	338	PF00069	0.329
MOD_ProDKin_1	8	14	PF00069	0.615
MOD_ProDKin_1	99	105	PF00069	0.734
TRG_DiLeu_BaEn_2	146	152	PF01217	0.451
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.555
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.508
TRG_DiLeu_LyEn_5	385	390	PF01217	0.269
TRG_ENDOCYTIC_2	175	178	PF00928	0.318
TRG_ENDOCYTIC_2	212	215	PF00928	0.507
TRG_ENDOCYTIC_2	296	299	PF00928	0.329
TRG_ENDOCYTIC_2	346	349	PF00928	0.329
TRG_ENDOCYTIC_2	66	69	PF00928	0.431
TRG_ER_diArg_1	186	188	PF00400	0.376
TRG_ER_diArg_1	2	4	PF00400	0.661
TRG_ER_diArg_1	226	229	PF00400	0.409
TRG_ER_diArg_1	234	236	PF00400	0.377
TRG_ER_diArg_1	36	39	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P559	Leptomonas seymouri	66%	99%
A0A0S4JM78	Bodo saltans	28%	100%
A0A1X0P5J7	Trypanosomatidae	49%	97%
A0A3Q8IJK4	Leishmania donovani	82%	100%
A0A422MXB6	Trypanosoma rangeli	48%	100%
A4IBK0	Leishmania infantum	82%	100%
C9ZZ44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFD3	Leishmania major	80%	100%
E9B6I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5DUR2	Trypanosoma cruzi	45%	100%