START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMX4_LEIBR

TriTrypDb:

LbrM.34.2980 , LBRM2903_340038400

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	635	639	PF00656	0.541
CLV_MEL_PAP_1	78	84	PF00089	0.389
CLV_NRD_NRD_1	333	335	PF00675	0.485
CLV_NRD_NRD_1	726	728	PF00675	0.446
CLV_PCSK_FUR_1	331	335	PF00082	0.421
CLV_PCSK_KEX2_1	333	335	PF00082	0.532
CLV_PCSK_KEX2_1	504	506	PF00082	0.468
CLV_PCSK_KEX2_1	569	571	PF00082	0.271
CLV_PCSK_KEX2_1	726	728	PF00082	0.447
CLV_PCSK_KEX2_1	805	807	PF00082	0.406
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.468
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.271
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.406
CLV_PCSK_SKI1_1	27	31	PF00082	0.594
CLV_PCSK_SKI1_1	363	367	PF00082	0.296
CLV_PCSK_SKI1_1	530	534	PF00082	0.577
CLV_PCSK_SKI1_1	569	573	PF00082	0.406
CLV_PCSK_SKI1_1	578	582	PF00082	0.376
CLV_PCSK_SKI1_1	591	595	PF00082	0.259
CLV_PCSK_SKI1_1	610	614	PF00082	0.339
CLV_PCSK_SKI1_1	647	651	PF00082	0.502
CLV_PCSK_SKI1_1	806	810	PF00082	0.399
CLV_PCSK_SKI1_1	87	91	PF00082	0.388
DEG_APCC_DBOX_1	427	435	PF00400	0.199
DOC_CYCLIN_RxL_1	644	655	PF00134	0.422
DOC_CYCLIN_yClb5_NLxxxL_5	486	495	PF00134	0.323
DOC_MAPK_gen_1	150	160	PF00069	0.287
DOC_MAPK_gen_1	213	221	PF00069	0.359
DOC_MAPK_gen_1	235	245	PF00069	0.463
DOC_MAPK_gen_1	286	296	PF00069	0.427
DOC_MAPK_gen_1	726	733	PF00069	0.412
DOC_MAPK_gen_1	805	814	PF00069	0.453
DOC_MAPK_MEF2A_6	238	245	PF00069	0.370
DOC_MAPK_MEF2A_6	617	626	PF00069	0.406
DOC_MAPK_MEF2A_6	805	814	PF00069	0.311
DOC_PP1_RVXF_1	114	121	PF00149	0.257
DOC_PP1_RVXF_1	568	575	PF00149	0.477
DOC_PP2B_LxvP_1	172	175	PF13499	0.352
DOC_PP2B_LxvP_1	212	215	PF13499	0.454
DOC_PP2B_LxvP_1	651	654	PF13499	0.537
DOC_PP4_FxxP_1	559	562	PF00568	0.348
DOC_PP4_FxxP_1	642	645	PF00568	0.444
DOC_USP7_MATH_1	447	451	PF00917	0.340
DOC_USP7_MATH_1	465	469	PF00917	0.319
DOC_USP7_MATH_1	50	54	PF00917	0.447
DOC_USP7_MATH_1	510	514	PF00917	0.546
DOC_USP7_MATH_1	645	649	PF00917	0.510
DOC_USP7_MATH_1	800	804	PF00917	0.406
DOC_USP7_MATH_1	98	102	PF00917	0.479
DOC_USP7_UBL2_3	196	200	PF12436	0.459
DOC_USP7_UBL2_3	530	534	PF12436	0.434
DOC_USP7_UBL2_3	805	809	PF12436	0.406
DOC_WW_Pin1_4	538	543	PF00397	0.368
DOC_WW_Pin1_4	813	818	PF00397	0.637
LIG_14-3-3_CanoR_1	186	194	PF00244	0.428
LIG_14-3-3_CanoR_1	289	296	PF00244	0.400
LIG_14-3-3_CanoR_1	32	38	PF00244	0.413
LIG_14-3-3_CanoR_1	363	372	PF00244	0.341
LIG_14-3-3_CanoR_1	432	438	PF00244	0.297
LIG_14-3-3_CanoR_1	578	583	PF00244	0.512
LIG_14-3-3_CanoR_1	591	596	PF00244	0.320
LIG_14-3-3_CanoR_1	698	703	PF00244	0.292
LIG_14-3-3_CanoR_1	75	79	PF00244	0.550
LIG_14-3-3_CanoR_1	795	801	PF00244	0.368
LIG_APCC_ABBA_1	349	354	PF00400	0.272
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.398
LIG_BRCT_BRCA1_1	488	492	PF00533	0.324
LIG_BRCT_BRCA1_1	58	62	PF00533	0.454
LIG_BRCT_BRCA1_1	638	642	PF00533	0.532
LIG_deltaCOP1_diTrp_1	737	740	PF00928	0.474
LIG_deltaCOP1_diTrp_1	74	82	PF00928	0.388
LIG_deltaCOP1_diTrp_1	772	778	PF00928	0.388
LIG_FHA_1	276	282	PF00498	0.405
LIG_FHA_1	367	373	PF00498	0.385
LIG_FHA_1	389	395	PF00498	0.340
LIG_FHA_1	407	413	PF00498	0.291
LIG_FHA_1	590	596	PF00498	0.304
LIG_FHA_1	654	660	PF00498	0.341
LIG_FHA_1	702	708	PF00498	0.452
LIG_FHA_2	121	127	PF00498	0.443
LIG_FHA_2	186	192	PF00498	0.487
LIG_FHA_2	340	346	PF00498	0.364
LIG_FHA_2	393	399	PF00498	0.199
LIG_FHA_2	6	12	PF00498	0.705
LIG_FHA_2	720	726	PF00498	0.501
LIG_KLC1_Yacidic_2	760	764	PF13176	0.445
LIG_LIR_Apic_2	639	645	PF02991	0.482
LIG_LIR_Gen_1	373	383	PF02991	0.199
LIG_LIR_Gen_1	489	498	PF02991	0.325
LIG_LIR_Gen_1	512	521	PF02991	0.418
LIG_LIR_Gen_1	55	62	PF02991	0.347
LIG_LIR_Gen_1	737	748	PF02991	0.422
LIG_LIR_Gen_1	93	100	PF02991	0.397
LIG_LIR_Nem_3	127	133	PF02991	0.326
LIG_LIR_Nem_3	310	316	PF02991	0.448
LIG_LIR_Nem_3	36	40	PF02991	0.464
LIG_LIR_Nem_3	373	379	PF02991	0.222
LIG_LIR_Nem_3	489	495	PF02991	0.592
LIG_LIR_Nem_3	512	517	PF02991	0.424
LIG_LIR_Nem_3	55	61	PF02991	0.344
LIG_LIR_Nem_3	554	558	PF02991	0.337
LIG_LIR_Nem_3	737	743	PF02991	0.393
LIG_LIR_Nem_3	772	778	PF02991	0.329
LIG_LRP6_Inhibitor_1	458	464	PF00058	0.199
LIG_PCNA_PIPBox_1	545	554	PF02747	0.223
LIG_PCNA_yPIPBox_3	432	446	PF02747	0.199
LIG_Pex14_1	579	583	PF04695	0.437
LIG_Pex14_1	58	62	PF04695	0.375
LIG_PTB_Apo_2	785	792	PF02174	0.388
LIG_PTB_Phospho_1	785	791	PF10480	0.387
LIG_Rb_pABgroove_1	346	354	PF01858	0.383
LIG_SH2_CRK	376	380	PF00017	0.221
LIG_SH2_CRK	555	559	PF00017	0.317
LIG_SH2_CRK	590	594	PF00017	0.423
LIG_SH2_STAP1	217	221	PF00017	0.403
LIG_SH2_STAP1	352	356	PF00017	0.376
LIG_SH2_STAT3	776	779	PF00017	0.463
LIG_SH2_STAT5	273	276	PF00017	0.306
LIG_SH2_STAT5	630	633	PF00017	0.586
LIG_SH2_STAT5	762	765	PF00017	0.440
LIG_SH2_STAT5	791	794	PF00017	0.426
LIG_SH3_3	100	106	PF00018	0.521
LIG_SH3_3	408	414	PF00018	0.327
LIG_SH3_3	416	422	PF00018	0.270
LIG_SH3_3	6	12	PF00018	0.613
LIG_SH3_3	623	629	PF00018	0.315
LIG_SUMO_SIM_par_1	239	244	PF11976	0.361
LIG_SUMO_SIM_par_1	522	527	PF11976	0.272
LIG_SUMO_SIM_par_1	729	734	PF11976	0.405
LIG_TRAF2_1	23	26	PF00917	0.495
LIG_TRAF2_1	320	323	PF00917	0.503
LIG_TRAF2_1	438	441	PF00917	0.335
LIG_TRAF2_2	175	180	PF00917	0.429
LIG_TRFH_1	538	542	PF08558	0.373
LIG_TYR_ITIM	588	593	PF00017	0.423
LIG_UBA3_1	143	151	PF00899	0.460
MOD_CK1_1	110	116	PF00069	0.574
MOD_CK1_1	201	207	PF00069	0.536
MOD_CK1_1	381	387	PF00069	0.265
MOD_CK1_1	392	398	PF00069	0.266
MOD_CK1_1	403	409	PF00069	0.280
MOD_CK1_1	497	503	PF00069	0.515
MOD_CK1_1	813	819	PF00069	0.741
MOD_CK2_1	120	126	PF00069	0.438
MOD_CK2_1	20	26	PF00069	0.507
MOD_CK2_1	317	323	PF00069	0.430
MOD_CK2_1	447	453	PF00069	0.364
MOD_CK2_1	465	471	PF00069	0.319
MOD_CK2_1	5	11	PF00069	0.696
MOD_CK2_1	652	658	PF00069	0.447
MOD_CK2_1	719	725	PF00069	0.488
MOD_GlcNHglycan	135	138	PF01048	0.307
MOD_GlcNHglycan	203	206	PF01048	0.678
MOD_GlcNHglycan	281	284	PF01048	0.345
MOD_GlcNHglycan	380	383	PF01048	0.382
MOD_GlcNHglycan	391	394	PF01048	0.281
MOD_GlcNHglycan	471	475	PF01048	0.275
MOD_GlcNHglycan	52	55	PF01048	0.495
MOD_GlcNHglycan	526	529	PF01048	0.359
MOD_GlcNHglycan	585	588	PF01048	0.473
MOD_GlcNHglycan	755	758	PF01048	0.484
MOD_GlcNHglycan	818	821	PF01048	0.600
MOD_GSK3_1	120	127	PF00069	0.338
MOD_GSK3_1	181	188	PF00069	0.463
MOD_GSK3_1	195	202	PF00069	0.500
MOD_GSK3_1	275	282	PF00069	0.436
MOD_GSK3_1	359	366	PF00069	0.446
MOD_GSK3_1	388	395	PF00069	0.294
MOD_GSK3_1	400	407	PF00069	0.290
MOD_GSK3_1	48	55	PF00069	0.475
MOD_GSK3_1	70	77	PF00069	0.517
MOD_GSK3_1	749	756	PF00069	0.442
MOD_GSK3_1	790	797	PF00069	0.440
MOD_LATS_1	277	283	PF00433	0.338
MOD_LATS_1	608	614	PF00433	0.305
MOD_N-GLC_1	118	123	PF02516	0.506
MOD_N-GLC_1	40	45	PF02516	0.448
MOD_N-GLC_1	698	703	PF02516	0.313
MOD_N-GLC_1	793	798	PF02516	0.383
MOD_NEK2_1	199	204	PF00069	0.340
MOD_NEK2_1	275	280	PF00069	0.428
MOD_NEK2_1	281	286	PF00069	0.384
MOD_NEK2_1	300	305	PF00069	0.306
MOD_NEK2_1	309	314	PF00069	0.319
MOD_NEK2_1	33	38	PF00069	0.429
MOD_NEK2_1	433	438	PF00069	0.303
MOD_NEK2_1	477	482	PF00069	0.471
MOD_NEK2_1	486	491	PF00069	0.543
MOD_NEK2_1	494	499	PF00069	0.472
MOD_NEK2_1	551	556	PF00069	0.321
MOD_NEK2_1	666	671	PF00069	0.372
MOD_NEK2_1	693	698	PF00069	0.371
MOD_NEK2_1	790	795	PF00069	0.505
MOD_NEK2_1	90	95	PF00069	0.370
MOD_NEK2_2	149	154	PF00069	0.368
MOD_NEK2_2	195	200	PF00069	0.481
MOD_NEK2_2	215	220	PF00069	0.232
MOD_NEK2_2	375	380	PF00069	0.341
MOD_NEK2_2	800	805	PF00069	0.413
MOD_OFUCOSY	747	753	PF10250	0.259
MOD_PIKK_1	11	17	PF00454	0.490
MOD_PIKK_1	532	538	PF00454	0.482
MOD_PIKK_1	540	546	PF00454	0.474
MOD_PK_1	48	54	PF00069	0.470
MOD_PKA_2	185	191	PF00069	0.479
MOD_PKA_2	285	291	PF00069	0.380
MOD_PKA_2	303	309	PF00069	0.325
MOD_PKA_2	33	39	PF00069	0.442
MOD_PKA_2	74	80	PF00069	0.551
MOD_PKA_2	794	800	PF00069	0.390
MOD_Plk_1	107	113	PF00069	0.608
MOD_Plk_1	118	124	PF00069	0.422
MOD_Plk_1	20	26	PF00069	0.531
MOD_Plk_1	241	247	PF00069	0.358
MOD_Plk_1	269	275	PF00069	0.387
MOD_Plk_1	309	315	PF00069	0.418
MOD_Plk_1	339	345	PF00069	0.400
MOD_Plk_1	400	406	PF00069	0.372
MOD_Plk_1	698	704	PF00069	0.362
MOD_Plk_1	719	725	PF00069	0.485
MOD_Plk_1	736	742	PF00069	0.492
MOD_Plk_1	781	787	PF00069	0.523
MOD_Plk_2-3	20	26	PF00069	0.637
MOD_Plk_2-3	719	725	PF00069	0.476
MOD_Plk_4	107	113	PF00069	0.567
MOD_Plk_4	241	247	PF00069	0.451
MOD_Plk_4	303	309	PF00069	0.464
MOD_Plk_4	392	398	PF00069	0.363
MOD_Plk_4	400	406	PF00069	0.422
MOD_Plk_4	447	453	PF00069	0.208
MOD_Plk_4	5	11	PF00069	0.515
MOD_Plk_4	578	584	PF00069	0.418
MOD_Plk_4	610	616	PF00069	0.333
MOD_Plk_4	666	672	PF00069	0.321
MOD_Plk_4	701	707	PF00069	0.505
MOD_Plk_4	719	725	PF00069	0.435
MOD_Plk_4	781	787	PF00069	0.457
MOD_ProDKin_1	538	544	PF00069	0.360
MOD_ProDKin_1	813	819	PF00069	0.638
MOD_SUMO_rev_2	20	29	PF00179	0.514
TRG_DiLeu_BaEn_2	724	730	PF01217	0.480
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.400
TRG_ENDOCYTIC_2	130	133	PF00928	0.385
TRG_ENDOCYTIC_2	376	379	PF00928	0.305
TRG_ENDOCYTIC_2	555	558	PF00928	0.361
TRG_ENDOCYTIC_2	590	593	PF00928	0.371
TRG_ER_diArg_1	16	19	PF00400	0.675
TRG_ER_diArg_1	330	333	PF00400	0.534
TRG_ER_diArg_1	748	751	PF00400	0.328
TRG_ER_diArg_1	78	81	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	647	652	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	759	764	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV37	Leptomonas seymouri	61%	100%
A0A0S4JPI8	Bodo saltans	26%	100%
A0A1X0P5E4	Trypanosomatidae	32%	100%
A0A3Q8IVD1	Leishmania donovani	83%	100%
A4IBJ5	Leishmania infantum	83%	100%
E9AFD1	Leishmania major	81%	100%
E9B6I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5C2X4	Trypanosoma cruzi	32%	100%