CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMX2_LEIBR

TriTrypDb:

LbrM.34.2960 , LBRM2903_340038200

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.578
CLV_C14_Caspase3-7	92	96	PF00656	0.714
CLV_NRD_NRD_1	142	144	PF00675	0.742
CLV_NRD_NRD_1	254	256	PF00675	0.466
CLV_NRD_NRD_1	405	407	PF00675	0.549
CLV_PCSK_FUR_1	140	144	PF00082	0.749
CLV_PCSK_KEX2_1	142	144	PF00082	0.742
CLV_PCSK_KEX2_1	253	255	PF00082	0.464
CLV_PCSK_KEX2_1	407	409	PF00082	0.537
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.478
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.537
CLV_PCSK_PC7_1	250	256	PF00082	0.495
CLV_PCSK_SKI1_1	216	220	PF00082	0.549
CLV_PCSK_SKI1_1	243	247	PF00082	0.458
CLV_PCSK_SKI1_1	250	254	PF00082	0.438
CLV_PCSK_SKI1_1	285	289	PF00082	0.673
CLV_PCSK_SKI1_1	400	404	PF00082	0.657
CLV_PCSK_SKI1_1	78	82	PF00082	0.721
DEG_SPOP_SBC_1	312	316	PF00917	0.711
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.526
DOC_MAPK_gen_1	173	181	PF00069	0.470
DOC_MAPK_gen_1	213	223	PF00069	0.532
DOC_MAPK_MEF2A_6	175	183	PF00069	0.471
DOC_PP1_RVXF_1	217	224	PF00149	0.614
DOC_PP1_RVXF_1	76	83	PF00149	0.475
DOC_PP2B_LxvP_1	38	41	PF13499	0.576
DOC_PP4_FxxP_1	187	190	PF00568	0.518
DOC_PP4_FxxP_1	82	85	PF00568	0.486
DOC_PP4_FxxP_1	87	90	PF00568	0.439
DOC_USP7_MATH_1	313	317	PF00917	0.769
DOC_USP7_MATH_1	90	94	PF00917	0.753
DOC_USP7_MATH_1	98	102	PF00917	0.683
DOC_WW_Pin1_4	307	312	PF00397	0.795
LIG_14-3-3_CanoR_1	180	184	PF00244	0.663
LIG_14-3-3_CanoR_1	72	80	PF00244	0.621
LIG_14-3-3_CanoR_1	8	15	PF00244	0.480
LIG_BRCT_BRCA1_1	105	109	PF00533	0.500
LIG_BRCT_BRCA1_1	137	141	PF00533	0.720
LIG_BRCT_BRCA1_1	3	7	PF00533	0.478
LIG_BRCT_BRCA1_1	99	103	PF00533	0.711
LIG_FHA_1	319	325	PF00498	0.588
LIG_FHA_1	362	368	PF00498	0.699
LIG_FHA_1	4	10	PF00498	0.404
LIG_FHA_1	51	57	PF00498	0.622
LIG_FHA_2	112	118	PF00498	0.552
LIG_FHA_2	130	136	PF00498	0.533
LIG_FHA_2	234	240	PF00498	0.522
LIG_Integrin_RGD_1	175	177	PF01839	0.687
LIG_LIR_Apic_2	184	190	PF02991	0.547
LIG_LIR_Gen_1	259	269	PF02991	0.669
LIG_LIR_Gen_1	351	361	PF02991	0.542
LIG_LIR_Nem_3	259	264	PF02991	0.534
LIG_PCNA_yPIPBox_3	396	410	PF02747	0.386
LIG_REV1ctd_RIR_1	79	84	PF16727	0.486
LIG_SH2_NCK_1	65	69	PF00017	0.473
LIG_SH2_STAT5	168	171	PF00017	0.629
LIG_SH2_STAT5	194	197	PF00017	0.328
LIG_SH3_3	222	228	PF00018	0.580
LIG_TRAF2_1	116	119	PF00917	0.522
LIG_TRAF2_1	182	185	PF00917	0.470
LIG_TRAF2_1	392	395	PF00917	0.497
LIG_TRAF2_1	41	44	PF00917	0.480
MOD_CK1_1	23	29	PF00069	0.571
MOD_CK1_1	303	309	PF00069	0.752
MOD_CK1_1	315	321	PF00069	0.722
MOD_CK1_1	351	357	PF00069	0.513
MOD_CK1_1	93	99	PF00069	0.657
MOD_CK2_1	111	117	PF00069	0.562
MOD_CK2_1	179	185	PF00069	0.473
MOD_CK2_1	302	308	PF00069	0.802
MOD_Cter_Amidation	404	407	PF01082	0.522
MOD_GlcNHglycan	100	103	PF01048	0.663
MOD_GlcNHglycan	210	213	PF01048	0.631
MOD_GlcNHglycan	75	78	PF01048	0.594
MOD_GSK3_1	179	186	PF00069	0.464
MOD_GSK3_1	268	275	PF00069	0.559
MOD_GSK3_1	299	306	PF00069	0.746
MOD_GSK3_1	307	314	PF00069	0.688
MOD_GSK3_1	315	322	PF00069	0.586
MOD_GSK3_1	89	96	PF00069	0.639
MOD_GSK3_1	98	105	PF00069	0.597
MOD_N-GLC_1	291	296	PF02516	0.773
MOD_N-GLC_1	299	304	PF02516	0.731
MOD_N-GLC_1	98	103	PF02516	0.600
MOD_NEK2_1	1	6	PF00069	0.429
MOD_NEK2_1	103	108	PF00069	0.503
MOD_NEK2_1	183	188	PF00069	0.446
MOD_NEK2_1	20	25	PF00069	0.391
MOD_NEK2_1	283	288	PF00069	0.718
MOD_NEK2_1	361	366	PF00069	0.620
MOD_NEK2_1	49	54	PF00069	0.575
MOD_NEK2_1	80	85	PF00069	0.711
MOD_NEK2_1	9	14	PF00069	0.458
MOD_NEK2_2	3	8	PF00069	0.411
MOD_PIKK_1	390	396	PF00454	0.368
MOD_PKA_2	179	185	PF00069	0.582
MOD_PKA_2	71	77	PF00069	0.619
MOD_Plk_1	183	189	PF00069	0.465
MOD_Plk_1	233	239	PF00069	0.508
MOD_Plk_2-3	111	117	PF00069	0.457
MOD_Plk_2-3	363	369	PF00069	0.706
MOD_Plk_4	20	26	PF00069	0.586
MOD_Plk_4	227	233	PF00069	0.462
MOD_Plk_4	256	262	PF00069	0.615
MOD_ProDKin_1	307	313	PF00069	0.789
TRG_DiLeu_BaEn_3	43	49	PF01217	0.465
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.437
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.562
TRG_ENDOCYTIC_2	149	152	PF00928	0.514
TRG_ENDOCYTIC_2	65	68	PF00928	0.458
TRG_ER_diArg_1	141	143	PF00400	0.629
TRG_ER_diArg_1	254	256	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT3	Leptomonas seymouri	64%	98%
A0A0S4JGE6	Bodo saltans	30%	100%
A0A1X0P6U9	Trypanosomatidae	43%	100%
A0A3Q8IMI0	Leishmania donovani	83%	100%
A0A3S5ISL5	Trypanosoma rangeli	43%	100%
A4IBJ3	Leishmania infantum	84%	100%
C9ZZ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFC9	Leishmania major	83%	99%
E9B6I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5DUR5	Trypanosoma cruzi	43%	100%