Protein-S-isoprenylcysteine O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyl protein specific carboxyl methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMX0_LEIBR

TriTrypDb:

LbrM.34.2940 , LBRM2903_340038000

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HMX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMX0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006481	C-terminal protein methylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018410	C-terminal protein amino acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043687	post-translational protein modification	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity	5	12
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	6	12
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0010340	carboxyl-O-methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0051998	protein carboxyl O-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.372
CLV_C14_Caspase3-7	91	95	PF00656	0.553
CLV_NRD_NRD_1	18	20	PF00675	0.425
CLV_NRD_NRD_1	180	182	PF00675	0.366
CLV_NRD_NRD_1	25	27	PF00675	0.374
CLV_PCSK_KEX2_1	18	20	PF00082	0.410
CLV_PCSK_KEX2_1	180	182	PF00082	0.375
CLV_PCSK_KEX2_1	25	27	PF00082	0.346
DOC_AGCK_PIF_2	75	80	PF00069	0.192
DOC_CYCLIN_RxL_1	22	32	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.256
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.188
DOC_MAPK_gen_1	22	30	PF00069	0.504
DOC_PP4_FxxP_1	85	88	PF00568	0.605
DOC_WW_Pin1_4	10	15	PF00397	0.516
DOC_WW_Pin1_4	99	104	PF00397	0.561
LIG_14-3-3_CanoR_1	161	166	PF00244	0.354
LIG_14-3-3_CanoR_1	180	187	PF00244	0.147
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_FHA_1	100	106	PF00498	0.552
LIG_FHA_1	108	114	PF00498	0.553
LIG_FHA_1	149	155	PF00498	0.353
LIG_FHA_1	186	192	PF00498	0.270
LIG_FHA_1	30	36	PF00498	0.366
LIG_FHA_2	11	17	PF00498	0.499
LIG_FHA_2	54	60	PF00498	0.403
LIG_FHA_2	89	95	PF00498	0.530
LIG_GBD_Chelix_1	73	81	PF00786	0.192
LIG_LIR_Apic_2	118	123	PF02991	0.556
LIG_LIR_Gen_1	94	104	PF02991	0.552
LIG_LIR_Nem_3	227	231	PF02991	0.477
LIG_LIR_Nem_3	250	255	PF02991	0.484
LIG_LIR_Nem_3	94	99	PF02991	0.531
LIG_NRBOX	148	154	PF00104	0.231
LIG_Pex14_2	201	205	PF04695	0.246
LIG_REV1ctd_RIR_1	136	145	PF16727	0.532
LIG_REV1ctd_RIR_1	228	238	PF16727	0.446
LIG_SH2_CRK	192	196	PF00017	0.257
LIG_SH2_NCK_1	120	124	PF00017	0.627
LIG_SH2_NCK_1	237	241	PF00017	0.481
LIG_SH2_PTP2	67	70	PF00017	0.360
LIG_SH2_SRC	104	107	PF00017	0.530
LIG_SH2_SRC	120	123	PF00017	0.435
LIG_SH2_SRC	237	240	PF00017	0.462
LIG_SH2_STAT5	104	107	PF00017	0.516
LIG_SH2_STAT5	194	197	PF00017	0.259
LIG_SH2_STAT5	200	203	PF00017	0.230
LIG_SH2_STAT5	229	232	PF00017	0.532
LIG_SH2_STAT5	247	250	PF00017	0.386
LIG_SH2_STAT5	67	70	PF00017	0.341
LIG_SH3_3	258	264	PF00018	0.500
LIG_SUMO_SIM_anti_2	43	50	PF11976	0.312
LIG_SUMO_SIM_par_1	40	46	PF11976	0.361
LIG_TRAF2_1	236	239	PF00917	0.449
MOD_CK1_1	2	8	PF00069	0.756
MOD_CK2_1	10	16	PF00069	0.569
MOD_GlcNHglycan	145	148	PF01048	0.431
MOD_GlcNHglycan	218	221	PF01048	0.447
MOD_GSK3_1	43	50	PF00069	0.281
MOD_N-GLC_1	107	112	PF02516	0.201
MOD_N-GLC_1	170	175	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.759
MOD_NEK2_1	148	153	PF00069	0.360
MOD_NEK2_1	204	209	PF00069	0.269
MOD_NEK2_1	230	235	PF00069	0.513
MOD_NEK2_1	248	253	PF00069	0.376
MOD_NEK2_1	256	261	PF00069	0.425
MOD_PIKK_1	185	191	PF00454	0.170
MOD_PKA_1	180	186	PF00069	0.186
MOD_PKA_2	179	185	PF00069	0.270
MOD_Plk_1	170	176	PF00069	0.246
MOD_Plk_1	238	244	PF00069	0.488
MOD_Plk_4	161	167	PF00069	0.339
MOD_Plk_4	221	227	PF00069	0.377
MOD_Plk_4	256	262	PF00069	0.497
MOD_Plk_4	40	46	PF00069	0.206
MOD_ProDKin_1	10	16	PF00069	0.511
MOD_ProDKin_1	99	105	PF00069	0.560
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.449
TRG_ENDOCYTIC_2	192	195	PF00928	0.257
TRG_ENDOCYTIC_2	67	70	PF00928	0.360
TRG_ER_diArg_1	17	19	PF00400	0.657
TRG_ER_diArg_1	231	234	PF00400	0.528
TRG_ER_diArg_1	24	26	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P511	Leptomonas seymouri	67%	100%
A0A0S4JHW1	Bodo saltans	44%	100%
A0A1X0P5F1	Trypanosomatidae	49%	100%
A0A3S7X9G8	Leishmania donovani	83%	100%
A0A422P2Y4	Trypanosoma rangeli	49%	100%
A2XX73	Oryza sativa subsp. indica	31%	100%
A4IBJ1	Leishmania infantum	83%	100%
C9ZZ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D6WJ77	Tribolium castaneum	36%	95%
E9AFC7	Leishmania major	83%	100%
E9B6I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O12947	Xenopus laevis	33%	92%
O60725	Homo sapiens	33%	94%
P32584	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P87014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q558K8	Dictyostelium discoideum	32%	100%
Q7XSR9	Oryza sativa subsp. japonica	31%	100%
Q9EQK7	Mus musculus	33%	94%
Q9WVM4	Rattus norvegicus	33%	94%
V5C2X9	Trypanosoma cruzi	48%	100%