1-alkyl-2-acetylglycerophosphocholine esterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase A1, putative

Species:

Leishmania braziliensis

UniProt:

A4HMW9_LEIBR

TriTrypDb:

LbrM.34.2930 , LBRM2903_340037900

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HMW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0016042	lipid catabolic process	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0052689	carboxylic ester hydrolase activity	4	13
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0016298	lipase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.313
CLV_PCSK_KEX2_1	232	234	PF00082	0.471
CLV_PCSK_KEX2_1	287	289	PF00082	0.347
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.466
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.347
CLV_PCSK_SKI1_1	115	119	PF00082	0.488
CLV_PCSK_SKI1_1	307	311	PF00082	0.507
CLV_PCSK_SKI1_1	57	61	PF00082	0.541
DEG_APCC_DBOX_1	106	114	PF00400	0.333
DOC_CKS1_1	323	328	PF01111	0.237
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.237
DOC_MAPK_DCC_7	115	124	PF00069	0.147
DOC_MAPK_gen_1	115	124	PF00069	0.340
DOC_MAPK_MEF2A_6	115	124	PF00069	0.194
DOC_MAPK_MEF2A_6	216	224	PF00069	0.313
DOC_MAPK_MEF2A_6	321	330	PF00069	0.164
DOC_MAPK_MEF2A_6	77	86	PF00069	0.279
DOC_PP1_RVXF_1	374	380	PF00149	0.193
DOC_PP2B_LxvP_1	29	32	PF13499	0.240
DOC_PP4_FxxP_1	323	326	PF00568	0.313
DOC_PP4_MxPP_1	80	83	PF00568	0.313
DOC_SPAK_OSR1_1	65	69	PF12202	0.147
DOC_USP7_MATH_1	15	19	PF00917	0.304
DOC_USP7_MATH_1	413	417	PF00917	0.197
DOC_USP7_MATH_1	44	48	PF00917	0.367
DOC_USP7_MATH_1	89	93	PF00917	0.252
DOC_USP7_UBL2_3	313	317	PF12436	0.259
DOC_WW_Pin1_4	322	327	PF00397	0.237
DOC_WW_Pin1_4	397	402	PF00397	0.266
DOC_WW_Pin1_4	409	414	PF00397	0.261
DOC_WW_Pin1_4	57	62	PF00397	0.365
DOC_WW_Pin1_4	91	96	PF00397	0.282
LIG_14-3-3_CanoR_1	405	409	PF00244	0.301
LIG_AP2alpha_2	299	301	PF02296	0.224
LIG_APCC_ABBA_1	328	333	PF00400	0.237
LIG_BIR_III_4	196	200	PF00653	0.234
LIG_FHA_1	26	32	PF00498	0.292
LIG_FHA_1	323	329	PF00498	0.226
LIG_FHA_1	422	428	PF00498	0.295
LIG_FHA_1	437	443	PF00498	0.487
LIG_FHA_2	183	189	PF00498	0.234
LIG_FHA_2	210	216	PF00498	0.320
LIG_FHA_2	313	319	PF00498	0.281
LIG_FHA_2	356	362	PF00498	0.366
LIG_FHA_2	379	385	PF00498	0.342
LIG_FHA_2	390	396	PF00498	0.339
LIG_LIR_Apic_2	299	304	PF02991	0.213
LIG_LIR_Gen_1	226	234	PF02991	0.277
LIG_LIR_Gen_1	251	260	PF02991	0.198
LIG_LIR_Gen_1	308	318	PF02991	0.252
LIG_LIR_Gen_1	340	350	PF02991	0.210
LIG_LIR_Nem_3	100	104	PF02991	0.289
LIG_LIR_Nem_3	308	314	PF02991	0.313
LIG_LIR_Nem_3	340	345	PF02991	0.205
LIG_LIR_Nem_3	378	382	PF02991	0.258
LIG_PCNA_yPIPBox_3	440	451	PF02747	0.257
LIG_Pex14_2	331	335	PF04695	0.279
LIG_REV1ctd_RIR_1	342	351	PF16727	0.203
LIG_SH2_CRK	116	120	PF00017	0.279
LIG_SH2_CRK	167	171	PF00017	0.217
LIG_SH2_CRK	311	315	PF00017	0.285
LIG_SH2_CRK	457	461	PF00017	0.273
LIG_SH2_NCK_1	245	249	PF00017	0.210
LIG_SH2_PTP2	121	124	PF00017	0.276
LIG_SH2_PTP2	52	55	PF00017	0.295
LIG_SH2_SRC	13	16	PF00017	0.363
LIG_SH2_STAP1	167	171	PF00017	0.224
LIG_SH2_STAP1	342	346	PF00017	0.232
LIG_SH2_STAT5	101	104	PF00017	0.212
LIG_SH2_STAT5	109	112	PF00017	0.192
LIG_SH2_STAT5	121	124	PF00017	0.191
LIG_SH2_STAT5	13	16	PF00017	0.311
LIG_SH2_STAT5	193	196	PF00017	0.314
LIG_SH2_STAT5	253	256	PF00017	0.248
LIG_SH2_STAT5	380	383	PF00017	0.324
LIG_SH2_STAT5	385	388	PF00017	0.305
LIG_SH2_STAT5	52	55	PF00017	0.379
LIG_SH2_STAT5	7	10	PF00017	0.311
LIG_SH3_3	294	300	PF00018	0.278
LIG_SH3_3	83	89	PF00018	0.164
LIG_SH3_5	3	7	PF00018	0.377
LIG_TRAF2_1	358	361	PF00917	0.330
LIG_TYR_ITIM	119	124	PF00017	0.313
LIG_UBA3_1	305	313	PF00899	0.236
MOD_CDK_SPK_2	409	414	PF00069	0.328
MOD_CDK_SPK_2	91	96	PF00069	0.315
MOD_CK1_1	378	384	PF00069	0.347
MOD_CK1_1	391	397	PF00069	0.286
MOD_CK1_1	407	413	PF00069	0.310
MOD_CK2_1	312	318	PF00069	0.268
MOD_CK2_1	355	361	PF00069	0.300
MOD_GlcNHglycan	18	21	PF01048	0.290
MOD_GlcNHglycan	188	192	PF01048	0.419
MOD_GlcNHglycan	235	238	PF01048	0.472
MOD_GlcNHglycan	289	292	PF01048	0.430
MOD_GlcNHglycan	431	434	PF01048	0.571
MOD_GlcNHglycan	91	94	PF01048	0.452
MOD_GSK3_1	16	23	PF00069	0.349
MOD_GSK3_1	277	284	PF00069	0.279
MOD_GSK3_1	287	294	PF00069	0.224
MOD_GSK3_1	33	40	PF00069	0.384
MOD_GSK3_1	385	392	PF00069	0.230
MOD_GSK3_1	403	410	PF00069	0.231
MOD_GSK3_1	87	94	PF00069	0.252
MOD_NEK2_1	129	134	PF00069	0.167
MOD_NEK2_1	166	171	PF00069	0.270
MOD_NEK2_1	182	187	PF00069	0.327
MOD_NEK2_1	25	30	PF00069	0.222
MOD_NEK2_1	305	310	PF00069	0.347
MOD_NEK2_1	37	42	PF00069	0.301
MOD_NEK2_1	375	380	PF00069	0.309
MOD_NEK2_1	403	408	PF00069	0.353
MOD_NEK2_2	7	12	PF00069	0.324
MOD_OFUCOSY	386	393	PF10250	0.481
MOD_OFUCOSY	41	48	PF10250	0.270
MOD_PIKK_1	204	210	PF00454	0.311
MOD_PIKK_1	277	283	PF00454	0.315
MOD_PKA_1	287	293	PF00069	0.147
MOD_PKA_2	224	230	PF00069	0.233
MOD_PKA_2	287	293	PF00069	0.276
MOD_PKA_2	404	410	PF00069	0.223
MOD_PKA_2	413	419	PF00069	0.324
MOD_Plk_2-3	246	252	PF00069	0.252
MOD_Plk_4	166	172	PF00069	0.273
MOD_Plk_4	291	297	PF00069	0.231
MOD_Plk_4	305	311	PF00069	0.285
MOD_Plk_4	33	39	PF00069	0.430
MOD_Plk_4	340	346	PF00069	0.264
MOD_Plk_4	375	381	PF00069	0.302
MOD_Plk_4	404	410	PF00069	0.328
MOD_Plk_4	413	419	PF00069	0.210
MOD_Plk_4	82	88	PF00069	0.324
MOD_ProDKin_1	322	328	PF00069	0.237
MOD_ProDKin_1	397	403	PF00069	0.271
MOD_ProDKin_1	409	415	PF00069	0.259
MOD_ProDKin_1	57	63	PF00069	0.370
MOD_ProDKin_1	91	97	PF00069	0.282
MOD_SUMO_rev_2	279	289	PF00179	0.249
MOD_SUMO_rev_2	369	378	PF00179	0.364
MOD_SUMO_rev_2	432	442	PF00179	0.367
TRG_DiLeu_BaEn_1	106	111	PF01217	0.204
TRG_DiLeu_BaEn_1	360	365	PF01217	0.328
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.147
TRG_ENDOCYTIC_2	101	104	PF00928	0.226
TRG_ENDOCYTIC_2	116	119	PF00928	0.184
TRG_ENDOCYTIC_2	121	124	PF00928	0.237
TRG_ENDOCYTIC_2	167	170	PF00928	0.209
TRG_ENDOCYTIC_2	253	256	PF00928	0.255
TRG_ENDOCYTIC_2	311	314	PF00928	0.302
TRG_ENDOCYTIC_2	342	345	PF00928	0.256
TRG_ENDOCYTIC_2	457	460	PF00928	0.269
TRG_ER_diArg_1	222	225	PF00400	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R1	Leptomonas seymouri	52%	100%
A0A0S4JLQ8	Bodo saltans	30%	97%
A0A1X0P5D8	Trypanosomatidae	34%	100%
A0A1X0P6A2	Trypanosomatidae	23%	100%
A0A3Q8IPQ3	Leishmania donovani	77%	100%
A0A3R7LD50	Trypanosoma rangeli	32%	100%
A0A3R7P367	Trypanosoma rangeli	24%	100%
A4IBJ0	Leishmania infantum	77%	100%
C9ZZ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFC6	Leishmania major	76%	100%
E9B6I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q13093	Homo sapiens	28%	100%
Q28017	Bos taurus	26%	100%
Q28262	Canis lupus familiaris	28%	100%
V5BD01	Trypanosoma cruzi	31%	100%
V5BTH3	Trypanosoma cruzi	29%	100%