LeishMANIAdb
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Calpain catalytic domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Calpain catalytic domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HMW7_LEIBR
TriTrypDb:
LbrM.34.2910 , LBRM2903_340037800 *
Length:
460

Annotations

LeishMANIAdb annotations

Possesses a conserved Fe2+ binding catalytic pocket. Might be involved in some unknown metabolic pathway.. Most similar to Chlamydomonas proteins A0A2K3DQH2 and A0A835WMM9.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HMW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 284 290 PF00089 0.498
CLV_NRD_NRD_1 139 141 PF00675 0.417
CLV_NRD_NRD_1 24 26 PF00675 0.430
CLV_NRD_NRD_1 270 272 PF00675 0.370
CLV_NRD_NRD_1 56 58 PF00675 0.518
CLV_PCSK_KEX2_1 26 28 PF00082 0.428
CLV_PCSK_KEX2_1 270 272 PF00082 0.370
CLV_PCSK_KEX2_1 56 58 PF00082 0.518
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.428
CLV_PCSK_SKI1_1 119 123 PF00082 0.393
CLV_PCSK_SKI1_1 140 144 PF00082 0.375
CLV_PCSK_SKI1_1 343 347 PF00082 0.480
CLV_PCSK_SKI1_1 363 367 PF00082 0.365
CLV_PCSK_SKI1_1 407 411 PF00082 0.443
CLV_Separin_Metazoa 293 297 PF03568 0.595
DEG_APCC_KENBOX_2 101 105 PF00400 0.721
DEG_Nend_Nbox_1 1 3 PF02207 0.428
DEG_SPOP_SBC_1 173 177 PF00917 0.754
DEG_SPOP_SBC_1 400 404 PF00917 0.706
DOC_CYCLIN_RxL_1 401 414 PF00134 0.638
DOC_MAPK_gen_1 343 352 PF00069 0.604
DOC_MAPK_RevD_3 11 26 PF00069 0.369
DOC_PP2B_LxvP_1 11 14 PF13499 0.369
DOC_PP2B_PxIxI_1 412 418 PF00149 0.617
DOC_USP7_MATH_1 157 161 PF00917 0.694
DOC_USP7_MATH_1 173 177 PF00917 0.726
DOC_USP7_MATH_1 203 207 PF00917 0.660
DOC_USP7_MATH_1 345 349 PF00917 0.692
DOC_USP7_MATH_1 365 369 PF00917 0.710
DOC_USP7_MATH_1 400 404 PF00917 0.604
DOC_WW_Pin1_4 241 246 PF00397 0.531
DOC_WW_Pin1_4 278 283 PF00397 0.558
DOC_WW_Pin1_4 377 382 PF00397 0.623
LIG_14-3-3_CanoR_1 128 134 PF00244 0.585
LIG_14-3-3_CanoR_1 225 231 PF00244 0.659
LIG_14-3-3_CanoR_1 296 304 PF00244 0.611
LIG_14-3-3_CanoR_1 401 409 PF00244 0.721
LIG_14-3-3_CanoR_1 83 87 PF00244 0.647
LIG_APCC_ABBA_1 393 398 PF00400 0.533
LIG_BRCT_BRCA1_1 168 172 PF00533 0.605
LIG_CtBP_PxDLS_1 96 102 PF00389 0.744
LIG_DCNL_PONY_1 1 4 PF03556 0.539
LIG_deltaCOP1_diTrp_1 323 326 PF00928 0.540
LIG_deltaCOP1_diTrp_1 414 418 PF00928 0.665
LIG_FHA_1 13 19 PF00498 0.358
LIG_FHA_1 163 169 PF00498 0.587
LIG_FHA_1 185 191 PF00498 0.609
LIG_FHA_1 82 88 PF00498 0.730
LIG_FHA_2 141 147 PF00498 0.576
LIG_FHA_2 175 181 PF00498 0.696
LIG_FHA_2 298 304 PF00498 0.568
LIG_FHA_2 427 433 PF00498 0.718
LIG_FHA_2 46 52 PF00498 0.643
LIG_FHA_2 98 104 PF00498 0.700
LIG_LIR_Gen_1 263 269 PF02991 0.525
LIG_LIR_Gen_1 6 16 PF02991 0.444
LIG_LIR_Nem_3 180 184 PF02991 0.653
LIG_LIR_Nem_3 229 233 PF02991 0.570
LIG_LIR_Nem_3 263 267 PF02991 0.541
LIG_LIR_Nem_3 368 372 PF02991 0.550
LIG_LIR_Nem_3 53 58 PF02991 0.727
LIG_LIR_Nem_3 6 11 PF02991 0.344
LIG_REV1ctd_RIR_1 52 59 PF16727 0.691
LIG_SH2_CRK 250 254 PF00017 0.631
LIG_SH2_CRK 8 12 PF00017 0.444
LIG_SH2_PTP2 264 267 PF00017 0.522
LIG_SH2_STAP1 8 12 PF00017 0.444
LIG_SH2_STAT5 221 224 PF00017 0.619
LIG_SH2_STAT5 240 243 PF00017 0.515
LIG_SH2_STAT5 264 267 PF00017 0.512
LIG_SH2_STAT5 369 372 PF00017 0.706
LIG_SH2_STAT5 453 456 PF00017 0.614
LIG_SH2_STAT5 8 11 PF00017 0.444
LIG_SH3_1 250 256 PF00018 0.641
LIG_SH3_1 338 344 PF00018 0.770
LIG_SH3_2 341 346 PF14604 0.780
LIG_SH3_3 110 116 PF00018 0.671
LIG_SH3_3 250 256 PF00018 0.607
LIG_SH3_3 262 268 PF00018 0.488
LIG_SH3_3 338 344 PF00018 0.770
LIG_SUMO_SIM_par_1 455 460 PF11976 0.691
LIG_WRC_WIRS_1 424 429 PF05994 0.697
MOD_CDK_SPxxK_3 278 285 PF00069 0.584
MOD_CK1_1 171 177 PF00069 0.739
MOD_CK1_1 286 292 PF00069 0.581
MOD_CK1_1 298 304 PF00069 0.572
MOD_CK1_1 380 386 PF00069 0.714
MOD_CK1_1 423 429 PF00069 0.702
MOD_CK1_1 6 12 PF00069 0.444
MOD_CK1_1 88 94 PF00069 0.623
MOD_CK2_1 140 146 PF00069 0.578
MOD_CK2_1 426 432 PF00069 0.739
MOD_CK2_1 97 103 PF00069 0.713
MOD_GlcNHglycan 146 150 PF01048 0.357
MOD_GlcNHglycan 205 208 PF01048 0.454
MOD_GlcNHglycan 309 312 PF01048 0.412
MOD_GlcNHglycan 384 387 PF01048 0.471
MOD_GlcNHglycan 61 64 PF01048 0.525
MOD_GlcNHglycan 87 90 PF01048 0.470
MOD_GSK3_1 129 136 PF00069 0.664
MOD_GSK3_1 158 165 PF00069 0.706
MOD_GSK3_1 168 175 PF00069 0.712
MOD_GSK3_1 330 337 PF00069 0.694
MOD_GSK3_1 373 380 PF00069 0.668
MOD_GSK3_1 401 408 PF00069 0.747
MOD_GSK3_1 81 88 PF00069 0.672
MOD_NEK2_1 172 177 PF00069 0.755
MOD_NEK2_1 184 189 PF00069 0.609
MOD_NEK2_1 21 26 PF00069 0.555
MOD_NEK2_1 81 86 PF00069 0.588
MOD_NEK2_2 39 44 PF00069 0.656
MOD_PK_1 420 426 PF00069 0.689
MOD_PKA_1 140 146 PF00069 0.634
MOD_PKA_2 127 133 PF00069 0.634
MOD_PKA_2 226 232 PF00069 0.596
MOD_PKA_2 286 292 PF00069 0.644
MOD_PKA_2 295 301 PF00069 0.628
MOD_PKA_2 400 406 PF00069 0.705
MOD_PKA_2 82 88 PF00069 0.589
MOD_Plk_2-3 428 434 PF00069 0.714
MOD_Plk_4 174 180 PF00069 0.672
MOD_Plk_4 273 279 PF00069 0.577
MOD_Plk_4 3 9 PF00069 0.287
MOD_Plk_4 330 336 PF00069 0.716
MOD_Plk_4 365 371 PF00069 0.627
MOD_Plk_4 39 45 PF00069 0.650
MOD_Plk_4 82 88 PF00069 0.665
MOD_ProDKin_1 241 247 PF00069 0.533
MOD_ProDKin_1 278 284 PF00069 0.568
MOD_ProDKin_1 377 383 PF00069 0.619
TRG_DiLeu_BaEn_1 195 200 PF01217 0.612
TRG_ENDOCYTIC_2 264 267 PF00928 0.522
TRG_ENDOCYTIC_2 369 372 PF00928 0.706
TRG_ENDOCYTIC_2 453 456 PF00928 0.597
TRG_ENDOCYTIC_2 8 11 PF00928 0.444
TRG_ER_diArg_1 25 28 PF00400 0.629
TRG_ER_diArg_1 269 271 PF00400 0.552
TRG_ER_diArg_1 284 287 PF00400 0.620
TRG_ER_diArg_1 55 57 PF00400 0.705
TRG_NES_CRM1_1 231 242 PF08389 0.617
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 407 412 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3G4 Leptomonas seymouri 60% 95%
A0A1X0P5E8 Trypanosomatidae 48% 100%
A0A3S7X9P9 Leishmania donovani 82% 100%
A4IBI8 Leishmania infantum 83% 100%
C9ZZ52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AFC4 Leishmania major 83% 100%
E9B6H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
V5DUR9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS