CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4HMW6_LEIBR

TriTrypDb:

LbrM.34.2900 , LBRM2903_340037700

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0008408	3'-5' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.275
CLV_NRD_NRD_1	173	175	PF00675	0.268
CLV_NRD_NRD_1	209	211	PF00675	0.276
CLV_NRD_NRD_1	340	342	PF00675	0.527
CLV_PCSK_KEX2_1	173	175	PF00082	0.279
CLV_PCSK_KEX2_1	188	190	PF00082	0.276
CLV_PCSK_KEX2_1	209	211	PF00082	0.276
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.256
CLV_PCSK_PC7_1	205	211	PF00082	0.287
CLV_PCSK_SKI1_1	13	17	PF00082	0.635
CLV_PCSK_SKI1_1	157	161	PF00082	0.287
CLV_PCSK_SKI1_1	166	170	PF00082	0.245
CLV_PCSK_SKI1_1	188	192	PF00082	0.381
CLV_PCSK_SKI1_1	90	94	PF00082	0.200
DEG_Nend_UBRbox_1	1	4	PF02207	0.736
DEG_SCF_FBW7_1	20	26	PF00400	0.617
DOC_ANK_TNKS_1	317	324	PF00023	0.404
DOC_CKS1_1	20	25	PF01111	0.700
DOC_CYCLIN_RxL_1	163	171	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.403
DOC_MAPK_gen_1	101	109	PF00069	0.495
DOC_MAPK_gen_1	188	195	PF00069	0.581
DOC_MAPK_gen_1	90	98	PF00069	0.516
DOC_MAPK_MEF2A_6	101	109	PF00069	0.501
DOC_MAPK_MEF2A_6	188	197	PF00069	0.492
DOC_MAPK_NFAT4_5	188	196	PF00069	0.581
DOC_PP1_RVXF_1	164	171	PF00149	0.487
DOC_USP7_MATH_1	70	74	PF00917	0.529
DOC_WW_Pin1_4	117	122	PF00397	0.565
DOC_WW_Pin1_4	19	24	PF00397	0.687
DOC_WW_Pin1_4	66	71	PF00397	0.510
LIG_14-3-3_CanoR_1	125	129	PF00244	0.501
LIG_14-3-3_CanoR_1	210	216	PF00244	0.501
LIG_14-3-3_CanoR_1	25	33	PF00244	0.694
LIG_14-3-3_CanoR_1	285	291	PF00244	0.390
LIG_14-3-3_CanoR_1	348	352	PF00244	0.554
LIG_BIR_III_2	305	309	PF00653	0.484
LIG_BRCT_BRCA1_1	267	271	PF00533	0.504
LIG_FHA_1	1	7	PF00498	0.675
LIG_FHA_1	118	124	PF00498	0.538
LIG_FHA_1	151	157	PF00498	0.459
LIG_FHA_1	212	218	PF00498	0.517
LIG_FHA_1	232	238	PF00498	0.345
LIG_FHA_1	244	250	PF00498	0.516
LIG_FHA_1	273	279	PF00498	0.538
LIG_FHA_1	311	317	PF00498	0.524
LIG_FHA_2	129	135	PF00498	0.558
LIG_FHA_2	333	339	PF00498	0.442
LIG_FHA_2	86	92	PF00498	0.581
LIG_LIR_Apic_2	317	322	PF02991	0.394
LIG_LIR_Gen_1	56	66	PF02991	0.685
LIG_LIR_Nem_3	10	15	PF02991	0.631
LIG_LIR_Nem_3	251	256	PF02991	0.476
LIG_LIR_Nem_3	268	274	PF02991	0.417
LIG_LIR_Nem_3	338	343	PF02991	0.551
LIG_LIR_Nem_3	56	62	PF02991	0.732
LIG_MLH1_MIPbox_1	267	271	PF16413	0.504
LIG_Pex14_1	315	319	PF04695	0.395
LIG_Rb_pABgroove_1	136	144	PF01858	0.487
LIG_REV1ctd_RIR_1	167	178	PF16727	0.537
LIG_SH2_CRK	83	87	PF00017	0.537
LIG_SH2_PTP2	319	322	PF00017	0.411
LIG_SH2_STAT3	81	84	PF00017	0.418
LIG_SH2_STAT5	215	218	PF00017	0.486
LIG_SH2_STAT5	270	273	PF00017	0.463
LIG_SH2_STAT5	290	293	PF00017	0.388
LIG_SH2_STAT5	319	322	PF00017	0.391
LIG_SH3_3	17	23	PF00018	0.608
LIG_SUMO_SIM_par_1	143	148	PF11976	0.477
LIG_WRC_WIRS_1	325	330	PF05994	0.558
MOD_CDK_SPxK_1	19	25	PF00069	0.720
MOD_CK1_1	115	121	PF00069	0.503
MOD_CK1_1	211	217	PF00069	0.501
MOD_CK1_1	28	34	PF00069	0.706
MOD_CK1_1	43	49	PF00069	0.536
MOD_CK1_1	60	66	PF00069	0.458
MOD_CK1_1	69	75	PF00069	0.475
MOD_CK2_1	332	338	PF00069	0.444
MOD_CK2_1	85	91	PF00069	0.538
MOD_GlcNHglycan	17	20	PF01048	0.666
MOD_GlcNHglycan	210	213	PF01048	0.287
MOD_GlcNHglycan	45	48	PF01048	0.704
MOD_GSK3_1	111	118	PF00069	0.568
MOD_GSK3_1	124	131	PF00069	0.557
MOD_GSK3_1	15	22	PF00069	0.635
MOD_GSK3_1	177	184	PF00069	0.400
MOD_GSK3_1	25	32	PF00069	0.616
MOD_GSK3_1	266	273	PF00069	0.613
MOD_GSK3_1	324	331	PF00069	0.535
MOD_GSK3_1	42	49	PF00069	0.464
MOD_GSK3_1	53	60	PF00069	0.659
MOD_GSK3_1	61	68	PF00069	0.655
MOD_N-GLC_1	60	65	PF02516	0.738
MOD_NEK2_1	128	133	PF00069	0.550
MOD_NEK2_1	145	150	PF00069	0.405
MOD_NEK2_1	15	20	PF00069	0.616
MOD_NEK2_1	195	200	PF00069	0.517
MOD_NEK2_1	266	271	PF00069	0.528
MOD_NEK2_1	328	333	PF00069	0.504
MOD_NEK2_1	33	38	PF00069	0.540
MOD_NEK2_1	378	383	PF00069	0.473
MOD_NEK2_1	99	104	PF00069	0.530
MOD_PIKK_1	150	156	PF00454	0.400
MOD_PIKK_1	178	184	PF00454	0.516
MOD_PIKK_1	25	31	PF00454	0.757
MOD_PIKK_1	272	278	PF00454	0.541
MOD_PK_1	203	209	PF00069	0.487
MOD_PKA_2	124	130	PF00069	0.501
MOD_PKA_2	208	214	PF00069	0.476
MOD_PKA_2	284	290	PF00069	0.389
MOD_PKA_2	347	353	PF00069	0.553
MOD_Plk_1	161	167	PF00069	0.581
MOD_Plk_4	124	130	PF00069	0.537
MOD_Plk_4	181	187	PF00069	0.400
MOD_Plk_4	211	217	PF00069	0.501
MOD_Plk_4	266	272	PF00069	0.588
MOD_ProDKin_1	117	123	PF00069	0.565
MOD_ProDKin_1	19	25	PF00069	0.693
MOD_ProDKin_1	66	72	PF00069	0.504
MOD_SUMO_rev_2	87	95	PF00179	0.581
TRG_ENDOCYTIC_2	83	86	PF00928	0.476
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.756
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS9	Leptomonas seymouri	79%	97%
A0A0S4JGY9	Bodo saltans	50%	100%
A0A1X0P5F6	Trypanosomatidae	67%	100%
A0A3R7KR79	Trypanosoma rangeli	67%	100%
A0A3S7X9G9	Leishmania donovani	88%	100%
A4IBI7	Leishmania infantum	88%	100%
C9ZZ53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AFC3	Leishmania major	88%	100%
E9B6H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BY58	Trypanosoma cruzi	67%	100%