TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMW4_LEIBR

TriTrypDb:

LbrM.34.2880 , LBRM2903_340037400

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.432
CLV_C14_Caspase3-7	368	372	PF00656	0.473
CLV_NRD_NRD_1	216	218	PF00675	0.591
CLV_NRD_NRD_1	318	320	PF00675	0.277
CLV_NRD_NRD_1	354	356	PF00675	0.401
CLV_PCSK_KEX2_1	215	217	PF00082	0.487
CLV_PCSK_SKI1_1	355	359	PF00082	0.505
CLV_PCSK_SKI1_1	6	10	PF00082	0.704
CLV_PCSK_SKI1_1	93	97	PF00082	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SPOP_SBC_1	360	364	PF00917	0.663
DOC_CYCLIN_RxL_1	352	363	PF00134	0.397
DOC_CYCLIN_RxL_1	90	97	PF00134	0.486
DOC_MAPK_gen_1	319	330	PF00069	0.424
DOC_MAPK_gen_1	61	70	PF00069	0.303
DOC_MAPK_MEF2A_6	167	174	PF00069	0.484
DOC_PP2B_LxvP_1	357	360	PF13499	0.613
DOC_USP7_MATH_1	115	119	PF00917	0.547
DOC_USP7_MATH_1	168	172	PF00917	0.705
DOC_USP7_MATH_1	179	183	PF00917	0.596
DOC_USP7_MATH_1	189	193	PF00917	0.684
DOC_USP7_MATH_1	198	202	PF00917	0.554
DOC_USP7_MATH_1	360	364	PF00917	0.689
DOC_WW_Pin1_4	194	199	PF00397	0.802
DOC_WW_Pin1_4	201	206	PF00397	0.654
DOC_WW_Pin1_4	209	214	PF00397	0.557
DOC_WW_Pin1_4	79	84	PF00397	0.421
LIG_14-3-3_CanoR_1	107	112	PF00244	0.340
LIG_14-3-3_CanoR_1	146	156	PF00244	0.483
LIG_14-3-3_CanoR_1	355	360	PF00244	0.374
LIG_AP2alpha_1	133	137	PF02296	0.417
LIG_BRCT_BRCA1_1	13	17	PF00533	0.528
LIG_FHA_1	178	184	PF00498	0.576
LIG_FHA_1	233	239	PF00498	0.365
LIG_FHA_1	7	13	PF00498	0.558
LIG_FHA_1	82	88	PF00498	0.392
LIG_FHA_2	189	195	PF00498	0.680
LIG_FHA_2	202	208	PF00498	0.739
LIG_FHA_2	32	38	PF00498	0.485
LIG_FHA_2	340	346	PF00498	0.552
LIG_FHA_2	366	372	PF00498	0.471
LIG_FHA_2	60	66	PF00498	0.396
LIG_LIR_Apic_2	26	32	PF02991	0.512
LIG_LIR_Gen_1	22	32	PF02991	0.519
LIG_LIR_Gen_1	235	245	PF02991	0.314
LIG_LIR_Nem_3	110	114	PF02991	0.371
LIG_LIR_Nem_3	22	28	PF02991	0.533
LIG_LIR_Nem_3	235	240	PF02991	0.361
LIG_NRBOX	273	279	PF00104	0.380
LIG_NRBOX	90	96	PF00104	0.489
LIG_Pex14_2	133	137	PF04695	0.373
LIG_Pex14_2	25	29	PF04695	0.508
LIG_SH2_SRC	311	314	PF00017	0.372
LIG_SH2_STAP1	267	271	PF00017	0.452
LIG_SH2_STAT5	111	114	PF00017	0.354
LIG_SH2_STAT5	311	314	PF00017	0.328
LIG_SH2_STAT5	42	45	PF00017	0.463
LIG_SH3_3	192	198	PF00018	0.553
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.455
LIG_TRAF2_1	372	375	PF00917	0.753
LIG_TRFH_1	111	115	PF08558	0.361
LIG_UBA3_1	277	281	PF00899	0.352
LIG_UBA3_1	74	81	PF00899	0.402
MOD_CDC14_SPxK_1	212	215	PF00782	0.494
MOD_CDK_SPxK_1	209	215	PF00069	0.504
MOD_CDK_SPxxK_3	209	216	PF00069	0.503
MOD_CK1_1	118	124	PF00069	0.581
MOD_CK1_1	201	207	PF00069	0.689
MOD_CK1_1	211	217	PF00069	0.661
MOD_CK1_1	363	369	PF00069	0.653
MOD_CK1_1	63	69	PF00069	0.346
MOD_CK2_1	118	124	PF00069	0.660
MOD_CK2_1	156	162	PF00069	0.491
MOD_CK2_1	188	194	PF00069	0.760
MOD_CK2_1	222	228	PF00069	0.558
MOD_CK2_1	31	37	PF00069	0.500
MOD_CK2_1	319	325	PF00069	0.273
MOD_CK2_1	339	345	PF00069	0.556
MOD_CK2_1	47	53	PF00069	0.341
MOD_CK2_1	63	69	PF00069	0.285
MOD_GlcNHglycan	117	120	PF01048	0.517
MOD_GlcNHglycan	149	152	PF01048	0.455
MOD_GlcNHglycan	186	189	PF01048	0.754
MOD_GlcNHglycan	191	194	PF01048	0.717
MOD_GlcNHglycan	200	203	PF01048	0.614
MOD_GlcNHglycan	303	307	PF01048	0.398
MOD_GSK3_1	114	121	PF00069	0.544
MOD_GSK3_1	184	191	PF00069	0.584
MOD_GSK3_1	19	26	PF00069	0.502
MOD_GSK3_1	194	201	PF00069	0.612
MOD_GSK3_1	2	9	PF00069	0.712
MOD_GSK3_1	27	34	PF00069	0.572
MOD_GSK3_1	355	362	PF00069	0.559
MOD_GSK3_1	363	370	PF00069	0.654
MOD_GSK3_1	59	66	PF00069	0.339
MOD_N-GLC_1	115	120	PF02516	0.549
MOD_N-GLC_1	19	24	PF02516	0.590
MOD_N-GLC_1	79	84	PF02516	0.446
MOD_N-GLC_2	147	149	PF02516	0.484
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	129	134	PF00069	0.556
MOD_NEK2_1	232	237	PF00069	0.342
MOD_NEK2_1	365	370	PF00069	0.560
MOD_NEK2_1	47	52	PF00069	0.495
MOD_PIKK_1	339	345	PF00454	0.442
MOD_PK_1	217	223	PF00069	0.477
MOD_PKA_1	319	325	PF00069	0.273
MOD_PKA_1	355	361	PF00069	0.383
MOD_PKA_2	60	66	PF00069	0.331
MOD_PKB_1	215	223	PF00069	0.464
MOD_Plk_1	115	121	PF00069	0.615
MOD_Plk_1	232	238	PF00069	0.324
MOD_Plk_1	269	275	PF00069	0.430
MOD_Plk_1	47	53	PF00069	0.473
MOD_Plk_4	107	113	PF00069	0.388
MOD_Plk_4	217	223	PF00069	0.597
MOD_Plk_4	47	53	PF00069	0.588
MOD_Plk_4	63	69	PF00069	0.254
MOD_ProDKin_1	194	200	PF00069	0.800
MOD_ProDKin_1	201	207	PF00069	0.655
MOD_ProDKin_1	209	215	PF00069	0.554
MOD_ProDKin_1	79	85	PF00069	0.423
MOD_SUMO_rev_2	201	211	PF00179	0.651
MOD_SUMO_rev_2	349	358	PF00179	0.449
MOD_SUMO_rev_2	77	83	PF00179	0.425
TRG_DiLeu_BaEn_1	326	331	PF01217	0.368
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.446
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.268
TRG_ENDOCYTIC_2	229	232	PF00928	0.521
TRG_ER_diArg_1	215	217	PF00400	0.487
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE1	Leptomonas seymouri	66%	100%
A0A0S4JHH3	Bodo saltans	48%	100%
A0A1X0P5G2	Trypanosomatidae	55%	100%
A0A3S7X9G6	Leishmania donovani	81%	100%
A0A422P2T5	Trypanosoma rangeli	54%	100%
A4IBI5	Leishmania infantum	80%	100%
C9ZZ56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AFC1	Leishmania major	80%	100%
E9B6H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BD06	Trypanosoma cruzi	55%	100%