UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

denn domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HMW3_LEIBR

TriTrypDb:

LbrM.34.2870 , LBRM2903_340037300

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.513
CLV_C14_Caspase3-7	409	413	PF00656	0.459
CLV_NRD_NRD_1	155	157	PF00675	0.209
CLV_NRD_NRD_1	366	368	PF00675	0.401
CLV_NRD_NRD_1	399	401	PF00675	0.308
CLV_PCSK_KEX2_1	155	157	PF00082	0.209
CLV_PCSK_KEX2_1	366	368	PF00082	0.641
CLV_PCSK_KEX2_1	399	401	PF00082	0.463
CLV_PCSK_SKI1_1	156	160	PF00082	0.416
CLV_PCSK_SKI1_1	399	403	PF00082	0.568
CLV_PCSK_SKI1_1	424	428	PF00082	0.551
CLV_PCSK_SKI1_1	508	512	PF00082	0.410
CLV_PCSK_SKI1_1	545	549	PF00082	0.520
DEG_APCC_DBOX_1	285	293	PF00400	0.462
DEG_APCC_DBOX_1	325	333	PF00400	0.496
DEG_SCF_FBW7_1	70	76	PF00400	0.535
DEG_SPOP_SBC_1	553	557	PF00917	0.603
DOC_CDC14_PxL_1	77	85	PF14671	0.481
DOC_CKS1_1	173	178	PF01111	0.421
DOC_CKS1_1	70	75	PF01111	0.501
DOC_PP1_SILK_1	329	334	PF00149	0.555
DOC_PP2B_LxvP_1	244	247	PF13499	0.377
DOC_PP2B_LxvP_1	266	269	PF13499	0.321
DOC_PP4_FxxP_1	173	176	PF00568	0.348
DOC_PP4_FxxP_1	183	186	PF00568	0.298
DOC_USP7_MATH_1	27	31	PF00917	0.596
DOC_USP7_MATH_1	288	292	PF00917	0.377
DOC_USP7_MATH_1	553	557	PF00917	0.700
DOC_USP7_MATH_1	73	77	PF00917	0.495
DOC_USP7_MATH_1	91	95	PF00917	0.361
DOC_USP7_UBL2_3	159	163	PF12436	0.421
DOC_WW_Pin1_4	128	133	PF00397	0.346
DOC_WW_Pin1_4	163	168	PF00397	0.326
DOC_WW_Pin1_4	172	177	PF00397	0.329
DOC_WW_Pin1_4	401	406	PF00397	0.592
DOC_WW_Pin1_4	69	74	PF00397	0.498
LIG_14-3-3_CanoR_1	189	194	PF00244	0.321
LIG_14-3-3_CanoR_1	384	394	PF00244	0.341
LIG_14-3-3_CanoR_1	514	524	PF00244	0.692
LIG_BRCT_BRCA1_1	100	104	PF00533	0.380
LIG_BRCT_BRCA1_1	31	35	PF00533	0.625
LIG_BRCT_BRCA1_1	318	322	PF00533	0.348
LIG_CtBP_PxDLS_1	176	180	PF00389	0.421
LIG_deltaCOP1_diTrp_1	409	415	PF00928	0.462
LIG_eIF4E_1	140	146	PF01652	0.421
LIG_FHA_1	101	107	PF00498	0.393
LIG_FHA_1	117	123	PF00498	0.338
LIG_FHA_1	194	200	PF00498	0.304
LIG_FHA_1	258	264	PF00498	0.360
LIG_FHA_1	276	282	PF00498	0.201
LIG_FHA_1	390	396	PF00498	0.301
LIG_FHA_1	460	466	PF00498	0.577
LIG_FHA_1	546	552	PF00498	0.731
LIG_FHA_1	60	66	PF00498	0.394
LIG_FHA_2	173	179	PF00498	0.418
LIG_FHA_2	339	345	PF00498	0.404
LIG_FHA_2	433	439	PF00498	0.432
LIG_HOMEOBOX	248	251	PF00046	0.346
LIG_LIR_Apic_2	182	186	PF02991	0.381
LIG_LIR_Apic_2	66	70	PF02991	0.421
LIG_LIR_Gen_1	101	106	PF02991	0.453
LIG_LIR_Gen_1	209	220	PF02991	0.321
LIG_LIR_Gen_1	249	258	PF02991	0.328
LIG_LIR_Gen_1	319	329	PF02991	0.303
LIG_LIR_Gen_1	351	361	PF02991	0.366
LIG_LIR_Gen_1	388	398	PF02991	0.324
LIG_LIR_Gen_1	429	436	PF02991	0.556
LIG_LIR_Gen_1	9	19	PF02991	0.638
LIG_LIR_Nem_3	101	105	PF02991	0.451
LIG_LIR_Nem_3	209	215	PF02991	0.340
LIG_LIR_Nem_3	249	253	PF02991	0.303
LIG_LIR_Nem_3	319	325	PF02991	0.315
LIG_LIR_Nem_3	347	352	PF02991	0.360
LIG_LIR_Nem_3	355	360	PF02991	0.480
LIG_LIR_Nem_3	388	394	PF02991	0.334
LIG_LIR_Nem_3	429	434	PF02991	0.555
LIG_LIR_Nem_3	456	461	PF02991	0.587
LIG_LIR_Nem_3	9	14	PF02991	0.579
LIG_LYPXL_SIV_4	70	78	PF13949	0.539
LIG_LYPXL_yS_3	80	83	PF13949	0.394
LIG_PDZ_Class_2	564	569	PF00595	0.460
LIG_Pex14_1	135	139	PF04695	0.321
LIG_Pex14_1	67	71	PF04695	0.522
LIG_REV1ctd_RIR_1	136	145	PF16727	0.377
LIG_REV1ctd_RIR_1	379	388	PF16727	0.481
LIG_SH2_CRK	102	106	PF00017	0.451
LIG_SH2_CRK	187	191	PF00017	0.302
LIG_SH2_CRK	353	357	PF00017	0.345
LIG_SH2_GRB2like	308	311	PF00017	0.488
LIG_SH2_NCK_1	71	75	PF00017	0.551
LIG_SH2_STAP1	102	106	PF00017	0.451
LIG_SH2_STAP1	353	357	PF00017	0.365
LIG_SH2_STAP1	448	452	PF00017	0.473
LIG_SH2_STAT5	102	105	PF00017	0.404
LIG_SH2_STAT5	144	147	PF00017	0.350
LIG_SH2_STAT5	272	275	PF00017	0.321
LIG_SH2_STAT5	368	371	PF00017	0.397
LIG_SH2_STAT5	71	74	PF00017	0.551
LIG_SH2_STAT5	95	98	PF00017	0.587
LIG_SH3_3	200	206	PF00018	0.316
LIG_SH3_3	253	259	PF00018	0.321
LIG_SH3_3	67	73	PF00018	0.485
LIG_SUMO_SIM_anti_2	290	296	PF11976	0.209
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.501
LIG_SUMO_SIM_par_1	125	131	PF11976	0.346
LIG_SUMO_SIM_par_1	3	10	PF11976	0.457
LIG_SUMO_SIM_par_1	390	397	PF11976	0.388
LIG_SUMO_SIM_par_1	546	552	PF11976	0.512
LIG_SxIP_EBH_1	274	286	PF03271	0.209
LIG_TRAF2_1	435	438	PF00917	0.435
LIG_TRAF2_1	58	61	PF00917	0.619
LIG_TYR_ITIM	100	105	PF00017	0.454
LIG_TYR_ITIM	142	147	PF00017	0.462
LIG_TYR_ITIM	78	83	PF00017	0.524
LIG_UBA3_1	331	338	PF00899	0.576
LIG_UBA3_1	356	363	PF00899	0.527
LIG_WRC_WIRS_1	190	195	PF05994	0.321
LIG_WW_1	269	272	PF00397	0.421
MOD_CK1_1	232	238	PF00069	0.408
MOD_CK1_1	404	410	PF00069	0.558
MOD_CK1_1	490	496	PF00069	0.663
MOD_CK1_1	517	523	PF00069	0.549
MOD_CK1_1	552	558	PF00069	0.600
MOD_CK2_1	432	438	PF00069	0.425
MOD_CK2_1	515	521	PF00069	0.739
MOD_CK2_1	55	61	PF00069	0.585
MOD_CK2_1	554	560	PF00069	0.633
MOD_Cter_Amidation	153	156	PF01082	0.209
MOD_GlcNHglycan	168	171	PF01048	0.321
MOD_GlcNHglycan	318	321	PF01048	0.460
MOD_GlcNHglycan	322	325	PF01048	0.390
MOD_GlcNHglycan	551	554	PF01048	0.663
MOD_GlcNHglycan	57	60	PF01048	0.631
MOD_GSK3_1	100	107	PF00069	0.400
MOD_GSK3_1	162	169	PF00069	0.382
MOD_GSK3_1	189	196	PF00069	0.311
MOD_GSK3_1	23	30	PF00069	0.597
MOD_GSK3_1	316	323	PF00069	0.438
MOD_GSK3_1	344	351	PF00069	0.365
MOD_GSK3_1	385	392	PF00069	0.390
MOD_GSK3_1	528	535	PF00069	0.713
MOD_GSK3_1	545	552	PF00069	0.712
MOD_GSK3_1	55	62	PF00069	0.556
MOD_GSK3_1	554	561	PF00069	0.640
MOD_GSK3_1	65	72	PF00069	0.432
MOD_LATS_1	336	342	PF00433	0.537
MOD_N-GLC_1	229	234	PF02516	0.421
MOD_N-GLC_1	309	314	PF02516	0.532
MOD_NEK2_1	100	105	PF00069	0.367
MOD_NEK2_1	106	111	PF00069	0.429
MOD_NEK2_1	14	19	PF00069	0.435
MOD_NEK2_1	179	184	PF00069	0.369
MOD_NEK2_1	193	198	PF00069	0.237
MOD_NEK2_1	348	353	PF00069	0.338
MOD_NEK2_1	375	380	PF00069	0.480
MOD_NEK2_1	385	390	PF00069	0.344
MOD_NEK2_1	547	552	PF00069	0.747
MOD_NEK2_1	554	559	PF00069	0.734
MOD_NEK2_2	352	357	PF00069	0.461
MOD_OFUCOSY	562	569	PF10250	0.464
MOD_PIKK_1	276	282	PF00454	0.321
MOD_PIKK_1	29	35	PF00454	0.625
MOD_PIKK_1	385	391	PF00454	0.370
MOD_PKA_2	14	20	PF00069	0.409
MOD_PKA_2	515	521	PF00069	0.487
MOD_PKB_1	514	522	PF00069	0.593
MOD_Plk_1	229	235	PF00069	0.395
MOD_Plk_1	23	29	PF00069	0.552
MOD_Plk_1	338	344	PF00069	0.479
MOD_Plk_1	375	381	PF00069	0.419
MOD_Plk_1	496	502	PF00069	0.598
MOD_Plk_1	545	551	PF00069	0.744
MOD_Plk_1	59	65	PF00069	0.452
MOD_Plk_2-3	432	438	PF00069	0.328
MOD_Plk_4	100	106	PF00069	0.356
MOD_Plk_4	14	20	PF00069	0.620
MOD_Plk_4	189	195	PF00069	0.321
MOD_Plk_4	288	294	PF00069	0.462
MOD_Plk_4	327	333	PF00069	0.542
MOD_Plk_4	344	350	PF00069	0.363
MOD_Plk_4	352	358	PF00069	0.391
MOD_Plk_4	496	502	PF00069	0.655
MOD_Plk_4	73	79	PF00069	0.534
MOD_ProDKin_1	128	134	PF00069	0.346
MOD_ProDKin_1	163	169	PF00069	0.326
MOD_ProDKin_1	172	178	PF00069	0.329
MOD_ProDKin_1	401	407	PF00069	0.600
MOD_ProDKin_1	69	75	PF00069	0.498
MOD_SUMO_for_1	362	365	PF00179	0.326
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.372
TRG_ENDOCYTIC_2	102	105	PF00928	0.447
TRG_ENDOCYTIC_2	144	147	PF00928	0.462
TRG_ENDOCYTIC_2	187	190	PF00928	0.302
TRG_ENDOCYTIC_2	353	356	PF00928	0.364
TRG_ENDOCYTIC_2	431	434	PF00928	0.461
TRG_ENDOCYTIC_2	80	83	PF00928	0.394
TRG_ER_diArg_1	155	157	PF00400	0.209
TRG_ER_diArg_1	332	335	PF00400	0.564
TRG_ER_diArg_1	366	368	PF00400	0.580
TRG_ER_diArg_1	398	400	PF00400	0.302
TRG_NES_CRM1_1	209	221	PF08389	0.377
TRG_NES_CRM1_1	280	290	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV44	Leptomonas seymouri	71%	100%
A0A1X0P6A9	Trypanosomatidae	57%	100%
A0A3Q8IGE3	Leishmania donovani	87%	100%
A0A3R7NUK9	Trypanosoma rangeli	55%	100%
A4IBI4	Leishmania infantum	87%	100%
E9AFC0	Leishmania major	86%	100%
E9B6H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q3U1T9	Mus musculus	25%	74%
Q6P3S1	Homo sapiens	23%	73%
V5DUS4	Trypanosoma cruzi	54%	100%