Dolichol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dolichol kinase

Gene product:

dolichol kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMW0_LEIBR

TriTrypDb:

LbrM.34.2840 , LBRM2903_340037000

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HMW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMW0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	9
GO:0019637	organophosphate metabolic process	3	11
GO:0043048	dolichyl monophosphate biosynthetic process	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004168	dolichol kinase activity	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.564
CLV_C14_Caspase3-7	490	494	PF00656	0.294
CLV_NRD_NRD_1	206	208	PF00675	0.432
CLV_NRD_NRD_1	210	212	PF00675	0.390
CLV_NRD_NRD_1	285	287	PF00675	0.283
CLV_NRD_NRD_1	418	420	PF00675	0.328
CLV_PCSK_KEX2_1	206	208	PF00082	0.434
CLV_PCSK_KEX2_1	212	214	PF00082	0.382
CLV_PCSK_KEX2_1	285	287	PF00082	0.276
CLV_PCSK_KEX2_1	418	420	PF00082	0.328
CLV_PCSK_KEX2_1	66	68	PF00082	0.374
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.382
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.316
CLV_PCSK_PC7_1	281	287	PF00082	0.304
CLV_PCSK_SKI1_1	212	216	PF00082	0.270
CLV_PCSK_SKI1_1	286	290	PF00082	0.236
CLV_PCSK_SKI1_1	423	427	PF00082	0.371
DEG_APCC_DBOX_1	346	354	PF00400	0.473
DEG_Nend_UBRbox_3	1	3	PF02207	0.367
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.236
DOC_MAPK_gen_1	211	218	PF00069	0.520
DOC_MAPK_gen_1	285	294	PF00069	0.436
DOC_MAPK_gen_1	69	78	PF00069	0.581
DOC_MAPK_MEF2A_6	211	218	PF00069	0.524
DOC_MAPK_MEF2A_6	22	30	PF00069	0.276
DOC_MAPK_MEF2A_6	355	364	PF00069	0.404
DOC_MAPK_NFAT4_5	22	30	PF00069	0.319
DOC_PP2B_LxvP_1	159	162	PF13499	0.439
DOC_PP2B_LxvP_1	23	26	PF13499	0.302
DOC_PP2B_LxvP_1	495	498	PF13499	0.254
DOC_PP2B_LxvP_1	511	514	PF13499	0.271
DOC_PP4_FxxP_1	546	549	PF00568	0.636
DOC_USP7_MATH_1	13	17	PF00917	0.419
DOC_USP7_MATH_1	434	438	PF00917	0.523
DOC_WW_Pin1_4	295	300	PF00397	0.271
DOC_WW_Pin1_4	41	46	PF00397	0.305
DOC_WW_Pin1_4	538	543	PF00397	0.718
DOC_WW_Pin1_4	545	550	PF00397	0.696
LIG_14-3-3_CanoR_1	211	217	PF00244	0.389
LIG_14-3-3_CanoR_1	255	260	PF00244	0.306
LIG_14-3-3_CanoR_1	418	422	PF00244	0.611
LIG_14-3-3_CanoR_1	533	543	PF00244	0.561
LIG_14-3-3_CanoR_1	67	72	PF00244	0.549
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.680
LIG_BRCT_BRCA1_1	233	237	PF00533	0.317
LIG_BRCT_BRCA1_1	250	254	PF00533	0.349
LIG_BRCT_BRCA1_1	410	414	PF00533	0.388
LIG_eIF4E_1	424	430	PF01652	0.577
LIG_FHA_1	442	448	PF00498	0.453
LIG_FHA_1	9	15	PF00498	0.344
LIG_FHA_2	299	305	PF00498	0.335
LIG_FHA_2	481	487	PF00498	0.354
LIG_HP1_1	498	502	PF01393	0.404
LIG_IRF3_LxIS_1	227	234	PF10401	0.393
LIG_IRF3_LxIS_1	360	367	PF10401	0.303
LIG_LIR_Apic_2	517	522	PF02991	0.633
LIG_LIR_Gen_1	110	120	PF02991	0.349
LIG_LIR_Gen_1	166	176	PF02991	0.295
LIG_LIR_Gen_1	191	197	PF02991	0.568
LIG_LIR_Gen_1	304	315	PF02991	0.236
LIG_LIR_Gen_1	356	366	PF02991	0.404
LIG_LIR_Gen_1	475	484	PF02991	0.283
LIG_LIR_Gen_1	55	64	PF02991	0.289
LIG_LIR_Gen_1	80	91	PF02991	0.335
LIG_LIR_Nem_3	110	115	PF02991	0.370
LIG_LIR_Nem_3	166	171	PF02991	0.345
LIG_LIR_Nem_3	191	196	PF02991	0.533
LIG_LIR_Nem_3	304	310	PF02991	0.247
LIG_LIR_Nem_3	356	362	PF02991	0.271
LIG_LIR_Nem_3	475	479	PF02991	0.276
LIG_LIR_Nem_3	540	546	PF02991	0.707
LIG_LIR_Nem_3	55	59	PF02991	0.289
LIG_LIR_Nem_3	80	86	PF02991	0.335
LIG_LIR_Nem_3	89	95	PF02991	0.424
LIG_NRBOX	507	513	PF00104	0.404
LIG_PCNA_TLS_4	418	426	PF02747	0.618
LIG_PCNA_yPIPBox_3	69	82	PF02747	0.381
LIG_Pex14_1	244	248	PF04695	0.288
LIG_PTB_Apo_2	424	431	PF02174	0.532
LIG_REV1ctd_RIR_1	112	119	PF16727	0.404
LIG_SH2_CRK	246	250	PF00017	0.294
LIG_SH2_CRK	372	376	PF00017	0.239
LIG_SH2_CRK	83	87	PF00017	0.394
LIG_SH2_GRB2like	327	330	PF00017	0.595
LIG_SH2_NCK_1	168	172	PF00017	0.313
LIG_SH2_NCK_1	83	87	PF00017	0.394
LIG_SH2_PTP2	182	185	PF00017	0.313
LIG_SH2_STAP1	168	172	PF00017	0.313
LIG_SH2_STAP1	246	250	PF00017	0.304
LIG_SH2_STAP1	474	478	PF00017	0.369
LIG_SH2_STAP1	49	53	PF00017	0.281
LIG_SH2_STAT3	331	334	PF00017	0.576
LIG_SH2_STAT5	107	110	PF00017	0.318
LIG_SH2_STAT5	112	115	PF00017	0.320
LIG_SH2_STAT5	137	140	PF00017	0.349
LIG_SH2_STAT5	168	171	PF00017	0.316
LIG_SH2_STAT5	182	185	PF00017	0.309
LIG_SH2_STAT5	248	251	PF00017	0.301
LIG_SH2_STAT5	271	274	PF00017	0.349
LIG_SH2_STAT5	335	338	PF00017	0.577
LIG_SH2_STAT5	359	362	PF00017	0.319
LIG_SH2_STAT5	424	427	PF00017	0.539
LIG_SH2_STAT5	56	59	PF00017	0.289
LIG_SH2_STAT5	92	95	PF00017	0.250
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.348
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.289
LIG_SUMO_SIM_par_1	185	191	PF11976	0.389
LIG_SUMO_SIM_par_1	271	277	PF11976	0.290
LIG_SUMO_SIM_par_1	384	389	PF11976	0.320
LIG_SUMO_SIM_par_1	459	465	PF11976	0.343
LIG_SUMO_SIM_par_1	5	11	PF11976	0.340
LIG_TYR_ITIM	54	59	PF00017	0.289
LIG_TYR_ITIM	81	86	PF00017	0.313
LIG_TYR_ITIM	90	95	PF00017	0.239
LIG_TYR_ITSM	164	171	PF00017	0.372
LIG_UBA3_1	508	516	PF00899	0.210
MOD_CDC14_SPxK_1	541	544	PF00782	0.630
MOD_CDK_SPxK_1	538	544	PF00069	0.624
MOD_CK1_1	155	161	PF00069	0.478
MOD_CK1_1	188	194	PF00069	0.400
MOD_CK1_1	202	208	PF00069	0.497
MOD_CK1_1	417	423	PF00069	0.584
MOD_CK1_1	534	540	PF00069	0.646
MOD_CK1_1	548	554	PF00069	0.729
MOD_CK1_1	55	61	PF00069	0.283
MOD_CK2_1	480	486	PF00069	0.302
MOD_GlcNHglycan	109	112	PF01048	0.404
MOD_GlcNHglycan	536	539	PF01048	0.411
MOD_GlcNHglycan	550	553	PF01048	0.429
MOD_GSK3_1	166	173	PF00069	0.339
MOD_GSK3_1	195	202	PF00069	0.582
MOD_GSK3_1	310	317	PF00069	0.285
MOD_GSK3_1	330	337	PF00069	0.402
MOD_GSK3_1	409	416	PF00069	0.294
MOD_GSK3_1	436	443	PF00069	0.524
MOD_GSK3_1	48	55	PF00069	0.280
MOD_GSK3_1	527	534	PF00069	0.692
MOD_GSK3_1	8	15	PF00069	0.370
MOD_N-GLC_1	145	150	PF02516	0.573
MOD_N-GLC_1	434	439	PF02516	0.320
MOD_NEK2_1	129	134	PF00069	0.284
MOD_NEK2_1	218	223	PF00069	0.291
MOD_NEK2_1	231	236	PF00069	0.341
MOD_NEK2_1	249	254	PF00069	0.386
MOD_NEK2_1	310	315	PF00069	0.276
MOD_NEK2_1	364	369	PF00069	0.304
MOD_NEK2_1	413	418	PF00069	0.431
MOD_NEK2_1	48	53	PF00069	0.298
MOD_PIKK_1	330	336	PF00454	0.435
MOD_PK_1	373	379	PF00069	0.367
MOD_PKA_1	212	218	PF00069	0.520
MOD_PKA_2	152	158	PF00069	0.453
MOD_PKA_2	212	218	PF00069	0.433
MOD_PKA_2	280	286	PF00069	0.515
MOD_PKA_2	417	423	PF00069	0.619
MOD_PKB_1	253	261	PF00069	0.284
MOD_PKB_1	371	379	PF00069	0.356
MOD_Plk_1	145	151	PF00069	0.377
MOD_Plk_1	386	392	PF00069	0.284
MOD_Plk_1	434	440	PF00069	0.538
MOD_Plk_4	129	135	PF00069	0.314
MOD_Plk_4	152	158	PF00069	0.418
MOD_Plk_4	185	191	PF00069	0.339
MOD_Plk_4	2	8	PF00069	0.340
MOD_Plk_4	261	267	PF00069	0.207
MOD_Plk_4	298	304	PF00069	0.341
MOD_Plk_4	409	415	PF00069	0.271
MOD_Plk_4	49	55	PF00069	0.288
MOD_Plk_4	77	83	PF00069	0.341
MOD_ProDKin_1	295	301	PF00069	0.271
MOD_ProDKin_1	41	47	PF00069	0.301
MOD_ProDKin_1	538	544	PF00069	0.720
MOD_ProDKin_1	545	551	PF00069	0.696
MOD_SUMO_for_1	62	65	PF00179	0.553
TRG_DiLeu_BaEn_1	20	25	PF01217	0.288
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.321
TRG_ENDOCYTIC_2	112	115	PF00928	0.333
TRG_ENDOCYTIC_2	168	171	PF00928	0.356
TRG_ENDOCYTIC_2	182	185	PF00928	0.404
TRG_ENDOCYTIC_2	246	249	PF00928	0.275
TRG_ENDOCYTIC_2	327	330	PF00928	0.534
TRG_ENDOCYTIC_2	359	362	PF00928	0.404
TRG_ENDOCYTIC_2	372	375	PF00928	0.380
TRG_ENDOCYTIC_2	56	59	PF00928	0.289
TRG_ENDOCYTIC_2	83	86	PF00928	0.338
TRG_ENDOCYTIC_2	92	95	PF00928	0.338
TRG_ER_diArg_1	211	214	PF00400	0.571
TRG_ER_diArg_1	278	281	PF00400	0.554
TRG_ER_diArg_1	284	286	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ90	Leptomonas seymouri	80%	91%
A0A1X0P5F5	Trypanosomatidae	50%	100%
A0A3Q8IJJ2	Leishmania donovani	88%	100%
A0A3R7KY54	Trypanosoma rangeli	51%	100%
A4IBI1	Leishmania infantum	88%	100%
C9ZZ59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9AFB7	Leishmania major	88%	100%
E9B6H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BTH9	Trypanosoma cruzi	50%	100%